Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKPYNWP)

DOT Name Gametogenetin (GGN)
Gene Name GGN
Related Disease
Breast cancer ( )
Breast carcinoma ( )
Hypogonadotropic hypogonadism ( )
Klinefelter syndrome ( )
Spermatogenic failure 69 ( )
UniProt ID
GGN_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15685
Sequence
MGNLQSEPSAGGGSRKVQPSDRAPDSRRTSLVEPEMTSQAMRLTRGLGVWFPGSATPPGL
MVPREPQASPSTLPLTLERPSPVMPPPEEAAAVSAPPPAPAGTLLPGPSKWQKPAGTPVP
RIRRLLEASHRGQGDPPSLRPLKPPPPPRQLSVKDTVPRAPSQFPPPLETWKPPPPLPSE
RQPADRRITPALATPASPPTESQAGPRNQGQTAGRARGGAPPHAGEGEMAQPADSESGLS
LLCKITFKSRPSLAPPAASSSLAAKASLGGGGGGGLFAASGAISYAEVLKQGPLPPGAAR
PLGEVSRGAQEAEGGDGDGEGCSGPPSAPASQARALPPPPYTTFPGSKPKFDWVSAPDGP
ERHFRFNGAGGGIGAPRRRAAALSGPWGSPPPPPEQIHSAPGPRRPAPALLAPPTFIFPA
PTNGEPMRPGPPGLQELPPLPPPTPPPTLQPPALQPTPLPVAPPLTPGLGHKESALAPTA
APALPPALAADQAPAPSPAPAPTVAEPSPPVSAPAPAAAPIKTRTRRNKGSRAARGATRK
DGLHGDGPRERATATVPDSSGGGGGGSGASQTGAANTRAARHWLPFQVLNSCPCKCYCHH
QPRHRRLPRNVSAWLSTSTNHLGEPPWVATIKLSGSLVAKLEHYDLQATHSN
Function May be involved in spermatogenesis.

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Breast cancer DIS7DPX1 Strong Genetic Variation [1]
Breast carcinoma DIS2UE88 Strong Genetic Variation [1]
Hypogonadotropic hypogonadism DIS8JSKR Strong Biomarker [2]
Klinefelter syndrome DISOUI7W Strong Biomarker [2]
Spermatogenic failure 69 DIS6VVNV Limited Autosomal recessive [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Gametogenetin (GGN). [4]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Gametogenetin (GGN). [5]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 increases the expression of Gametogenetin (GGN). [7]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of Gametogenetin (GGN). [6]
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References

1 GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.Breast Cancer Res Treat. 2019 Feb;174(1):65-78. doi: 10.1007/s10549-018-5052-z. Epub 2018 Nov 19.
2 Possible role of androgen receptor gene in therapeutic response of infertile men with hypogonadotropic hypogonadism.Syst Biol Reprod Med. 2019 Aug;65(4):326-332. doi: 10.1080/19396368.2019.1590478. Epub 2019 Apr 28.
3 Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia. Hum Reprod. 2020 Jan 1;35(1):240-252. doi: 10.1093/humrep/dez246.
4 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
5 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
6 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
7 Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-beta-dependent mechanisms. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.