General Information of Disease (ID: DISCSPTN)

Disease Name Acute myelogenous leukaemia
Synonyms
leukemia, acute myeloid; acute non lymphoblastic leukaemia; leukemia, acute myeloid, susceptibility to; leukemia, acute myelogenous; acute non lymphoblastic leukemia; acute myelogenous leukemias; acute myelocytic leukaemia; acute Nonlymphocytic leukaemia; acute myeloid leukaemia (AML); acute nonlymphocytic leukemia; leukemia, acute myeloid, somatic; acute myeloblastic leukaemia; acute nonlymphocytic leukaemia; leukemia, myelocytic, acute; acute granulocytic leukemia; leukemia, acute myeloid, autosomal dominant, somatic mutation; leukemia, acute myeloid, reduced survival in, somatic; leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation; AML; hematopoeitic - acute Myleogenous leukaemia (AML); acute myeloid leukemia (AML); myeloid leukemia, acute; acute myelocytic leukemia; acute myeloblastic leukemia; hematopoeitic - acute Myleogenous leukemia (AML); AML - acute myeloid leukaemia; acute myelogenous leukaemia; ANLL; AML - acute myeloid leukemia; acute granulocytic leukaemia; acute myelogenous leukemia; acute myeloid leukemia; myeloid leukemia, acute, M4/M4Eo subtype, somatic; acute myeloid leukemia, somatic; acute Nonlymphocytic leukemia
Disease Class 2A41: BCR-ABL1-negative chronic myeloid leukaemia
Definition
Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.
Disease Hierarchy
DISMN944: Myeloid leukaemia
DISDQFDI: Acute leukaemia
DISCSPTN: Acute myelogenous leukaemia
ICD Code
ICD-11
ICD-11: 2A41
ICD-10
ICD-10: C92.2
Expand ICD-11
'XH8AA5
Disease Identifiers
MONDO ID
MONDO_0018874
MESH ID
D015470
UMLS CUI
C0023467
OMIM ID
601626
MedGen ID
9730
HPO ID
HP:0004808
Orphanet ID
519
SNOMED CT ID
1162928000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 15 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aldesleukin DM4YMIS Approved NA [1]
Alemtuzumab DMZL3IV Approved Antibody [2]
Azacitidine DMTA5OE Approved Small molecular drug [3]
Clofarabine DMCVJ86 Approved Small molecular drug [4]
Cytarabine DMZD5QR Approved Small molecular drug [5]
Daunorubicin DMQUSBT Approved Small molecular drug [6]
Decitabine DMQL8XJ Approved Small molecular drug [7]
Doxorubicin DMVP5YE Approved Small molecular drug [8]
Etoposide DMNH3PG Approved Small molecular drug [9]
Fludarabine DMVRLT7 Approved Small molecular drug [10]
Idarubicin DMM0XGL Approved Small molecular drug [11]
Mitoxantrone DMM39BF Approved Small molecular drug [12]
Sulindac DM2QHZU Approved Small molecular drug [13]
Thioguanine DM7NKEV Approved Small molecular drug [14]
Tretinoin DM49DUI Approved Small molecular drug [15]
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⏷ Show the Full List of 15 Drug(s)
This Disease is Treated as An Indication in 11 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AG-221 DMS0ZBI Phase 3 NA [16]
CP-868596 DMZIM37 Phase 3 Small molecular drug [16]
MLN4924 DMP36KD Phase 3 Small molecular drug [16]
Sapacitabine DM704AN Phase 3 Small molecular drug [16]
Nerofe DMVVBY8 Phase 2 Peptide [17]
CUDC-907 DMHIQDC Phase 1/2 Small molecular drug [18]
GTB-3550 DMK2RIB Phase 1/2 Recombinant protein [19]
HuM-195-Ac-225 DMIU1HY Phase 1/2 NA [16]
OXi4503 DM8133S Phase 1/2 Small molecular drug [16]
NK100 DMC4HT7 Phase 1 Cell therapy [20]
Tepoditamab DMC84Y9 Phase 1 Antibody [21]
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⏷ Show the Full List of 11 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 689 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABL2 TT1A6HL Limited Genetic Variation [22]
AGR2 TT9K86S Limited Genetic Variation [23]
AGRP TT4DE1O Limited Genetic Variation [24]
AHCY TTE2KUJ Limited Altered Expression [25]
AKR1C3 TT5ZWB6 Limited Biomarker [26]
ANG TTURHFP Limited Altered Expression [27]
ANPEP TTPHMWB Limited Altered Expression [28]
APOBEC3G TTP96KH Limited Altered Expression [29]
ASRGL1 TT4WT91 Limited Biomarker [30]
ATG7 TTLVB9Z Limited Altered Expression [31]
AXL TTZPY6J Limited Genetic Variation [32]
BAK1 TTFM7V0 Limited Biomarker [33]
BCL11A TTR61MW Limited Altered Expression [34]
BMI1 TTIPNSR Limited Biomarker [35]
BMP1 TT0L58T Limited Biomarker [36]
BTG1 TTL7N2W Limited Biomarker [37]
BUB1 TT78309 Limited Altered Expression [38]
CACNA2D3 TTN7T29 Limited Genetic Variation [23]
CALR TTUZ7OA Limited Biomarker [39]
CASP2 TT12VNG Limited Altered Expression [40]
CASP9 TTB6T7O Limited Altered Expression [41]
CASR TTBUYHA Limited Biomarker [42]
CCL17 TTMPHAE Limited Altered Expression [43]
CCL22 TTBTWI1 Limited Altered Expression [43]
CCND3 TT1JXNR Limited Genetic Variation [44]
CCNE2 TTLDRGX Limited Biomarker [45]
CD14 TT6I7DC Limited Biomarker [46]
CD19 TTW640A Limited Biomarker [42]
CD1A TTBGTFN Limited Biomarker [47]
CD2 TTJDUNO Limited Biomarker [48]
CD200 TT0BE68 Limited Altered Expression [49]
CD274 TT8ZLTI Limited Biomarker [50]
CD40 TT1ERKL Limited Altered Expression [51]
CD47 TT28S46 Limited Biomarker [52]
CD58 TT5KSBY Limited Biomarker [53]
CD59 TTBGTEJ Limited Biomarker [54]
CD80 TT89Z17 Limited Biomarker [55]
CDA TTQ12RK Limited Biomarker [56]
CDC25A TTLZS4Q Limited Biomarker [57]
CDC25B TTR0SWN Limited Altered Expression [58]
CDCA8 TT04YCM Limited Genetic Variation [23]
CDK1 TTH6V3D Limited Altered Expression [59]
CDK5R1 TTBYM6V Limited Genetic Variation [60]
CDK8 TTBJR4L Limited Altered Expression [61]
CDK9 TT1LVF2 Limited Biomarker [62]
CEBPB TTUI35N Limited Biomarker [63]
CES1 TTMF541 Limited Altered Expression [64]
CHN2 TT39YVO Limited Genetic Variation [23]
CHRNA1 TT54JVQ Limited Genetic Variation [23]
CHRNA7 TTLA931 Limited Genetic Variation [23]
CNTLN TT8MI6U Limited Genetic Variation [23]
CSF1 TT0IQER Limited Biomarker [65]
CTLA4 TTI2S1D Limited Altered Expression [66]
CXCL12 TT4UGTF Limited Biomarker [67]
CXCR4 TTBID49 Limited Biomarker [67]
CYP1A2 TTS1DTU Limited Biomarker [68]
DDIT4 TTVEOY6 Limited Altered Expression [69]
DKK1 TTE3RAC Limited Altered Expression [70]
DNMT3B TT6VZ78 Limited Altered Expression [71]
DPP10 TTOVUPC Limited Genetic Variation [23]
E2F1 TTASI04 Limited Altered Expression [72]
EGR1 TTE8LGD Limited Biomarker [73]
EIF4E TTZGCP6 Limited Altered Expression [74]
EIF4EBP1 TTKGEBL Limited Biomarker [75]
ELANE TTPLTSQ Limited Altered Expression [76]
ENG TTB30LE Limited Altered Expression [77]
EPHB2 TTKPV6O Limited Posttranslational Modification [78]
ETS2 TT9AH0M Limited Altered Expression [79]
EZH1 TTNJA0C Limited Altered Expression [80]
FCGR2B TT5RWKQ Limited Biomarker [81]
FES TTLBY21 Limited Biomarker [44]
FGF1 TTMY81X Limited Genetic Variation [82]
FGF4 TTCEKVZ Limited Biomarker [83]
FKBP4 TTHY0FT Limited Genetic Variation [84]
FLT1 TT1VAUK Limited Biomarker [85]
FOLR1 TTVC37M Limited Biomarker [86]
FUS TTKGYZ9 Limited Altered Expression [87]
FUT4 TTNV1KZ Limited Altered Expression [88]
FYN TT2B9KF Limited Altered Expression [89]
G6PD TTKN8W0 Limited Biomarker [90]
GCLM TTNFESW Limited Altered Expression [91]
GGT1 TTZVT7O Limited Genetic Variation [92]
GLI1 TTJOMH6 Limited Altered Expression [93]
HDAC1 TT6R7JZ Limited Biomarker [94]
HDAC10 TTYHPU6 Limited Genetic Variation [23]
HDAC9 TT8M4E1 Limited Biomarker [95]
HEXIM1 TTFOKAH Limited Biomarker [96]
HLA-G TTLKFB3 Limited Altered Expression [97]
HOXA13 TTN26OM Limited Genetic Variation [98]
HPGDS TTCYE56 Limited Genetic Variation [99]
HSP90AA1 TT78R5H Limited Biomarker [100]
IDO1 TTZJYKH Limited Biomarker [101]
IL17F TT2B6PS Limited Genetic Variation [102]
IL2 TTF89GD Limited Biomarker [103]
IL2RB TT9721Y Limited Altered Expression [104]
INPP5D TTTP2Z1 Limited Genetic Variation [105]
ITGA4 TTJMF9P Limited Altered Expression [106]
ITGA6 TT165T3 Limited Biomarker [107]
ITGAM TTB69FJ Limited Biomarker [108]
JAK1 TT6DM01 Limited Biomarker [109]
KDM7A TT0NYMP Limited Genetic Variation [23]
KDR TTUTJGQ Limited Biomarker [110]
KIR2DL1 TT4UXPE Limited Genetic Variation [111]
KLRK1 TTLRN4A Limited Biomarker [112]
LGALS3 TTFPQV7 Limited Biomarker [113]
LIF TTGZ5WN Limited Altered Expression [114]
LINGO1 TTZYQ80 Limited Genetic Variation [23]
LRP1 TTF2V7I Limited Genetic Variation [115]
MAP2K7 TT6QY3J Limited Biomarker [116]
MAP3K20 TTTUZ3O Limited Altered Expression [117]
MAP3K7 TTJQT60 Limited Altered Expression [118]
MAPK10 TT056SO Limited Genetic Variation [23]
MAPK12 TTYT93M Limited Genetic Variation [23]
MAPK8 TT0K6EO Limited Biomarker [119]
MAZ TT059DA Limited Altered Expression [120]
MCL1 TTL53M6 Limited Altered Expression [121]
MET TTNDSF4 Limited Genetic Variation [122]
METAP2 TTZL0OI Limited Genetic Variation [23]
MLANA TT362RB Limited Biomarker [123]
MME TT5TKPM Limited Biomarker [46]
MSI2 TTTXQF6 Limited Biomarker [124]
MSLN TT4RXME Limited Altered Expression [125]
MTDH TTH6SA5 Limited Biomarker [126]
MVD TTE5J6X Limited Biomarker [127]
MYB TT8V13P Limited Biomarker [128]
NCR1 TTQNRJM Limited Altered Expression [129]
NEDD8 TTNDC4K Limited Biomarker [62]
NFKB2 TTKLNRV Limited Genetic Variation [84]
NQO1 TT8XK6L Limited Genetic Variation [130]
NR1H3 TTECBXN Limited Altered Expression [131]
NR1I3 TTRANFM Limited Biomarker [42]
NR4A1 TTMXE2Q Limited Biomarker [132]
NR4A3 TTJQB49 Limited Posttranslational Modification [133]
NT5E TTK0O6Y Limited Biomarker [134]
NTF3 TTZHKV9 Limited Genetic Variation [135]
PAM TTF4ZPC Limited Genetic Variation [23]
PARP1 TTVDSZ0 Limited Biomarker [136]
PCSK5 TTPFWHU Limited Genetic Variation [23]
PCSK6 TT75LN9 Limited Genetic Variation [23]
PDE4D TTSKMI8 Limited Genetic Variation [23]
PDE5A TTJ0IQB Limited Genetic Variation [23]
PDGFRA TT8FYO9 Limited Biomarker [137]
PF4 TTSG7Q5 Limited Altered Expression [138]
PIM1 TTTN5QW Limited Altered Expression [139]
PIM3 TTCGOIN Limited Biomarker [140]
PLA2G4C TTBYG4O Limited Genetic Variation [23]
PLK1 TTH4IP0 Limited Biomarker [141]
PLK2 TT976FS Limited Biomarker [142]
PLN TTMCVJF Limited Biomarker [143]
PRKAR1A TTNAHEX Limited Biomarker [42]
PRKCQ TT1MS7X Limited Genetic Variation [23]
PTAFR TTQL5VC Limited Biomarker [144]
PTGS1 TT8NGED Limited Genetic Variation [23]
PTK2B TTTEFBV Limited Biomarker [145]
PTPN11 TT7WUAV Limited Genetic Variation [146]
PTPN14 TTNIR6C Limited Genetic Variation [23]
RASA1 TTPNZ1F Limited Genetic Variation [147]
RBCK1 TTIKUVC Limited Genetic Variation [23]
RHCG TTN5MZ3 Limited Genetic Variation [23]
ROBO1 TTND1YP Limited Genetic Variation [23]
RPS6KA2 TT0ZW9O Limited Genetic Variation [23]
RRM1 TTWP0NS Limited Genetic Variation [148]
RUNX2 TTD6SZ8 Limited Altered Expression [149]
S100A6 TT716MY Limited Altered Expression [150]
S100A8 TT4AF6N Limited Altered Expression [151]
SATB1 TTLFRIC Limited Biomarker [152]
SLC26A4 TT7X02I Limited Biomarker [153]
TERF1 TT1Y6J2 Limited Altered Expression [154]
THRA TTTSEPU Limited Biomarker [155]
TIE1 TTT4236 Limited Altered Expression [156]
TK1 TTP3QRF Limited Biomarker [157]
TMBIM6 TT7QSMG Limited Biomarker [158]
TNFRSF10B TTW20TU Limited Altered Expression [159]
TOP1 TTGTQHC Limited Genetic Variation [160]
TPP1 TTOVYPT Limited Altered Expression [161]
TPSD1 TTNWD8O Limited Altered Expression [162]
TPT1 TT3PTB6 Limited Genetic Variation [60]
TRIM24 TT9Q7AE Limited Altered Expression [163]
USP44 TTJLTNM Limited Genetic Variation [23]
XIAP TTK3WBU Limited Biomarker [164]
XPO1 TTCJUR4 Limited Genetic Variation [165]
ABCC8 TTP835K Disputed Genetic Variation [166]
ANXA2 TT4YANI Disputed Biomarker [167]
CDK4 TT0PG8F Disputed Biomarker [168]
CNR2 TTMSFAW Disputed Altered Expression [169]
CSF2RA TT6MP2Z Disputed Altered Expression [170]
FOLR2 TTT54CI Disputed Biomarker [171]
HSF1 TTN6STZ Disputed Biomarker [172]
HSP90AB1 TTH5YN2 Disputed Altered Expression [173]
IRF3 TTYR7OH Disputed Biomarker [174]
KEAP1 TT3Z6Y9 Disputed Biomarker [175]
SELE TT1PL7M Disputed Biomarker [176]
SIRT2 TTLKF5M Disputed Altered Expression [177]
TMPRSS11D TTWHYC8 Disputed Biomarker [178]
UGCG TTPHEX3 Disputed Biomarker [179]
VDR TTK59TV Disputed Altered Expression [180]
ABCC3 TTVLG21 moderate Genetic Variation [181]
AKR1B1 TTFBNVI moderate Biomarker [182]
AKT2 TTH24WI moderate Genetic Variation [23]
APP TTE4KHA moderate Biomarker [128]
ASIC2 TTVMWLP moderate Genetic Variation [23]
CACNA1B TT4FDG6 moderate Genetic Variation [23]
CACNA1E TTYRP0M moderate Genetic Variation [23]
CACNA2D1 TTFK1JQ moderate Genetic Variation [23]
CALCA TTVSFJW moderate Biomarker [183]
CD96 TT83C4X moderate Biomarker [184]
CHEK2 TT9ABMF Moderate Autosomal dominant [185]
CRTC1 TT4GO0F moderate Genetic Variation [23]
CTAG1A TTE5ITK moderate Biomarker [186]
CXXC5 TTVS4C3 moderate Altered Expression [187]
CYP3A4 TTWP7HQ moderate Altered Expression [188]
DCK TTJOCE4 moderate Genetic Variation [189]
DCLK1 TTOHTCY moderate Genetic Variation [23]
DLK1 TTF4AVB moderate Genetic Variation [190]
EPHA3 TTHS2LR moderate Biomarker [191]
EPHA4 TTG84D3 moderate Genetic Variation [23]
EPHA6 TTFAHWI moderate Genetic Variation [23]
ERBB4 TTWALCO moderate Genetic Variation [23]
ETS1 TTTGPSD moderate Altered Expression [192]
F12 TTRJSMV moderate Genetic Variation [23]
FABP4 TTHWMFZ moderate Biomarker [193]
FCER2 TTCH6MU moderate Genetic Variation [23]
FDXR TT3W4IX moderate Biomarker [182]
FTO TTFW3BT moderate Biomarker [194]
GPR39 TTTPCNU moderate Genetic Variation [23]
GRIA4 TTPJR0G moderate Genetic Variation [23]
GRIK5 TTO6LI7 moderate Genetic Variation [23]
GRIN2B TTN9D8E moderate Genetic Variation [23]
GRK5 TTTCXO0 moderate Genetic Variation [23]
HDAC3 TT4YWTO moderate Biomarker [195]
HDAC4 TTTQGH8 moderate Genetic Variation [23]
HMGA2 TTSTVM0 moderate Altered Expression [196]
IGFBP2 TTU4QSN moderate Biomarker [197]
IL15 TTJFA35 moderate Biomarker [198]
IL15RA TTGN89I moderate Genetic Variation [23]
KCNB2 TT5PFNG moderate Genetic Variation [23]
KCNH1 TT9XKUC moderate Genetic Variation [23]
KCNN1 TT9R6BE moderate Genetic Variation [23]
KISS1 TTU2O6T moderate Genetic Variation [23]
LYZ TTAOZBW moderate Altered Expression [199]
MAP3K19 TTRHJA3 moderate Genetic Variation [23]
MMP3 TTUZ2L5 moderate Genetic Variation [23]
MTTP TTUS1RD moderate Biomarker [200]
NR5A2 TTAU3SY moderate Biomarker [201]
NRP1 TTIPJCB moderate Genetic Variation [23]
PABPC1 TTHC8EF moderate Genetic Variation [23]
PDCD1 TTNBFWK moderate Biomarker [202]
PDGFD TTSN0GA moderate Genetic Variation [23]
PEBP1 TT1BGU8 moderate Biomarker [203]
PHGDH TT8DRCK moderate Genetic Variation [23]
PIN1 TTJNTSI moderate Altered Expression [204]
PRTN3 TT5MLC4 moderate Biomarker [205]
RARG TT1Q3IE moderate Biomarker [206]
ROR1 TTDEJAU moderate Genetic Variation [23]
RPSA TTLUW5B moderate Biomarker [207]
S100A3 TTCDFR1 moderate Altered Expression [208]
SELL TT2IYXF moderate Biomarker [209]
SGCG TTSMT9W moderate Genetic Variation [23]
SLC1A6 TT6KMPN moderate Genetic Variation [23]
SLC30A8 TTXIGT7 moderate Genetic Variation [23]
SMYD3 TTKLJYX moderate Genetic Variation [23]
STAB1 TTJFEOC moderate Genetic Variation [23]
SYK TT2HUPM moderate Biomarker [210]
TF TT8WXAV moderate Genetic Variation [23]
TLR2 TTY7ZHS moderate Biomarker [211]
TLR9 TTSHG0T moderate Genetic Variation [212]
TNFRSF18 TTG6LA7 moderate Biomarker [213]
TOP2B TT4NVEM moderate Altered Expression [214]
USP13 TTVJIO2 moderate Genetic Variation [23]
WEE1 TTJFOAL moderate Biomarker [215]
WRN TT2H5WQ moderate Genetic Variation [23]
ZAP70 TTUMHT8 moderate Genetic Variation [23]
ABCC2 TTFLHJV Strong Altered Expression [216]
ACKR3 TTRQJTC Strong Biomarker [217]
ACLY TT0Z6Y2 Strong Altered Expression [218]
ADGRL1 TTM5OJN Strong Altered Expression [219]
ADGRL3 TTQST3U Strong Genetic Variation [219]
ADM TTV14YH Strong Biomarker [220]
ADRA1A TTNGILX Strong Biomarker [217]
ADRA2B TTWM4TY Strong Biomarker [217]
ANGPT1 TTWNQ1T Strong Biomarker [221]
ANGPT2 TTKLQTJ Strong Biomarker [222]
ANK1 TTKFPMH Strong Altered Expression [223]
ANXA5 TT2Z83I Strong Biomarker [224]
ANXA8 TTSW16P Strong Altered Expression [225]
APOA4 TTNC3WS Strong Altered Expression [226]
AQP9 TTQEI32 Strong Therapeutic [227]
ARHGEF3 TT1R5DZ Strong Altered Expression [228]
ATR TT8ZYBQ Strong Biomarker [229]
AURKA TTPS3C0 Strong Biomarker [230]
AURKB TT9RTBL Strong Biomarker [231]
BBC3 TT7JUKC Strong Altered Expression [232]
BCAT1 TTES57P Strong Altered Expression [233]
BCL2A1 TTGT9C7 Strong Biomarker [234]
BCL2L1 TTRE6AX Strong Biomarker [235]
BMPR2 TTGKF90 Strong Altered Expression [236]
BMX TTN2I9E Strong Biomarker [237]
BRCA2 TTUARD6 Strong Genetic Variation [238]
BRD4 TTSRAOU Strong Biomarker [141]
BRD9 TTR7L5Y Strong Altered Expression [239]
BRIP1 TTZV7LJ Strong Biomarker [240]
BRS3 TTKYEPM Strong Biomarker [217]
BTLA TTER58P Strong Biomarker [241]
C5AR1 TTHXFA1 Strong Biomarker [242]
CACNA1G TT729IR Strong Posttranslational Modification [243]
CALCRL TTY6O0Q Strong Altered Expression [244]
CAPN1 TT1WBIJ Strong Biomarker [245]
CAPN2 TTG5QB7 Strong Biomarker [224]
CARM1 TTIZQFJ Strong Biomarker [246]
CASP7 TTM7Y45 Strong Biomarker [224]
CBL TT7QT13 Strong Genetic Variation [247]
CBS TTVZJ7G Strong Altered Expression [248]
CCL3 TT8I4WB Strong Biomarker [249]
CCN1 TTPK79J Strong Genetic Variation [250]
CD27 TTDO1MV Strong Biomarker [251]
CD276 TT6CQUM Strong Altered Expression [252]
CD300A TTI2YFK Strong Altered Expression [253]
CD44 TTWFBT7 Strong Biomarker [113]
CD52 TTQT5S9 Strong Altered Expression [254]
CD55 TT5Z9WY Strong Biomarker [255]
CD7 TTP6B8O Strong Biomarker [256]
CD70 TTNCIE0 Strong Biomarker [251]
CD74 TTCMYP9 Strong Biomarker [113]
CD86 TT53XHB Strong Altered Expression [257]
CD9 TTZEIBV Strong Altered Expression [258]
CDC25C TTESBNC Strong Biomarker [259]
CDH2 TT1WS0T Strong Altered Expression [260]
CDK19 TTNABU9 Strong Altered Expression [261]
CDK6 TTO0FDJ Strong Biomarker [262]
CDK7 TTQYF7G Strong Biomarker [263]
CDKL1 TTBTI6P Strong Biomarker [264]
CDKN1C TTBSUAR Strong Genetic Variation [265]
CEL TTTRNQW Strong Genetic Variation [266]
CFLAR TTJZQYH Strong Biomarker [267]
CGA TTFC29G Strong Genetic Variation [268]
CGB3 TTUH273 Strong Genetic Variation [268]
CHIT1 TTDYX6T Strong Genetic Variation [269]
CLEC4C TT7YT06 Strong Genetic Variation [23]
CMA1 TT8VUE0 Strong Altered Expression [270]
CNTFR TTT2F9E Strong Biomarker [271]
CR1 TTEA8OW Strong Biomarker [255]
CREBBP TTFRCTK Strong Genetic Variation [272]
CRLF2 TTRMZ0N Strong Genetic Variation [273]
CSNK1A1 TTFQEMX Strong Biomarker [263]
CTCFL TTY0RZT Strong Biomarker [274]
CTDSP1 TTHZAF0 Strong Biomarker [275]
CTSG TTQAJF1 Strong Biomarker [276]
CTSH TT3G406 Strong Biomarker [224]
CTSK TTDZN01 Strong Biomarker [277]
CXCL2 TTZF0K2 Strong Biomarker [278]
CXCL9 TTWE5PB Strong Biomarker [279]
CXCR6 TT2BVUA Strong Biomarker [217]
CYBB TT5T8MR Strong Biomarker [280]
CYP2C19 TTZ58XG Strong Genetic Variation [281]
CYP2D6 TTVG215 Strong Genetic Variation [282]
CYP2E1 TTWVHQ5 Strong Genetic Variation [23]
DBH TTYIP79 Strong Biomarker [283]
DHODH TTLVP78 Strong Biomarker [284]
DICER1 TTTEOPU Strong Altered Expression [285]
DOT1L TTSZ8T1 Strong Biomarker [286]
DPP8 TTJGLZF Strong Biomarker [287]
DPP9 TTNDUL7 Strong Biomarker [287]
DYRK1A TTSBVFO Strong Biomarker [288]
E2F3 TTWIJYH Strong Altered Expression [289]
EBI3 TTJF68X Strong Biomarker [290]
EDNRA TTKRD0G Strong Biomarker [217]
EGFL7 TT7WD0H Strong Biomarker [291]
EHMT2 TTS6RZT Strong Biomarker [292]
EIF2AK2 TTXEZJ4 Strong Biomarker [293]
ENAH TTY36UA Strong Biomarker [294]
EP300 TTGH73N Strong Altered Expression [295]
EPHA1 TTLFZVU Strong Altered Expression [296]
EPHB4 TTI4ZX2 Strong Biomarker [297]
ERN1 TTKIAT3 Strong Biomarker [298]
ESRRB TTKF0XS Strong Biomarker [299]
EYA2 TTUY9C6 Strong Biomarker [300]
F11R TT3C8EG Strong Biomarker [178]
F2R TTL935N Strong Altered Expression [301]
FANCA TTV5HJS Strong Biomarker [240]
FANCF TTNZKFJ Strong Biomarker [240]
FAS TT7LTUJ Strong Altered Expression [302]
FCGR1A TTZK4I3 Strong Biomarker [303]
FCGR3A TTIFOC0 Strong Biomarker [112]
FCGRT TTKLPHO Strong Biomarker [304]
FER TTRA9G0 Strong Genetic Variation [305]
FGF19 TTGCH11 Strong Altered Expression [306]
FHIT TTMS54D Strong Genetic Variation [23]
FOXM1 TTD3KOX Strong Biomarker [307]
FOXP1 TT0MUCI Strong Genetic Variation [23]
FTH1 TT975ZT Strong Altered Expression [308]
GAS6 TT69QD2 Strong Altered Expression [309]
GHRHR TTG4R8V Strong Biomarker [310]
GLI2 TT045OH Strong Biomarker [311]
GLIPR1 TTEQF1O Strong Biomarker [312]
GLUL TTURQ2G Strong Biomarker [313]
GPER1 TTDSB34 Strong Biomarker [314]
GPR132 TTNBW4F Strong Biomarker [315]
GPR84 TTG0MQD Strong Biomarker [316]
GPRC5D TTHRAPJ Strong Biomarker [315]
GRN TT0LWE3 Strong Biomarker [166]
GUSB TTHS7CM Strong Biomarker [317]
GZMB TTKEPHX Strong Altered Expression [318]
HCK TT42OGM Strong Biomarker [319]
HDAC2 TTSHTOI Strong Biomarker [320]
HDAC8 TTT6LFV Strong Biomarker [321]
HDC TTV9GOF Strong Biomarker [103]
HGF TT4V2JM Strong Biomarker [65]
HMOX1 TTI6V2A Strong Biomarker [322]
HNF4A TT2F3CD Strong Biomarker [323]
HNRNPA1 TTPJ9XK Strong Biomarker [324]
HOXA11 TTEX4ZA Strong Altered Expression [325]
HOXA5 TTXSVQP Strong Posttranslational Modification [326]
HOXA7 TTMRE4Q Strong Biomarker [327]
HSPA9 TTMTPG3 Strong Biomarker [328]
HSPB1 TT9AZWY Strong Altered Expression [329]
HTR1B TTK8CXU Strong Altered Expression [330]
ICOS TTE5VP6 Strong Altered Expression [331]
ID1 TTBXVDE Strong Altered Expression [332]
IFNAR1 TTSYFMA Strong Biomarker [333]
IGFBP7 TTUQ01B Strong Biomarker [334]
IKZF2 TTKT5NV Strong Biomarker [335]
IL1R1 TTWOTEA Strong Biomarker [336]
IL1RAP TTWS50K Strong Biomarker [337]
IL7 TT8FRMO Strong Altered Expression [220]
IMP3 TTEJA2R Strong Biomarker [338]
IRAK1 TTXAJWN Strong Biomarker [339]
IRAK4 TTILUKB Strong Biomarker [340]
IRF8 TTHUBNK Strong Genetic Variation [341]
ITGAL TT48WR6 Strong Altered Expression [342]
ITGAV TTT1R2L Strong Altered Expression [343]
ITGB2 TTIJWR7 Strong Biomarker [344]
ITPR1 TT5HWAT Strong Altered Expression [345]
JUN TTS7IR5 Strong Biomarker [346]
KAT6B TTH4VJL Strong Genetic Variation [347]
KCNH2 TTQ6VDM Strong Altered Expression [348]
KCNJ5 TTEO25X Strong Biomarker [349]
KDM1A TTNR0UQ Strong Altered Expression [350]
KDM4A TTZHPB8 Strong Biomarker [351]
KDM4C TTV8CRH Strong Biomarker [352]
KDM5A TTIG67W Strong Biomarker [353]
KDM5B TTCLI75 Strong Biomarker [353]
KDM6B TTDIJUQ Strong Biomarker [354]
KIR2DS2 TTV3CFI Strong Genetic Variation [355]
KLF4 TTTI53X Strong Biomarker [356]
LAG3 TTNVXAW Strong Biomarker [66]
LAIR1 TTSI7A8 Strong Biomarker [357]
LAMP2 TTULDG7 Strong Altered Expression [358]
LATS2 TTML7FG Strong Altered Expression [359]
LCK TT860QF Strong Biomarker [360]
LIFR TTID542 Strong Genetic Variation [361]
LILRB2 TTHC6XU Strong Biomarker [362]
LILRB4 TTREOKA Strong Altered Expression [363]
LIN28A TTO50LN Strong Biomarker [364]
LIPE TTLUQ8E Strong Biomarker [365]
LONP1 TTM1VPZ Strong Altered Expression [139]
LPAR1 TTQ6S1K Strong Biomarker [224]
LPAR2 TTB7Y8I Strong Biomarker [217]
LTB TTHQ6US Strong Altered Expression [366]
LYN TT1RWNJ Strong Biomarker [367]
MAGEA3 TTWSKHD Strong Altered Expression [368]
MAP3K10 TT9FN4J Strong Biomarker [369]
MAP3K5 TTOQCD8 Strong Biomarker [370]
MAP4K1 TTSHWUP Strong Altered Expression [371]
MAPK7 TTU6FSC Strong Biomarker [372]
MARK2 TTAJ45Y Strong Biomarker [373]
MELK TTBZOTY Strong Biomarker [374]
MERTK TTO7LKR Strong Altered Expression [375]
MIA TT5HNVS Strong Biomarker [310]
MKNK1 TTEZAUX Strong Biomarker [376]
MKNK2 TTRECN3 Strong Biomarker [377]
MPL TTIHYA4 Strong Biomarker [378]
MS4A1 TTUE541 Strong Biomarker [379]
MSI1 TTSM4BA Strong Biomarker [124]
MUC1 TTBHFYQ Strong Altered Expression [380]
NCF1 TTZ4JC3 Strong Biomarker [381]
NES TTHZ752 Strong Altered Expression [382]
NME1 TTDY8JH Strong Genetic Variation [383]
NOP2 TTBLG3H Strong Biomarker [384]
NOTCH2 TT82FVD Strong Altered Expression [385]
NOTCH4 TTXDIK2 Strong Genetic Variation [386]
NR1H2 TTXA6PH Strong Genetic Variation [387]
NRP2 TTRXUVC Strong Biomarker [388]
NSD1 TTTSJ3H Strong Genetic Variation [389]
OGG1 TTRU01G Strong Altered Expression [390]
P2RY14 TT72OKI Strong Altered Expression [391]
PAK4 TT7Y3BZ Strong Biomarker [392]
PARG TT39J16 Strong Biomarker [393]
PAWR TT3I4WV Strong Altered Expression [394]
PBK TTMY6BZ Strong Altered Expression [395]
PDCD1LG2 TTW14O3 Strong Altered Expression [396]
PDE4B TTVIAT9 Strong Biomarker [224]
PDGFRB TTI7421 Strong Biomarker [397]
PDK1 TTCZOF2 Strong Altered Expression [398]
PDK2 TTJGCKM Strong Altered Expression [399]
