Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKNYRZR)

DOT Name	Alpha-1,3-galactosyltransferase 2 (A3GALT2)
Synonyms	EC 2.4.1.87; Isoglobotriaosylceramide synthase; iGb3 synthase; iGb3S
Gene Name	A3GALT2
UniProt ID	A3LT2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	2.4.1.87
Pfam ID	PF03414
Sequence	MALKEGLRAWKRIFWRQILLTLGLLGLFLYGLPKFRHLEALIPMGVCPSATMSQLRDNFT GALRPWARPEVLTCTPWGAPIIWDGSFDPDVAKQEARQQNLTIGLTIFAVGRYLEKYLER FLETAEQHFMAGQSVMYYVFTELPGAVPRVALGPGRRLPVERVARERRWQDVSMARMRTL HAALGGLPGREAHFMFCMDVDQHFSGTFGPEALAESVAQLHSWHYHWPSWLLPFERDAHS AAAMAWGQGDFYNHAAVFGGSVAALRGLTAHCAGGLDWDRARGLEARWHDESHLNKFFWL HKPAKVLSPEFCWSPDIGPRAEIRRPRLLWAPKGYRLLRN
Function	Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures.
Tissue Specificity	Expressed in thymus and monocyte derived dendritic cells.
KEGG Pathway	Glycosphingolipid biosynthesis - globo and isoglobo series (hsa00603 ) Metabolic pathways (hsa01100 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Alpha-1,3-galactosyltransferase 2 (A3GALT2).	[1]
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References

1	Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.