Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTM1JKTC)

DOT Name Sperm acrosome membrane-associated protein 3 (SPACA3)
Synonyms
Cancer/testis antigen 54; CT54; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; Lysozyme-like protein 3; Sperm lysozyme-like protein 1; Sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA
Gene Name SPACA3
Related Disease
Acute myelogenous leukaemia ( )
Neoplasm ( )
Testicular cancer ( )
UniProt ID
SACA3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00062
Sequence
MVSALRGAPLIRVHSSPVSSPSVSGPRRLVSCLSSQSSALSQSGGGSTSAAGIEARSRAL
RRRWCPAGIMLLALVCLLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAY
FTSGFNAAALDYEADGSTNNGIFQINSRRWCSNLTPNVPNVCRMYCSDLLNPNLKDTVIC
AMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
Tissue Specificity The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Acute myelogenous leukaemia DISCSPTN Strong Altered Expression [1]
Neoplasm DISZKGEW Strong Altered Expression [1]
Testicular cancer DIS6HNYO Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Sperm acrosome membrane-associated protein 3 (SPACA3). [2]
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References

1 The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies.Clin Cancer Res. 2004 Oct 1;10(19):6544-50. doi: 10.1158/1078-0432.CCR-04-0911.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.