PDK3 TTDEQIP Strong Altered Expression [399]
PFKFB3 TTTHMQJ Strong Biomarker [400]
PIM2 TT69J2Z Strong Altered Expression [401]
PLAUR TTNOSTX Strong Altered Expression [402]
PLCB1 TTLPGU7 Strong Biomarker [403]
PLCG1 TT6T4JI Strong Altered Expression [404]
PMEL TT8MK59 Strong Biomarker [405]
PPME1 TTXQ54R Strong Altered Expression [406]
PRDX4 TTPBL9I Strong Altered Expression [407]
PRDX5 TTLPJWH Strong Altered Expression [408]
PREP TTNGKET Strong Biomarker [409]
PRKCA TTFJ8Q1 Strong Biomarker [410]
PRKCD TT7A1BO Strong Altered Expression [411]
PRKCH TTONI0R Strong Altered Expression [412]
PRKDC TTK3PY9 Strong Genetic Variation [413]
PRMT1 TTVOJAI Strong Biomarker [414]
PRMT5 TTR1D7X Strong Altered Expression [415]
PSMB9 TTOUSTQ Strong Genetic Variation [416]
PTBP1 TTWMX0U Strong Biomarker [417]
PTK7 TTXH2ZN Strong Altered Expression [418]
PTP4A2 TT1MHKD Strong Altered Expression [419]
PTP4A3 TT7YM8D Strong Biomarker [420]
PTPRC TTUS45N Strong Biomarker [421]
RAC1 TT2M9CG Strong Altered Expression [422]
REL TT1ZCTH Strong Biomarker [423]
REN TTB2MXP Strong Biomarker [424]
RET TT4DXQT Strong Biomarker [425]
RGS2 TTKB7T3 Strong Biomarker [224]
RNF6 TT4S09X Strong Biomarker [426]
ROBO4 TT3S9TY Strong Altered Expression [427]
RPS6KA1 TTIXKA4 Strong Biomarker [428]
RPS6KA3 TTUM2ZR Strong Biomarker [429]
RTN4R TTVRZUO Strong Biomarker [430]
RUNX1 TTWIN3H Strong Autosomal dominant [185]
RXRA TT6PEUO Strong Altered Expression [431]
S100A9 TT0TMQG Strong Altered Expression [432]
S1PR2 TTVSMOH Strong Biomarker [433]
S1PR3 TTDYP7I Strong Altered Expression [434]
SCN4A TT84DRB Strong Biomarker [220]
SELPLG TTS5K8U Strong Biomarker [435]
SEMA3A TTVKD3S Strong Altered Expression [436]
SEPTIN6 TTAGE7U Strong Altered Expression [437]
SF3B1 TTL2WUI Strong Altered Expression [121]
SGK1 TTTV8EJ Strong Biomarker [224]
SIK1 TT1H6LC Strong Biomarker [438]
SIK3 TTW6L4V Strong Biomarker [439]
SLC12A3 TTP362L Strong Biomarker [440]
SLC19A1 TT09I7D Strong Genetic Variation [441]
SLC22A16 TTITAVR Strong Altered Expression [442]
SLC29A1 TTLXAKE Strong Altered Expression [443]
SLC38A1 TT1YE9Z Strong Biomarker [444]
SLC3A2 TT5CZSM Strong Biomarker [445]
SLC40A1 TT6Y1PG Strong Altered Expression [446]
SLC7A5 TTPH2JB Strong Biomarker [445]
SLCO1B1 TTFGXEB Strong Biomarker [447]
SMAD1 TT9GR53 Strong Biomarker [448]
SMAD6 TTON5JB Strong Altered Expression [448]
SMYD2 TT7YJFO Strong Altered Expression [449]
SOCS3 TTI0ME6 Strong Posttranslational Modification [450]
SPARC TTBQFM7 Strong Biomarker [451]
SPTBN1 TTS9BDA Strong Genetic Variation [23]
SRGN TTCHB06 Strong Altered Expression [452]
SRPK1 TTU3WV6 Strong Biomarker [453]
SRR TTZFUY6 Strong Altered Expression [454]
SSTR4 TTAE1BR Strong Biomarker [217]
STAT3 TTHJT3X Strong Altered Expression [396]
STAT6 TTWOE1T Strong Biomarker [455]
STC1 TTDLUER Strong Altered Expression [456]
TBK1 TTMP03S Strong Biomarker [457]
TBX21 TTNF9PH Strong Altered Expression [458]
TDG TTEXRQD Strong Biomarker [459]
TEK TT9VGXW Strong Genetic Variation [460]
TERT TTQY2EJ Strong Autosomal dominant [185]
TERT TTQY2EJ Strong Biomarker [461]
TFRC TT8MG4S Strong Biomarker [462]
THPO TTCG5PE Strong Biomarker [463]
TIAM1 TTNU6I5 Strong Altered Expression [464]
TIGIT TTWNL74 Strong Altered Expression [465]
TLR7 TTRJ1K4 Strong Biomarker [466]
TNFRSF11A TT3K9S2 Strong Biomarker [467]
TNFRSF14 TTWGTC1 Strong Altered Expression [241]
TNFRSF1B TT63WSF Strong Altered Expression [468]
TNFRSF4 TTL31H0 Strong Biomarker [331]
TNFRSF8 TT2GM5R Strong Biomarker [469]
TNFRSF9 TTPW9LJ Strong Biomarker [470]
TNFSF10 TTA5MS9 Strong Biomarker [471]
TNFSF13 TTOI1RM Strong Biomarker [472]
TNFSF4 TTBW580 Strong Biomarker [331]
TNKS TTVUSO7 Strong Genetic Variation [473]
TOP2A TTCGY2K Strong Biomarker [474]
TRAF6 TTCDR6M Strong Biomarker [475]
TRH TT2Z39D Strong Biomarker [476]
TRPM2 TTEBMN7 Strong Altered Expression [477]
TRPV2 TTBECWA Strong Biomarker [478]
TSG101 TTHU7JA Strong Biomarker [479]
TUBB2A TTJ2PTI Strong Biomarker [224]
TUSC2 TTJ8O14 Strong Altered Expression [87]
TXNIP TTTLDZK Strong Altered Expression [480]
TXNRD1 TTR7UJ3 Strong Biomarker [481]
UBE2E2 TTXJEOF Strong Biomarker [482]
UBE2T TT0A1R8 Strong Biomarker [240]
ULK1 TT4D7MJ Strong Altered Expression [483]
USP10 TT5IH09 Strong Biomarker [484]
USP2 TTUEQ1W Strong Biomarker [485]
VEGFC TT0QUFV Strong Biomarker [486]
VEGFD TTOM5H4 Strong Biomarker [487]
VSIR TT51SK8 Strong Biomarker [488]
WAS TTE8T73 Strong Genetic Variation [489]
WNK1 TTJ9UMX Strong Biomarker [490]
WNT5A TTKG7F8 Strong Biomarker [323]
WWP1 TTBWMKT Strong Biomarker [491]
ABCC4 TTUEAFL Definitive Genetic Variation [492]
ADAMTS13 TTUREBK Definitive Altered Expression [493]
ALOX12 TT12ABZ Definitive Biomarker [494]
ALPI TTHYMUV Definitive Biomarker [495]
ATF4 TTQCKWT Definitive Genetic Variation [496]
BACH1 TT2ME4S Definitive Biomarker [497]
BIRC2 TTQ5LRD Definitive Altered Expression [498]
CBLB TTHRAIJ Definitive Genetic Variation [499]
CBR1 TTVG0SN Definitive Altered Expression [500]
CBX7 TTBN3HC Definitive Altered Expression [501]
CCL11 TTCF05Y Definitive Altered Expression [502]
CD22 TTM6QSK Definitive Altered Expression [503]
CEBPA TT5LWG1 Definitive Autosomal dominant [504]
COASY TT4YO0Z Definitive Altered Expression [505]
COL18A1 TT63DI9 Definitive Genetic Variation [23]
CSF1R TT7MRDV Definitive Altered Expression [65]
CXCL13 TT0NIZ1 Definitive Posttranslational Modification [506]
DCPS TTLSW9V Definitive Biomarker [507]
DDX58 TTVB0O3 Definitive Biomarker [508]
DFFB TT2SRE0 Definitive Biomarker [509]
DIABLO TTN74LE Definitive Altered Expression [510]
DLL4 TTV23LH Definitive Altered Expression [511]
DNMT3L TT3FDAV Definitive Genetic Variation [512]
ENPP3 TTD4TKP Definitive Biomarker [513]
FAT1 TTGUJYV Definitive Altered Expression [514]
FGR TTPOGS1 Definitive Altered Expression [515]
FOXO1 TTLRVIA Definitive Biomarker [516]
FSCN1 TTTRS9B Definitive Biomarker [517]
GGH TTZJRL0 Definitive Genetic Variation [518]
GPRC6A TTI1PRE Definitive Biomarker [519]
GSK3A TTQWAU1 Definitive Biomarker [520]
HDAC6 TT5ZKDI Definitive Biomarker [521]
HIPK2 TTOB49C Definitive Biomarker [522]
IAPP TTHN8EM Definitive Biomarker [495]
ICOSLG TTB9Z8R Definitive Altered Expression [523]
ID2 TTW8A5N Definitive Altered Expression [524]
IL1RL1 TT4GZA4 Definitive Biomarker [525]
IL7R TTAWI51 Definitive Altered Expression [526]
ILK TT7ALZG Definitive Biomarker [527]
ITGA2 TTSJ542 Definitive Genetic Variation [528]
ITGA5 TTHIZP9 Definitive Altered Expression [343]
JMJD1C TTBISK4 Definitive Altered Expression [529]
KCNQ1 TT846HF Definitive Biomarker [530]
KHDRBS1 TTAT6C7 Definitive Altered Expression [531]
LPAR3 TTE2YJR Definitive Biomarker [519]
MAD1L1 TTNE9U7 Definitive Altered Expression [532]
MMP15 TTNSTO3 Definitive Biomarker [533]
MRGPRX1 TTIX6PK Definitive Biomarker [519]
MTR TTUTO39 Definitive Genetic Variation [534]
MYCN TT9JBY5 Definitive Biomarker [535]
NCL TTK1V5Q Definitive Biomarker [536]
NELL1 TT7H4BF Definitive Genetic Variation [23]
OPRK1 TTQW87Y Definitive Biomarker [537]
OXER1 TT7WBSV Definitive Biomarker [519]
PLA2R1 TTHKW7D Definitive Biomarker [538]
PNLIP TTXMY0J Definitive Biomarker [539]
PTPN1 TTELIN2 Definitive Biomarker [540]
PTPRJ TTWMKXP Definitive Biomarker [541]
RACK1 TTJ10AL Definitive Biomarker [542]
RALBP1 TTVSRUA Definitive Biomarker [543]
RIPK1 TTVJHX8 Definitive Biomarker [543]
ROCK1 TTZN7RP Definitive Biomarker [544]
RRM2 TT1S4LJ Definitive Altered Expression [545]
RUNX3 TTKCVO7 Definitive Altered Expression [149]
S100A12 TTQ4ESF Definitive Biomarker [183]
SAA1 TTY0DN9 Definitive Altered Expression [226]
SCN10A TT90XZ8 Definitive Altered Expression [546]
SETD2 TTPC3H4 Definitive Genetic Variation [547]
SETD7 TTJ0FSU Definitive Biomarker [449]
SGO1 TTBPKGD Definitive Biomarker [548]
SIK2 TTCUGZR Definitive Biomarker [549]
SIRPA TTBRJS9 Definitive Altered Expression [550]
SLC1A5 TTF7WRM Definitive Biomarker [551]
SLC22A1 TTM5Q4V Definitive Biomarker [552]
SLC9A1 TTGSEFH Definitive Altered Expression [553]
SMPD1 TTJTM88 Definitive Genetic Variation [554]
SPN TTOZAX0 Definitive Biomarker [555]
SVIL TTBLQS5 Definitive Genetic Variation [23]
TCL1A TTUKRDV Definitive Genetic Variation [556]
TP53BP1 TTX4UE9 Definitive Biomarker [557]
TYRO3 TTIEMFN Definitive Altered Expression [314]
UBE3A TTUZX6V Definitive Biomarker [558]
USP1 TTG9MT5 Definitive Biomarker [559]
WDR5 TT7OFWB Definitive Biomarker [560]
------------------------------------------------------------------------------------
⏷ Show the Full List of 689 DTT(s)
This Disease Is Related to 22 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC5 DTYVM24 Limited Biomarker [561]
SLC5A8 DTE3TAW Limited Biomarker [562]
SLCO6A1 DTIFXNS Limited Genetic Variation [99]
ABCA3 DT2T6VQ moderate Altered Expression [563]
SLC1A4 DTC54PX moderate Genetic Variation [23]
SLC20A2 DTFD4VB moderate Genetic Variation [23]
SLC34A1 DT42EWA moderate Genetic Variation [23]
SLC35F3 DTEHSG0 moderate Genetic Variation [23]
SLC39A11 DTEOAND moderate Genetic Variation [23]
SLC9A9 DT8LP62 moderate Genetic Variation [23]
ABCB5 DTKVEXO Strong Altered Expression [564]
ABCC11 DTWN7FC Strong Genetic Variation [166]
ATP7A DT0LT17 Strong Biomarker [565]
SLC22A4 DT2EG60 Strong Altered Expression [566]
SLC25A10 DTJYKDQ Strong Altered Expression [567]
SLC25A19 DTT82QK Strong Genetic Variation [568]
SLC25A3 DTCRIWV Strong Altered Expression [569]
SLC27A5 DT0TQS3 Strong Genetic Variation [266]
SLC28A3 DT4YL5R Strong Altered Expression [570]
SLC2A3 DT9SQ3L Strong Biomarker [571]
SLC2A5 DTOR02F Strong Biomarker [572]
SLC4A1 DTB0Q3P Strong Biomarker [573]
------------------------------------------------------------------------------------
⏷ Show the Full List of 22 DTP(s)
This Disease Is Related to 35 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ACP3 DEDW5H6 Limited Altered Expression [574]
AKR1C4 DEAJN47 Limited Biomarker [575]
BAAT DERA3OF Limited Biomarker [576]
BCO1 DE6BOK3 Limited Genetic Variation [23]
EPHX1 DELB4KP Limited Altered Expression [577]
FARS2 DE0WGR8 Limited Genetic Variation [23]
HPRT1 DEVXTP5 Limited Biomarker [578]
LAP3 DENZF0O Limited Genetic Variation [23]
NT5C DE4E31Z Limited Altered Expression [579]
PCYT1A DEQYXD4 Limited Biomarker [580]
UBASH3B DE10BJ5 Limited Biomarker [581]
G6PC3 DEE1B8O Disputed Genetic Variation [582]
GCLC DESYL1F Disputed Biomarker [179]
SULT1A1 DEYWLRK Disputed Altered Expression [583]
ADH4 DEOCWU3 moderate Genetic Variation [23]
CYP4F12 DED26GV moderate Genetic Variation [23]
DDAH1 DEY0TQC moderate Genetic Variation [23]
GLS DE3E0VT moderate Biomarker [584]
MGST1 DEAPJSO moderate Genetic Variation [23]
MTARC1 DE1VDSF moderate Genetic Variation [23]
ALDH1A1 DE2JP1Y Strong Biomarker [585]
CMPK1 DEMPH4I Strong Biomarker [279]
CYP7A1 DEDZRQ1 Strong Biomarker [586]
EGLN3 DEMQTKH Strong Genetic Variation [23]
GSTM1 DEYZEJA Strong Biomarker [587]
NAT2 DER7TA0 Strong Genetic Variation [588]
PMM2 DEBRX3L Strong Biomarker [589]
SCLY DEH4TD6 Strong Altered Expression [590]
TGM6 DEUWCVD Strong Biomarker [591]
TPMT DEFQ8VO Strong Altered Expression [592]
ABO DESIA7R Definitive Biomarker [593]
ASNS DEXISVQ Definitive Altered Expression [594]
CBR3 DEIVKZ8 Definitive Biomarker [500]
NAT10 DEZV4AP Definitive Altered Expression [595]
UGP2 DE4U39Y Definitive Biomarker [505]
------------------------------------------------------------------------------------
⏷ Show the Full List of 35 DME(s)
This Disease Is Related to 1355 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CHIC2 OTNE3T6Z No Known Unknown [596]
ABI1 OT5H4M62 Limited Genetic Variation [597]
ACOXL OTW680HT Limited Genetic Variation [23]
ACSL5 OT3L9XO3 Limited Biomarker [598]
ACSL6 OT0TT8P8 Limited Biomarker [599]
ADAM23 OTVWT6JZ Limited Genetic Variation [23]
ADAMTS9 OTV3Q0DS Limited Genetic Variation [23]
ADARB2 OTDJKS39 Limited Genetic Variation [23]
ADD1 OTTF68DC Limited Genetic Variation [600]
ADD2 OTRCPCD2 Limited Genetic Variation [23]
ADGRB3 OT1EWGRW Limited Genetic Variation [23]
ADGRG1 OTQBB8NT Limited Biomarker [601]
AGFG2 OTXQZHCR Limited Altered Expression [602]
AHI1 OT8K2YWY Limited Genetic Variation [23]
ALX4 OTNS9A29 Limited Genetic Variation [23]
AMER1 OT8EFJPM Limited Genetic Variation [603]
ANKRD16 OTZD4JUO Limited Genetic Variation [23]
ANKRD28 OTRBREQ9 Limited Biomarker [505]
AP3B1 OTYTIH5Q Limited Genetic Variation [23]
APOBEC3B OTHLNI51 Limited Genetic Variation [604]
APTX OTPAS5G8 Limited Biomarker [605]
ARHGAP31 OTUYTF4I Limited Genetic Variation [23]
ARHGEF10L OTUAMHIZ Limited Genetic Variation [23]
ARHGEF12 OTM2D3LT Limited Biomarker [606]
ARHGEF2 OTBQTFRT Limited Biomarker [606]
ARHGEF33 OTHJW0AL Limited Genetic Variation [23]
ARHGEF7 OT9BPJCL Limited Biomarker [607]
ARID1B OTILK3Q7 Limited Biomarker [608]
ARID3A OTZZ4SFP Limited Biomarker [608]
ARID5A OTQT7CG9 Limited Genetic Variation [23]
ARNT OTMSIEZY Limited Altered Expression [609]
ARR3 OTRZ00CH Limited Biomarker [42]
ARSD OTAHW9M8 Limited Biomarker [610]
ARTN OTWIWGL6 Limited Genetic Variation [24]
ASCC1 OTH4VAP9 Limited Biomarker [607]
ASF1B OTKXX12I Limited Genetic Variation [23]
ATAD1 OTJ02XFL Limited Biomarker [611]
ATF1 OT251CI0 Limited Genetic Variation [612]
ATP8A2 OTDZC2ZT Limited Genetic Variation [23]
ATP8B1 OTALGS63 Limited Genetic Variation [23]
B3GALT5 OTWXPEMU Limited Genetic Variation [23]
BCL2L11 OTNQQWFJ Limited Biomarker [428]
BCL3 OT1M5B95 Limited Biomarker [613]
BID OTOSHSHU Limited Genetic Variation [23]
BLVRB OTHCFN2C Limited Genetic Variation [614]
BTBD9 OTWQ6GA3 Limited Genetic Variation [23]
C10orf90 OT6DNZC4 Limited Genetic Variation [23]
C4orf19 OTJMU7N6 Limited Genetic Variation [23]
CAMK1D OTU24HAU Limited Genetic Variation [23]
CAMK1G OT1VEDLV Limited Genetic Variation [23]
CAMLG OTTSRY39 Limited Altered Expression [615]
CAV2 OT1FGRQX Limited Genetic Variation [23]
CBFA2T2 OTNOIB23 Limited Biomarker [616]
CBFB OTIAC6W4 Limited Unknown [617]
CC2D2A OTFGRGFR Limited Genetic Variation [23]
CCDC3 OTUE809X Limited Genetic Variation [23]
CCL19 OTQ2UJMH Limited Genetic Variation [23]
CCL3L1 OTQXCYB1 Limited Biomarker [618]
CCN3 OTOW5YL4 Limited Biomarker [619]
CCN4 OT69BER9 Limited Genetic Variation [23]
CDC37L1 OTGKTFAC Limited Genetic Variation [23]
CDH13 OTD2CYM5 Limited Genetic Variation [23]
CDK14 OT385ZH1 Limited Genetic Variation [23]
CDX2 OTCG4TSY Limited Biomarker [620]
CEBPZ OT11BATG Limited Genetic Variation [621]
CEMIP OTK80FYN Limited Genetic Variation [23]
CEP192 OTBLFV7T Limited Genetic Variation [23]
CFHR1 OT72R16T Limited Biomarker [622]
CHCHD6 OT8F9BHW Limited Genetic Variation [23]
CHGA OTXYX5JH Limited Genetic Variation [23]
CIB3 OT97EYB9 Limited Genetic Variation [23]
CILK1 OTWOYEYP Limited Altered Expression [117]
CKMT2 OT1KNPI1 Limited Biomarker [623]
CLC OTYMYR85 Limited Altered Expression [615]
CLSTN2 OT2PJYHX Limited Genetic Variation [23]
CMIP OTZN8Z4A Limited Genetic Variation [23]
CORO1A OTVAZOHC Limited Posttranslational Modification [624]
CRABP1 OTISDG5X Limited Biomarker [625]
CRACR2A OTJUGSVE Limited Genetic Variation [23]
CRADD OT02TZ4S Limited Altered Expression [626]
CSGALNACT1 OTBML9D9 Limited Genetic Variation [23]
CSMD2 OT541Z3W Limited Genetic Variation [23]
CSN2 OT22C0PD Limited Biomarker [627]
CTDSPL OTZJ0CZK Limited Biomarker [628]
CTNNA1 OTFC725Z Limited Genetic Variation [23]
CXADR OT9ZP02A Limited Biomarker [42]
DCAF6 OT3EYK1J Limited Genetic Variation [23]
DCLRE1C OTW3KB1I Limited Biomarker [629]
DDX10 OTH48438 Limited Biomarker [630]
DDX41 OT6KEIHP Limited Genetic Variation [631]
DDX43 OTK1RYSK Limited Posttranslational Modification [632]
DESI1 OTFNIW98 Limited Biomarker [633]
DIAPH3 OTPOT23F Limited Genetic Variation [23]
DLAT OT9LBJVN Limited Biomarker [634]
DMP1 OTBWBWW7 Limited Altered Expression [635]
DNAH17 OT4G6E70 Limited Genetic Variation [23]
DNAJC1 OTCKFOZ0 Limited Genetic Variation [23]
DNER OT2GH2E5 Limited Biomarker [636]
DNTT OTFSEF12 Limited Altered Expression [637]
DOCK10 OTI3MBLV Limited Genetic Variation [23]
DOK5 OT2XWUPN Limited Genetic Variation [23]
DUSP7 OT6Z5AHP Limited Altered Expression [638]
EAF2 OTSOET5L Limited Genetic Variation [639]
EDIL3 OTDVVNS0 Limited Genetic Variation [640]
EFNA2 OTEAUKRX Limited Biomarker [641]
EFNA5 OTOH4DRR Limited Altered Expression [642]
ELF1 OTV5LKIA Limited Biomarker [641]
ELF2 OTEI347F Limited Biomarker [641]
ELF3 OTUTLEQO Limited Biomarker [643]
ELF4 OT167PR5 Limited Biomarker [644]
ELL OTCBN5LF Limited Genetic Variation [645]
ELOF1 OT8BXS5U Limited Biomarker [641]
EMC3 OTY2H39E Limited Biomarker [646]
ENDOG OT5IM7B3 Limited Biomarker [647]
EPB41 OTGCFPV8 Limited Biomarker [648]
EPS15 OT7NPP8U Limited Genetic Variation [649]
FAM107B OT5RG4J0 Limited Genetic Variation [23]
FBH1 OTDJBKO1 Limited Genetic Variation [23]
FCGR2C OTNLMNYB Limited Biomarker [81]
FGF13 OTHNNVSG Limited Altered Expression [650]
FGF3 OT9PK2SI Limited Genetic Variation [651]
FMN2 OTUY7BSV Limited Genetic Variation [23]
FMNL2 OT9OVWCV Limited Genetic Variation [23]
FNBP1 OTSJ5KKA Limited Genetic Variation [147]
FOSB OTW6C05J Limited Altered Expression [652]
FOXO4 OT90X9LN Limited Altered Expression [653]
FRK OTEKV1SC Limited Genetic Variation [654]
FRMD4A OTJDTIK2 Limited Genetic Variation [23]
FRMD8 OTTH5DUJ Limited Genetic Variation [23]
FRZB OTTO3DPY Limited Posttranslational Modification [655]
FSTL5 OT18C29S Limited Genetic Variation [23]
FXR1 OTEMQ1SR Limited Genetic Variation [23]
GAB2 OTBFN705 Limited Altered Expression [656]
GADD45GIP1 OT4IZ4TP Limited Altered Expression [657]
GBX1 OTLJ8UR9 Limited Biomarker [658]
GBX2 OTW0ZI4D Limited Biomarker [658]
GDPD5 OTUM65JL Limited Genetic Variation [23]
GLCCI1 OTU0R1CU Limited Genetic Variation [23]
GSTK1 OTDNGWAF Limited Genetic Variation [99]
GTF2H4 OTPD1DIU Limited Genetic Variation [84]
GYPA OTABU4YV Limited Biomarker [659]
GYPB OTESHUIX Limited Biomarker [659]
GYPE OTBHAG6A Limited Biomarker [659]
H2AC4 OTMFQ662 Limited Genetic Variation [23]
HAVCR2 OTOL603T Limited Altered Expression [660]
HCLS1 OTX7WGYN Limited Altered Expression [104]
HDGFL2 OTWX2GHS Limited Genetic Variation [23]
HIVEP3 OTM3QT3L Limited Genetic Variation [23]
HLA-DOA OTZE5Q7R Limited Biomarker [661]
HLX OT7DTH46 Limited Genetic Variation [662]
HNRNPH1 OTFRWOLM Limited Genetic Variation [663]
HOXA10 OTB6GQ09 Limited Altered Expression [664]
HOXB1 OTGC0EKI Limited Altered Expression [665]
HOXB5 OTU74TB8 Limited Altered Expression [665]
HOXB6 OT3TFQ0U Limited Altered Expression [666]
HOXB7 OTC7WYU8 Limited Altered Expression [665]
HOXB8 OTKHOD17 Limited Altered Expression [665]
HOXB9 OTMVHQOU Limited Altered Expression [665]
HOXD11 OT9XGA4G Limited Genetic Variation [667]
HOXD13 OTWSC8TF Limited Biomarker [668]
HSPB2 OTS01646 Limited Altered Expression [329]
IGSF21 OTUFCXBS Limited Genetic Variation [23]
IKBKG OTNWJWSD Limited Altered Expression [669]
IKZF1 OTCW1FKL Limited Genetic Variation [670]
IL1F10 OTJAASGC Limited Genetic Variation [23]
IL27RA OTSQBAKI Limited Altered Expression [671]
IL6ST OT1N9C70 Limited Altered Expression [672]
ILKAP OT2A6FSA Limited Genetic Variation [23]
INPP4B OTLROA7G Limited Altered Expression [673]
INTS1 OT7TY1M1 Limited Biomarker [674]
INTS2 OT2N5TCK Limited Genetic Variation [651]
INVS OT8KPESR Limited Biomarker [675]
IPO11 OTG19WN0 Limited Genetic Variation [23]
ISCA1 OTU230MC Limited Genetic Variation [23]
JDP2 OTW35WKX Limited Genetic Variation [23]
KANSL3 OTWXDTLY Limited Genetic Variation [23]
KAT2A OTN0W2SW Limited Biomarker [676]
KAT5 OTL7257A Limited Biomarker [677]
KHSRP OTDHZARB Limited Altered Expression [104]
KLF6 OTQY9S7F Limited Altered Expression [678]
KLHL9 OTRGEG3Z Limited Genetic Variation [23]
KMT2E OTYOLNOG Limited Posttranslational Modification [679]
KNL1 OT4Q3LHV Limited Genetic Variation [680]
KRT31 OTB6RCAH Limited Biomarker [681]
KSR2 OTSMUL59 Limited Biomarker [682]
LARS1 OT4557NF Limited Genetic Variation [23]
LAT2 OTWJDKIH Limited Altered Expression [683]
LBX1 OTQJHICM Limited Genetic Variation [684]
LDB3 OTGQL1AM Limited Biomarker [685]
LIMS1 OT729S0T Limited Genetic Variation [120]
LMLN OTQF0JPY Limited Biomarker [675]
LNX1 OTZWFMAZ Limited Genetic Variation [23]
LRPPRC OTXSK5LP Limited Altered Expression [672]
LRRC3B OT9VDGPR Limited Genetic Variation [23]
MAP1S OT5WUD4C Limited Genetic Variation [23]
MAPK8IP2 OTDUHLN0 Limited Biomarker [686]
MARCHF4 OTK43VNA Limited Genetic Variation [23]
MATN1 OTBRTCTQ Limited Biomarker [687]
MBD2 OTUQPP0R Limited Biomarker [194]
ME3 OT3XMLYG Limited Genetic Variation [23]
MEAK7 OT9A8JSO Limited Genetic Variation [23]
MED1 OTOO24C4 Limited Altered Expression [688]
MEIS1 OTH9DKAD Limited Biomarker [689]
MIP OTEBLU3E Limited Altered Expression [690]
MLC1 OTCNZLSP Limited Biomarker [691]
MLLT1 OT41UZU5 Limited Genetic Variation [645]
MLLT3 OTXH4DDG Limited Genetic Variation [692]
MNAT1 OTXLOYCB Limited Biomarker [640]
MNDA OTCTKR47 Limited Biomarker [693]
MRTFA OTCVXASM Limited Biomarker [694]
MS4A14 OTX8BPFZ Limited Genetic Variation [23]
MVP OTJGHJRB Limited Biomarker [216]
MYO18B OTGYY4NK Limited Genetic Variation [23]
MYOT OTCEW5XW Limited Biomarker [695]
NAT9 OT4ZKCRS Limited Biomarker [696]
NBN OT73B5MD Limited Genetic Variation [697]
NCEH1 OTZ66CKX Limited Genetic Variation [23]
NCOA2 OTMQFPBB Limited Biomarker [698]
NCR2 OT2H13BX Limited Altered Expression [699]
NEO1 OTGJ1997 Limited Genetic Variation [700]
NEUROD6 OTLFL6K8 Limited Genetic Variation [23]
NKG7 OTXDD006 Limited Altered Expression [161]
NLRP2 OTJA81JU Limited Genetic Variation [697]
NME2 OTCYGLHV Limited Altered Expression [701]
NMU OTW9X7BQ Limited Altered Expression [702]
NNAT OTNRLO7G Limited Biomarker [703]
NOMO1 OTIALEI1 Limited Altered Expression [704]
NRG3 OTIFZ5CT Limited Genetic Variation [23]
NTM OTHF0UQU Limited Genetic Variation [23]
NUDC OT073JKX Limited Biomarker [705]
NUP50 OTOZ98K3 Limited Genetic Variation [23]
NVL OTWTGVTI Limited Genetic Variation [23]
NWD2 OTN47UBK Limited Genetic Variation [23]
OLFML3 OTDN45FN Limited Genetic Variation [23]
OPN1LW OTFNUZ7O Limited Altered Expression [74]
OSCP1 OTZ4IFGJ Limited Altered Expression [652]
P4HB OTTYNYPF Limited Biomarker [706]
PAG1 OTFOJUIQ Limited Altered Expression [74]
PARD3B OTGZ43YI Limited Genetic Variation [23]
PARP15 OTYO1C46 Limited Biomarker [707]
PCBP3 OT6EX9N6 Limited Genetic Variation [23]
PCBP4 OTDLL4NB Limited Altered Expression [74]
PCGF2 OTIY1J5L Limited Altered Expression [708]
PDE8B OT4217NK Limited Genetic Variation [23]
PDLIM4 OT23LZYY Limited Posttranslational Modification [709]
PEG3 OTHQW98S Limited Genetic Variation [23]
PER2 OTU2B1DJ Limited Altered Expression [609]
PHAX OTSHNJ6B Limited Genetic Variation [23]
PHF6 OT8DXI40 Limited Genetic Variation [710]
PHYKPL OTQGELZD Limited Genetic Variation [23]
PICALM OTQVRPMQ Limited Biomarker [711]
PIK3R3 OTXGJ8N1 Limited Altered Expression [104]
PKHD1 OTAH8SMF Limited Genetic Variation [23]
PLA2G5 OTQRSKCZ Limited Genetic Variation [23]
PLAGL2 OT6AP4V2 Limited Altered Expression [712]
PLCG2 OTGVC9MY Limited Genetic Variation [23]
PLEKHB1 OTC7TNAX Limited Genetic Variation [23]
PLXDC2 OTS1FUV6 Limited Genetic Variation [23]
PLXNA2 OTNNBJMQ Limited Genetic Variation [23]
PNN OT0HXICH Limited Biomarker [713]
POGLUT1 OTDX7GZD Limited Altered Expression [714]
POLD4 OTG578YH Limited Genetic Variation [715]
POLE4 OTCMWUT6 Limited Genetic Variation [715]
POLG2 OTDBMZJB Limited Altered Expression [104]
POLR1D OTOCZQNA Limited Genetic Variation [23]
POLR3A OT5MSK10 Limited Genetic Variation [23]
PPFIA2 OT34BLXJ Limited Genetic Variation [23]
PPIG OTZ8BTTM Limited Genetic Variation [716]
PPL OTTM4WDO Limited Genetic Variation [23]
PPP1R14C OTZ3F6D2 Limited Genetic Variation [23]
PPP2R2C OTXK0SDM Limited Genetic Variation [23]
PRAP1 OT48QD82 Limited Biomarker [717]
PRRX1 OTTZK5G8 Limited Genetic Variation [718]
PRXL2A OTR4X7UH Limited Genetic Variation [23]
PSG11 OTLZJVLL Limited Genetic Variation [23]
PSMD12 OTWICA51 Limited Altered Expression [104]
PTGES3 OTPPQWI0 Limited Genetic Variation [60]
PTPA OTRGFOI7 Limited Altered Expression [719]
PTPRD OTZPJ3GX Limited Genetic Variation [23]
PTPRG OT9N2WOF Limited Genetic Variation [23]
QPRT OT6SKKLL Limited Genetic Variation [720]
