| DOT Name |
Pro-neuregulin-4, membrane-bound isoform (NRG4)
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| Synonyms |
Pro-NRG4 |
| Gene Name |
NRG4
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| UniProt ID |
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| 3D Structure |
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| Pfam ID |
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| Sequence |
MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSN
LFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
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| Function |
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
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| KEGG Pathway |
- ErbB sig.ling pathway (hsa04012 )
- Amyotrophic lateral sclerosis (hsa05014 )
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| Reactome Pathway |
- Signaling by ERBB4 (R-HSA-1236394 )
- SHC1 events in ERBB2 signaling (R-HSA-1250196 )
- PI3K events in ERBB4 signaling (R-HSA-1250342 )
- SHC1 events in ERBB4 signaling (R-HSA-1250347 )
- Nuclear signaling by ERBB4 (R-HSA-1251985 )
- PIP3 activates AKT signaling (R-HSA-1257604 )
- GRB2 events in ERBB2 signaling (R-HSA-1963640 )
- PI3K events in ERBB2 signaling (R-HSA-1963642 )
- Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
- RAF/MAP kinase cascade (R-HSA-5673001 )
- ERBB2 Regulates Cell Motility (R-HSA-6785631 )
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
- ERBB2 Activates PTK6 Signaling (R-HSA-8847993 )
- Downregulation of ERBB2 signaling (R-HSA-8863795 )
- Signaling by ERBB2 KD Mutants (R-HSA-9664565 )
- Signaling by ERBB2 TMD/JMD mutants (R-HSA-9665686 )
- Signaling by ERBB2 (R-HSA-1227986 )
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