Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTDYE3XK)

DOT Name	Putative protein CASTOR3P (GATS)
Synonyms	CASTOR3 pseudogene; STAG3 opposite strand transcript protein
Gene Name	GATS
UniProt ID	CAST3_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF13840 ; PF18700
Sequence	MSCRGRGAGGRWNSTSWSTGCKLPASPRRVSRCSPTGLIKLAFLFSKTRCKFFSLTETPE DYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGMTKIAKSVIAPLAD QNISVFMLSTYQTDFILVLKRDLPFVTHTLSSEFTILWSVARL

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Brilinta	DMBR01X	Approved	Putative protein CASTOR3P (GATS) increases the Acute coronary syndrome ADR of Brilinta.	[1]
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References

1	Effect of genetic variations on ticagrelor plasma levels and clinical outcomes. Eur Heart J. 2015 Aug 1;36(29):1901-12.