RAB10 OT8ZN26V Limited Genetic Variation [23]
RAB11FIP4 OTIGHER7 Limited Genetic Variation [23]
RAB20 OTP9OOVS Limited Genetic Variation [23]
RAD51B OTCJVRMY Limited Genetic Variation [23]
RAG1 OTV131E4 Limited Genetic Variation [721]
RARS1 OTHPZ6JN Limited Biomarker [722]
RASA2 OTL06RG2 Limited Genetic Variation [147]
RASGRP4 OT15PWN4 Limited Biomarker [723]
RBBP4 OTG3BT3M Limited Biomarker [724]
RBP1 OTRP1MFC Limited Altered Expression [725]
RCL1 OT7O00YX Limited Genetic Variation [23]
REEP5 OTZU4TJI Limited Genetic Variation [726]
RGPD2 OTMUZ0HX Limited Altered Expression [602]
RGS7 OTDQA90X Limited Genetic Variation [23]
RNF126 OTTECSYY Limited Genetic Variation [23]
RNPS1 OT7G4COD Limited Genetic Variation [23]
RPN1 OTEG4KU9 Limited Biomarker [727]
RPS24 OTSNKIL5 Limited Genetic Variation [23]
RPTOR OT4TQZ9F Limited Genetic Variation [23]
SALL4 OTC08PR5 Limited Altered Expression [728]
SBF2 OTBB8NO8 Limited Genetic Variation [23]
SCAPER OT7S3B3P Limited Genetic Variation [23]
SDC4 OTKUVUGZ Limited Biomarker [729]
SEPTIN11 OTX2O0ZX Limited Genetic Variation [730]
SEPTIN5 OT6JTJBO Limited Genetic Variation [731]
SEPTIN7 OTJI08YX Limited Genetic Variation [732]
SEPTIN9 OT1VMRFQ Limited Genetic Variation [23]
SFRP5 OTLCVVSH Limited Altered Expression [733]
SHROOM3 OTQKC5X2 Limited Genetic Variation [23]
SIGLEC7 OTNDLURR Limited Altered Expression [104]
SLC2A4RG OTW3LX8D Limited Biomarker [606]
SLC35G1 OTKZUA8O Limited Biomarker [633]
SMPD3 OTHQBETH Limited Genetic Variation [734]
SMR3B OTL5HNM8 Limited Biomarker [420]
SNTG1 OT6GBQHI Limited Genetic Variation [23]
SNX9 OTLNQ0ZM Limited Genetic Variation [23]
SORBS1 OTWH8762 Limited Genetic Variation [23]
SORCS2 OTBF3DYK Limited Genetic Variation [23]
SPATA6L OTCQ01F6 Limited Genetic Variation [23]
SPESP1 OTWXKKTJ Limited Genetic Variation [735]
SPG7 OT8OY9ST Limited Biomarker [42]
SRBD1 OTL1QJSP Limited Genetic Variation [23]
SSBP2 OTYG1G80 Limited Biomarker [736]
ST6GALNAC5 OTH91ETM Limited Genetic Variation [23]
ST7 OTZG8RC6 Limited Genetic Variation [737]
ST8SIA3 OTG9MXV9 Limited Genetic Variation [23]
STIM2 OTYNXAW0 Limited Genetic Variation [23]
SUCLG2 OT0KHLY2 Limited Genetic Variation [23]
SUZ12 OT655XF8 Limited Biomarker [738]
TACC2 OTW4M7HI Limited Genetic Variation [23]
TAF15 OTNE038N Limited Altered Expression [739]
TBCC OTBF0X8R Limited Biomarker [740]
TC2N OT6482WN Limited Genetic Variation [23]
TENM2 OTPLUYEF Limited Genetic Variation [23]
TESC OTI8C76M Limited Biomarker [440]
TET3 OT76U3YF Limited Biomarker [741]
THSD7B OTMDDIPT Limited Genetic Variation [23]
TMED10 OTUXSHH7 Limited Genetic Variation [60]
TMED5 OT70W1J8 Limited Genetic Variation [23]
TMEM248 OT0PHW5T Limited Genetic Variation [23]
TMEM260 OTICII2L Limited Genetic Variation [23]
TMEM266 OTM17VHD Limited Genetic Variation [23]
TMEM87B OTXT7BCU Limited Genetic Variation [23]
TNFRSF10C OTVHOL9B Limited Altered Expression [742]
TNFRSF10D OTOSRDJT Limited Altered Expression [742]
TNFSF8 OTDYGDJ3 Limited Altered Expression [743]
TOPORS OT1ERFFQ Limited Genetic Variation [23]
TP73 OT0LUO47 Limited Genetic Variation [23]
TRIM13 OTQIUACB Limited Biomarker [42]
TRIM34 OTJ11U33 Limited Genetic Variation [23]
TRIM6 OTBSMX0B Limited Genetic Variation [23]
TRIP11 OT4FJEAR Limited Biomarker [744]
TRPS1 OT7XPPEL Limited Genetic Variation [745]
TSPAN33 OTH6C0WU Limited Genetic Variation [746]
ARHGAP24 OTCQCEZS Disputed Altered Expression [747]
ATG5 OT4T5SMS Disputed Biomarker [748]
ATRNL1 OTY5JUX2 Disputed Genetic Variation [749]
BABAM2 OTOY7FNT Disputed Genetic Variation [750]
CCL13 OTNX0JD0 Disputed Biomarker [751]
CCL27 OTUZYC61 Disputed Genetic Variation [749]
CCND2 OTDULQF9 Disputed Genetic Variation [752]
CHST9 OT1DEZRM Disputed Biomarker [753]
CLOCK OTNEOJY7 Disputed Biomarker [754]
CORT OTX3GUHB Disputed Genetic Variation [755]
CXCL5 OTZOUPCA Disputed Biomarker [751]
DHX15 OT4F98TK Disputed Genetic Variation [756]
DLX4 OTLWVCN4 Disputed Altered Expression [757]
FIP1L1 OTF91GTL Disputed Genetic Variation [758]
GNA12 OT3IRZH3 Disputed Biomarker [166]
GNG11 OTHIXBGW Disputed Biomarker [759]
KLF1 OT1FK08U Disputed Altered Expression [760]
LGALS12 OTNTQULB Disputed Altered Expression [761]
LPXN OTUNV3CK Disputed Genetic Variation [762]
MRGPRF OT74OZ2Z Disputed Biomarker [688]
NT5DC3 OTRHBVM5 Disputed Altered Expression [763]
PDLIM3 OTVXQC81 Disputed Genetic Variation [749]
PLAG1 OTT9AJQY Disputed Biomarker [764]
PLCE1 OTJISZOX Disputed Genetic Variation [765]
POU4F1 OTMHYGWQ Disputed Altered Expression [766]
RBFOX2 OTXY1WVH Disputed Biomarker [688]
REG1A OTMHUH1D Disputed Altered Expression [569]
RMDN3 OTKO7AUM Disputed Altered Expression [767]
SHMT1 OTIINA3J Disputed Genetic Variation [534]
SUMO1 OTJFD4P5 Disputed Altered Expression [768]
TAS2R10 OT4RWZZD Disputed Altered Expression [769]
TET1 OTZDHT1D Disputed Biomarker [770]
A1CF OTJBKFA1 moderate Genetic Variation [23]
A2ML1 OTWNUXIS moderate Biomarker [771]
AACS OTGGPR6J moderate Genetic Variation [23]
ABI3BP OTW8DN50 moderate Genetic Variation [23]
ABTB2 OTK5YA5E moderate Genetic Variation [23]
ACACA OT5CQPZY moderate Genetic Variation [23]
ADCY7 OTAWMGP3 moderate Altered Expression [253]
AFF3 OTR0705Z moderate Genetic Variation [23]
AFF4 OTTL5Y8R moderate Genetic Variation [23]
AHCYL2 OTGG9KYG moderate Genetic Variation [23]
AK9 OTWYT1VS moderate Genetic Variation [23]
AMELX OTIN26MM moderate Biomarker [772]
ANK2 OTWB4R1Y moderate Genetic Variation [23]
ANK3 OTJ3IRBP moderate Genetic Variation [23]
ANKRD55 OT62KZII moderate Genetic Variation [23]
ANP32B OT3SQMLU moderate Altered Expression [773]
APLF OTYUR3AH moderate Genetic Variation [23]
ARHGEF1 OTXU4HBW moderate Biomarker [774]
ARHGEF18 OTOXEK8Y moderate Genetic Variation [23]
ARL5C OT3SIDP7 moderate Genetic Variation [23]
ASAH1 OT1DNGXL moderate Altered Expression [121]
ASB15 OTI0ZVLJ moderate Genetic Variation [23]
ATL2 OT93AUOO moderate Genetic Variation [23]
ATP2C2 OTGIHTYQ moderate Genetic Variation [23]
AUTS2 OTAEXHSC moderate Genetic Variation [23]
BPIFB2 OTXWTWQ9 moderate Genetic Variation [23]
BTBD8 OT3A3RD7 moderate Genetic Variation [23]
C19orf47 OTLG5FQG moderate Genetic Variation [23]
C2orf76 OTIIU4DI moderate Genetic Variation [23]
C7orf33 OTWZ1FAE moderate Genetic Variation [23]
C9 OT7I5FDX moderate Genetic Variation [23]
C9orf153 OT4GKX8W moderate Genetic Variation [23]
CACNB1 OTV42SIT moderate Genetic Variation [23]
CADM2 OT45PVKC moderate Genetic Variation [23]
CALD1 OTNJKJ6Q moderate Genetic Variation [23]
CCDC144A OTN9UZHR moderate Genetic Variation [23]
CCDC149 OT7S7MU9 moderate Genetic Variation [23]
CCDC18 OT0S9DA2 moderate Genetic Variation [23]
CCDC39 OTXRCVUD moderate Genetic Variation [23]
CCDC66 OTE8VSSO moderate Genetic Variation [23]
CCER1 OTVA38PS moderate Genetic Variation [23]
CCL28 OTY6XNQ7 moderate Biomarker [775]
CCNA1 OTX4HD45 moderate Altered Expression [776]
CD244 OTSMR85N moderate Altered Expression [777]
CECR2 OTF54V3W moderate Genetic Variation [23]
CFAP299 OTOSLSAM moderate Genetic Variation [23]
CHEK2 OT8ZPCNS Moderate Autosomal dominant [185]
CHGB OT7SAQT2 moderate Biomarker [778]
CHPT1 OT4FJ0K3 moderate Biomarker [779]
CLN8 OT0D4CB5 moderate Genetic Variation [23]
CNOT7 OTJBKCPI moderate Genetic Variation [23]
COL11A2 OT3BQUBH moderate Biomarker [136]
COL15A1 OTTFKK18 moderate Genetic Variation [23]
COL22A1 OTSWGZRD moderate Genetic Variation [23]
COL23A1 OTYE0N3I moderate Genetic Variation [23]
COL26A1 OTMS7RNF moderate Genetic Variation [23]
COL4A2 OTJK1LKN moderate Genetic Variation [23]
COL4A3 OT6SB8X5 moderate Genetic Variation [23]
COL6A5 OTJT8O80 moderate Genetic Variation [23]
CPNE4 OTTAGM5L moderate Genetic Variation [23]
CREB3L1 OT2JHIHM moderate Genetic Variation [23]
CREB5 OTJDUJPI moderate Genetic Variation [23]
CSMD1 OTIVDSC4 moderate Genetic Variation [23]
CTAG1B OTIQGW6U moderate Biomarker [186]
CTNNA2 OTJ8G92T moderate Genetic Variation [23]
DAB1 OTPL9MA3 moderate Genetic Variation [23]
DCTN6 OTI8PIN9 moderate Altered Expression [780]
DECR1 OTCDIR6X moderate Biomarker [781]
DEFB127 OTDLYU1I moderate Genetic Variation [23]
DENND6A OTA8JL8H moderate Genetic Variation [23]
DGKB OTTT9SZJ moderate Genetic Variation [23]
DIMT1 OT9J5J1C moderate Genetic Variation [23]
DLST OTBDF9HJ moderate Genetic Variation [23]
DMGDH OTPJEWQ8 moderate Genetic Variation [23]
DOCK3 OTF3YS2W moderate Genetic Variation [23]
DOK6 OTX55OIF moderate Altered Expression [782]
DPH1 OT0QU3JY moderate Genetic Variation [23]
DR1 OTR081M4 moderate Genetic Variation [23]
ELMO1 OTY2ORXK moderate Genetic Variation [23]
ELN OTFSO7PG moderate Biomarker [783]
EML6 OTE1MUQS moderate Genetic Variation [23]
EPHA10 OT1XJGFG moderate Genetic Variation [23]
ERMP1 OT9CIEO2 moderate Genetic Variation [23]
ETV4 OT8C98UZ moderate Genetic Variation [23]
EVPL OTZIAFEK moderate Biomarker [784]
EXTL3 OT2BRUBN moderate Genetic Variation [23]
FAM149A OTMDM0RI moderate Genetic Variation [23]
FAM3D OTM3GWFP moderate Genetic Variation [23]
FANCM OTNJG99Z moderate Biomarker [240]
FBXO21 OTM8L5VY moderate Genetic Variation [23]
FETUB OT7V07NI moderate Genetic Variation [23]
FGF12 OTBM9QIO moderate Genetic Variation [23]
FIS1 OT2HL10J moderate Altered Expression [222]
FOXI1 OT2UFOE2 moderate Genetic Variation [23]
FSD2 OTJYRESG moderate Genetic Variation [23]
GAB1 OTQKE6V4 moderate Genetic Variation [23]
GALNT14 OT9BSDDQ moderate Genetic Variation [23]
GALNT2 OTZZ5386 moderate Genetic Variation [23]
GBE1 OTK2N05B moderate Genetic Variation [23]
GCFC2 OTC7FRXL moderate Genetic Variation [23]
GFI1B OTRDW8YO moderate Biomarker [785]
GLB1L2 OTLI6HCH moderate Genetic Variation [23]
GLIS1 OTBDNB26 moderate Genetic Variation [23]
GOLT1B OTC6QPW3 moderate Biomarker [786]
GP2 OTB6TMGY moderate Genetic Variation [23]
GPAT3 OTJUGPK0 moderate Genetic Variation [23]
GPR161 OT80FYA3 moderate Genetic Variation [23]
GPR26 OTBDYUOH moderate Genetic Variation [23]
GRAMD4 OT1HXEPM moderate Genetic Variation [23]
GRID1 OTJ3WIKC moderate Genetic Variation [23]
GRK6 OT4LZTP9 moderate Genetic Variation [23]
HECTD3 OTTGP4OK moderate Genetic Variation [23]
HECW1 OT1PVAZA moderate Genetic Variation [23]
HOMER2 OT4JGKJF moderate Genetic Variation [23]
HOXA4 OTNVTQDT moderate Posttranslational Modification [787]
HOXB3 OT9UC5PE moderate Altered Expression [71]
HPR OTXSC9UB moderate Altered Expression [788]
HPS1 OTKS5I7T moderate Genetic Variation [23]
HS3ST4 OTO0UBFN moderate Genetic Variation [23]
ICE1 OTOXTBUH moderate Genetic Variation [23]
IFI27 OTI2XGIT moderate Altered Expression [780]
IL36RN OT5CO95A moderate Genetic Variation [23]
IQUB OTT1VKEF moderate Genetic Variation [23]
IRF2 OTAZRUW3 moderate Altered Expression [673]
ITPK1 OTP4PGL6 moderate Genetic Variation [23]
ITPRID1 OT9MH0BX moderate Genetic Variation [23]
KANK1 OT2E7A6W moderate Genetic Variation [23]
KCNAB1 OT25GJE9 moderate Genetic Variation [23]
KCNIP3 OTCQPEM4 moderate Genetic Variation [23]
KCNJ15 OTZT6EQB moderate Genetic Variation [23]
KHNYN OT5ZFS95 moderate Genetic Variation [23]
KIAA0513 OT7AVTFB moderate Genetic Variation [23]
KIAA0930 OTVJ73LN moderate Genetic Variation [23]
KIAA1958 OTTI1DB4 moderate Genetic Variation [23]
KIF2A OT2WQ6QD moderate Genetic Variation [23]
KLF9 OTBFEJRQ moderate Genetic Variation [23]
KPNA1 OTEMVAJ6 moderate Genetic Variation [23]
KRT83 OTNQ040R moderate Genetic Variation [23]
LDLRAD3 OTYAKC55 moderate Genetic Variation [23]
LDLRAD4 OTQUX50Z moderate Genetic Variation [23]
LHFPL3 OTG1EI22 moderate Genetic Variation [23]
LHX4 OTVX3J6S moderate Genetic Variation [23]
LINGO2 OT3N88Q1 moderate Genetic Variation [23]
LMX1B OTM8145D moderate Genetic Variation [23]
LRBA OTOUZN9G moderate Genetic Variation [23]
LRRTM2 OTSBFPUI moderate Genetic Variation [23]
LRRTM4 OTYJ4348 moderate Genetic Variation [23]
LTBP1 OTR7Q75L moderate Genetic Variation [23]
MACROD2 OTNQCHC6 moderate Genetic Variation [23]
MAP6 OTPUI00F moderate Genetic Variation [23]
MARCKSL1 OT13J2FM moderate Altered Expression [789]
MEGF9 OTDQWTY4 moderate Genetic Variation [23]
METAP1D OT144G80 moderate Genetic Variation [23]
MINAR1 OTV1X2R0 moderate Genetic Variation [23]
MLIP OTMT7AII moderate Genetic Variation [23]
MPC2 OT0GHXGG moderate Genetic Variation [23]
MROH7 OTY4H57Y moderate Genetic Variation [23]
MRPL19 OTRBKF6R moderate Genetic Variation [23]
MRPL28 OT4LUTZU moderate Posttranslational Modification [790]
MRPS27 OTN9DA0V moderate Genetic Variation [23]
MSC OTBRPZL5 moderate Genetic Variation [791]
MTMR3 OTBIT23O moderate Genetic Variation [23]
MYCT1 OTZ8A9L3 moderate Altered Expression [792]
MYO1D OTP2RGPN moderate Genetic Variation [23]
MYO3B OTVD4TNG moderate Genetic Variation [23]
NAB2 OTG4BDF3 moderate Genetic Variation [23]
NAV2 OTGAOL01 moderate Genetic Variation [23]
NAV3 OT97M1TR moderate Genetic Variation [23]
NDUFA5 OTR848KZ moderate Genetic Variation [23]
NDUFB6 OTIXNT91 moderate Genetic Variation [23]
NEDD4L OT1B19RU moderate Genetic Variation [23]
NEMP1 OTWN3S47 moderate Genetic Variation [23]
NEURL3 OTA3ALQO moderate Genetic Variation [23]
NFATC2 OTK5T6HZ moderate Genetic Variation [23]
NFYA OTWFFOVH moderate Genetic Variation [23]
NLGN1 OTGHRRFQ moderate Genetic Variation [23]
NR2F6 OTNVO2B6 moderate Altered Expression [793]
NSD3 OT3677ZG moderate Biomarker [794]
NT5DC2 OTPDRGGN moderate Genetic Variation [23]
NUGGC OTKQLKWO moderate Genetic Variation [23]
NUP153 OTCAS0AR moderate Genetic Variation [23]
NXT1 OT0VO6AY moderate Posttranslational Modification [790]
OARD1 OTNNWATS moderate Genetic Variation [23]
OAS3 OT6E5FYS moderate Genetic Variation [23]
OR6C1 OTQJ455N moderate Genetic Variation [23]
OR6C75 OT8GMUU7 moderate Genetic Variation [23]
OR6P1 OTR1JPLJ moderate Genetic Variation [23]
OR6Y1 OTMHRAGN moderate Genetic Variation [23]
OTUB2 OTZUMPH2 moderate Genetic Variation [23]
OVCA2 OT5LSKCS moderate Genetic Variation [23]
P2RX5 OTLBR20R moderate Biomarker [201]
PAFAH1B1 OT9T2TCJ moderate Genetic Variation [795]
PALLD OTZ2MUJZ moderate Genetic Variation [23]
PALM2AKAP2 OTI618VF moderate Genetic Variation [23]
PCDH15 OTU9C2EH moderate Genetic Variation [23]
PDZD2 OTPPVRGY moderate Genetic Variation [23]
PDZRN3 OTQ891OS moderate Genetic Variation [23]
PGS1 OTHL9ZKS moderate Genetic Variation [23]
PHACTR1 OTAMPX9V moderate Genetic Variation [23]
PHF23 OTVF5VZC moderate Altered Expression [796]
PI16 OTJY2N6U moderate Genetic Variation [23]
PLAC8L1 OTHF4LKX moderate Genetic Variation [23]
PMAIP1 OTXEE550 moderate Genetic Variation [115]
POMGNT2 OT0S9Z0J moderate Genetic Variation [23]
PRAM1 OTZN3DWD moderate Biomarker [797]
PRKAA1 OT7TNF0L moderate Biomarker [323]
PRKAA2 OTU1KZPV moderate Biomarker [323]
PRKAB1 OT1OG4QZ moderate Biomarker [323]
PROX2 OTVUW0GJ moderate Genetic Variation [23]
PRSS35 OT09H6WH moderate Genetic Variation [23]
PRSS54 OTZVEVQZ moderate Genetic Variation [23]
PSMD9 OT6Y5CC3 moderate Altered Expression [780]
PSMF1 OTX84WLQ moderate Genetic Variation [23]
PTPRA OTZA82J1 moderate Biomarker [207]
PYROXD2 OTJIX22S moderate Genetic Variation [23]
RAB36 OTL30F2P moderate Genetic Variation [23]
RAB3GAP1 OT4DQ8F2 moderate Genetic Variation [23]
RAD51C OTUD6SY5 moderate Biomarker [240]
RALGAPB OTY8CGA3 moderate Biomarker [771]
RASGRP3 OTEMEV3P moderate Genetic Variation [23]
RBFOX3 OTL0F3D6 moderate Genetic Variation [23]
RIMBP2 OTUNSVUJ moderate Genetic Variation [23]
RITA1 OTUH8IPS moderate Biomarker [798]
RNF187 OTXTN1HP moderate Genetic Variation [23]
RTEL1 OTI3PJCT Moderate Autosomal dominant [185]
RTN4RL1 OTDKKOE7 moderate Genetic Variation [23]
S100Z OTBSHFJR moderate Genetic Variation [23]
SASH1 OTQA8BD4 moderate Genetic Variation [23]
SAXO1 OT7M6PLA moderate Genetic Variation [23]
SBK1 OTCO4NEI moderate Genetic Variation [23]
SEC14L6 OTQ190TS moderate Genetic Variation [23]
SEMA5A OTUOIOJV moderate Genetic Variation [23]
SEMG1 OT6Z4BPQ moderate Biomarker [778]
SEZ6L OT5Z9CUA moderate Genetic Variation [23]
SFRP1 OT0U9G41 moderate Altered Expression [799]
SFRP2 OT8GZ0CA moderate Altered Expression [800]
SGSM3 OTIB1P8A moderate Altered Expression [801]
SH3RF2 OT2IVOK4 moderate Genetic Variation [23]
SH3RF3 OTK9VVUU moderate Genetic Variation [23]
SHANK2 OTSQTPFQ moderate Genetic Variation [23]
SHISA6 OTWBCJ8O moderate Genetic Variation [23]
SLC25A44 OTHHPC3C moderate Genetic Variation [23]
SMARCA1 OT0Y6PTU moderate Biomarker [802]
SNX30 OTMGQSAM moderate Genetic Variation [23]
SPINK4 OTHTCW94 moderate Genetic Variation [23]
SPSB1 OTGY26U4 moderate Genetic Variation [23]
SRP72 OTPV73W7 Moderate Autosomal dominant [185]
ST18 OTPRIMTA moderate Genetic Variation [23]
STK32C OTN4HBAA moderate Genetic Variation [23]
STOX1 OTED3YVO moderate Genetic Variation [23]
SUB1 OTK71JYU moderate Posttranslational Modification [790]
SUN5 OTUVKA6R moderate Genetic Variation [23]
SV2B OTAO5WIU moderate Genetic Variation [23]
SYCE1 OTTOIXW8 moderate Genetic Variation [23]
SYT2 OTJYGTY4 moderate Genetic Variation [23]
TBC1D5 OTNHLLAX moderate Genetic Variation [23]
TDRD12 OTP8B2UY moderate Genetic Variation [23]
TENM4 OT91K3FC moderate Genetic Variation [23]
THSD7A OT7249HH moderate Genetic Variation [23]
TICAM2 OTK7GIJ5 moderate Altered Expression [780]
TLE6 OTB84O0U moderate Genetic Variation [23]
TMED7 OTONO8E6 moderate Altered Expression [780]
TMEM14A OTANQA6G moderate Genetic Variation [23]
TMEM161B OTHVICQS moderate Genetic Variation [23]
TMEM259 OTVH9HD8 moderate Genetic Variation [23]
TMOD1 OTTRYF9Y moderate Genetic Variation [23]
TNFSF18 OT3ANRX1 moderate Altered Expression [803]
TNR OTVJGAFN moderate Genetic Variation [23]
TNRC6A OT493IOM moderate Genetic Variation [23]
TRAK1 OTMQVYNP moderate Genetic Variation [23]
TRIM46 OTFE7WZW moderate Genetic Variation [23]
TTC21A OTBJ9JKF moderate Genetic Variation [23]
TTLL11 OTWXLE1J moderate Genetic Variation [23]
TTLL5 OTUKOVEM moderate Genetic Variation [23]
TTN OT0LZ058 moderate Genetic Variation [23]
AAAS OTJT9T23 Strong Biomarker [128]
AADAC OT8VACT2 Strong Genetic Variation [804]
ABR OTZQK8JF Strong Altered Expression [805]
ACER3 OTIVQBG5 Strong Biomarker [806]
ACOT7 OT7C68YV Strong Altered Expression [807]
ADAM28 OT3GBVHL Strong Altered Expression [808]
ADAR OTQNOHR8 Strong Altered Expression [809]
ADGRE2 OTUYJVYG Strong Biomarker [810]
ADGRE5 OTTSB84Q Strong Biomarker [810]
ADIPOR1 OT65ZFZN Strong Biomarker [811]
AEBP2 OTOAZJ55 Strong Genetic Variation [812]
AFDN OTTRU341 Strong Biomarker [813]
AFF1 OTT2C78E Strong Biomarker [814]
AGRN OTWJENAZ Strong Biomarker [224]
AK6 OT84OHHP Strong Biomarker [815]
AKAP12 OTCVRDDX Strong Genetic Variation [23]
AKAP13 OTOZAR14 Strong Genetic Variation [816]
AKIP1 OT7XPG27 Strong Biomarker [278]
ALG3 OTPOL1QW Strong Altered Expression [817]
ALPP OTZU4G9W Strong Biomarker [495]
ANKRD26 OT2ENKKV Strong Autosomal dominant [185]
ANP32A OTRHPFO2 Strong Biomarker [818]
ANXA3 OTDD8OI7 Strong Altered Expression [432]
ANXA4 OTUCRYXL Strong Biomarker [224]
ANXA6 OT9KIQ0Y Strong Biomarker [224]
APAF1 OTJWIVY0 Strong Biomarker [819]
APOBEC3A OTYO6F5P Strong Altered Expression [820]
ARC OTN2QQPG Strong Biomarker [821]
ARID4A OT1XKBZ0 Strong Biomarker [822]
ARIH2 OTJYJQJ8 Strong Biomarker [823]
ARPP19 OTZS3IT6 Strong Altered Expression [406]
ASB2 OTF9LV7L Strong Genetic Variation [23]
ASH2L OT3HG324 Strong Altered Expression [824]
ASMTL OTPUGCZO Strong Biomarker [224]
ASPG OT5E2EKR Strong Biomarker [825]
ASS1 OT4ZMG0Q Strong Biomarker [826]
ASXL2 OTNG4E2M Strong Genetic Variation [827]
ATF2 OTNIZPEA Strong Altered Expression [828]
ATF5 OT03QCLM Strong Biomarker [829]
ATP1B1 OTTO6ZP4 Strong Biomarker [224]
BACH2 OT17GS18 Strong Biomarker [830]
BASP1 OTF4VS5G Strong Biomarker [831]
BCAR1 OTKT2C2N Strong Altered Expression [832]
BCL10 OT47MCLI Strong Biomarker [833]
BCL2L10 OTYXQJ3I Strong Biomarker [834]
BCLAF1 OT7T8H6A Strong Biomarker [835]
BCOR OTG013AX Strong Genetic Variation [836]
BCORL1 OTPTFQN5 Strong Genetic Variation [837]
BCS1L OT5PY5CY Strong Biomarker [838]
BEST2 OT48WOL1 Strong Genetic Variation [839]
BEX1 OTBQIF0H Strong Altered Expression [840]
BHLHE41 OTY9GJ1Y Strong Biomarker [813]
BLM OTEJOAJX Strong Biomarker [240]
BMPR1A OTQOA4ZH Strong Altered Expression [841]
BRCA1 OT5BN6VH Strong Biomarker [240]
BST1 OTAV5SE7 Strong Biomarker [842]
C10orf53 OTAPN6SD Strong Genetic Variation [843]
CACUL1 OT6P1ZVP Strong Biomarker [844]
CADM1 OTRWG9QS Strong Biomarker [845]
CAMK1 OTRN55RE Strong Biomarker [357]
CAMK4 OT47RDGV Strong Biomarker [846]
CAPG OTJ86KI6 Strong Biomarker [476]
CARD8 OTXXZYWU Strong Altered Expression [287]
CARTPT OTTE4V9S Strong Biomarker [847]
CASZ1 OTWJ2OR8 Strong Posttranslational Modification [848]
CBFA2T3 OTOJ10S1 Strong Biomarker [849]
CBLL2 OTB4AD3V Strong Altered Expression [850]
CCDC50 OTSE1YM5 Strong Altered Expression [502]
CCDC6 OTXRQDYG Strong Genetic Variation [568]
CCNT2 OTBDRH1J Strong Biomarker [851]
CCS OTXHT3QO Strong Genetic Variation [852]
CD177 OTS79FNF Strong Altered Expression [853]
CD226 OT4UG0KB Strong Biomarker [465]
CD300LF OTQWJGSR Strong Biomarker [854]
CD302 OTX580VU Strong Biomarker [855]
CD48 OT83ZNPP Strong Biomarker [856]
CD53 OT9U5OXJ Strong Biomarker [857]
CD63 OT2UGZA9 Strong Biomarker [858]
CD79A OTOJC8DV Strong Altered Expression [859]
CD81 OTQFXNAZ Strong Altered Expression [860]
CD82 OTH8MC64 Strong Altered Expression [861]
CD93 OT6HZT6H Strong Altered Expression [862]
CDCA3 OTUI8QK3 Strong Altered Expression [71]
CDK20 OTOLNN68 Strong Biomarker [264]
CDK2AP2 OTR99SJ8 Strong Posttranslational Modification [863]
CDKN2D OT2TTZPZ Strong Genetic Variation [864]
CDKN3 OTBE3H07 Strong Biomarker [865]
CEBPD OTNBIPMY Strong Biomarker [866]
CEBPE OTKZA25M Strong Altered Expression [867]
CENPV OTPQ0KT9 Strong Altered Expression [868]
CHD1 OT9R9G0H Strong Genetic Variation [869]
CHD4 OTBDEHDP Strong Biomarker [870]
CHD8 OTS7A6AF Strong Biomarker [794]
CHMP5 OTQWZL6R Strong Genetic Variation [23]
CHORDC1 OT3W6F1U Strong Biomarker [871]
CIB1 OT4BVCRU Strong Biomarker [872]
CIP2A OTVS2GXA Strong Biomarker [406]
CIR1 OTKP5JKH Strong Biomarker [349]
CITED2 OT812TV7 Strong Genetic Variation [74]
CKMT1A OTCINHH5 Strong Biomarker [873]
CLPB OT1I0IBK Strong Altered Expression [874]
CLTC OTBFASMA Strong Biomarker [573]
CNTNAP1 OT5Y03EU Strong Altered Expression [875]
COL12A1 OTHLTV53 Strong Biomarker [876]
CP OTM8JE4Y Strong Genetic Variation [23]
CPNE3 OTCR3WG2 Strong Altered Expression [877]
CPT1A OTI862QH Strong Biomarker [878]
CRIP1 OT0EICG3 Strong Biomarker [879]
CRISPLD2 OTVSFHTL Strong Altered Expression [226]
CRYL1 OT0SJSJM Strong Biomarker [880]
CST3 OTNZ6AO4 Strong Biomarker [224]
CTC1 OTRJY7QD Strong Biomarker [240]
CTCF OT8ZB70U Strong Genetic Variation [881]
CTSZ OTSCX2LL Strong Biomarker [224]
CUEDC2 OTWMOLAJ Strong Biomarker [109]
CUL2 OTPF83PG Strong Biomarker [109]
DAP OT5YLL7E Strong Biomarker [882]
DAPK1 OTNCNUCO Strong Biomarker [883]
DAPK2 OTWODUQG Strong Altered Expression [884]
DCC OT2C1SHW Strong Genetic Variation [885]
DCDC2 OTSUFH1H Strong Biomarker [886]
DDA1 OTAZIAIH Strong Biomarker [887]
DDIT3 OTI8YKKE Strong Biomarker [888]
DDT OTF5HTYL Strong Genetic Variation [889]
DDX18 OTKB9C3S Strong Genetic Variation [890]
DERL1 OTJUS74N Strong Genetic Variation [891]
DGUOK OT78HUZB Strong Altered Expression [892]
DHDDS OTVLYBUS Strong Genetic Variation [23]
DIXDC1 OT87DXEG Strong Altered Expression [893]
DKC1 OTX7DJR6 Strong Biomarker [894]
DOCK11 OTFSTN6A Strong Altered Expression [895]
DOCK2 OTZTS3PA Strong Biomarker [422]
DOCK5 OT63I0CL Strong Altered Expression [896]
DOCK6 OTPNUVLT Strong Genetic Variation [897]
DOK1 OTGVRLW6 Strong Biomarker [898]
DOK2 OTIJ38UF Strong Biomarker [898]
DOK7 OTR2V7HO Strong Altered Expression [899]
DPP6 OTWW3H0K Strong Genetic Variation [23]
DRAM1 OTIJTXEN Strong Biomarker [900]
E2F4 OTB3JFH4 Strong Genetic Variation [901]
EBF1 OTZ61YYH Strong Genetic Variation [23]
EBF3 OTB0IWLW Strong Posttranslational Modification [902]
EEF1A1 OT00THXS Strong Altered Expression [903]
EFS OT06O7XL Strong Biomarker [904]
EGR2 OTAVQ78J Strong Altered Expression [905]
EHD3 OTOKC2G5 Strong Posttranslational Modification [224]
EIF1 OTB4GZ0V Strong Altered Expression [454]
EIF2S1 OTM0GDTP Strong Altered Expression [906]
EIF2S2 OTXF0B09 Strong Altered Expression [906]
