Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTJG7RMT)

DOT Name	Sorting nexin-11 (SNX11)
Gene Name	SNX11
UniProt ID	SNX11_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	4IKB; 4IKD; 6KOI; 6KOJ; 6KOK
Pfam ID	PF00787
Sequence	MGFWCRMSENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRY REFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDS QLHLFLQSQLSVPEIEACVQGRSTMTVSDAILRYAMSNCGWAQEERQSSSHLAKGDQPKS CCFLPRSGRRSSPSPPPSEEKDHLEVWAPVVDSEVPSLESPTLPPLSSPLCCDFGRPKEG TSTLQSVRRAVGGDHAVPLDPGQLETVLEK
Function	Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

3 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ciclosporin	DMAZJFX	Approved	Ciclosporin increases the expression of Sorting nexin-11 (SNX11).	[1]
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Sorting nexin-11 (SNX11).	[2]
Urethane	DM7NSI0	Phase 4	Urethane increases the expression of Sorting nexin-11 (SNX11).	[3]
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References

1	Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
2	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
3	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.