Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTEZ79V2)

DOT Name	Low density lipoprotein (LDLR)
Gene Name	LDLR
UniProt ID	E1B4S5_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF07645
Sequence	IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Isotretinoin	DM4QTBN	Approved	Low density lipoprotein (LDLR) increases the Lipids abnormal ADR of Isotretinoin.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.