EIF2S3 OTARRES9 Strong Altered Expression [906]
EIF3D OTDOMP80 Strong Biomarker [907]
EIF4B OTE8TXA8 Strong Biomarker [428]
ELF5 OTLRU8YF Strong Biomarker [908]
ELK1 OTH9MXD6 Strong Altered Expression [828]
ELOC OT0XHHWP Strong Biomarker [109]
ENO2 OTRODL0T Strong Biomarker [224]
EP400 OTVQ75NX Strong Biomarker [909]
EPC1 OT3Q25ND Strong Biomarker [909]
EPC2 OTTG0W9R Strong Biomarker [909]
EPS8 OTZ6ES6V Strong Altered Expression [910]
ERC1 OTYBGGNO Strong Genetic Variation [23]
ERVW-1 OTWV8DXJ Strong Altered Expression [911]
ESPL1 OTMGEVOK Strong Altered Expression [912]
ETV6 OTCZMG61 Strong Autosomal dominant [185]
EXOSC3 OTNCF906 Strong Genetic Variation [913]
EXOSC5 OTADUQ7H Strong Altered Expression [914]
FADD OTV7GFHH Strong Biomarker [915]
FANCC OTTIDM3P Strong Biomarker [916]
FANCD2 OTVEB5LF Strong Biomarker [240]
FANCE OTKRPBW1 Strong Biomarker [240]
FANCG OT7MC8TZ Strong Biomarker [240]
FANCI OTW8E3SC Strong Biomarker [240]
FANCL OTJC7QPQ Strong Biomarker [240]
FBXL2 OT5EZ7PD Strong Altered Expression [917]
FBXO8 OTZNGJGW Strong Altered Expression [918]
FBXO9 OTW5P5JF Strong Biomarker [850]
FBXW4 OTEGSZOX Strong Genetic Variation [804]
FCGR3B OTSLSPZG Strong Biomarker [112]
FEZ1 OTWCXPRE Strong Biomarker [919]
FH OTEQWU6Q Strong Altered Expression [920]
FHL2 OT0OAYWT Strong Altered Expression [921]
FLI1 OT0EV3LX Strong Altered Expression [922]
FLT3LG OTU0YGC4 Strong Altered Expression [923]
FLYWCH1 OTWZVRX2 Strong Altered Expression [924]
FOXN3 OTOJYJZP Strong Biomarker [925]
FOXO3 OTHXQG4P Strong Altered Expression [926]
FRYL OTBN3XHN Strong Genetic Variation [927]
FTL OTYQA8A6 Strong Altered Expression [308]
FUBP1 OT77SC9N Strong Biomarker [928]
FUT6 OTBZUQ7F Strong Altered Expression [88]
FUT7 OTJF6BSN Strong Biomarker [929]
FXYD6 OTHOQXGF Strong Biomarker [224]
FZD1 OTZATHVS Strong Altered Expression [930]
FZD3 OTIWDN78 Strong Biomarker [931]
FZD4 OTGLZIE0 Strong Biomarker [519]
FZD6 OTBCPII8 Strong Biomarker [932]
FZD9 OTTZ9MKK Strong Posttranslational Modification [933]
FZR1 OT0WGWZS Strong Altered Expression [934]
GAS2L1 OTGFPWYN Strong Biomarker [224]
GAS7 OT0M5TNY Strong Biomarker [935]
GATA2 OTBP2QQ2 Strong Autosomal dominant [185]
GFI1 OT9HB9H8 Strong Genetic Variation [936]
GHRH OT94U6MO Strong Biomarker [310]
GLI3 OTKDOE94 Strong Genetic Variation [23]
GLIS2 OTOUUV1X Strong Biomarker [937]
GNL3 OTILGYO4 Strong Biomarker [938]
GOLGA6A OTHU9MRX Strong Biomarker [192]
GORASP1 OTQS91S7 Strong Genetic Variation [23]
GPR42 OTEB0ROY Strong Biomarker [217]
GPR68 OT1NXSMN Strong Altered Expression [245]
GPRC5C OT45AJT3 Strong Biomarker [315]
GSPT1 OT18H1B0 Strong Biomarker [939]
GTF2I OTUYL1TQ Strong Biomarker [476]
GZMA OT43R33L Strong Altered Expression [226]
H1-0 OTRLJK4Z Strong Biomarker [224]
H1-1 OTSS815G Strong Genetic Variation [940]
H4C1 OTB71W46 Strong Altered Expression [941]
HCST OTILCB4K Strong Biomarker [942]
HERC5 OTZ5PR39 Strong Biomarker [586]
HES1 OT8P19W2 Strong Biomarker [943]
HEY1 OTJQL0I3 Strong Biomarker [385]
HHEX OTLIUVYX Strong Biomarker [944]
HIC1 OTI9TWY4 Strong Biomarker [945]
HIP1 OT7AKCFQ Strong Altered Expression [946]
HLA-C OTV38BUJ Strong Genetic Variation [947]
HLA-DMB OT17HGXJ Strong Biomarker [380]
HLA-DOB OTKADDUB Strong Genetic Variation [386]
HLF OTTRK9XN Strong Biomarker [865]
HMMR OT4M0JTZ Strong Biomarker [948]
HNRNPK OTNPRM8U Strong Biomarker [949]
HOXA2 OT6G6ZIK Strong Altered Expression [950]
HOXA3 OTIX5XFB Strong Biomarker [950]
HOXB2 OTTD6HMV Strong Biomarker [951]
HOXB4 OTH1HRW5 Strong Altered Expression [885]
HOXC11 OT8NMHM6 Strong Genetic Variation [952]
HOXC13 OT52AVNA Strong Genetic Variation [23]
HOXC4 OT52VJ6V Strong Altered Expression [953]
HOXC5 OTPQTLKZ Strong Altered Expression [953]
HOXC6 OTBCRAZV Strong Altered Expression [953]
HOXD10 OT0NOWU2 Strong Biomarker [954]
HPSE2 OTGEPP8V Strong Genetic Variation [23]
HS3ST3B1 OTK53GUD Strong Biomarker [955]
IBTK OTB2GM4G Strong Biomarker [956]
ICMT OT8CNKBO Strong Biomarker [957]
ID4 OTPMJ39I Strong Posttranslational Modification [958]
IFI30 OT9DERT1 Strong Biomarker [224]
IFITM3 OT2QP8D3 Strong Altered Expression [959]
IGF2BP1 OT9G360P Strong Biomarker [960]
IGF2BP2 OT4ZSEEE Strong Altered Expression [961]
IKBKE OT5VYOSM Strong Biomarker [457]
IL17B OTS86H50 Strong Biomarker [962]
IL17RB OT0KDNSF Strong Biomarker [962]
IL18R1 OT83XMPQ Strong Biomarker [290]
INO80C OTKXHGET Strong Biomarker [73]
IRF7 OTC1A2PQ Strong Altered Expression [963]
IRX3 OTLJ48FG Strong Altered Expression [964]
IST1 OTSFEZ2O Strong Genetic Variation [940]
ITGA2B OT4Y17PY Strong Genetic Variation [23]
ITGAX OTOGIMHE Strong Genetic Variation [23]
ITGBL1 OTJDHE17 Strong Biomarker [965]
ITPKB OTSVVPAV Strong Biomarker [966]
JAG1 OT3LGT6K Strong Altered Expression [967]
JUND OTNKACJD Strong Altered Expression [652]
KAT7 OTUN98IC Strong Biomarker [968]
KAT8 OT5LPQTR Strong Altered Expression [969]
KATNB1 OT7CLZKS Strong Biomarker [178]
KCNH4 OTHJ8WTU Strong Altered Expression [828]
KCNH8 OT3I5FLB Strong Altered Expression [828]
KDM3B OTZU5J5S Strong Altered Expression [970]
KDM6A OTZM3MJJ Strong Genetic Variation [971]
KIR2DL5B OTSV0JL9 Strong Genetic Variation [355]
KIR3DS1 OTJWIO4T Strong Biomarker [972]
KLF5 OT1ABI9N Strong Altered Expression [973]
KLHL1 OTAX6SAD Strong Altered Expression [216]
KLRD1 OTMYLOV4 Strong Biomarker [974]
KMT2B OTMMAZQX Strong Biomarker [975]
KMT2C OTC59BCO Strong Genetic Variation [976]
KRT20 OT4RB40L Strong Biomarker [379]
KRT7 OTLT3JFN Strong Altered Expression [590]
L3MBTL1 OT8M52QY Strong Genetic Variation [977]
L3MBTL2 OTKX1XIX Strong Genetic Variation [977]
LAMP5 OTC672RM Strong Altered Expression [502]
LAMTOR2 OTHEDISB Strong Posttranslational Modification [863]
LARP4B OT2HI0QE Strong Biomarker [978]
LBH OT87AT1X Strong Biomarker [178]
LBR OT1HG3HG Strong Genetic Variation [979]
LCP2 OT57KE22 Strong Biomarker [381]
LDOC1 OTWZH4O9 Strong Biomarker [70]
LEF1 OTWS5I5H Strong Biomarker [980]
LEO1 OTAPF4PA Strong Altered Expression [981]
LEUTX OTZV9IH0 Strong Genetic Variation [982]
LIG3 OT48SKET Strong Altered Expression [983]
LIN28B OTVWP0FN Strong Altered Expression [984]
LLGL1 OTAIQSXZ Strong Altered Expression [985]
LPP OT6TU8SE Strong Biomarker [986]
LRG1 OTLD0KWA Strong Biomarker [987]
LYL1 OTCNOV1M Strong Biomarker [988]
MACROH2A1 OTV2DQDD Strong Biomarker [989]
MAD2L2 OT24ZO59 Strong Biomarker [240]
MAFB OTH2N3T8 Strong Altered Expression [990]
MAGEB2 OTAGUVU5 Strong Altered Expression [368]
MAK16 OTD546E5 Strong Biomarker [417]
MAML2 OT1TSVAR Strong Genetic Variation [991]
MARK1 OTP7KL47 Strong Altered Expression [438]
MATK OTVOJJLJ Strong Biomarker [360]
MBD3 OTRL76H5 Strong Biomarker [896]
MBD4 OTWR9YXE Strong Biomarker [992]
MCAT OTH07FIW Strong Altered Expression [270]
MCF2L2 OTOGFMIH Strong Biomarker [993]
MCTS1 OT7SAOJP Strong Altered Expression [270]
MED12 OTQZ4D2X Strong Genetic Variation [710]
MEF2C OTZGF1Y5 Strong Biomarker [439]
MEFV OTRJ6S6K Strong Genetic Variation [994]
MEIS2 OTG4ADLM Strong Biomarker [995]
METTL14 OT6TPQMH Strong Biomarker [996]
MIXL1 OT584VOQ Strong Biomarker [423]
MLF1 OTC5BKHU Strong Biomarker [997]
MLLT11 OTG5RVHC Strong Genetic Variation [998]
MLLT6 OTOC9OGX Strong Genetic Variation [999]
MLXIPL OTR9MLLW Strong Altered Expression [1000]
MNX1 OTXP9FH1 Strong Genetic Variation [1001]
MOGS OT99MBGB Strong Genetic Variation [1002]
MOK OTQK7M9V Strong Altered Expression [1003]
MORC3 OT81NKVT Strong Biomarker [1004]
MPI OTBH6ZK1 Strong Biomarker [589]
MPST OTCDPH5D Strong Biomarker [369]
MS4A3 OT0CEJOO Strong Biomarker [1005]
MSTO1 OT37XCNP Strong Biomarker [369]
MSX1 OT5U41ZP Strong Altered Expression [1006]
MT3 OTVCZ7HI Strong Posttranslational Modification [1007]
MTF2 OTNL1O2O Strong Biomarker [1008]
MTHFD2 OT1LQSGX Strong Altered Expression [1009]
MTSS1 OT5DTDO2 Strong Biomarker [1010]
MUL1 OT2JC9YR Strong Altered Expression [850]
MX1 OT6X8G5T Strong Biomarker [224]
MYBL2 OTZ3JX8Q Strong Genetic Variation [1011]
MYH8 OT9F350W Strong Genetic Variation [1012]
MYH9 OT94Z706 Strong Altered Expression [1013]
MYOF OTRFC3IJ Strong Biomarker [1014]
MZB1 OT071TET Strong Altered Expression [1015]
NBEAL2 OTMCAXWR Strong Biomarker [966]
NBR1 OTVRL7J9 Strong Altered Expression [1016]
NCALD OTJZ8UEL Strong Altered Expression [1017]
NCOR1 OT04XNOU Strong Biomarker [1018]
NCR3 OT20M764 Strong Biomarker [1019]
NDRG2 OT5L6KD7 Strong Biomarker [466]
NDUFA2 OTNSTATK Strong Biomarker [1020]
NELL2 OTS4MJZ7 Strong Biomarker [388]
NEUROD1 OTZQ7QJ2 Strong Biomarker [813]
NF1 OTC29NHH Strong Genetic Variation [1021]
NFATC1 OT4TMERS Strong Biomarker [1022]
NFE2 OTLM94BI Strong Genetic Variation [1023]
NIPA1 OT9ODC8X Strong Biomarker [236]
NKD1 OTY3MO97 Strong Altered Expression [1024]
NOL3 OT1K0L0D Strong Biomarker [1025]
NPAS2 OTMRT2TS Strong Biomarker [1026]
NR2C2 OTDZWVOJ Strong Biomarker [118]
NRM OTK7F9XZ Strong Biomarker [1027]
NRROS OT9WNOKY Strong Biomarker [1028]
NSMCE2 OTJXLDC9 Strong Biomarker [1029]
NT5C3A OT67KZJA Strong Genetic Variation [1030]
NUDCD1 OT8DS3CX Strong Biomarker [914]
NUP205 OTJKHCY6 Strong Biomarker [1031]
NUP214 OTWEA19O Strong Biomarker [1032]
NUP43 OTDF5K8Y Strong Biomarker [264]
ORC5 OTFPW8DE Strong Genetic Variation [1033]
PA2G4 OT7IG7HT Strong Altered Expression [1034]
PAF1 OTDDGUBQ Strong Posttranslational Modification [1035]
PALB2 OT6DNDBG Strong Biomarker [240]
PARP9 OT7K4494 Strong Genetic Variation [23]
PBX3 OT8WMVM4 Strong Altered Expression [1036]
PCDH17 OTRK0M05 Strong Altered Expression [1037]
PDC OT1UUVYY Strong Biomarker [1038]
PDCD4 OTZ6NXUX Strong Biomarker [1039]
PDIA3 OTHPQ0Q3 Strong Biomarker [1040]
PELI1 OTMLBCLC Strong Biomarker [1041]
PER3 OTVKYVJA Strong Altered Expression [609]
PHLPP2 OTXB1OUI Strong Altered Expression [1042]
PIGN OTHHTJKX Strong Altered Expression [1043]
PIP OTH719AH Strong Biomarker [1044]
PIP4K2A OTO9JO9U Strong Altered Expression [1045]
PIP4K2B OTF1VGJ9 Strong Altered Expression [1045]
PIP4K2C OTHRWR93 Strong Biomarker [1045]
PIR OT8ALXHU Strong Biomarker [1046]
PKD1 OT5ALRZ5 Strong Biomarker [1047]
PLAAT4 OTI66SAJ Strong Biomarker [1048]
PLEC OTU4XDEG Strong Biomarker [1049]
PLS3 OTYBM4PK Strong Altered Expression [1050]
PLSCR1 OTGY9B5T Strong Genetic Variation [1051]
PM20D1 OTXXNQ5K Strong Posttranslational Modification [791]
PNO1 OT010GIS Strong Biomarker [417]
POLR2A OTHJQ1DZ Strong Biomarker [1052]
POT1 OTNBXJCQ Strong Genetic Variation [1053]
POTEF OTV3WXYE Strong Altered Expression [1054]
POU5F1B OT0FKQ51 Strong Biomarker [1055]
PPP1R13B OTC88VQO Strong Biomarker [1056]
PPP1R13L OTNCPLWE Strong Altered Expression [921]
PPP1R1A OTGTAGCV Strong Genetic Variation [1057]
PPP2R2A OT9297OG Strong Altered Expression [1058]
PRC1 OTHD0XS0 Strong Biomarker [1059]
PRDM1 OTQLSVBS Strong Altered Expression [1060]
PRDM16 OT0BGA27 Strong Biomarker [1061]
PRDM5 OTU1GB68 Strong Biomarker [119]
PRDM6 OTKY12D9 Strong Biomarker [1041]
PRDX3 OTLB2WEU Strong Biomarker [1062]
PREX1 OTUTPVA9 Strong Biomarker [1063]
PRKACB OT6RMDCE Strong Biomarker [1064]
PRKD2 OTIFSVI8 Strong Altered Expression [1065]
PRKN OTJBN41W Strong Altered Expression [850]
PRM3 OT6574BF Strong Biomarker [1066]
PRPF31 OTSJ0Z1Y Strong Altered Expression [1067]
PRPF8 OTU39JZI Strong Genetic Variation [1068]
PRRT2 OTCJUBDO Strong Biomarker [410]
PRSS27 OTC4G4UF Strong Biomarker [1069]
PSMA7 OTPHI6ST Strong Biomarker [1070]
PSMC6 OTG8997V Strong Biomarker [264]
PTPRR OT790UA2 Strong Genetic Variation [843]
PTPRU OTHDO0QG Strong Altered Expression [569]
PVR OT3N91T7 Strong Biomarker [465]
PXDN OTFGGM9R Strong Biomarker [224]
QRSL1 OTJDU2UG Strong Altered Expression [1071]
RAB27A OT9SQRWY Strong Biomarker [1072]
RAB27B OTPF9D0K Strong Biomarker [1073]
RAB40B OTCA9ZF5 Strong Biomarker [1074]
RABGEF1 OTWC3Z3R Strong Genetic Variation [23]
RALB OTFH203X Strong Biomarker [1075]
RAMAC OTAFAKPR Strong Biomarker [1072]
RAP1GDS1 OTH70UHD Strong Biomarker [1076]
RASGRP1 OTX9WN2E Strong Biomarker [605]
RBM25 OTVOUOAG Strong Altered Expression [1077]
RBM39 OTCMPTF9 Strong Biomarker [417]
RBMS3 OTFSC9MR Strong Biomarker [417]
RCBTB1 OTAYELI8 Strong Biomarker [192]
REM1 OTUXL0HC Strong Biomarker [1078]
RFC3 OT1MS7AO Strong Altered Expression [1079]
RIPK3 OTL1D484 Strong Biomarker [543]
RMDN1 OTE1NB6U Strong Altered Expression [767]
RMDN2 OTK5WSFI Strong Altered Expression [767]
RMI1 OT1ZVTFL Strong Genetic Variation [1080]
RNASE3 OTVE2XD1 Strong Biomarker [1081]
RNF2 OTFPLOIN Strong Biomarker [1082]
ROBO2 OTFJ9FQW Strong Altered Expression [1083]
RPP14 OT4OYFSK Strong Posttranslational Modification [863]
RPRM OTNNBAS1 Strong Posttranslational Modification [1084]
RPS14 OTB90KV5 Strong Biomarker [1085]
RPS15A OT0BUA12 Strong Biomarker [1086]
RPS19 OTBKGP48 Strong Biomarker [1087]
RRAS OTBBF28C Strong Genetic Variation [1088]
RREB1 OT62460U Strong Altered Expression [1089]
RRM2B OTE8GBUR Strong Biomarker [1090]
RTL1 OTOT33IM Strong Biomarker [405]
RUNX1 OTU7J84H Strong Autosomal dominant [185]
RUVBL2 OTGWJ4T4 Strong Biomarker [128]
SALL1 OTYYZGLH Strong Biomarker [1091]
SARDH OTQ49Q27 Strong Biomarker [520]
SBDS OTHDCCIB Strong Biomarker [240]
SCIN OT6U09OL Strong Altered Expression [1092]
SCPEP1 OT43LYEZ Strong Biomarker [275]
SDS OT5WTJ2M Strong Biomarker [573]
SEPTIN2 OT3G33TM Strong Altered Expression [437]
SETBP1 OTKGCOSR Strong Genetic Variation [1093]
SETD1A OTVVWRIC Strong Biomarker [1094]
SETMAR OTE2MIMZ Strong Genetic Variation [1095]
SF3B2 OTNW2U4Y Strong Genetic Variation [1096]
SF3B6 OTPRKS6S Strong Posttranslational Modification [863]
SGCZ OTVGTEOD Strong Genetic Variation [23]
SGK3 OTQ6QO99 Strong Biomarker [1097]
SH3BGRL OTUOCTMT Strong Biomarker [1098]
SH3BP5 OTOOEGUJ Strong Biomarker [1099]
SHB OTF2HSC0 Strong Altered Expression [1100]
SIPA1L3 OTNYFUM3 Strong Genetic Variation [1101]
SIX1 OT70YYWM Strong Biomarker [1102]
SKI OT4KJ8F6 Strong Altered Expression [1103]
SLC12A9 OTR7VRAK Strong Biomarker [1104]
SLU7 OTZUUICN Strong Genetic Variation [1068]
SLX4 OTF6236I Strong Biomarker [240]
SMAD5 OTQNSVCQ Strong Genetic Variation [1105]
SMARCA5 OT5GR4Z2 Strong Altered Expression [1106]
SMARCC1 OTUOMBE7 Strong Biomarker [802]
SMC3 OTWGFRHD Strong Genetic Variation [1107]
SMC4 OTEJE6AG Strong Biomarker [1108]
SMG1 OTTS3SXE Strong Biomarker [1109]
SNAI1 OTDPYAMC Strong Biomarker [1110]
SNAP91 OTE3EXWZ Strong Biomarker [711]
SNF8 OTRQA2AI Strong Altered Expression [1111]
SNRNP200 OTSAU864 Strong Biomarker [1112]
SOAT1 OTB4Y5RJ Strong Biomarker [1113]
SOCS2 OTBPNKJQ Strong Altered Expression [1078]
SOS1 OTTCWXC3 Strong Genetic Variation [1114]
SOX12 OT93P8C9 Strong Altered Expression [1115]
SOX17 OT9H4WWE Strong Altered Expression [1116]
SOX18 OTPUMHWA Strong Altered Expression [1117]
SOX6 OTT0W0LE Strong Altered Expression [1118]
SOX7 OTOZOFAG Strong Biomarker [1119]
SPACA3 OTM1JKTC Strong Altered Expression [1120]
SPANXA1 OTMK3QIS Strong Altered Expression [1121]
SPI1 OTVCA1D0 Strong Altered Expression [222]
SPINK1 OTSUVAL2 Strong Biomarker [1122]
SPINK2 OTSFBT0G Strong Biomarker [1123]
SRI OT4R3EAC Strong Biomarker [1124]
SRL OT7IEBWZ Strong Biomarker [520]
SRRM2 OTSIMMC9 Strong Biomarker [417]
SRSF1 OTF61HOV Strong Biomarker [843]
SSX2 OT2Z6RLL Strong Altered Expression [1003]
ST3GAL4 OTNENJZQ Strong Altered Expression [929]
STK3 OTLNSCQD Strong Biomarker [1125]
STUB1 OTSUYI9A Strong Biomarker [888]
STX11 OTHFRSFP Strong Biomarker [1126]
SYBU OT3FQV7N Strong Altered Expression [767]
SYCE1L OTXU44F3 Strong Altered Expression [216]
SYCP1 OTWFV4KA Strong Biomarker [275]
SYCP3 OTKOF54H Strong Altered Expression [1127]
SYNE1 OTSBSLUH Strong Genetic Variation [518]
SYNE2 OTBUXGQ0 Strong Genetic Variation [1128]
SYNGR1 OT0MBUK5 Strong Biomarker [224]
SYT1 OTVTPOI6 Strong Biomarker [490]
TAF1 OTDYS5G4 Strong Biomarker [1129]
TAF12 OTQZII5O Strong Biomarker [1130]
TAF4 OTPIRFEF Strong Altered Expression [1130]
TAL1 OTX4K6QZ Strong Altered Expression [590]
TAP2 OTWSYFI7 Strong Altered Expression [1131]
TAT OT2CJ91O Strong Biomarker [1132]
TBCE OTGBSTKS Strong Biomarker [1133]
TBP OT6C0S52 Strong Biomarker [1130]
TCEA2 OT1OS9TY Strong Biomarker [224]
TCF21 OT393IMA Strong Biomarker [1134]
TCIM OTARUXQF Strong Genetic Variation [1135]
TERT OT085VVA Strong Autosomal dominant [185]
TFE3 OTM99ZWH Strong Genetic Variation [1136]
TFPI2 OTZCRWOR Strong Altered Expression [1137]
TFR2 OTMYCCEO Strong Genetic Variation [1138]
TGIF1 OTN9VHAG Strong Biomarker [1139]
THAP10 OTCMT4L7 Strong Biomarker [1140]
TIFA OTIRCVG7 Strong Biomarker [1141]
TIGAR OTR7NMRJ Strong Biomarker [1142]
TIMM8A OTDX9687 Strong Genetic Variation [1143]
TIMP2 OT8S1RRP Strong Genetic Variation [1144]
TIMP3 OTDGQAD1 Strong Biomarker [1145]
TLE1 OT50MRZ1 Strong Biomarker [1146]
TLE4 OT4QEH6T Strong Genetic Variation [23]
TLE5 OTEH0BFG Strong Biomarker [1147]
TMEM11 OTL9HDEY Strong Biomarker [589]
TMEM18 OT05YQ1E Strong Altered Expression [1148]
TMPRSS11F OTRUQ164 Strong Altered Expression [1149]
TNFSF9 OTV9L89D Strong Altered Expression [257]
TPD52 OTPKSK43 Strong Altered Expression [1150]
TPD52L2 OTTOG0NK Strong Biomarker [928]
TPM3 OT5RU5G6 Strong Biomarker [1151]
TRADD OTBOSJHO Strong Biomarker [1152]
TRAF2 OT1MEZZN Strong Biomarker [1153]
TRAF3 OT5TQBGV Strong Genetic Variation [212]
TRAF7 OTW8Q5TF Strong Biomarker [1154]
TRAIP OTMPT9Y2 Strong Biomarker [1141]
TREML1 OTMJD2HI Strong Genetic Variation [528]
TRIM62 OT15YO6N Strong Altered Expression [1155]
TRIO OT71X1AK Strong Biomarker [476]
TSC22D1 OTN4GFWD Strong Altered Expression [1156]
TSGA10 OTIF1O1T Strong Biomarker [1157]
TSPAN3 OT7WS6ZI Strong Altered Expression [530]
TSTD1 OT5DMKFX Strong Biomarker [178]
TTC4 OTAPMYXU Strong Biomarker [1158]
AIFM1 OTKPWB7Q Definitive Biomarker [1159]
AP2A1 OTEFZB21 Definitive Altered Expression [1160]
AP5M1 OTDLWEBL Definitive Genetic Variation [1161]
ARID5B OTUQ4CQY Definitive Genetic Variation [670]
ASXL1 OTX931AW Definitive Genetic Variation [795]
ATF7IP OTU6ZA7F Definitive Biomarker [1162]
ATXN1 OTQF0HNR Definitive Biomarker [1163]
BAALC OTUZSRVF Definitive Altered Expression [1164]
BAD OT63ERYM Definitive Biomarker [1165]
BAG1 OTRQNIA4 Definitive Genetic Variation [23]
BARD1 OTTC0Z9Y Definitive Altered Expression [1166]
BCAS3 OTDVAX6B Definitive Biomarker [1167]
BCL11B OT8KKCVJ Definitive Genetic Variation [1168]
BCL2L12 OTS6IFZY Definitive Altered Expression [1169]
BIRC6 OTCQJAB0 Definitive Biomarker [1170]
BSPH1 OTLLM5JY Definitive Biomarker [1171]
BUB1B OT8KME51 Definitive Altered Expression [1172]
CALM2 OTNYA92F Definitive Biomarker [711]
CD200R1 OT65Q9M6 Definitive Altered Expression [1173]
CD72 OTPOJID2 Definitive Biomarker [1174]
CDC73 OT6JASZ1 Definitive Biomarker [1035]
CEBPA OTOM9OE4 Definitive Autosomal dominant [504]
CEBPG OTGNAX3H Definitive Biomarker [1175]
CETN1 OTGQ8JOZ Definitive Biomarker [1176]
CHFR OTRAD2TT Definitive Altered Expression [1177]
CIITA OTRJNZFO Definitive Altered Expression [1178]
CLEC4D OTT7X1UC Definitive Biomarker [855]
CLEC7A OTRTBH27 Definitive Genetic Variation [211]
CNDP2 OTJR9436 Definitive Genetic Variation [23]
COP1 OT6J2K12 Definitive Altered Expression [1179]
CPQ OTTNZNLD Definitive Altered Expression [1180]
DAXX OTX6O7PL Definitive Biomarker [1181]
DEXI OT60W9CN Definitive Biomarker [1178]
DOCK1 OTCFV3ON Definitive Biomarker [895]
DOCK4 OTH3XY8B Definitive Genetic Variation [1182]
DTX2 OT7QLDU4 Definitive Genetic Variation [1183]
E2F7 OTWW358N Definitive Altered Expression [1184]
EIF3A OTFABY9G Definitive Altered Expression [1185]
ELOVL6 OTB26UJJ Definitive Genetic Variation [1186]
EOMES OTB9VQFA Definitive Biomarker [1187]
ERG OTOTX9VU Definitive Altered Expression [1188]
FCHSD2 OTKXLIJ6 Definitive Altered Expression [1189]
FXYD5 OT81DIOD Definitive Biomarker [1190]
FZD5 OTXFFY56 Definitive Biomarker [930]
GABARAP OTAQUX6E Definitive Biomarker [1191]
GNA15 OTFYRZGV Definitive Biomarker [505]
GNMT OT0O2OQO Definitive Posttranslational Modification [1192]
GPR151 OT7EACU6 Definitive Biomarker [519]
GPX3 OT6PK94R Definitive Posttranslational Modification [1193]
GRB10 OTCKXGRC Definitive Biomarker [1194]
H1-2 OT0AVI4M Definitive Genetic Variation [23]
HLTF OTRX2OSF Definitive Genetic Variation [1195]
HOMER3 OTQ6D9X1 Definitive Biomarker [1196]
HOXA1 OTMSOJ7D Definitive Altered Expression [950]
HS3ST2 OTWFA0GJ Definitive Biomarker [494]
IER5 OTJPTXMD Definitive Altered Expression [1197]
IRF9 OTK4MYQJ Definitive Altered Expression [1198]
JAM3 OTX0F9QL Definitive Genetic Variation [1199]
KDM2B OTDMCVW7 Definitive Biomarker [1200]
KIAA1549L OT80HUVY Definitive Biomarker [1201]
LGALS9 OT7MF91K Definitive Biomarker [1202]
LGR6 OTPZ1PWR Definitive Biomarker [519]
MAGT1 OTQSAV5C Definitive Biomarker [495]
MAP2K4 OTZPZX11 Definitive Genetic Variation [1203]
MCC OTQVI1EM Definitive Biomarker [1204]
METTL3 OTSXP1M3 Definitive Altered Expression [1205]
MN1 OTVQR4R9 Definitive Biomarker [1206]
MPP1 OTA2ENZQ Definitive Genetic Variation [492]
MPRIP OT5FV5NS Definitive Biomarker [543]
MRGPRX3 OTRKCCDS Definitive Biomarker [519]
MRGPRX4 OTOBHZVA Definitive Biomarker [519]
MT1E OTXJKU4Y Definitive Biomarker [1207]
MXD1 OTS5CTHX Definitive Altered Expression [532]
MYH10 OTXN2WXS Definitive Biomarker [1208]
MYO18A OT2YPT7O Definitive Genetic Variation [1209]
NANOG OTUEY1FM Definitive Altered Expression [1210]
ND4 OT4RQVAA Definitive Genetic Variation [1211]
NEBL OT2WH1NC Definitive Biomarker [1212]
NECTIN2 OTIE0W6O Definitive Biomarker [465]
NFYB OTXSE7KW Definitive Biomarker [1197]
NMS OTFYS4LO Definitive Biomarker [1213]
NUMB OTMB586Q Definitive Altered Expression [1214]
OIP5 OTI5C2DE Definitive Altered Expression [580]
OLIG2 OTMCN6D3 Definitive Biomarker [1215]
PBX1 OTORABGO Definitive Genetic Variation [23]
PBX2 OTEBYCAW Definitive Biomarker [1216]
PDCD7 OTK5YO7J Definitive Altered Expression [222]
PGP OT6QQ7OR Definitive Biomarker [1217]
PLCB4 OTPA0QHW Definitive Biomarker [1218]
POU1F1 OTXT8A5C Definitive Genetic Variation [1219]
POU2F1 OTK7ELJ0 Definitive Biomarker [552]
PRDM2 OT8L7CGX Definitive Posttranslational Modification [1220]
PRIMA1 OT9ITT3P Definitive Genetic Variation [115]
PRPF40B OTBPUXVD Definitive Genetic Variation [1221]
PTPRE OTOD5NID Definitive Altered Expression [1222]
PTPRT OTV5TXNN Definitive Genetic Variation [23]
PURA OT975ELW Definitive Genetic Variation [1223]
PURB OTCDDKYB Definitive Biomarker [1224]
RAC2 OTAOHFNH Definitive Biomarker [1225]
RAP1A OT5RH6TI Definitive Biomarker [1226]
RAP1GAP OTC31ONQ Definitive Altered Expression [1227]
RASGRF1 OTNWJ7EN Definitive Biomarker [259]
RBM45 OTWTHD77 Definitive Biomarker [1228]
RCOR1 OTREADPC Definitive Biomarker [1229]
RHEBL1 OTPOMM5J Definitive Altered Expression [1230]
RHOH OT1J9SEB Definitive Altered Expression [1231]
RING1 OTCWTAX0 Definitive Genetic Variation [386]
ROBO3 OTPVG40S Definitive Biomarker [508]
RPS6 OTT4D1LN Definitive Altered Expression [232]
S100A10 OTI71243 Definitive Genetic Variation [913]
SDF4 OTQ7WFYW Definitive Biomarker [1176]
SF3A1 OTI733D7 Definitive Genetic Variation [1221]
SHKBP1 OTJXWLEH Definitive Genetic Variation [1232]
SIGLEC5 OTYC440J Definitive Biomarker [1233]
SIN3A OTM8OZWV Definitive Altered Expression [843]
SMARCA2 OTSGJ8SV Definitive Genetic Variation [1234]
SMARCD2 OTQTBWHW Definitive Biomarker [802]
SMC1A OT9ZMRK9 Definitive Biomarker [1235]
SORL1 OTQ8FFNS Definitive Altered Expression [1236]
SPHKAP OT5RHUYJ Definitive Altered Expression [1237]
SPRED1 OTKX7P8G Definitive Posttranslational Modification [1238]
SPRY4 OT2VK9N0 Definitive Biomarker [1239]
SRXN1 OTYDBO4L Definitive Biomarker [1167]
SRY OT516T6D Definitive Altered Expression [1117]
TAF7L OTPDZ6XV Definitive Altered Expression [580]
TANK OTZSGFIK Definitive Biomarker [1141]
TAOK2 OTNUMOZ1 Definitive Biomarker [1240]
TCL1B OT4CSO39 Definitive Genetic Variation [556]
TERF2IP OT3M5P3G Definitive Biomarker [1226]
TMEM132D OTV6I4Z0 Definitive Genetic Variation [23]
TPR OTUBBA4W Definitive Biomarker [1241]
TTC5 OTWW9ME0 Definitive Biomarker [1242]
------------------------------------------------------------------------------------
⏷ Show the Full List of 1355 DOT(s)

References

1 Interleukin-2. A review of its pharmacological properties and therapeutic use in patients with cancer. Drugs. 1993 Sep;46(3):446-514.
