Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTDN5YLP)

DOT Name	Uncharacterized protein CXorf51A (CXORF51A)
Gene Name	CXORF51A
UniProt ID	CX05A_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAKVTSEPQKPNEDVDEQTPSTSSTKGRKKGKTPRQRRSRSGVKGLKTTRKAKRPLRGSS SQKAGETNTPAGKPKKARGPILRGRYHRLKEKMKKEEADKEQSETSVL

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Uncharacterized protein CXorf51A (CXORF51A).	[1]
Methotrexate	DM2TEOL	Approved	Methotrexate increases the expression of Uncharacterized protein CXorf51A (CXORF51A).	[2]
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References

1	Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
2	Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.