Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTCXD1HX)

DOT Name	BPI fold-containing family A member 3 (BPIFA3)
Synonyms	Short palate, lung and nasal epithelium carcinoma-associated protein 3
Gene Name	BPIFA3
Related Disease	Melanoma ( )
UniProt ID	BPIA3_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF01273
Sequence	MMCPLWRLLIFLGLLALPLAPHKQPWPGLAQAHRDNKSTLARIIAQGLIKHNAESRIQNI HFGDRLNASAQVAPGLVGWLISGRKHQQQQESSINITNIQLDCGGIQISFHKEWFSANIS LEFDLELRPSFDNNIVKMCAHMSIVVEFWLEKDEFGRRDLVIGKCDAEPSSVHVAILTEA IPPKMNQFLYNLKENLQKVLPHMVESQVCPLIGEILGQLDVKLLKSLIEQEAAHEPTHHE TSQPSACQAGESPS

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Melanoma	DIS1RRCY	Definitive	Genetic Variation	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of BPI fold-containing family A member 3 (BPIFA3).	[2]
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References

1	Genome-wide association study identifies three new melanoma susceptibility loci.Nat Genet. 2011 Oct 9;43(11):1108-13. doi: 10.1038/ng.959.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.