2 Fludarabine-melphalan conditioning for AML and MDS: alemtuzumab reduces acute and chronic GVHD without affecting long-term outcomes. Biol Blood Marrow Transplant. 2009 May;15(5):610-7.
3 Azacitidine FDA Label
4 Clofarabine FDA Label
5 Cytarabine FDA Label
6 Daunorubicin FDA Label
7 Decitabine FDA Label
8 Doxorubicin FDA Label
9 Etoposide FDA Label
10 Fludarabine FDA Label
11 Idarubicin FDA Label
12 Mitoxantrone FDA Label
13 Sulindac FDA Label
14 Thioguanine FDA Label
15 Tretinoin FDA Label
16 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
17 ClinicalTrials.gov (NCT03059615) A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS. U.S. National Institutes of Health.
18 ClinicalTrials.gov (NCT04278768) Dose Escalation/ Expansion Trial of CA-4948 as Monotherapy and in Combination With Azacitidine or Venetoclax in Patients With AML or MDS. U.S. National Institutes of Health.
19 ClinicalTrials.gov (NCT03214666) GTB-3550 (CD16/IL-15/CD33) Tri-Specific Killer Engager (TriKE) for High Risk Heme Malignancies. U.S. National Institutes of Health.
20 ClinicalTrials.gov (NCT03081780) Open Label Dose Escalation Trial of an Adaptive Natural Killer (NK) Cell Infusion (FATE-NK100) With Subcutaneous IL-2 in Adults With Refractory or Relapsed Acute Myelogenous Leukemia (AML). U.S.National Institutes of Health.
21 ClinicalTrials.gov (NCT03038230) MCLA-117 in Acute Myelogenous Leukemia. U.S. National Institutes of Health.
22 Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line.Br J Haematol. 2002 Nov;119(2):454-8. doi: 10.1046/j.1365-2141.2002.03850.x.
23 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.Oncotarget. 2017 Jan 31;8(5):7891-7899. doi: 10.18632/oncotarget.13631.
24 A novel MLL-AF10 fusion mRNA variant in a patient with acute myeloid leukemia detected by a new asymmetric reverse transcription PCR method.Leukemia. 1997 Sep;11(9):1588-93. doi: 10.1038/sj.leu.2400758.
25 Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.Blood. 2009 Sep 24;114(13):2733-43. doi: 10.1182/blood-2009-03-213496. Epub 2009 Jul 28.
26 Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.J Med Chem. 2019 Apr 11;62(7):3590-3616. doi: 10.1021/acs.jmedchem.9b00090. Epub 2019 Mar 25.
27 Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia.Int J Cancer. 2002 Sep 1;101(1):86-94. doi: 10.1002/ijc.10566.
28 CML with Megakaryocytic Blast Crisis: Report of 3 Cases.Pathol Oncol Res. 2019 Jul;25(3):1253-1258. doi: 10.1007/s12253-018-0484-7. Epub 2018 Oct 25.
29 Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia.Blood. 1997 Sep 1;90(5):1968-76.
30 Acute myeloid leukaemia niche regulates response to L-asparaginase.Br J Haematol. 2019 Aug;186(3):420-430. doi: 10.1111/bjh.15920. Epub 2019 May 1.
31 Evaluation of ATG7 and Light Chain 3 (LC3) Autophagy Genes Expression in AML Patients.Iran J Pharm Res. 2019 Spring;18(2):1060-1066. doi: 10.22037/ijpr.2019.1100682.
32 Gilteritinib Likely New Standard Care for AML.Cancer Discov. 2019 Jun;9(6):OF6. doi: 10.1158/2159-8290.CD-NB2019-046. Epub 2019 Apr 1.
33 Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML.Cell Death Dis. 2019 Dec 4;10(12):917. doi: 10.1038/s41419-019-2156-2.
34 BCL11A and MDR1 expressions have prognostic impact in patients with acute myeloid leukemia treated with chemotherapy.Pharmacogenomics. 2018 Mar;19(4):343-348. doi: 10.2217/pgs-2017-0157. Epub 2018 Feb 22.
35 The Study of SALL4 Gene and BMI-1 Gene Expression in Acute Myeloid Leukemia Patients.Lab Med. 2020 May 6;51(3):265-270. doi: 10.1093/labmed/lmz056.
36 Cytogenetic heterogeneity of acute myeloid leukaemia (AML) with trilineage dysplasia: Japan Adult Leukaemia Study Group-AML 92 study.Br J Haematol. 2003 Jan;120(1):56-62. doi: 10.1046/j.1365-2141.2003.03981.x.
37 Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia.Proteomics. 2004 Nov;4(11):3456-63. doi: 10.1002/pmic.200400968.
38 Expression of hBUB1 in acute myeloid leukemia.Leuk Lymphoma. 2002 Feb;43(2):385-91. doi: 10.1080/10428190290006206.
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296 Expression of Eph A4, Eph B2 and Eph B4 receptors in AML.Pathol Oncol Res. 2014 Oct;20(4):901-7. doi: 10.1007/s12253-014-9767-9. Epub 2014 Apr 25.
297 EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT.Blood Adv. 2017 Aug 28;1(20):1635-1644. doi: 10.1182/bloodadvances.2017005694. eCollection 2017 Sep 12.
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300 Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogenesis.Mol Cell Biol. 2017 Jun 15;37(13):e00585-16. doi: 10.1128/MCB.00585-16. Print 2017 Jul 1.
301 Immunotoxins in cancer therapy: Review and update.Int Rev Immunol. 2017 Jul 4;36(4):207-219. doi: 10.1080/08830185.2017.1284211. Epub 2017 Mar 1.
302 The poly(ADP-ribose) polymerase inhibitor olaparib induces up-regulation of death receptors in primary acute myeloid leukemia blasts by NF-B activation.Cancer Lett. 2018 Jun 1;423:127-138. doi: 10.1016/j.canlet.2018.03.008. Epub 2018 Mar 8.
303 CD64-targeted HO-1 RNA interference enhances chemosensitivity in orthotopic model of acute myeloid leukemia and patient-derived bone marrow cells.Biomaterials. 2020 Feb;230:119651. doi: 10.1016/j.biomaterials.2019.119651. Epub 2019 Nov 22.
304 Human GM-CSF receptor alpha-chain gene is highly polymorphic but not rearranged in AML.Leukemia. 1992 Sep;6(9):893-7.
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306 Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients.Genet Mol Res. 2015 May 18;14(2):5181-7. doi: 10.4238/2015.May.18.8.
307 FOXM1 contributes to treatment failure in acute myeloid leukemia.JCI Insight. 2018 Aug 9;3(15):e121583. doi: 10.1172/jci.insight.121583. eCollection 2018 Aug 9.
308 Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia.Eur J Haematol. 2019 Feb;102(2):131-142. doi: 10.1111/ejh.13183. Epub 2018 Nov 28.
309 ssExpression level of GAS6-mRNA influences the prognosis of acute myeloid leukemia patients with allogeneic hematopoietic stem cell transplantation.Biosci Rep. 2019 May 21;39(5):BSR20190389. doi: 10.1042/BSR20190389. Print 2019 May 31.
310 A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone.Br J Haematol. 2018 May;181(4):476-485. doi: 10.1111/bjh.15207. Epub 2018 Apr 16.
311 Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia.Int J Nanomedicine. 2017 Nov 23;12:8427-8442. doi: 10.2147/IJN.S147659. eCollection 2017.
312 Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.Oncol Rep. 2013 Nov;30(5):2254-62. doi: 10.3892/or.2013.2716. Epub 2013 Sep 4.
313 Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis.Histopathology. 2018 Jul;73(1):101-108. doi: 10.1111/his.13509. Epub 2018 Apr 19.
314 Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3761-3765. doi: 10.1016/j.bmcl.2018.10.013. Epub 2018 Oct 11.
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316 GPR84 sustains aberrant -catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.Blood. 2014 Nov 20;124(22):3284-94. doi: 10.1182/blood-2013-10-532523. Epub 2014 Oct 7.
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318 DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.Cancer Biomark. 2019;25(1):43-51. doi: 10.3233/CBM-182176.
319 Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):450-461. doi: 10.1016/j.bbadis.2016.11.013. Epub 2016 Nov 11.
320 HDAC2-dependent miRNA signature in acute myeloid leukemia.FEBS Lett. 2019 Sep;593(18):2574-2584. doi: 10.1002/1873-3468.13521. Epub 2019 Jul 19.
321 HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.Cell Stem Cell. 2015 Nov 5;17(5):597-610. doi: 10.1016/j.stem.2015.08.004. Epub 2015 Sep 18.
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323 LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4/AMPK/WNT5A signaling pathway.Hematol Oncol. 2019 Oct;37(4):474-482. doi: 10.1002/hon.2651. Epub 2019 Aug 5.
324 microRNA-451-modulated hnRNP A1 takes a part in granulocytic differentiation regulation and acute myeloid leukemia.Oncotarget. 2017 Jul 18;8(33):55453-55466. doi: 10.18632/oncotarget.19325. eCollection 2017 Aug 15.
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326 Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b.Cancer Cell Int. 2019 Apr 29;19:114. doi: 10.1186/s12935-019-0808-z. eCollection 2019.
327 All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.Cell Mol Biol (Noisy-le-grand). 2016 Jan 22;62(1):63-6.
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329 Hsp27: a novel therapeutic target for pediatric M4/M5 acute myeloid leukemia.Oncol Rep. 2013 Apr;29(4):1459-66. doi: 10.3892/or.2013.2274. Epub 2013 Feb 5.
330 Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target.Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14.
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332 Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.Blood. 2016 May 12;127(19):2322-6. doi: 10.1182/blood-2015-11-677708. Epub 2016 Mar 4.
333 Differential requirements for myeloid leukemia IFN- conditioning determine graft-versus-leukemia resistance and sensitivity.J Clin Invest. 2017 Jun 30;127(7):2765-2776. doi: 10.1172/JCI85736. Epub 2017 Jun 12.
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346 JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia.Leukemia. 2017 May;31(5):1196-1205. doi: 10.1038/leu.2016.329. Epub 2016 Nov 14.
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357 The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.Nat Cell Biol. 2015 May;17(5):665-77. doi: 10.1038/ncb3158. Epub 2015 Apr 27.
358 Azacitidine resistance caused by LAMP2 deficiency: a therapeutic window for the use of autophagy inhibitors in MDS/AML patients?.Autophagy. 2019 May;15(5):927-929. doi: 10.1080/15548627.2019.1586259. Epub 2019 Mar 1.
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363 LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells.Cell Mol Immunol. 2020 Mar;17(3):272-282. doi: 10.1038/s41423-019-0321-2. Epub 2019 Nov 7.
364 Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia.Cell Death Dis. 2017 Jun 1;8(6):e2849. doi: 10.1038/cddis.2017.253.
365 Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.Blood. 2017 Mar 9;129(10):1320-1332. doi: 10.1182/blood-2016-08-734798. Epub 2017 Jan 3.
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367 Next-generation sequencing and molecular cytogenetic characterization of ETV6-LYN fusion due to chromosomes 1, 8 and 12 rearrangement in acute myeloid leukemia.Cancer Genet. 2017 Dec;218-219:15-19. doi: 10.1016/j.cancergen.2017.09.001. Epub 2017 Sep 13.
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371 Prognostic Value of mRNA Expression of MAP4K Family in Acute Myeloid Leukemia.Technol Cancer Res Treat. 2019 Jan 1;18:1533033819873927. doi: 10.1177/1533033819873927.
372 MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.Cell Death Dis. 2018 Jul 26;9(8):814. doi: 10.1038/s41419-018-0837-x.
373 Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia.Oncogene. 2017 May 4;36(18):2589-2598. doi: 10.1038/onc.2016.416. Epub 2016 Nov 7.
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377 Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia.Eur J Med Chem. 2017 Oct 20;139:762-772. doi: 10.1016/j.ejmech.2017.08.006. Epub 2017 Aug 3.
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381 Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.Leuk Lymphoma. 2019 Jul;60(7):1697-1708. doi: 10.1080/10428194.2018.1543880. Epub 2018 Dec 20.
382 Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia.Oncotarget. 2016 Apr 26;7(17):24455-65. doi: 10.18632/oncotarget.8227.
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384 RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.Nat Commun. 2018 Mar 21;9(1):1163. doi: 10.1038/s41467-018-03513-4.
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422 FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways.Haematologica. 2019 Dec;104(12):2418-2428. doi: 10.3324/haematol.2018.208843. Epub 2019 Apr 11.
423 A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.Oncotarget. 2014 Dec 30;5(24):12675-93. doi: 10.18632/oncotarget.2564.
424 The impact of At1r inhibition via losartan on the anti-leukaemic effects of doxorubicin in acute myeloid leukaemia.J Renin Angiotensin Aldosterone Syst. 2019 Apr-Jun;20(2):1470320319851310. doi: 10.1177/1470320319851310.
425 RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia.Leukemia. 2018 Oct;32(10):2189-2202. doi: 10.1038/s41375-018-0102-4. Epub 2018 Mar 22.
426 Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway.Front Pharmacol. 2018 Jun 26;9:673. doi: 10.3389/fphar.2018.00673. eCollection 2018.
427 Clinical and prognostic implications of Roundabout 4 (robo4) in adult patients with acute myeloid leukemia.PLoS One. 2015 Mar 20;10(3):e0119831. doi: 10.1371/journal.pone.0119831. eCollection 2015.
428 FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM.Cancers (Basel). 2019 Nov 20;11(12):1827. doi: 10.3390/cancers11121827.
429 RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.Leukemia. 2018 Mar;32(3):597-605. doi: 10.1038/leu.2017.284. Epub 2017 Sep 15.
430 Identification of miRNA-mRNA Network Associated with Acute Myeloid Leukemia Survival.Med Sci Monit. 2017 Oct 1;23:4705-4714. doi: 10.12659/msm.903989.
431 A phase I dose escalation study of oral bexarotene in combination with intravenous decitabine in patients with AML.Am J Hematol. 2014 Aug;89(8):E103-8. doi: 10.1002/ajh.23735. Epub 2014 Apr 28.
432 Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR.Int J Oncol. 2018 Mar;52(3):656-678. doi: 10.3892/ijo.2017.4233. Epub 2017 Dec 28.
433 Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.Blood. 2017 Feb 9;129(6):771-782. doi: 10.1182/blood-2016-06-720433. Epub 2016 Dec 12.
434 Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice.Leukemia. 2020 Mar;34(3):721-734. doi: 10.1038/s41375-019-0577-7. Epub 2019 Oct 21.
435 Cladribine, cytarabine and idarubicin (CLA-Ida) salvage chemotherapy in relapsed acute myeloid leukemia (AML).Leuk Lymphoma. 2017 May;58(5):1068-1075. doi: 10.1080/10428194.2016.1235274. Epub 2016 Oct 13.
436 SEMA3A partially reverses VEGF effects through binding to neuropilin-1.Stem Cell Res. 2017 Jul;22:70-78. doi: 10.1016/j.scr.2017.05.012. Epub 2017 Jun 3.
437 Expression of septin 2 and association with clinicopathological parameters in colorectal cancer.Oncol Lett. 2019 Sep;18(3):2376-2383. doi: 10.3892/ol.2019.10528. Epub 2019 Jun 26.
438 MEF2C Phosphorylation Is Required forChemotherapy Resistance in Acute Myeloid Leukemia.Cancer Discov. 2018 Apr;8(4):478-497. doi: 10.1158/2159-8290.CD-17-1271. Epub 2018 Feb 5.
439 Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.Blood. 2020 Jan 2;135(1):56-70. doi: 10.1182/blood.2019001576.
440 How many surgically-treated angiomyolipomas are related to tuberous sclerosis complex? Insights from a retrospective multicenter study.Minerva Urol Nefrol. 2020 Apr;72(2):200-206. doi: 10.23736/S0393-2249.19.03522-7. Epub 2019 Oct 10.
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442 Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.Apoptosis. 2015 Aug;20(8):1099-108. doi: 10.1007/s10495-015-1137-x.
443 Expression Levels of Human Equilibrative Nucleoside Transporter 1 and Deoxycytidine Kinase Enzyme as Prognostic Factors in Patients with Acute Myeloid Leukemia Treated with Cytarabine.Chemotherapy. 2016;61(6):313-8. doi: 10.1159/000445370. Epub 2016 Apr 28.
444 High expression of SLC38A1 predicts poor prognosis in patients with de novo acute myeloid leukemia.J Cell Physiol. 2019 Nov;234(11):20322-20328. doi: 10.1002/jcp.28632. Epub 2019 Apr 4.
445 CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.Cancer Cell. 2016 Nov 14;30(5):792-805. doi: 10.1016/j.ccell.2016.10.003. Epub 2016 Oct 27.
446 Low ferroportin expression in AML is correlated with good risk cytogenetics, improved outcomes and increased sensitivity to chemotherapy.Leuk Res. 2019 May;80:1-10. doi: 10.1016/j.leukres.2019.02.011. Epub 2019 Feb 28.
447 Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia. Clin Pharmacol Ther. 2016 Jun;99(6):651-60.
448 High expression levels of SMAD3 and SMAD7 at diagnosis predict poor prognosis in acute myeloid leukemia patients undergoing chemotherapy.Cancer Gene Ther. 2019 May;26(5-6):119-127. doi: 10.1038/s41417-018-0044-z. Epub 2018 Sep 4.
449 SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.Oncotarget. 2017 Mar 7;8(10):16712-16727. doi: 10.18632/oncotarget.15147.
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451 SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment.Oncol Rep. 2015 Sep;34(3):1406-14. doi: 10.3892/or.2015.4114. Epub 2015 Jul 8.
452 lncRNA SNHG3 facilitates acute myeloid leukemia cell growth via the regulation of miR-758-3p/SRGN axis.J Cell Biochem. 2020 Feb;121(2):1023-1031. doi: 10.1002/jcb.29336. Epub 2019 Aug 26.
453 SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0.
454 MIF-Induced Stromal PKC/IL8 Is Essential in Human Acute Myeloid Leukemia.Cancer Res. 2017 Jan 15;77(2):303-311. doi: 10.1158/0008-5472.CAN-16-1095. Epub 2016 Nov 21.
455 Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner.Leukemia. 2018 Mar;32(3):588-596. doi: 10.1038/leu.2017.261. Epub 2017 Aug 18.
456 Stanniocalcin1 gene expression in patients with acute leukemia: impact on response to therapy and disease outcome.Int J Lab Hematol. 2016 Feb;38(1):81-9. doi: 10.1111/ijlh.12445. Epub 2015 Nov 7.
457 The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.Blood Adv. 2018 Dec 11;2(23):3428-3442. doi: 10.1182/bloodadvances.2018016733.
458 MicroRNA-29b mediates altered innate immune development in acute leukemia.J Clin Invest. 2016 Dec 1;126(12):4404-4416. doi: 10.1172/JCI85413. Epub 2016 Oct 24.
459 Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners.J Biol Chem. 2019 Mar 29;294(13):4898-4910. doi: 10.1074/jbc.RA118.006795. Epub 2019 Jan 31.
460 Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.Leukemia. 2009 Jul;23(7):1345-8. doi: 10.1038/leu.2009.66. Epub 2009 Apr 2.
461 MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia.Ann Hematol. 2018 Jan;97(1):63-72. doi: 10.1007/s00277-017-3158-8. Epub 2017 Oct 27.
462 Affinity separation and subsequent terminal differentiation of acute myeloid leukemia cells using the human transferrin receptor (CD71) as a capture target.Analyst. 2019 May 13;144(10):3369-3380. doi: 10.1039/c8an02357c.
463 Thrombopoietin mimetics for patients with myelodysplastic syndromes.Cochrane Database Syst Rev. 2017 Sep 30;9(9):CD009883. doi: 10.1002/14651858.CD009883.pub2.
464 Increased levels of a chromosome 21-encoded tumour invasion and metastasis factor (TIAM1) mRNA in bone marrow of Down syndrome children during the acute phase of AML(M7).Genes Chromosomes Cancer. 1998 Sep;23(1):61-6.
465 Monitoring TIGIT/DNAM-1 and PVR/PVRL2 Immune Checkpoint Expression Levels in Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia.Biol Blood Marrow Transplant. 2019 May;25(5):861-867. doi: 10.1016/j.bbmt.2019.01.013. Epub 2019 Jan 11.
466 NDRG2 and TLR7 as novel DNA methylation prognostic signatures for acute myelocytic leukemia.J Cell Physiol. 2020 Apr;235(4):3790-3797. doi: 10.1002/jcp.29273. Epub 2019 Oct 15.
467 NF-B-dependent RANKL expression in a mouse model of immature T-cell leukemia.Biochem Biophys Res Commun. 2019 Mar 5;510(2):272-277. doi: 10.1016/j.bbrc.2019.01.089. Epub 2019 Jan 30.
468 Increased Regulatory T Cells in Peripheral Blood of Acute Myeloid Leukemia Patients Rely on Tumor Necrosis Factor (TNF)--TNF Receptor-2 Pathway.Front Immunol. 2018 Jun 5;9:1274. doi: 10.3389/fimmu.2018.01274. eCollection 2018.
469 CD30 Expression Is Rare in Myeloid Leukemia Cutis: A Study of 55 Cases and Implications for Routine Diagnostic Algorithms.Am J Dermatopathol. 2017 May;39(5):351-357. doi: 10.1097/DAD.0000000000000755.
470 CD33-Specific Chimeric Antigen Receptor T Cells with Different Co-Stimulators Showed Potent Anti-Leukemia Efficacy and Different Phenotype.Hum Gene Ther. 2018 May;29(5):626-639. doi: 10.1089/hum.2017.241. Epub 2018 Mar 19.
471 Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.Cancers (Basel). 2019 Feb 22;11(2):260. doi: 10.3390/cancers11020260.
472 Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.Haematologica. 2019 Oct;104(10):2006-2016. doi: 10.3324/haematol.2018.192062. Epub 2019 Feb 28.
473 EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology.SLAS Discov. 2019 Mar;24(3):398-413. doi: 10.1177/2472555218816276. Epub 2019 Jan 7.
474 Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.Mol Oncol. 2019 Oct;13(10):2062-2078. doi: 10.1002/1878-0261.12541. Epub 2019 Aug 31.
475 The effect of marrow stromal cells on TRAF6 expression levels in myeloma cells.Oncol Lett. 2017 Aug;14(2):1464-1470. doi: 10.3892/ol.2017.6322. Epub 2017 Jun 6.
476 Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.Leuk Res. 2008 Jun;32(6):944-53. doi: 10.1016/j.leukres.2007.11.038. Epub 2008 Feb 21.
477 TRPM2 in Cancer.Cell Calcium. 2019 Jun;80:8-17. doi: 10.1016/j.ceca.2019.03.002. Epub 2019 Mar 6.
478 Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner.Int J Cancer. 2015 Oct 15;137(8):1855-69. doi: 10.1002/ijc.29573. Epub 2015 May 8.
479 Clinical implications of aberrant TSG101 transcripts in acute myeloblastic leukemia.Leuk Lymphoma. 2000 Feb;36(5-6):463-6. doi: 10.3109/10428190009148393.
480 BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia.BMC Cancer. 2018 Jul 11;18(1):731. doi: 10.1186/s12885-018-4661-6.
481 Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.Redox Biol. 2019 Jun;24:101153. doi: 10.1016/j.redox.2019.101153. Epub 2019 Mar 8.
482 Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.Biochem Pharmacol. 2017 Mar 15;128:12-25. doi: 10.1016/j.bcp.2016.12.022. Epub 2016 Dec 30.
483 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
484 A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.Genes Chromosomes Cancer. 2018 Oct;57(10):522-524. doi: 10.1002/gcc.22646. Epub 2018 Aug 14.
485 Whole transcriptome sequencing reveals a KMT2A-USP2 fusion in infant acute myeloid leukemia.Genes Chromosomes Cancer. 2019 Sep;58(9):669-672. doi: 10.1002/gcc.22751. Epub 2019 Apr 8.
486 Effect of High VEGF-C mRNA Expression on Achievement of Complete Remission in Adult Acute Myeloid Leukemia.Transl Oncol. 2018 Jun;11(3):567-574. doi: 10.1016/j.tranon.2018.02.018. Epub 2018 Mar 12.
487 Functional improvements in patients with lymphangioleiomyomatosis after sirolimus: an observational study.Orphanet J Rare Dis. 2018 Feb 20;13(1):34. doi: 10.1186/s13023-018-0775-9.
488 VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML.Oncoimmunology. 2018 Jul 11;7(9):e1469594. doi: 10.1080/2162402X.2018.1469594. eCollection 2018.
489 Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53() murine model.Oncoimmunology. 2018 Jul 30;7(9):e1468954. doi: 10.1080/2162402X.2018.1468954. eCollection 2018.
490 NF-B/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.Leukemia. 2015 Mar;29(3):535-47. doi: 10.1038/leu.2014.231. Epub 2014 Aug 5.
491 The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia.Leukemia. 2018 Apr;32(4):911-919. doi: 10.1038/leu.2017.342. Epub 2017 Dec 6.
492 An unexpected protein interaction promotes drug resistance in leukemia.Nat Commun. 2017 Nov 16;8(1):1547. doi: 10.1038/s41467-017-01678-y.
493 ADAMTS-13 activity reduction in plasma of acute myeloid leukemia predicts poor prognosis after bone marrow transplantation.Hematology. 2019 Dec;24(1):129-133. doi: 10.1080/10245332.2018.1532648. Epub 2018 Oct 16.
494 DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups.Br J Haematol. 2012 Oct;159(2):182-90. doi: 10.1111/bjh.12029. Epub 2012 Aug 28.
495 Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells.Oncogene. 2017 Mar;36(11):1487-1502. doi: 10.1038/onc.2016.310. Epub 2016 Nov 21.
496 Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.Oncogene. 2018 Feb 8;37(6):787-797. doi: 10.1038/onc.2017.376. Epub 2017 Oct 23.
497 High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors.Cancer Res. 2011 Mar 1;71(5):1999-2009. doi: 10.1158/0008-5472.CAN-10-3018. Epub 2011 Jan 6.
498 Expression and Relationship of SAMHD1 with Other Apoptotic and Autophagic Genes in Acute Myeloid Leukemia Patients.Acta Haematol. 2020;143(1):51-59. doi: 10.1159/000500822. Epub 2019 Aug 21.
499 Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.Blood. 2007 Aug 1;110(3):1022-4. doi: 10.1182/blood-2006-12-061176. Epub 2007 May 2.
500 Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia.Eur J Clin Pharmacol. 2012 Dec;68(12):1577-86. doi: 10.1007/s00228-012-1291-9. Epub 2012 May 5.
501 CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.Cell Rep. 2019 Feb 12;26(7):1906-1918.e8. doi: 10.1016/j.celrep.2019.01.050.
502 Features of non-activation dendritic state and immune deficiency in blastic plasmacytoid dendritic cell neoplasm (BPDCN).Blood Cancer J. 2019 Dec 6;9(12):99. doi: 10.1038/s41408-019-0262-0.
503 B-cell transcription factor expression and immunoglobulin gene rearrangement frequency in acute myeloid leukemia with t(8;21)(q22;q22).Am J Clin Pathol. 2013 Sep;140(3):355-62. doi: 10.1309/AJCPFBCFXP94AKWJ.
504 Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.
505 Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML.Leukemia. 2011 Dec;25(12):1825-33. doi: 10.1038/leu.2011.172. Epub 2011 Jul 15.
506 Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.Ann Hematol. 2012 Dec;91(12):1861-70. doi: 10.1007/s00277-012-1537-8. Epub 2012 Aug 15.
507 Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.Cancer Cell. 2018 Mar 12;33(3):386-400.e5. doi: 10.1016/j.ccell.2018.01.012. Epub 2018 Feb 22.
508 RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1897-902. doi: 10.1073/pnas.1019059108. Epub 2011 Jan 11.
509 GM-CSF-DFF40: a novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells.Apoptosis. 2013 Jul;18(7):882-95. doi: 10.1007/s10495-013-0840-8.
510 Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients.Leuk Res. 2010 Oct;34(10):1308-13. doi: 10.1016/j.leukres.2009.11.030. Epub 2010 Jan 12.
511 Cross-talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway.Carcinogenesis. 2013 Mar;34(3):667-77. doi: 10.1093/carcin/bgs386. Epub 2012 Dec 13.
512 Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.J Biol Chem. 2011 Dec 2;286(48):41479-41488. doi: 10.1074/jbc.M111.284687. Epub 2011 Oct 6.
513 Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms.J Hematol Oncol. 2011 Sep 27;4:39. doi: 10.1186/1756-8722-4-39.
514 The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia.Leukemia. 2012 May;26(5):918-26. doi: 10.1038/leu.2011.319. Epub 2011 Nov 25.
515 The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.Blood. 2013 Sep 12;122(11):1900-13. doi: 10.1182/blood-2012-11-466425. Epub 2013 Jul 29.
516 Transcriptomic analysis of the PI3K/Akt signaling pathway reveals the dual role of the c-Jun oncogene in cytotoxicity and the development of resistance in HL-60 leukemia cells in response to arsenic trioxide.Adv Clin Exp Med. 2017 Dec;26(9):1335-1342. doi: 10.17219/acem/65475.
517 Clinical significance of the TNF- receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia.Cytokine. 2018 Nov;111:523-529. doi: 10.1016/j.cyto.2018.05.025. Epub 2018 Jun 1.
518 Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia.PLoS One. 2017 Mar 9;12(3):e0173472. doi: 10.1371/journal.pone.0173472. eCollection 2017.
519 Characterization of upregulated adhesion GPCRs in acute myeloid leukemia.Transl Res. 2019 Oct;212:26-35. doi: 10.1016/j.trsl.2019.05.004. Epub 2019 May 17.
520 Discovery of novel glycogen synthase kinase-3 inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia.Eur J Med Chem. 2019 Jun 1;171:221-234. doi: 10.1016/j.ejmech.2019.03.039. Epub 2019 Mar 20.
521 Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.J Med Chem. 2018 Jul 26;61(14):6056-6074. doi: 10.1021/acs.jmedchem.8b00393. Epub 2018 Jul 14.
522 Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.Am J Cancer Res. 2019 Jan 1;9(1):94-107. eCollection 2019.
523 Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells.Front Immunol. 2018 Sep 26;9:2227. doi: 10.3389/fimmu.2018.02227. eCollection 2018.
524 LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia.Mol Med Rep. 2017 Sep;16(3):3687-3693. doi: 10.3892/mmr.2017.7029. Epub 2017 Jul 18.
525 IL1RL1 is dynamically expressed on Cbfb-MYH11(+) leukemia stem cells and promotes cell survival.Sci Rep. 2019 Feb 11;9(1):1729. doi: 10.1038/s41598-018-38408-3.
526 Tumor infiltrating lymphocytes from acute myeloid leukemia marrow can be reverted to CD45RA+ central memory state by reactivation in SIP (Simulated Infective Protocol).Immunobiology. 2019 Jul;224(4):526-531. doi: 10.1016/j.imbio.2019.05.001. Epub 2019 May 2.
527 Mechanisms and consequences of constitutive activation of integrin-linked kinase in acute myeloid leukemia.Cytokine Growth Factor Rev. 2018 Oct;43:1-7. doi: 10.1016/j.cytogfr.2018.06.001. Epub 2018 Jun 7.
528 Downregulation of TREM-like transcript-1 and collagen receptor 2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.Haematologica. 2019 Jun;104(6):1244-1255. doi: 10.3324/haematol.2018.188904. Epub 2018 Dec 13.
529 JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis.Leukemia. 2019 Jun;33(6):1400-1410. doi: 10.1038/s41375-018-0354-z. Epub 2019 Jan 8.
530 LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p.Life Sci. 2020 Jan 15;241:117161. doi: 10.1016/j.lfs.2019.117161. Epub 2019 Dec 11.
531 Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.Blood. 2019 Jan 10;133(2):168-179. doi: 10.1182/blood-2018-02-833475. Epub 2018 Nov 29.
532 Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome.Leuk Res. 2013 Nov;37(11):1538-44. doi: 10.1016/j.leukres.2013.07.022. Epub 2013 Oct 3.
533 The prognostic value of matrix metalloproteinase-7 and matrix metalloproteinase-15 in acute myeloid leukemia.J Cell Biochem. 2019 Jun;120(6):10613-10624. doi: 10.1002/jcb.28351. Epub 2019 Feb 27.
534 Genetic variation in the folate metabolic pathway and risk of childhood leukemia.Blood. 2010 May 13;115(19):3923-9. doi: 10.1182/blood-2009-10-249722. Epub 2010 Jan 25.
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537 A novel monoclonal antibody, KOR-SA3544 which reacts to Philadelphia chromosome-positive acute lymphoblastic leukemia cells with high sensitivity.Leukemia. 1995 Jul;9(7):1233-9.
538 Aberrant methylation of the M-type phospholipase A(2) receptor gene in leukemic cells.BMC Cancer. 2012 Dec 5;12:576. doi: 10.1186/1471-2407-12-576.
539 Combined effects of FLT3 and NF-B selective inhibitors on acute myeloid leukemia in vivo.J Biochem Mol Toxicol. 2012 Jan;26(1):35-43. doi: 10.1002/jbt.20411. Epub 2011 Sep 16.
540 Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.Cancer Res. 2018 Jan 1;78(1):75-87. doi: 10.1158/0008-5472.CAN-17-0946. Epub 2017 Nov 9.
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542 RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells.Mol Cell Biochem. 2013 Dec;384(1-2):197-202. doi: 10.1007/s11010-013-1798-0. Epub 2013 Sep 3.
543 Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway.Leukemia. 2017 May;31(5):1154-1165. doi: 10.1038/leu.2016.287. Epub 2016 Oct 17.
544 MiR-592 functions as a tumor suppressor in acute myeloid leukemia by targeting ROCK1 and predicts patients' prognosis.Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1610-1619. doi: 10.26355/eurrev_201902_17120.
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546 Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.Target Oncol. 2019 Jun;14(3):351-364. doi: 10.1007/s11523-019-00638-4.
547 SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints.Leukemia. 2019 Nov;33(11):2585-2598. doi: 10.1038/s41375-019-0456-2. Epub 2019 Apr 9.
548 A novel treatment strategy targeting shugoshin 1 in hematological malignancies.Leuk Res. 2013 Jan;37(1):76-82. doi: 10.1016/j.leukres.2012.10.002. Epub 2012 Oct 24.
549 LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.Mol Cell. 2018 Mar 15;69(6):1017-1027.e6. doi: 10.1016/j.molcel.2018.02.011. Epub 2018 Mar 8.
550 Engagement of SIRP inhibits growth and induces programmed cell death in acute myeloid leukemia cells.PLoS One. 2013;8(1):e52143. doi: 10.1371/journal.pone.0052143. Epub 2013 Jan 8.
551 Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6.
552 Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.Exp Hematol. 2019 Aug;76:38-48.e2. doi: 10.1016/j.exphem.2019.07.002. Epub 2019 Jul 8.
553 Induction of apoptosis and differentiation by Na/H exchanger 1 modulation in acute myeloid leukemia cells.Biochem Biophys Res Commun. 2019 Nov 19;519(4):887-893. doi: 10.1016/j.bbrc.2019.09.087. Epub 2019 Sep 25.
554 Midostaurin treatment in FLT3-mutated acute myeloid leukemia and systemic mastocytosis.Expert Rev Clin Pharmacol. 2017 Nov;10(11):1177-1189. doi: 10.1080/17512433.2017.1387051. Epub 2017 Oct 10.
555 A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia.Cancer Res. 2019 Jul 1;79(13):3372-3382. doi: 10.1158/0008-5472.CAN-18-0189. Epub 2019 May 7.
556 TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow.Am J Hematol. 2013 Dec;88(12):1055-61. doi: 10.1002/ajh.23567. Epub 2013 Sep 30.
557 Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias.Leuk Res. 2017 Jun;57:112-118. doi: 10.1016/j.leukres.2017.03.011. Epub 2017 Mar 21.
558 E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBP for ubiquitin-mediated proteasome degradation.Cell Death Dis. 2013 Apr 18;4(4):e590. doi: 10.1038/cddis.2013.120.
559 Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.Mol Cancer Ther. 2013 Dec;12(12):2651-62. doi: 10.1158/1535-7163.MCT-13-0103-T. Epub 2013 Oct 15.
560 Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.Cancer Lett. 2018 Sep 1;431:150-160. doi: 10.1016/j.canlet.2018.05.034. Epub 2018 May 30.
561 Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia.Leukemia. 2001 Oct;15(10):1544-53. doi: 10.1038/sj.leu.2402236.
562 DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication.Blood. 2008 Sep 1;112(5):2013-6. doi: 10.1182/blood-2008-01-128595. Epub 2008 Jun 19.
563 Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration.Leukemia. 2008 Aug;22(8):1576-86. doi: 10.1038/leu.2008.103. Epub 2008 May 8.
564 Expression of ABCB5 gene in hematological malignances and its significance.Leuk Lymphoma. 2012 Jun;53(6):1211-5. doi: 10.3109/10428194.2011.637214. Epub 2011 Dec 7.
565 Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors.Molecules. 2018 Aug 23;23(9):2126. doi: 10.3390/molecules23092126.
566 OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
567 Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients.Leuk Res. 2017 Feb;53:57-64. doi: 10.1016/j.leukres.2016.12.004. Epub 2016 Dec 20.
568 Thalidomide in Combination with Chemotherapy in Treating Elderly Patients with Acute Myeloid Leukemia.Oncol Res Treat. 2018;41(7-8):461-465. doi: 10.1159/000487804. Epub 2018 Jul 6.
569 NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells.Leukemia. 2016 Feb;30(2):473-83. doi: 10.1038/leu.2015.234. Epub 2015 Aug 26.
570 Concentrative nucleoside transporter 3 as a prognostic indicator for favorable outcome of t(8;21)-positive acute myeloid leukemia patients after cytarabine-based chemotherapy.Oncol Rep. 2015 Jul;34(1):488-94. doi: 10.3892/or.2015.3959. Epub 2015 May 7.
571 Downregulation of GLUT3 Promotes Apoptosis and Chemosensitivity of Acute Myeloid Leukemia Cells via EGFR Signaling.Arch Iran Med. 2018 Feb 1;21(2):73-78.
572 Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential.Cancer Cell. 2016 Nov 14;30(5):779-791. doi: 10.1016/j.ccell.2016.09.006. Epub 2016 Oct 13.
573 A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity.Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110051. doi: 10.1016/j.msec.2019.110051. Epub 2019 Aug 19.
574 Potential mechanisms of resistance to cytarabine in AML patients.Leuk Res. 2002 Jul;26(7):621-9. doi: 10.1016/s0145-2126(01)00184-9.
575 Detection and subcellular localization of an AML1 chimeric protein in the t(8;21) positive acute myeloid leukemia.Oncogene. 1996 Jan 18;12(2):437-44.
576 BAT-25 and BAT-26, two mononucleotide microsatellites, are not sensitive markers of microsatellite instability in acute myeloid leukaemia.Br J Haematol. 2004 Jan;124(2):160-5. doi: 10.1046/j.1365-2141.2003.04750.x.
577 Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug-metabolizing enzymes and apoptotic signaling.Mol Carcinog. 2019 May;58(5):808-819. doi: 10.1002/mc.22973. Epub 2019 Jan 28.
578 Quantification of X-chromosome inactivation patterns in haematological samples using the DNA PCR-based HUMARA assay.Leukemia. 1996 Feb;10(2):362-7.
579 5'-(3')-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine.Haematologica. 2004 May;89(5):617-9.
580 Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern.Med Oncol. 2013 Mar;30(1):368. doi: 10.1007/s12032-012-0368-8. Epub 2013 Jan 6.
581 Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.Blood. 2005 Feb 1;105(3):1246-55. doi: 10.1182/blood-2004-05-2041. Epub 2004 Sep 23.
582 Genetic analysis and clinical picture of severe congenital neutropenia in Israel.Pediatr Blood Cancer. 2015 Jan;62(1):103-8. doi: 10.1002/pbc.25251. Epub 2014 Oct 4.
583 Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities.Oncotarget. 2017 Nov 1;8(60):102150-102160. doi: 10.18632/oncotarget.22235. eCollection 2017 Nov 24.
584 Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2.
585 Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.Haematologica. 2017 Jun;102(6):1054-1065. doi: 10.3324/haematol.2016.159053. Epub 2017 Mar 9.
586 Construction of prognostic risk prediction model based on high-throughput sequencing expression profile data in childhood acute myeloid leukemia.Blood Cells Mol Dis. 2019 Jul;77:43-50. doi: 10.1016/j.bcmd.2019.03.008. Epub 2019 Mar 28.
587 Copy number variability analysis of pharmacogenes in patients with lymphoma, leukemia, hepatocellular, and lung carcinoma using The Cancer Genome Atlas data.Pharmacogenet Genomics. 2015 Jan;25(1):1-7. doi: 10.1097/FPC.0000000000000097.
588 Relationship between NAT2 polymorphisms and onset risk of acute leukemia: a systematic review and meta-analysis.Eur Rev Med Pharmacol Sci. 2019 Nov;23(21):9259-9266. doi: 10.26355/eurrev_201911_19418.
589 Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy.Biomaterials. 2018 Jun;167:132-142. doi: 10.1016/j.biomaterials.2018.03.025. Epub 2018 Mar 14.
590 Pattern of expression and their clinical implications of the GATA family, stem cell leukemia gene, and EVI1 in leukemia and myelodysplastic syndromes.Leuk Lymphoma. 1996 Nov;23(5-6):431-6. doi: 10.3109/10428199609054850.
591 Positional cloning and next-generation sequencing identified a TGM6 mutation in a large Chinese pedigree with acute myeloid leukaemia.Eur J Hum Genet. 2015 Feb;23(2):218-23. doi: 10.1038/ejhg.2014.67. Epub 2014 Apr 23.
592 Thiopurine methyltransferase activity in children with acute myeloid leukemia.Oncol Lett. 2018 Oct;16(4):4699-4706. doi: 10.3892/ol.2018.9191. Epub 2018 Jul 23.
593 ABO Blood Type Incompatibility Is Not a Risk Factor of Outcomes for Acute Myeloid Leukemia (AML) Patients After Unmanipulated Haplo-identical Peripheral Blood Hematopoietic Stem Cell Transplantation.Ann Transplant. 2019 Jun 14;24:350-358. doi: 10.12659/AOT.916004.
594 Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase.Oncotarget. 2017 Jun 19;8(66):109915-109923. doi: 10.18632/oncotarget.18565. eCollection 2017 Dec 15.
595 NAT10 upregulation indicates a poor prognosis in acute myeloid leukemia.Curr Probl Cancer. 2020 Apr;44(2):100491. doi: 10.1016/j.currproblcancer.2019.06.006. Epub 2019 Jul 2.
596 Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
597 t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines.Genes Chromosomes Cancer. 2001 Sep;32(1):1-10. doi: 10.1002/gcc.1160.
598 Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13).Genes Chromosomes Cancer. 1999 Nov;26(3):192-202. doi: 10.1002/(sici)1098-2264(199911)26:3<192::aid-gcc2>3.0.co;2-e.
599 Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.PLoS One. 2016 May 12;11(5):e0155660. doi: 10.1371/journal.pone.0155660. eCollection 2016.
600 T-cell acute lymphoblastic leukemia with add(1)(p36) and del(12)(p11) following acute myelocytic leukemia with partial deletion of 9p.Cancer Genet Cytogenet. 2004 Apr 1;150(1):62-5. doi: 10.1016/j.cancergencyto.2003.08.003.
601 High GPR56 surface expression correlates with a leukemic stem cell gene signature in CD34-positive AML.Cancer Med. 2019 Apr;8(4):1771-1778. doi: 10.1002/cam4.2053. Epub 2019 Mar 7.
602 Transforming activities of the NUP98-KMT2A fusion gene associated with myelodysplasia and acute myeloid leukemia.Haematologica. 2020 Jul;105(7):1857-1867. doi: 10.3324/haematol.2019.219188. Epub 2019 Sep 26.
603 WTX is rarely mutated in acute myeloid leukemia.Haematologica. 2008 Jun;93(6):947-8. doi: 10.3324/haematol.12509. Epub 2008 May 6.
604 Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML.J Hum Genet. 2015 Dec;60(12):749-54. doi: 10.1038/jhg.2015.105. Epub 2015 Sep 10.
605 The clinically relevant pharmacogenomic changes in acute myelogenous leukemia.Pharmacogenomics. 2012 Aug;13(11):1257-69. doi: 10.2217/pgs.12.102.
606 Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2145-50. doi: 10.1073/pnas.040569197.
607 CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.Mol Cancer Res. 2005 Oct;3(10):585-96. doi: 10.1158/1541-7786.MCR-05-0111.
608 Glasdegib plus intensive/nonintensive chemotherapy in untreated acute myeloid leukemia: BRIGHT AML 1019 Phase III trials.Future Oncol. 2019 Nov;15(31):3531-3545. doi: 10.2217/fon-2019-0373. Epub 2019 Sep 13.
609 Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia.Anticancer Res. 2015 Dec;35(12):6615-22.
610 B-lymphoid/myeloid stem cell origin in Ph-positive acute leukemia with myeloid markers.Leuk Res. 1993 Jul;17(7):549-55. doi: 10.1016/0145-2126(93)90083-w.
611 Semi-quantitative study of calcitonin gene methylation in myelodysplastic syndrome.Chin Med J (Engl). 1998 Aug;111(8):690-3.
612 Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.Hum Mol Genet. 2003 Sep 15;12(18):2349-58. doi: 10.1093/hmg/ddg237. Epub 2003 Jul 22.
613 BCL3 Expression Is a Potential Prognostic and Predictive Biomarker in Acute Myeloid Leukemia of FAB Subtype M2.Pathol Oncol Res. 2019 Apr;25(2):541-548. doi: 10.1007/s12253-018-0476-7. Epub 2018 Oct 25.
614 Mutations within the FLR exon of NF1 are rare in myelodysplastic syndromes and acute myelocytic leukemias.Leukemia. 1993 Jul;7(7):1058-60.
615 Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.Haematologica. 2002 Jun;87(6):569-77.
616 Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.Apoptosis. 2013 Aug;18(8):963-79. doi: 10.1007/s10495-013-0842-6.
617 Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8. doi: 10.1038/ng1015. Epub 2002 Nov 18.
618 Synthesis of a novel cytokine and its gene (LD78) expressions in hematopoietic fresh tumor cells and cell lines.J Clin Invest. 1989 Dec;84(6):1707-12. doi: 10.1172/JCI114353.
619 A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.Blood. 2006 Sep 1;108(5):1716-23. doi: 10.1182/blood-2006-04-016113. Epub 2006 May 2.
620 The microRNA miR-196b acts as a tumor suppressor in Cdx2-driven acute myeloid leukemia.Haematologica. 2020 Jun;105(6):e285-e289. doi: 10.3324/haematol.2019.223297. Epub 2019 Sep 26.
621 A tool compound targeting the core binding factor Runt domain to disrupt binding to CBF in leukemic cells.Leuk Lymphoma. 2018 Sep;59(9):2188-2200. doi: 10.1080/10428194.2017.1410882. Epub 2017 Dec 18.
622 Coculture of native human acute myelogenous leukemia blasts with fibroblasts and osteoblasts results in an increase of vascular endothelial growth factor levels.Eur J Haematol. 2005 Jan;74(1):24-34. doi: 10.1111/j.1600-0609.2004.00333.x.
623 Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.Clin Cancer Res. 2007 Feb 1;13(3):1019-28. doi: 10.1158/1078-0432.CCR-06-1602.
624 Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias.Am J Hematol. 2005 Dec;80(4):282-7. doi: 10.1002/ajh.20503.
625 RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18694-9. doi: 10.1073/pnas.0704433104. Epub 2007 Nov 13.
626 Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR.Pediatr Hematol Oncol. 2006 Mar;23(2):115-27. doi: 10.1080/08880010500457780.
627 STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.Blood. 1996 Mar 1;87(5):1692-7.
628 MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia.Oncogene. 2012 Jan 5;31(1):80-92. doi: 10.1038/onc.2011.208. Epub 2011 Jun 6.
629 Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model.Leuk Res. 1996 Jul;20(7):581-9. doi: 10.1016/0145-2126(96)00004-5.
630 Inv(11)(p15q22)/NUP98-DDX10 fusion and isoforms in a new case of de novo acute myeloid leukemia.Cancer Genet. 2013 Mar;206(3):92-6. doi: 10.1016/j.cancergen.2013.02.001. Epub 2013 Mar 20.
631 DDX41 mutations in myeloid neoplasms are associated with male gender, TP53 mutations and high-risk disease.Am J Hematol. 2019 Jul;94(7):757-766. doi: 10.1002/ajh.25486. Epub 2019 May 7.
632 DDX43 promoter is frequently hypomethylated and may predict a favorable outcome in acute myeloid leukemia.Leuk Res. 2014 May;38(5):601-7. doi: 10.1016/j.leukres.2014.02.012. Epub 2014 Mar 3.
633 p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells.Oncogene. 1996 Sep 5;13(5):1017-26.
634 p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia.Leuk Res. 2005 May;29(5):557-64. doi: 10.1016/j.leukres.2004.11.003. Epub 2005 Jan 26.
635 Human DMTF1 antagonizes DMTF1 regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.Biochim Biophys Acta. 2015 Sep;1849(9):1198-208. doi: 10.1016/j.bbagrm.2015.07.009. Epub 2015 Jul 15.
636 RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.Blood. 2019 Jul 4;134(1):59-73. doi: 10.1182/blood.2018893982. Epub 2019 Apr 25.
637 Differential expression of terminal transferase (TdT) in acute lymphocytic leukaemia expressing myeloid antigens and TdT positive acute myeloid leukaemia as compared to myeloid antigen negative acute lymphocytic leukaemia.Br J Haematol. 1993 Jul;84(3):416-22. doi: 10.1111/j.1365-2141.1993.tb03095.x.
638 Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia.Cancer Lett. 2003 Sep 25;199(2):185-92. doi: 10.1016/s0304-3835(03)00352-5.
639 Apoptosis induction and growth suppression by U19/Eaf2 is mediated through its ELL-binding domain.Prostate. 2007 Feb 1;67(2):146-53. doi: 10.1002/pros.20481.
640 Partial deletion of chromosome 1 in a case of acute myelocytic leukemia.Cancer Genet Cytogenet. 2002 Nov;139(1):60-2. doi: 10.1016/s0165-4608(02)00597-6.
641 The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases.Leuk Res. 2003 May;27(5):387-92. doi: 10.1016/s0145-2126(02)00214-x.
642 Combination of chemotherapy and gemtuzumab ozogamicin in adult Philadelphia positive acute lymphoblastic leukemia patient harboring CD33 expression.Int J Hematol. 2008 Sep;88(2):209-211. doi: 10.1007/s12185-008-0123-2. Epub 2008 Aug 1.
643 Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.Blood. 2012 Aug 2;120(5):1107-17. doi: 10.1182/blood-2011-11-394932. Epub 2012 Jun 7.
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646 A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Blood. 2004 Apr 1;103(7):2744-52. doi: 10.1182/blood-2003-07-2280. Epub 2003 Dec 4.
647 Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia.Oncogene. 2007 Apr 5;26(16):2299-307. doi: 10.1038/sj.onc.1210043. Epub 2006 Oct 16.
648 Low expression of MDS1-EVI1-like-1 (MEL1) and EVI1-like-1 (EL1) genes in favorable-risk acute myeloid leukemia.Exp Hematol. 2003 Nov;31(11):1066-72. doi: 10.1016/j.exphem.2003.08.003.
649 The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner.Cancer Res. 1997 Mar 1;57(5):799-802.
650 Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells.Leukemia. 2006 Jun;20(6):979-86. doi: 10.1038/sj.leu.2404203.
651 International scoring system for evaluating prognosis in myelodysplastic syndromes.Blood. 1997 Mar 15;89(6):2079-88.
652 HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.Leukemia. 2013 Jun;27(6):1358-68. doi: 10.1038/leu.2012.366. Epub 2012 Dec 18.
653 Identification of T-lymphocytic leukemia-initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease.Blood. 2011 Jun 30;117(26):7112-20. doi: 10.1182/blood-2011-01-329078. Epub 2011 May 11.
654 Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation.Genes Chromosomes Cancer. 2005 Mar;42(3):269-79. doi: 10.1002/gcc.20147.
655 Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia.Br J Haematol. 2008 Sep;142(5):745-53. doi: 10.1111/j.1365-2141.2008.07242.x. Epub 2008 Jun 3.
656 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.J Biol Chem. 2008 Oct 10;283(41):27444-27451. doi: 10.1074/jbc.M709703200. Epub 2008 Aug 11.
657 CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.PLoS One. 2014 Feb 10;9(2):e85328. doi: 10.1371/journal.pone.0085328. eCollection 2014.
658 Activation of HLXB9 by juxtaposition with MYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1).Genes Chromosomes Cancer. 2005 Feb;42(2):170-8. doi: 10.1002/gcc.20113.
659 S-phase DNA content and aneuploidy of immunophenotypic defined subpopulations in acute myeloid leukemia determined by multi-parameter flow cytometry.Leuk Res. 1991;15(9):827-35. doi: 10.1016/0145-2126(91)90467-8.
660 IL-21-mediated expansion of V9V2 T cells is limited by the Tim-3 pathway.Int Immunopharmacol. 2019 Apr;69:136-142. doi: 10.1016/j.intimp.2019.01.027. Epub 2019 Jan 29.
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662 Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.Blood. 2006 Dec 1;108(12):3916-8. doi: 10.1182/blood-2006-05-022921. Epub 2006 Aug 10.
663 Proteomics of acute myeloid leukaemia: Cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications.Oncogene. 2006 Nov 9;25(53):7041-58. doi: 10.1038/sj.onc.1209689. Epub 2006 May 29.
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666 Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.Leukemia. 2002 Jul;16(7):1293-301. doi: 10.1038/sj.leu.2402532.
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668 Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice.Sci Rep. 2019 Nov 20;9(1):17213. doi: 10.1038/s41598-019-53610-7.
669 ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.Oncogene. 2009 Feb 26;28(8):1099-109. doi: 10.1038/onc.2008.457. Epub 2008 Dec 15.
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673 IRF2-INPP4B-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells.Biol Res. 2019 Mar 15;52(1):11. doi: 10.1186/s40659-019-0218-7.
674 Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis.Leukemia. 2013 Apr;27(5):1072-9. doi: 10.1038/leu.2012.369. Epub 2012 Dec 21.
675 Quantification of CBFbeta/MYH11 fusion transcript by real time RT-PCR in patients with INV(16) acute myeloid leukemia.Leukemia. 2001 Jul;15(7):1072-80. doi: 10.1038/sj.leu.2402159.
676 The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML.Leukemia. 2019 Nov;33(11):2628-2639. doi: 10.1038/s41375-019-0581-y. Epub 2019 Oct 1.
677 Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis.Cancer Sci. 2008 Aug;99(8):1523-7. doi: 10.1111/j.1349-7006.2008.00865.x.
678 Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.PLoS Genet. 2013;9(10):e1003765. doi: 10.1371/journal.pgen.1003765. Epub 2013 Oct 10.
679 Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.Haematologica. 2014 Sep;99(9):1456-64. doi: 10.3324/haematol.2013.101386. Epub 2014 Jun 3.
680 AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14).Oncogene. 2000 Sep 7;19(38):4446-50. doi: 10.1038/sj.onc.1203789.
681 Investigation of methylation at Hha I sites using the hypervariable probe M27 beta allows improved clonal analysis in myeloid leukaemia and demonstrates differences in methylation between leukaemic and remission samples.Leukemia. 1994 Jan;8(1):190-4.
682 hKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cells.Mol Cancer Ther. 2008 Sep;7(9):2798-806. doi: 10.1158/1535-7163.MCT-08-0276.
683 Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation.Br J Haematol. 2011 Jun;153(5):612-22. doi: 10.1111/j.1365-2141.2011.08586.x. Epub 2011 Apr 13.
684 Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).Genes Chromosomes Cancer. 2003 Jan;36(1):107-12. doi: 10.1002/gcc.10139.
685 Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders.Br J Haematol. 2008 May;141(4):504-11. doi: 10.1111/j.1365-2141.2008.07072.x. Epub 2008 Mar 3.
686 Venetoclax Combined With Low-Dose Cytarabine for Previously Untreated Patients With Acute Myeloid Leukemia: Results From a Phase Ib/II Study.J Clin Oncol. 2019 May 20;37(15):1277-1284. doi: 10.1200/JCO.18.01600. Epub 2019 Mar 20.
687 The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia.Haematologica. 2005 Dec;90(12):1699-701.
688 Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.Cancer Res. 2010 Jun 15;70(12):4949-60. doi: 10.1158/0008-5472.CAN-09-1962. Epub 2010 May 25.
689 The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation.Stem Cell Reports. 2019 May 14;12(5):1069-1083. doi: 10.1016/j.stemcr.2019.03.010. Epub 2019 Apr 25.
690 AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma.Blood. 2003 May 15;101(10):3778-83. doi: 10.1182/blood-2002-08-2641. Epub 2003 Jan 30.
691 Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.Cancer Cell. 2011 Sep 13;20(3):357-69. doi: 10.1016/j.ccr.2011.07.016.
692 Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLLAF9 translocation.Mol Med Rep. 2020 Feb;21(2):883-893. doi: 10.3892/mmr.2019.10849. Epub 2019 Nov 26.
693 MNDA binds NPM/B23 and the NPM-MLF1 chimera generated by the t(3;5) associated with myelodysplastic syndrome and acute myeloid leukemia.Exp Hematol. 1997 Oct;25(11):1111-7.
694 Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function.Mol Cell Biol. 2006 Aug;26(15):5809-26. doi: 10.1128/MCB.00024-06.
695 A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences.Genomics. 1999 Apr 1;57(1):24-35. doi: 10.1006/geno.1999.5765.
696 Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids.Br J Haematol. 1990 Aug;75(4):489-95. doi: 10.1111/j.1365-2141.1990.tb07787.x.
697 NBS1 rs1805794G>C polymorphism is associated with decreased risk of acute myeloid leukemia in a Chinese population.Mol Biol Rep. 2013 May;40(5):3749-56. doi: 10.1007/s11033-012-2451-9. Epub 2013 Jan 3.
698 Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.Int J Hematol. 2014 Jan;99(1):21-31. doi: 10.1007/s12185-013-1466-x. Epub 2013 Nov 21.
699 Survival in acute myeloid leukemia is associated with NKp44 splice variants.Oncotarget. 2016 May 31;7(22):32933-45. doi: 10.18632/oncotarget.8782.
700 A case of childhood acute myeloid leukemia AML (M5) with a neocentric chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter) and tetrasomy of chromosomes 8 and 21.Cancer Genet Cytogenet. 2009 Sep;193(2):123-6. doi: 10.1016/j.cancergencyto.2009.05.001.
701 Differentiation inhibitory factor nm23 as a new prognostic factor in acute monocytic leukemia.Blood. 1996 Nov 1;88(9):3555-61.
702 Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias.Blood. 2004 Sep 15;104(6):1833-40. doi: 10.1182/blood-2003-10-3577. Epub 2004 Jun 8.
703 Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia.Carcinogenesis. 2002 Apr;23(4):559-64. doi: 10.1093/carcin/23.4.559.
704 Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia.Oncogene. 2013 Nov 14;32(46):5359-68. doi: 10.1038/onc.2013.40. Epub 2013 Mar 11.
705 The nuclear migration gene NudC and human hematopoiesis.Leuk Lymphoma. 2000 Nov;39(5-6):447-54. doi: 10.3109/10428190009113375.
706 Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML.Blood. 2011 Jun 2;117(22):5931-40. doi: 10.1182/blood-2010-08-304485. Epub 2011 Apr 6.
707 Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population.Genet Test Mol Biomarkers. 2016 Nov;20(11):696-701. doi: 10.1089/gtmb.2016.0007. Epub 2016 Sep 9.
708 Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.Eur J Haematol. 2008 Aug;81(2):112-22. doi: 10.1111/j.1600-0609.2008.01083.x. Epub 2008 Jun 28.
709 RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.Cancer Res. 2007 Mar 1;67(5):1997-2005. doi: 10.1158/0008-5472.CAN-06-3093.
710 Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically.Leukemia. 2019 Jul;33(7):1620-1634. doi: 10.1038/s41375-019-0390-3. Epub 2019 Feb 8.
711 Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.Exp Hematol. 2012 Dec;40(12):1016-27. doi: 10.1016/j.exphem.2012.08.001. Epub 2012 Aug 8.
712 The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells.Leukemia. 2011 Apr;25(4):655-62. doi: 10.1038/leu.2010.301. Epub 2011 Jan 25.
713 cDNA cloning of human myeloperoxidase: decrease in myeloperoxidase mRNA upon induction of HL-60 cells.Proc Natl Acad Sci U S A. 1987 Apr;84(7):2057-61. doi: 10.1073/pnas.84.7.2057.
714 Human CAP10-Like Protein 46kDa Gene Promotes Malignancy in Colorectal Cancer.OMICS. 2017 May;21(5):266-274. doi: 10.1089/omi.2017.0037.
715 The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.Blood. 1995 Sep 15;86(6):2073-6.
716 Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.Eur J Cancer Prev. 2008 Apr;17(2):125-32. doi: 10.1097/CEJ.0b013e3282b6fd68.
717 High expression of urokinase plasminogen activator receptor (UPA-R) in acute myeloid leukemia (AML) is associated with worse prognosis.Am J Hematol. 2005 May;79(1):26-35. doi: 10.1002/ajh.20337.
718 NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).Blood. 1999 Jul 15;94(2):741-7.
719 A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity.Cancer Lett. 2020 Jan 1;468:1-13. doi: 10.1016/j.canlet.2019.10.007. Epub 2019 Oct 5.
720 Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.Biochem Biophys Res Commun. 2017 Jan 22;482(4):802-807. doi: 10.1016/j.bbrc.2016.11.114. Epub 2016 Nov 23.
721 Expression of recombination activating genes-1 and-2 immunoglobulin heavy chain gene rearrangements in acute myeloid leukemia: evaluation of biological and clinical significance in a series of 76 uniformly treated patients and review of the literature.Haematologica. 2003 Mar;88(3):268-74.
722 A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia.Haematologica. 2007 Jun;92(6):744-52. doi: 10.3324/haematol.10869.
723 RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.J Biol Chem. 2002 Aug 23;277(34):30508-14. doi: 10.1074/jbc.M111330200. Epub 2002 Mar 5.
724 Routine expression profiling of microarray gene signatures in acute leukaemia by real-time PCR of human bone marrow.Br J Haematol. 2005 Jul;130(2):233-48. doi: 10.1111/j.1365-2141.2005.05594.x.
725 The expression of cellular retinoid binding proteins in non-APL leukemic cells and its association with retinoid sensitivity.Leuk Lymphoma. 2002 Apr;43(4):851-8. doi: 10.1080/10428190290016999.
726 Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia.Ann Hematol. 2005 Jun;84(6):368-75. doi: 10.1007/s00277-005-1035-3. Epub 2005 Mar 24.
727 Development of a dual-color, double fusion FISH assay to detect RPN1/EVI1 gene fusion associated with inv(3), t(3;3), and ins(3;3) in patients with myelodysplasia and acute myeloid leukemia.Am J Hematol. 2010 Aug;85(8):569-74. doi: 10.1002/ajh.21746.
728 Expression pattern and prognostic implication of SALL4 gene in myeloid leukemias: a case-control study.Scand J Clin Lab Invest. 2019 Feb-Apr;79(1-2):65-70. doi: 10.1080/00365513.2018.1555854. Epub 2019 Jan 12.
729 Methylation profiling in acute myeloid leukemia.Blood. 2001 May 1;97(9):2823-9. doi: 10.1182/blood.v97.9.2823.
730 FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23).Leukemia. 2004 May;18(5):998-1005. doi: 10.1038/sj.leu.2403334.
731 MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11).Leuk Lymphoma. 2014 Mar;55(3):662-7. doi: 10.3109/10428194.2013.809528. Epub 2013 Aug 20.
732 AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25).Cancer Res. 1999 Sep 1;59(17):4261-5.
733 Secreted-frizzled related protein 1 is a transcriptional repression target of the t(8;21) fusion protein in acute myeloid leukemia.Blood. 2011 Dec 15;118(25):6638-48. doi: 10.1182/blood-2011-05-354712. Epub 2011 Oct 26.
734 Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Blood. 2008 May 1;111(9):4716-22. doi: 10.1182/blood-2007-10-113068. Epub 2008 Feb 25.
735 Virulence determinants in vancomycin-resistant Enterococcus faecium vanB: clonal distribution, prevalence and significance of esp and hyl in Australian patients with haematological disorders.J Hosp Infect. 2008 Feb;68(2):137-44. doi: 10.1016/j.jhin.2007.10.017.
736 Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.Oncogene. 2007 Jul 19;26(33):4797-805. doi: 10.1038/sj.onc.1210281. Epub 2007 Feb 19.
737 Mutational analysis of the ST7 gene in human myeloid tumor cell lines.Oncol Rep. 2003 Nov-Dec;10(6):1737-9.
738 Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia.Blood. 2012 May 31;119(22):5071-7. doi: 10.1182/blood-2012-01-406116. Epub 2012 Feb 27.
739 Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia.Cancer Res. 2002 Oct 1;62(19):5408-12.
740 Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis.Leukemia. 2006 Jul;20(7):1211-6. doi: 10.1038/sj.leu.2404239. Epub 2006 May 11.
741 Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.Blood. 2009 Jul 2;114(1):144-7. doi: 10.1182/blood-2009-03-210039. Epub 2009 May 6.
742 TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.Haematologica. 2005 May;90(5):612-24.
743 CD30L up-regulates CD30 and IL-4 expression by T cells.FEBS Lett. 2001 Nov 23;508(3):418-22. doi: 10.1016/s0014-5793(01)03076-9.
744 Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution.Blood. 1997 Dec 1;90(11):4271-7.
745 Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia.Blood. 2007 May 1;109(9):4023-7. doi: 10.1182/blood-2006-01-031781. Epub 2007 Jan 23.
746 Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis.Blood. 2007 Apr 15;109(8):3244-52. doi: 10.1182/blood-2006-09-046672. Epub 2006 Dec 7.
747 The role of p73 in hematological malignancies.Leukemia. 2006 May;20(5):757-66. doi: 10.1038/sj.leu.2404166.
748 Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia.Cell Death Dis. 2017 Jul 13;8(7):e2927. doi: 10.1038/cddis.2017.317.
749 A case of angioimmunoblastic T-cell non-Hodgkin lymphoma with a neocentric inv dup(1).Cancer Genet Cytogenet. 2010 Oct 1;202(1):38-42. doi: 10.1016/j.cancergencyto.2010.06.004.
750 High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome.Leukemia. 2010 Dec;24(12):2048-55. doi: 10.1038/leu.2010.211. Epub 2010 Sep 23.
751 The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells.Br J Haematol. 2009 Jun;145(6):761-74. doi: 10.1111/j.1365-2141.2009.07691.x. Epub 2009 Apr 20.
752 Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia.Leukemia. 2017 Jun;31(6):1278-1285. doi: 10.1038/leu.2016.332. Epub 2016 Nov 15.
753 Examination of copy number variations of CHST9 in multiple types of hematologic malignancies.Cancer Genet Cytogenet. 2010 Dec;203(2):176-9. doi: 10.1016/j.cancergencyto.2010.07.132.
754 Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Cell. 2016 Apr 7;165(2):303-16. doi: 10.1016/j.cell.2016.03.015.
755 Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.EBioMedicine. 2017 Dec;26:112-125. doi: 10.1016/j.ebiom.2017.11.013. Epub 2017 Nov 21.
756 Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.Hum Mol Genet. 2019 Dec 15;28(24):4173-4185. doi: 10.1093/hmg/ddz261.
757 BP1 overexpression is associated with adverse prognosis in de novo acute myeloid leukemia.Leuk Lymphoma. 2016;57(4):828-34. doi: 10.3109/10428194.2015.1088648. Epub 2015 Dec 23.
758 Atypical Phenotype and Treatment Response Pattern in a Patient with FIP1L1-PDGFR Mutation.Acta Haematol. 2018;140(2):67-70. doi: 10.1159/000492485. Epub 2018 Sep 5.
759 Identification of new markers discriminating between myeloid and lymphoid acute leukemia.Hematology. 2010 Aug;15(4):193-203. doi: 10.1179/102453310X12647083620769.
760 Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia.Am J Hematol. 2009 Feb;84(2):79-86. doi: 10.1002/ajh.21332.
761 Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis.J Leukoc Biol. 2016 Oct;100(4):657-664. doi: 10.1189/jlb.1HI0316-134R. Epub 2016 Jun 2.
762 ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9.Genes Chromosomes Cancer. 2016 Mar;55(3):242-50. doi: 10.1002/gcc.22327. Epub 2015 Nov 6.
763 The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia.J Virol. 2005 May;79(9):5249-58. doi: 10.1128/JVI.79.9.5249-5258.2005.
764 MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1.Oncotarget. 2016 May 3;7(18):25276-90. doi: 10.18632/oncotarget.8252.
765 Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.J Clin Oncol. 2009 Feb 10;27(5):782-90. doi: 10.1200/JCO.2008.19.3748. Epub 2008 Dec 29.
766 AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.Cancer Res. 2010 May 15;70(10):3985-95. doi: 10.1158/0008-5472.CAN-09-3604. Epub 2010 May 11.
767 Beclin-1 and hypoxia-inducible factor-1 genes expression: Potential biomarkers in acute leukemia patients.Cancer Biomark. 2016 Mar 18;16(4):619-26. doi: 10.3233/CBM-160603.
768 SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia.Cancer Lett. 2015 Feb 1;357(1):297-306. doi: 10.1016/j.canlet.2014.11.052. Epub 2014 Nov 28.
769 Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia.Immunol Lett. 2010 May 4;130(1-2):115-24. doi: 10.1016/j.imlet.2009.12.007. Epub 2009 Dec 11.
770 Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC.Haematologica. 2020 Jan;105(1):148-160. doi: 10.3324/haematol.2018.208835. Epub 2019 Apr 11.
771 Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia.J Clin Oncol. 1997 May;15(5):1796-802. doi: 10.1200/JCO.1997.15.5.1796.
772 Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes.Mol Cancer Ther. 2018 Dec;17(12):2575-2585. doi: 10.1158/1535-7163.MCT-18-0186. Epub 2018 Sep 28.
773 APRIL gene expression in a cohort of Egyptian acute myeloid leukemia patients: Clinical and prognostic significance.Cancer Genet. 2018 Jan;220:24-31. doi: 10.1016/j.cancergen.2017.10.003. Epub 2017 Oct 24.
774 CD9 in acute myeloid leukemia: Prognostic role and usefulness to target leukemic stem cells.Cancer Med. 2019 Mar;8(3):1279-1288. doi: 10.1002/cam4.2007. Epub 2019 Feb 10.
775 A Phase I/II Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed Refractory Acute Myeloid Leukemia.Clin Cancer Res. 2019 Jul 15;25(14):4231-4237. doi: 10.1158/1078-0432.CCR-18-3886. Epub 2019 Apr 16.
776 Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.Blood. 2012 Jun 7;119(23):5492-501. doi: 10.1182/blood-2011-07-365890. Epub 2012 Apr 23.
777 Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML.Leukemia. 2019 Jan;33(1):64-74. doi: 10.1038/s41375-018-0180-3. Epub 2018 Jun 26.
778 Guadecitabine (SGI-110): an investigational drug for the treatment of myelodysplastic syndrome and acute myeloid leukemia.Expert Opin Investig Drugs. 2019 Oct;28(10):835-849. doi: 10.1080/13543784.2019.1667331. Epub 2019 Sep 19.
779 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
780 c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.J Cell Biochem. 2008 Aug 15;104(6):2091-106. doi: 10.1002/jcb.21765.
781 The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia.Int J Mol Sci. 2019 Nov 28;20(23):6003. doi: 10.3390/ijms20236003.
782 DOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemia.Cancer Med. 2019 Oct;8(14):6393-6402. doi: 10.1002/cam4.2540. Epub 2019 Sep 4.
783 Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern.Blood Adv. 2019 Oct 22;3(20):3111-3122. doi: 10.1182/bloodadvances.2019000518.
784 Coexistence of p210(BCR-ABL) and CBF-MYH11 fusion genes in myeloid leukemia: A report of 4 cases.Oncol Lett. 2017 Nov;14(5):5171-5178. doi: 10.3892/ol.2017.6812. Epub 2017 Aug 24.
785 Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome.Haematologica. 2018 Apr;103(4):614-625. doi: 10.3324/haematol.2017.167288. Epub 2018 Jan 11.
786 Intermediate-dose cytarabine plus G-CSF as mobilization regimen for newly diagnosed multiple myeloma and heavily pre-treated patients with hematological and non-hematological malignancies.Transfus Apher Sci. 2019 Jun;58(3):318-322. doi: 10.1016/j.transci.2019.03.018. Epub 2019 Mar 29.
787 Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia.Mol Med Rep. 2015 May;11(5):3948-54. doi: 10.3892/mmr.2015.3196. Epub 2015 Jan 13.
788 Nuclear retinoid receptors are involved in N-(4-hydroxyphenyl) retinamide (Fenretinide)-induced gene expression and growth inhibition in HL-60 acute myeloid leukemia cells. Leuk Lymphoma. 2004 May;45(5):979-85.
789 CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age.Ann Hematol. 2007 May;86(5):329-37. doi: 10.1007/s00277-007-0269-7. Epub 2007 Mar 6.
790 Prognostic impact of p15 gene aberrations in acute leukemia.Leuk Lymphoma. 2017 Feb;58(2):257-265. doi: 10.1080/10428194.2016.1201574. Epub 2016 Jul 12.
791 Use of methylation profiling to identify significant differentially methylated genes in bone marrow mesenchymal stromal cells from acute myeloid leukemia.Int J Mol Med. 2018 Feb;41(2):679-686. doi: 10.3892/ijmm.2017.3271. Epub 2017 Nov 17.
792 Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo.Front Pharmacol. 2018 Sep 18;9:1045. doi: 10.3389/fphar.2018.01045. eCollection 2018.
793 NR2F6 Expression Correlates with Pelvic Lymph Node Metastasis and Poor Prognosis in Early-Stage Cervical Cancer.Int J Mol Sci. 2016 Oct 20;17(10):1694. doi: 10.3390/ijms17101694.
794 NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.Mol Cell. 2015 Dec 17;60(6):847-59. doi: 10.1016/j.molcel.2015.10.033. Epub 2015 Nov 25.
795 Prognostic Significance of Complex Karyotypes in Acute Myeloid Leukemia.Curr Treat Options Oncol. 2019 Feb 11;20(2):15. doi: 10.1007/s11864-019-0612-y.
796 NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells.Leuk Res. 2016 Jun;45:1-7. doi: 10.1016/j.leukres.2016.03.006. Epub 2016 Mar 30.
797 KIT and FLT3 receptor tyrosine kinase mutations in acute myeloid leukemia with favorable cytogenetics: two novel mutations and selective occurrence in leukemia subtypes and age groups.Exp Mol Pathol. 2008 Dec;85(3):227-31. doi: 10.1016/j.yexmp.2008.09.004. Epub 2008 Oct 11.
798 Mutated and non-mutated TP53 as targets in the treatment of leukaemia.Br J Haematol. 2008 May;141(4):445-53. doi: 10.1111/j.1365-2141.2008.07046.x. Epub 2008 Mar 12.
799 Hypermethylation of secreted frizzled-related proteins predicts poor prognosis in non-M3 acute myeloid leukemia.Onco Targets Ther. 2017 Jul 20;10:3635-3644. doi: 10.2147/OTT.S136502. eCollection 2017.
800 Prognostic Significance of Secreted Frizzled-Related Protein 2 Expression in Cytogenetically Normal Primary Acute Myeloid Leukemia.Am J Med Sci. 2015 Nov;350(5):369-73. doi: 10.1097/MAJ.0000000000000567.
801 Stabilization of NF-B-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.Cell Rep. 2018 Jan 9;22(2):350-358. doi: 10.1016/j.celrep.2017.12.055.
802 SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia.Mol Cancer Res. 2018 May;16(5):791-804. doi: 10.1158/1541-7786.MCR-17-0493. Epub 2018 Feb 26.
803 Generation and preclinical characterization of a Fc-optimized GITR-Ig fusion protein for induction of NK cell reactivity against leukemia.Mol Ther. 2013 Apr;21(4):877-86. doi: 10.1038/mt.2013.11. Epub 2013 Feb 5.
804 Early induction intensification with cladribine, cytarabine, and mitoxantrone (CLAM) in AML patients treated with the DAC induction regimen: a prospective, non-randomized, phase II study of the Polish Adult Leukemia Group (PALG).Leuk Lymphoma. 2020 Mar;61(3):588-603. doi: 10.1080/10428194.2019.1678151. Epub 2019 Oct 29.
805 ABR, a novel inducer of transcription factor C/EBP, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia.Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28.
806 ACER3 supports development of acute myeloid leukemia.Biochem Biophys Res Commun. 2016 Sep 9;478(1):33-38. doi: 10.1016/j.bbrc.2016.07.099. Epub 2016 Jul 25.
807 Expression level of ACOT7 influences the prognosis in acute myeloid leukemia patients.Cancer Biomark. 2019;26(4):441-449. doi: 10.3233/CBM-182287.
808 ADAM28 promotes tumor growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation.Cancer Lett. 2019 Feb 1;442:193-201. doi: 10.1016/j.canlet.2018.10.028. Epub 2018 Oct 26.
809 ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.Cancer Manag Res. 2019 Sep 20;11:8547-8555. doi: 10.2147/CMAR.S210504. eCollection 2019.
810 CD97 is a critical regulator of acute myeloid leukemia stem cell function.J Exp Med. 2019 Oct 7;216(10):2362-2377. doi: 10.1084/jem.20190598. Epub 2019 Aug 1.
811 LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1.Mol Cancer. 2018 Aug 22;17(1):127. doi: 10.1186/s12943-018-0879-9.
812 The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes.Br J Haematol. 2016 Jul;174(2):292-301. doi: 10.1111/bjh.14056. Epub 2016 Mar 28.
813 The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.Nat Commun. 2018 Apr 24;9(1):1622. doi: 10.1038/s41467-018-03854-0.
814 Clinical and molecular epidemiology of neonatal leukemia in Brazil.Leuk Lymphoma. 2015 Apr;56(4):903-9. doi: 10.3109/10428194.2014.938327. Epub 2015 Jan 30.
815 hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.Nat Commun. 2019 Aug 23;10(1):3812. doi: 10.1038/s41467-019-11795-5.
816 Myelodysplastic syndrome in children: differentiation from acute myeloid leukemia with a low blast count.Leukemia. 1997 Feb;11(2):206-11. doi: 10.1038/sj.leu.2400558.
817 Aberrant mannosylation profile and FTX/miR-342/ALG3-axis contribute to development of drug resistance in acute myeloid leukemia.Cell Death Dis. 2018 Jun 7;9(6):688. doi: 10.1038/s41419-018-0706-7.
818 ANP32A regulates histone H3 acetylation and promotes leukemogenesis.Leukemia. 2018 Jul;32(7):1587-1597. doi: 10.1038/s41375-018-0010-7. Epub 2018 Feb 2.
819 Low expression of APAF-1XL in acute myeloid leukemia may be associated with the failure of remission induction therapy.Braz J Med Biol Res. 2008 Jul;41(7):571-8. doi: 10.1590/s0100-879x2008000700004.
820 Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.Cancer Res. 2017 Sep 1;77(17):4579-4588. doi: 10.1158/0008-5472.CAN-16-3394. Epub 2017 Jun 27.
821 An ARC-Regulated IL1/Cox-2/PGE2/-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.Cancer Res. 2019 Mar 15;79(6):1165-1177. doi: 10.1158/0008-5472.CAN-18-0921. Epub 2019 Jan 23.
822 Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.J Natl Cancer Inst. 2008 Sep 3;100(17):1247-59. doi: 10.1093/jnci/djn253. Epub 2008 Aug 26.
823 The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.Oncogene. 2018 May;37(19):2532-2544. doi: 10.1038/s41388-018-0131-5. Epub 2018 Feb 20.
824 Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.Leuk Lymphoma. 2017 May;58(5):1207-1218. doi: 10.1080/10428194.2016.1235272. Epub 2016 Oct 13.
825 Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia.Cancer Chemother Pharmacol. 2018 Jan;81(1):217-222. doi: 10.1007/s00280-017-3459-6. Epub 2017 Nov 8.
826 Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.Blood. 2015 Jun 25;125(26):4060-8. doi: 10.1182/blood-2014-10-608133. Epub 2015 Apr 20.
827 Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study.Ann Hematol. 2019 Jan;98(1):83-91. doi: 10.1007/s00277-018-3492-5. Epub 2018 Sep 24.
828 Genome-wide characterization of lncRNAs in acute myeloid leukemia.Brief Bioinform. 2018 Jul 20;19(4):627-635. doi: 10.1093/bib/bbx007.
829 Arsenic trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways.Leuk Lymphoma. 2017 Oct;58(10):2426-2438. doi: 10.1080/10428194.2017.1289522. Epub 2017 Mar 9.
830 Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.Nat Genet. 2011 May;43(5):470-5. doi: 10.1038/ng.796. Epub 2011 Mar 27.
831 Methylation-associated silencing of BASP1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.Exp Mol Med. 2018 Apr 20;50(4):1-8. doi: 10.1038/s12276-018-0067-4.
832 NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients.Oncotarget. 2017 Jun 16;8(44):76003-76014. doi: 10.18632/oncotarget.18537. eCollection 2017 Sep 29.
833 The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells.Br J Haematol. 2002 Aug;118(2):521-34. doi: 10.1046/j.1365-2141.2002.03637.x.
834 BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia.Oncotarget. 2017 Jul 18;8(29):47103-47109. doi: 10.18632/oncotarget.17482.
835 miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.Leukemia. 2018 Feb;32(2):573. doi: 10.1038/leu.2017.310. Epub 2017 Dec 22.
836 Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery.Cancer. 2019 Mar 1;125(5):712-725. doi: 10.1002/cncr.31837. Epub 2018 Nov 27.
837 C-terminal RUNX1 mutation in familial platelet disorder with predisposition to myeloid malignancies.Int J Hematol. 2018 Dec;108(6):652-657. doi: 10.1007/s12185-018-2514-3. Epub 2018 Aug 6.
838 Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia.Cancer Genet. 2020 Jan;240:15-22. doi: 10.1016/j.cancergen.2019.10.006. Epub 2019 Nov 1.
839 KIR Donor Selection: Feasibility in Identifying better Donors.Biol Blood Marrow Transplant. 2019 Jan;25(1):e28-e32. doi: 10.1016/j.bbmt.2018.08.022. Epub 2018 Aug 24.
840 BEX1 acts as a tumor suppressor in acute myeloid leukemia.Oncotarget. 2015 Aug 28;6(25):21395-405. doi: 10.18632/oncotarget.4095.
841 A new signaling cascade linking BMP4, BMPR1A, Np73 and NANOG impacts on stem-like human cell properties and patient outcome.Cell Death Dis. 2018 Sep 27;9(10):1011. doi: 10.1038/s41419-018-1042-7.
842 CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia.Cells. 2019 Dec 5;8(12):1580. doi: 10.3390/cells8121580.
843 Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.Mol Cells. 2018 May 31;41(5):465-475. doi: 10.14348/molcells.2018.0051. Epub 2018 May 15.
844 CRL4(DCAF2) negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis.J Exp Med. 2018 Aug 6;215(8):1999-2017. doi: 10.1084/jem.20180210. Epub 2018 Jul 17.
845 Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.Mol Carcinog. 2015 Dec;54(12):1815-9. doi: 10.1002/mc.22252. Epub 2014 Dec 9.
846 A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.Cell Signal. 2015 Feb;27(2):204-14. doi: 10.1016/j.cellsig.2014.11.007. Epub 2014 Nov 15.
847 Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia.Mol Ther. 2015 Jan;23(1):184-91. doi: 10.1038/mt.2014.164. Epub 2014 Sep 1.
848 Identification of DNA methylation prognostic signature of acute myelocytic leukemia.PLoS One. 2018 Jun 22;13(6):e0199689. doi: 10.1371/journal.pone.0199689. eCollection 2018.
849 The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.Mol Cancer Res. 2019 Jul;17(7):1468-1479. doi: 10.1158/1541-7786.MCR-18-1327. Epub 2019 Apr 23.
850 Loss of FBXO9 Enhances Proteasome Activity and Promotes Aggressiveness in Acute Myeloid Leukemia.Cancers (Basel). 2019 Nov 3;11(11):1717. doi: 10.3390/cancers11111717.
851 MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2.Int J Hematol. 2017 Aug;106(2):258-265. doi: 10.1007/s12185-017-2232-2. Epub 2017 Apr 13.
852 Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA.Blood Adv. 2018 Oct 23;2(20):2724-2731. doi: 10.1182/bloodadvances.2018016840.
853 Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera.Blood. 2000 Apr 15;95(8):2569-76.
854 CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation.Mol Oncol. 2019 Oct;13(10):2107-2120. doi: 10.1002/1878-0261.12549. Epub 2019 Aug 20.
855 Examination of CD302 as a potential therapeutic target for acute myeloid leukemia.PLoS One. 2019 May 10;14(5):e0216368. doi: 10.1371/journal.pone.0216368. eCollection 2019.
856 Secreted 3-integrin enhances natural killer cell activity against acute myeloid leukemia cells.PLoS One. 2014 Jun 11;9(2):e98936. doi: 10.1371/journal.pone.0098936. eCollection 2014.
857 Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia.Molecules. 2019 Jun 3;24(11):2103. doi: 10.3390/molecules24112103.
858 Leukemia-derived exosomes induced IL-8 production in bone marrow stromal cells to protect the leukemia cells against chemotherapy.Life Sci. 2019 Mar 15;221:187-195. doi: 10.1016/j.lfs.2019.02.003. Epub 2019 Feb 2.
859 RUNX1 Mutations Can Lead to Aberrant Expression of CD79a and PAX5 in Acute Myelogenous Leukemias: A Potential Diagnostic Pitfall.Pathobiology. 2019;86(2-3):162-166. doi: 10.1159/000493688. Epub 2018 Nov 5.
860 Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia.Oncotarget. 2016 Sep 20;7(38):62377-62385. doi: 10.18632/oncotarget.11481.
861 CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/-catenin signaling pathway.Pediatr Res. 2019 Jun;85(7):1024-1031. doi: 10.1038/s41390-019-0370-3. Epub 2019 Mar 12.
862 CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.Cell Stem Cell. 2015 Oct 1;17(4):412-21. doi: 10.1016/j.stem.2015.08.008. Epub 2015 Sep 18.
863 Epigenetic dysregulation of the DAP kinase/p14/HDM2/p53/Apaf-1 apoptosis pathway in acute leukaemias.J Clin Pathol. 2008 Jul;61(7):844-7. doi: 10.1136/jcp.2007.047324.
864 Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.Leukemia. 1996 Dec;10(12):1897-900.
865 Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.Blood. 2019 Jul 18;134(3):263-276. doi: 10.1182/blood.2018862383. Epub 2019 May 10.
866 The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood. 2007 May 1;109(9):3895-905. doi: 10.1182/blood-2006-08-040147. Epub 2007 Jan 18.
867 CEBPE expression is an independent prognostic factor for acute myeloid leukemia.J Transl Med. 2019 Jun 4;17(1):188. doi: 10.1186/s12967-019-1944-x.
868 CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex.Leukemia. 2019 Jul;33(7):1608-1619. doi: 10.1038/s41375-019-0382-3. Epub 2019 Jan 24.
869 Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22).Mol Cancer. 2015 Apr 11;14:81. doi: 10.1186/s12943-015-0353-x.
870 Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.Blood. 2015 Sep 17;126(12):1462-72. doi: 10.1182/blood-2015-03-631606. Epub 2015 Aug 11.
871 C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.Leukemia. 2018 Mar;32(3):828-836. doi: 10.1038/leu.2017.280. Epub 2017 Sep 5.
872 The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia.Leukemia. 2009 Feb;23(2):251-61. doi: 10.1038/leu.2008.300. Epub 2008 Nov 6.
873 The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.Nat Med. 2017 Mar;23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13.
874 Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.Cancer Discov. 2019 Jul;9(7):890-909. doi: 10.1158/2159-8290.CD-19-0117. Epub 2019 May 2.
875 A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.BMC Cancer. 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5.
876 NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214.Cytogenet Genome Res. 2015;146(4):279-84. doi: 10.1159/000441464. Epub 2015 Oct 31.
877 High expression of CPNE3 predicts adverse prognosis in acute myeloid leukemia.Cancer Sci. 2017 Sep;108(9):1850-1857. doi: 10.1111/cas.13311. Epub 2017 Aug 20.
878 High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia.EBioMedicine. 2016 Dec;14:55-64. doi: 10.1016/j.ebiom.2016.11.025. Epub 2016 Nov 22.
879 Weighted Gene Coexpression Network Analysis Identifies Cysteine-Rich Intestinal Protein 1 (CRIP1) as a Prognostic Gene Associated with Relapse in Patients with Acute Myeloid Leukemia.Med Sci Monit. 2019 Oct 2;25:7396-7406. doi: 10.12659/MSM.918092.
880 Buffy coat-derived platelets cryopreserved using a new method: Results from a pivotal clinical trial on thrombocytopenic patients with acute leukaemia.Transfus Apher Sci. 2019 Dec;58(6):102666. doi: 10.1016/j.transci.2019.10.008. Epub 2019 Nov 5.
881 HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries.J Vis Exp. 2019 Mar 31;(145):10.3791/59382. doi: 10.3791/59382.
882 CD33, CD96 and Death Associated Protein Kinase (DAPK) Expression Are Associated with the Survival Rate and/or Response to the Chemotherapy in the Patients with Acute Myeloid Leukemia (AML).Med Sci Monit. 2017 Apr 9;23:1725-1732. doi: 10.12659/msm.900305.
883 The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.Crit Rev Oncol Hematol. 2014 Apr;90(1):1-16. doi: 10.1016/j.critrevonc.2013.10.003. Epub 2013 Oct 12.
884 Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. J Leukoc Biol. 2017 Dec;102(6):1357-1370. doi: 10.1189/jlb.1A0317-132R. Epub 2017 Oct 4.
885 Identification of differentially methylated markers among cytogenetic risk groups of acute myeloid leukemia.Epigenetics. 2015;10(6):526-35. doi: 10.1080/15592294.2015.1048060.
886 Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nat Commun. 2017 Dec 13;8(1):2099. doi: 10.1038/s41467-017-02290-w.
887 LncRNA HOTTIP promotes proliferation and cell cycle progression of acute myeloid leukemia cells.Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2908-2915. doi: 10.26355/eurrev_201904_17569.
888 Next Generation Sequencing in AML-On the Way to Becoming a New Standard for Treatment Initiation and/or Modulation?.Cancers (Basel). 2019 Feb 21;11(2):252. doi: 10.3390/cancers11020252.
889 Pre-diagnostic serum concentrations of organochlorines and risk of acute myeloid leukemia: A nested case-control study in the Norwegian Janus Serum Bank Cohort.Environ Int. 2019 Apr;125:229-235. doi: 10.1016/j.envint.2019.01.066. Epub 2019 Feb 2.
890 Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.Blood. 2011 Jul 28;118(4):903-15. doi: 10.1182/blood-2010-11-318022. Epub 2011 Jun 7.
891 Translocation t(1;9) is a recurrent cytogenetic abnormality associated with progression of essential thrombocythemia patients displaying the JAK2 V617F mutation.Leuk Res. 2011 Sep;35(9):1188-92. doi: 10.1016/j.leukres.2011.02.001. Epub 2011 Mar 3.
892 Real-time quantitative PCR assays for deoxycytidine kinase, deoxyguanosine kinase and 5'-nucleotidase mRNA measurement in cell lines and in patients with leukemia.Leukemia. 2002 Mar;16(3):386-92. doi: 10.1038/sj.leu.2402388.
893 DIXDC1 promotes the growth of acute myeloid leukemia cells by upregulating the Wnt/-catenin signaling pathway.Biomed Pharmacother. 2018 Nov;107:1548-1555. doi: 10.1016/j.biopha.2018.08.144. Epub 2018 Sep 5.
894 Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies.Ann N Y Acad Sci. 2009 Sep;1176:178-90. doi: 10.1111/j.1749-6632.2009.04565.x.
895 High expression of DOCK2 indicates good prognosis in acute myeloid leukemia.J Cancer. 2019 Oct 15;10(24):6088-6094. doi: 10.7150/jca.33244. eCollection 2019.
896 MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia.FASEB J. 2019 Apr;33(4):5268-5286. doi: 10.1096/fj.201801035R. Epub 2019 Jan 22.
897 Tracing the development of acute myeloid leukemia in CBL syndrome.Blood. 2014 Mar 20;123(12):1883-6. doi: 10.1182/blood-2013-10-533844. Epub 2014 Feb 3.
898 Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.J Cell Physiol. 2018 Sep;233(9):6604-6614. doi: 10.1002/jcp.26271. Epub 2018 Mar 14.
899 Prognostic role of DOK family adapters in acute myeloid leukemia.Cancer Gene Ther. 2019 Sep;26(9-10):305-312. doi: 10.1038/s41417-018-0052-z. Epub 2018 Oct 22.
900 miR-199a-5p Represses Protective Autophagy and Overcomes Chemoresistance by Directly Targeting DRAM1 in Acute Myeloid Leukemia.J Oncol. 2019 Sep 15;2019:5613417. doi: 10.1155/2019/5613417. eCollection 2019.
901 Mutations of the E2F4 gene in hematological malignancies having microsatellite instability.Blood. 2000 Feb 15;95(4):1509-10.
902 Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia.J Exp Clin Cancer Res. 2015 Jan 22;34(1):4. doi: 10.1186/s13046-014-0118-1.
903 Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase.Int J Mol Sci. 2017 Jul 5;18(7):1440. doi: 10.3390/ijms18071440.
904 The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysis.BMC Cancer. 2019 Apr 25;19(1):389. doi: 10.1186/s12885-019-5602-8.
905 Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support.Leukemia. 2020 Feb;34(2):391-403. doi: 10.1038/s41375-019-0568-8. Epub 2019 Sep 6.
906 Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.Cell Rep. 2018 Oct 30;25(5):1109-1117.e5. doi: 10.1016/j.celrep.2018.10.021.
907 Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.Mol Cell Biochem. 2018 Jan;438(1-2):191-198. doi: 10.1007/s11010-017-3127-5. Epub 2017 Aug 12.
908 EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.Cancer Sci. 2016 Dec;107(12):1745-1754. doi: 10.1111/cas.13080. Epub 2016 Nov 25.
909 Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.Leukemia. 2014 May;28(5):1081-91. doi: 10.1038/leu.2013.316. Epub 2013 Oct 29.
910 A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia.J Exp Clin Cancer Res. 2018 Jan 22;37(1):12. doi: 10.1186/s13046-018-0682-x.
911 Silver nanoparticles exhibit size-dependent differential toxicity and induce expression of syncytin-1 in FA-AML1 and MOLT-4 leukaemia cell lines.Mutagenesis. 2016 Nov;31(6):695-702. doi: 10.1093/mutage/gew043. Epub 2016 Aug 30.
912 Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.PLoS One. 2018 Jan 25;13(1):e0191734. doi: 10.1371/journal.pone.0191734. eCollection 2018.
913 Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.Cell Death Dis. 2018 May 1;9(5):516. doi: 10.1038/s41419-018-0511-3.
914 Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells.Clin Cancer Res. 2005 Jun 15;11(12):4504-11. doi: 10.1158/1078-0432.CCR-05-0036.
915 Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.Oncotarget. 2017 Aug 4;8(40):68208-68220. doi: 10.18632/oncotarget.19919. eCollection 2017 Sep 15.
916 Discussing and managing hematologic germ line variants.Blood. 2016 Nov 24;128(21):2497-2503. doi: 10.1182/blood-2016-06-716704.
917 F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.Blood. 2012 Mar 29;119(13):3132-41. doi: 10.1182/blood-2011-06-358911. Epub 2012 Feb 8.
918 HLA-G expression on blasts and tolerogenic cells in patients affected by acute myeloid leukemia.J Immunol Res. 2014;2014:636292. doi: 10.1155/2014/636292. Epub 2014 Mar 13.
919 Fasciculation and elongation zeta-1 protein (FEZ1) interacts with the retinoic acid receptor and participates in transcriptional regulation of the Hoxb4 gene.FEBS Open Bio. 2017 Dec 9;8(1):4-14. doi: 10.1002/2211-5463.12338. eCollection 2018 Jan.
920 Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia.Onco Targets Ther. 2019 May 1;12:3295-3304. doi: 10.2147/OTT.S194549. eCollection 2019.
921 Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia.Cancer Gene Ther. 2019 Feb;26(1-2):17-25. doi: 10.1038/s41417-018-0027-0. Epub 2018 Jun 18.
922 BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.Mol Cell. 2015 Jun 18;58(6):1028-39. doi: 10.1016/j.molcel.2015.04.011. Epub 2015 May 14.
923 Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia.Blood Adv. 2019 Oct 22;3(20):3052-3061. doi: 10.1182/bloodadvances.2019000197.
924 Increased FLYWCH1 Expression is Negatively Correlated with Wnt/-catenin Target Gene Expression in Acute Myeloid Leukemia Cells.Int J Mol Sci. 2019 Jun 4;20(11):2739. doi: 10.3390/ijms20112739.
925 Novel tumor-suppressor FOXN3 is downregulated in adult acute myeloid leukemia.Oncol Lett. 2019 Aug;18(2):1521-1529. doi: 10.3892/ol.2019.10424. Epub 2019 May 31.
926 Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients.BMC Cancer. 2019 Sep 18;19(1):930. doi: 10.1186/s12885-019-5967-8.
927 Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.Cancer Genet Cytogenet. 2007 Sep;177(2):143-6. doi: 10.1016/j.cancergencyto.2007.05.021.
928 Association of Leukemia Target Genes Tet2, Bcl2, and Slc23a2 in Vitamin C Pathways.Cancer Genomics Proteomics. 2019 Sep-Oct;16(5):333-344. doi: 10.21873/cgp.20138.
929 Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia.Biochim Biophys Acta. 2014 Sep;1842(9):1681-92. doi: 10.1016/j.bbadis.2014.06.014. Epub 2014 Jun 19.
930 Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation.Leuk Res. 2018 Apr;67:99-108. doi: 10.1016/j.leukres.2018.01.020. Epub 2018 Jan 31.
931 Investigating the microRNA-mRNA regulatory network in acute myeloid leukemia.Oncol Lett. 2017 Oct;14(4):3981-3988. doi: 10.3892/ol.2017.6686. Epub 2017 Jul 28.
932 lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/-catenin signaling pathway.Am J Transl Res. 2019 Nov 15;11(11):7104-7114. eCollection 2019.
933 Methylation status of the promoter region of the human frizzled 9 gene in acute myeloid leukemia.Mol Med Rep. 2016 Aug;14(2):1339-44. doi: 10.3892/mmr.2016.5387. Epub 2016 Jun 10.
934 CDH1 (E-cadherin) expression independently affects clinical outcome in acute myeloid leukemia with normal cytogenetics.Clin Chem Lab Med. 2017 Jan 1;55(1):123-131. doi: 10.1515/cclm-2016-0205.
935 MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.Haematologica. 2006 Sep;91(9):1287-8.
936 LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.Leukemia. 2020 Mar;34(3):746-758. doi: 10.1038/s41375-019-0614-6. Epub 2019 Nov 1.
937 CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.Br J Haematol. 2019 Feb;184(3):337-347. doi: 10.1111/bjh.15725. Epub 2018 Dec 28.
938 Gene expression profiling of HL-60 cells following knockdown of nucleostemin using DNA microarrays.Oncol Rep. 2014 Aug;32(2):739-47. doi: 10.3892/or.2014.3240. Epub 2014 Jun 6.
939 Glutathione S-transferase gene polymorphisms and susceptibility to acute myeloid leukemia: meta-analyses.Jpn J Clin Oncol. 2014 Nov;44(11):1070-81. doi: 10.1093/jjco/hyu121. Epub 2014 Aug 21.
940 Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation.Clin Epigenetics. 2019 Oct 12;11(1):141. doi: 10.1186/s13148-019-0738-6.
941 MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML.Exp Hematol. 2015 Sep;43(9):794-802.e4. doi: 10.1016/j.exphem.2015.05.010. Epub 2015 Jun 11.
942 Motor skill delays in pre-school children with leukemia one year after treatment: Hematopoietic stem cell transplantation therapy as an important risk factor.PLoS One. 2017 Oct 24;12(10):e0186787. doi: 10.1371/journal.pone.0186787. eCollection 2017.
943 MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1.Tumour Biol. 2016 Jun;37(6):7461-71. doi: 10.1007/s13277-015-4581-x. Epub 2015 Dec 17.
944 RUNX1 cooperates with FLT3-ITD to induce leukemia.J Exp Med. 2017 Mar 6;214(3):737-752. doi: 10.1084/jem.20160927. Epub 2017 Feb 17.
945 Detection of Novel t(12;17)(p12;p13) in Relapsed Refractory Acute Myeloid Leukemia by Anchored Multiplex PCR(AMP)-based Next-Generation Sequencing.Appl Immunohistochem Mol Morphol. 2019 Mar;27(3):e28-e31. doi: 10.1097/PAI.0000000000000477.
946 Prognostic significance of huntingtin interacting protein 1 expression on patients with acute myeloid leukemia.Sci Rep. 2017 Apr 28;7:45960. doi: 10.1038/srep45960.
947 Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.Bone Marrow Transplant. 2018 Sep;53(9):1170-1179. doi: 10.1038/s41409-018-0123-7. Epub 2018 Mar 16.
948 The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells.Oncotarget. 2016 Nov 8;7(45):73960-73970. doi: 10.18632/oncotarget.12170.
949 Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region.Leuk Res. 2019 Jan;76:15-23. doi: 10.1016/j.leukres.2018.11.007. Epub 2018 Nov 17.
950 The Role of the HOXA Gene Family in Acute Myeloid Leukemia.Genes (Basel). 2019 Aug 16;10(8):621. doi: 10.3390/genes10080621.
951 The role of HOXB2 and HOXB3 in acute myeloid leukemia.Biochem Biophys Res Commun. 2015 Nov 27;467(4):742-7. doi: 10.1016/j.bbrc.2015.10.071. Epub 2015 Oct 22.
952 Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13).Cancer Res. 2002 Aug 15;62(16):4571-4.
953 Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells.Leukemia. 1998 Nov;12(11):1724-32. doi: 10.1038/sj.leu.2401106.
954 MiR-10b regulates the proliferation and apoptosis of pediatric acute myeloid leukemia through targeting HOXD10.Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7371-7378. doi: 10.26355/eurrev_201811_16275.
955 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1 (HS3ST3B1) promotes angiogenesis and proliferation by induction of VEGF in acute myeloid leukemia cells.J Cell Biochem. 2015 Jun;116(6):1101-12. doi: 10.1002/jcb.25066.
956 Abivertinib, a novel BTK inhibitor: Anti-Leukemia effects and synergistic efficacy with homoharringtonine in acute myeloid leukemia.Cancer Lett. 2019 Oct 1;461:132-143. doi: 10.1016/j.canlet.2019.07.008. Epub 2019 Jul 13.
957 A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.J Med Chem. 2019 Jul 11;62(13):6035-6046. doi: 10.1021/acs.jmedchem.9b00145. Epub 2019 Jun 19.
958 The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.PLoS One. 2014 May 8;9(5):e96822. doi: 10.1371/journal.pone.0096822. eCollection 2014.
959 High IFITM3 expression predicts adverse prognosis in acute myeloid leukemia.Cancer Gene Ther. 2020 Feb;27(1-2):38-44. doi: 10.1038/s41417-019-0093-y. Epub 2019 Mar 29.
960 Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia.J Hematol Oncol. 2017 Jul 11;10(1):138. doi: 10.1186/s13045-017-0507-y.
961 IGF2BP2 Overexpression Indicates Poor Survival in Patients with Acute Myelocytic Leukemia.Cell Physiol Biochem. 2018;51(4):1945-1956. doi: 10.1159/000495719. Epub 2018 Dec 4.
962 Leukemic IL-17RB signaling regulates leukemic survival and chemoresistance.FASEB J. 2019 Aug;33(8):9565-9576. doi: 10.1096/fj.201900099R. Epub 2019 May 28.
963 Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.Cell Death Dis. 2014 Dec 4;5(12):e1557. doi: 10.1038/cddis.2014.502.
964 Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia.Cell Rep. 2018 Jan 16;22(3):638-652. doi: 10.1016/j.celrep.2017.12.063.
965 Hypermethylation of ITGBL1 is associated with poor prognosis in acute myeloid leukemia.J Cell Physiol. 2019 Jun;234(6):9438-9446. doi: 10.1002/jcp.27629. Epub 2018 Oct 14.
966 A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis.Oncotarget. 2015 Oct 13;6(31):30664-74. doi: 10.18632/oncotarget.5133.
967 Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein.Mol Cell Biochem. 2010 Jul;340(1-2):7-14. doi: 10.1007/s11010-010-0394-9. Epub 2010 Feb 16.
968 HBO1 is required for the maintenance of leukaemia stem cells.Nature. 2020 Jan;577(7789):266-270. doi: 10.1038/s41586-019-1835-6. Epub 2019 Dec 11.
969 Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.Cancer Res. 2017 Apr 1;77(7):1753-1762. doi: 10.1158/0008-5472.CAN-16-2374. Epub 2017 Feb 15.
970 KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.Leuk Lymphoma. 2018 Jan;59(1):204-213. doi: 10.1080/10428194.2017.1324156. Epub 2017 May 25.
971 Loss of KDM6A confers drug resistance in acute myeloid leukemia.Leukemia. 2020 Jan;34(1):50-62. doi: 10.1038/s41375-019-0497-6. Epub 2019 Jun 14.
972 Comparison of the KIR3DS1/Bw4 distribution in Chinese healthy and acute myeloid leukemia individuals.Hum Immunol. 2015 Mar;76(2-3):79-82. doi: 10.1016/j.humimm.2015.01.024. Epub 2015 Jan 27.
973 MicroRNA-21 promotes proliferation in acute myeloid leukemia by targeting Krppel-like factor 5.Oncol Lett. 2019 Sep;18(3):3367-3372. doi: 10.3892/ol.2019.10667. Epub 2019 Jul 25.
974 KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid leukemia.J Immunol. 2015 May 1;194(9):4222-30. doi: 10.4049/jimmunol.1402124. Epub 2015 Mar 25.
975 Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.Exp Hematol. 2019 Jan;69:37-42. doi: 10.1016/j.exphem.2018.10.001. Epub 2018 Oct 10.
976 MLL-rearranged acute myeloid leukemia: Influence of the genetic partner in allo-HSCT response and prognostic factor of MLL 3' region mRNA expression.Eur J Haematol. 2018 May;100(5):436-443. doi: 10.1111/ejh.13037. Epub 2018 Mar 1.
977 Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.Blood. 2010 Oct 14;116(15):2812-21. doi: 10.1182/blood-2010-02-270611. Epub 2010 Jun 28.
978 La-related protein 4B maintains murine MLL-AF9 leukemia stem cell self-renewal by regulating cell cycle progression.Exp Hematol. 2015 Apr;43(4):309-18.e2. doi: 10.1016/j.exphem.2014.12.003. Epub 2014 Dec 20.
979 Sister chromatid exchanges in leukemic patients.Cancer Genet Cytogenet. 1985 Feb 1;15(1-2):169-75. doi: 10.1016/0165-4608(85)90145-1.
980 Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.Leukemia. 2020 Apr;34(4):1027-1037. doi: 10.1038/s41375-019-0635-1. Epub 2019 Nov 22.
981 LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.Cancer Res. 2014 Jun 1;74(11):3043-53. doi: 10.1158/0008-5472.CAN-13-2321. Epub 2014 Mar 31.
982 The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13).Genes Chromosomes Cancer. 2014 Apr;53(4):299-308. doi: 10.1002/gcc.22140. Epub 2014 Jan 21.
983 The Association between PARP1 and LIG3 Expression Levels and Chromosomal Translocations in Acute Myeloid Leukemia Patients.Cell J. 2018 Jul;20(2):204-210. doi: 10.22074/cellj.2018.5210. Epub 2018 Mar 18.
984 LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.Mol Cancer Res. 2017 Mar;15(3):294-303. doi: 10.1158/1541-7786.MCR-16-0275-T. Epub 2016 Dec 23.
985 The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.J Exp Med. 2013 Jan 14;210(1):15-22. doi: 10.1084/jem.20120596. Epub 2012 Dec 31.
986 A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas.Cytogenet Cell Genet. 2001;95(3-4):153-6. doi: 10.1159/000059338.
987 Leucine-Rich Alpha-2-Glycoprotein1 Gene Interferes with Regulation of Apoptosis in Leukemia KASUMI-1 Cells.Med Sci Monit. 2018 Nov 20;24:8348-8356. doi: 10.12659/MSM.911249.
988 The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.Leukemia. 2019 Aug;33(8):1868-1880. doi: 10.1038/s41375-018-0361-0. Epub 2019 Jan 30.
989 H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia.Cancer Genet. 2018 Apr;222-223:9-12. doi: 10.1016/j.cancergen.2018.01.004. Epub 2018 Feb 17.
990 DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts.Leuk Lymphoma. 2015;56(10):2914-22. doi: 10.3109/10428194.2015.1015123. Epub 2015 Jul 6.
991 First case of B ALL with KMT2A-MAML2 rearrangement: a case report.BMC Cancer. 2017 May 23;17(1):363. doi: 10.1186/s12885-017-3368-4.
992 MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML.Blood. 2018 Oct 4;132(14):1526-1534. doi: 10.1182/blood-2018-05-852566. Epub 2018 Jul 26.
993 Novel Disease Risk Model for Patients with Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Cell Transplantation.Biol Blood Marrow Transplant. 2020 Jan;26(1):197-203. doi: 10.1016/j.bbmt.2019.09.006. Epub 2019 Sep 10.
994 Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia.Int J Hematol. 2012 Mar;95(3):285-90. doi: 10.1007/s12185-012-1022-0. Epub 2012 Feb 18.
995 MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.Cell Rep. 2016 Jul 12;16(2):498-507. doi: 10.1016/j.celrep.2016.05.094. Epub 2016 Jun 23.
996 METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification.Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28.
997 NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.PLoS Genet. 2019 Nov 1;15(11):e1008463. doi: 10.1371/journal.pgen.1008463. eCollection 2019 Nov.
998 Involvement of AF1q/MLLT11 in the progression of ovarian cancer.Oncotarget. 2017 Apr 4;8(14):23246-23264. doi: 10.18632/oncotarget.15574.
999 [Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):444-6.
1000 ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.Oncotarget. 2016 Jun 21;7(25):38347-38358. doi: 10.18632/oncotarget.9520.
1001 Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.Genes Chromosomes Cancer. 2018 Jul;57(7):359-365. doi: 10.1002/gcc.22538. Epub 2018 Apr 30.
1002 Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia.J Pediatr Hematol Oncol. 2006 Nov;28(11):763-7. doi: 10.1097/01.mph.0000243660.48808.72.
1003 Targeting the arginine metabolic brake enhances immunotherapy for leukaemia.Int J Cancer. 2019 Oct 15;145(8):2201-2208. doi: 10.1002/ijc.32028. Epub 2019 Jan 11.
1004 Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia: A case report.Medicine (Baltimore). 2018 Jul;97(28):e11501. doi: 10.1097/MD.0000000000011501.
1005 Ecotropic viral integration site 1 regulates the progression of acute myeloid leukemia via MS4A3-mediated TGF/EMT signaling pathway.Oncol Lett. 2018 Aug;16(2):2701-2708. doi: 10.3892/ol.2018.8890. Epub 2018 Jun 4.
1006 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma.Leuk Lymphoma. 2014 Aug;55(8):1893-903. doi: 10.3109/10428194.2013.864762. Epub 2014 Feb 17.
1007 Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation.J Transl Med. 2014 Jun 25;12:182. doi: 10.1186/1479-5876-12-182.
1008 Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy.Cancer Discov. 2018 Nov;8(11):1376-1389. doi: 10.1158/2159-8290.CD-17-0841. Epub 2018 Aug 16.
1009 Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.Eur Rev Med Pharmacol Sci. 2019 Feb;23(3):1203-1213. doi: 10.26355/eurrev_201902_17013.
1010 Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia.PLoS One. 2015 May 21;10(5):e0125783. doi: 10.1371/journal.pone.0125783. eCollection 2015.
1011 circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression.Blood. 2019 Oct 31;134(18):1533-1546. doi: 10.1182/blood.2019000802.
1012 Truncation of MYH8 tail in AML: a novel prognostic marker with increase cell migration and epithelial-mesenchymal transition utilizing RAF/MAPK pathway.Carcinogenesis. 2020 Jul 10;41(6):817-827. doi: 10.1093/carcin/bgz146.
1013 Prognostic impact of MYH9 expression on patients with acute myeloid leukemia.Oncotarget. 2017 Jan 3;8(1):156-163. doi: 10.18632/oncotarget.10613.
1014 Identification of prognostic genes in the acute myeloid leukemia immune microenvironment based on TCGA data analysis.Cancer Immunol Immunother. 2019 Dec;68(12):1971-1978. doi: 10.1007/s00262-019-02408-7. Epub 2019 Oct 24.
1015 High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature.Leuk Lymphoma. 2013 Aug;54(8):1652-7. doi: 10.3109/10428194.2012.753445. Epub 2012 Dec 27.
1016 Expression of autophagy genes in acute myeloid leukemia: associations with clinical characteristics and prognosis.Neoplasma. 2018 Sep 19;65(5):807-814. doi: 10.4149/neo_2018_171028N691. Epub 2018 Jun 17.
1017 High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia.J Transl Med. 2019 May 20;17(1):166. doi: 10.1186/s12967-019-1904-5.
1018 Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells.BMC Genomics. 2015 Apr 17;16(1):309. doi: 10.1186/s12864-015-1445-0.
1019 Correction: NKp30 expression is a prognostic immune biomarker for stratification of patients with intermediate-risk acute myeloid leukemia.Oncotarget. 2019 Sep 10;10(52):5493. doi: 10.18632/oncotarget.27198. eCollection 2019 Sep 10.
1020 Antioxidant and selective anticancer activities of two Euphorbia species in human acute myeloid leukemia.Biomed Pharmacother. 2017 Jun;90:375-385. doi: 10.1016/j.biopha.2017.03.072. Epub 2017 Apr 2.
1021 NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome.Leukemia. 2018 Dec;32(12):2536-2545. doi: 10.1038/s41375-018-0147-4. Epub 2018 Jun 5.
1022 Nuclear factor of activated T-cells, NFATC1, governs FLT3(ITD)-driven hematopoietic stem cell transformation and a poor prognosis in AML.J Hematol Oncol. 2019 Jul 8;12(1):72. doi: 10.1186/s13045-019-0765-y.
1023 Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.Blood. 2019 Apr 18;133(16):1766-1777. doi: 10.1182/blood-2018-09-875047. Epub 2019 Feb 12.
1024 Low NKD1 expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemia.Tumour Biol. 2017 Apr;39(4):1010428317699123. doi: 10.1177/1010428317699123.
1025 Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia.Br J Haematol. 2014 Nov;167(3):376-84. doi: 10.1111/bjh.13054. Epub 2014 Jul 31.
1026 NPAS2 regulates proliferation of acute myeloid leukemia cells via CDC25A-mediated cell cycle progression and apoptosis.J Cell Biochem. 2019 May;120(5):8731-8741. doi: 10.1002/jcb.28160. Epub 2018 Dec 9.
1027 Thiotepa, Fludarabine, and Busulfan Conditioning Regimen before T Cell-Replete Haploidentical Transplantation with Post-Transplant Cyclophosphamide for Acute Myeloid Leukemia: A Bicentric Experience of 100 Patients.Biol Blood Marrow Transplant. 2019 Sep;25(9):1803-1809. doi: 10.1016/j.bbmt.2019.05.014. Epub 2019 May 22.
1028 LRRC33 is a novel binding and potential regulating protein of TGF-1 function in human acute myeloid leukemia cells.PLoS One. 2019 Oct 10;14(10):e0213482. doi: 10.1371/journal.pone.0213482. eCollection 2019.
1029 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.J Hematol Oncol. 2014 Sep 23;7:68. doi: 10.1186/s13045-014-0068-2.
1030 NT5C3 polymorphisms and outcome of first induction chemotherapy in acute myeloid leukemia.Pharmacogenet Genomics. 2014 Sep;24(9):436-41. doi: 10.1097/FPC.0000000000000072.
1031 LncRNA SNHG1 overexpression regulates the proliferation of acute myeloid leukemia cells through miR-488-5p/NUP205 axis.Eur Rev Med Pharmacol Sci. 2019 Jul;23(13):5896-5903. doi: 10.26355/eurrev_201907_18334.
1032 NUP214 in Leukemia: It's More than Transport.Cells. 2019 Jan 21;8(1):76. doi: 10.3390/cells8010076.
1033 Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.Hum Genet. 2001 Apr;108(4):304-9. doi: 10.1007/s004390100498.
1034 Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells.Clin Cancer Res. 2016 Jul 1;22(13):3320-7. doi: 10.1158/1078-0432.CCR-15-2282. Epub 2016 Jan 26.
1035 PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.Oncotarget. 2018 Apr 24;9(31):22123-22136. doi: 10.18632/oncotarget.25204. eCollection 2018 Apr 24.
1036 Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival.Theranostics. 2018 Jul 30;8(16):4359-4371. doi: 10.7150/thno.26900. eCollection 2018.
1037 Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia.J Transl Med. 2019 Mar 29;17(1):102. doi: 10.1186/s12967-019-1851-1.
1038 Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.Cancer Res. 2004 Aug 15;64(16):5570-7. doi: 10.1158/0008-5472.CAN-04-0050.
1039 A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells.Oncotarget. 2017 Jul 12;8(44):76174-76188. doi: 10.18632/oncotarget.19192. eCollection 2017 Sep 29.
1040 Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells.Onco Targets Ther. 2018 May 17;11:2925-2935. doi: 10.2147/OTT.S162407. eCollection 2018.
1041 PRISM: methylation pattern-based, reference-free inference of subclonal makeup.Bioinformatics. 2019 Jul 15;35(14):i520-i529. doi: 10.1093/bioinformatics/btz327.
1042 Transcription factor C/EBP- induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells.Cell Death Differ. 2016 Jul;23(7):1232-42. doi: 10.1038/cdd.2016.1. Epub 2016 Feb 12.
1043 PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.Oncotarget. 2017 May 2;8(18):29887-29905. doi: 10.18632/oncotarget.15136.
1044 Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression.Sci Rep. 2018 Sep 13;8(1):13741. doi: 10.1038/s41598-018-32205-8.
1045 PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.Cancer Genet. 2019 Apr;233-234:56-66. doi: 10.1016/j.cancergen.2019.04.002. Epub 2019 Apr 11.
1046 Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.Leukemia. 2010 Feb;24(2):429-37. doi: 10.1038/leu.2009.247. Epub 2009 Dec 10.
1047 Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated.BMC Med Genet. 2015 Jun 17;16:39. doi: 10.1186/s12881-015-0185-y.
1048 RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.Leukemia. 2020 Apr;34(4):1017-1026. doi: 10.1038/s41375-019-0639-x. Epub 2019 Nov 18.
1049 Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients.Leukemia. 2017 May;31(5):1069-1078. doi: 10.1038/leu.2016.324. Epub 2016 Nov 11.
1050 The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia.Cancers (Basel). 2019 Oct 26;11(11):1663. doi: 10.3390/cancers11111663.
1051 Wogonoside induces depalmitoylation and translocation of PLSCR1 and N-RAS in primary acute myeloid leukaemia cells.J Cell Mol Med. 2018 Apr;22(4):2117-2130. doi: 10.1111/jcmm.13481. Epub 2018 Jan 29.
1052 Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia.Exp Cell Res. 2019 Nov 15;384(2):111653. doi: 10.1016/j.yexcr.2019.111653. Epub 2019 Sep 28.
1053 Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis.Oncotarget. 2015 Sep 22;6(28):25109-20. doi: 10.18632/oncotarget.4668.
1054 Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome.Leukemia. 2000 Oct;14(10):1757-65. doi: 10.1038/sj.leu.2401897.
1055 Low Expression of Pseudogene POU5F1B Affects Diagnosis and Prognosis in Acute Myeloid Leukemia (AML).Med Sci Monit. 2019 Jul 4;25:4952-4959. doi: 10.12659/MSM.914352.
1056 Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis.Cell J. 2017 Spring;19(Suppl 1):9-26. doi: 10.22074/cellj.2017.4908. Epub 2017 May 17.
1057 Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.Leukemia. 2014 Feb;28(2):311-20. doi: 10.1038/leu.2013.338. Epub 2013 Nov 13.
1058 The protein phosphatase 2A regulatory subunit B55 is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.Biochim Biophys Acta. 2014 Sep;1843(9):1969-77. doi: 10.1016/j.bbamcr.2014.05.006. Epub 2014 May 21.
1059 Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.Nat Commun. 2014 Jun 23;5:4177. doi: 10.1038/ncomms5177.
1060 Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia.J Hematol Oncol. 2017 Jun 19;10(1):124. doi: 10.1186/s13045-017-0486-z.
1061 PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.J Clin Invest. 2018 Aug 1;128(8):3250-3264. doi: 10.1172/JCI99862. Epub 2018 Jul 23.
1062 MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.Leuk Lymphoma. 2015 Feb;56(2):460-71. doi: 10.3109/10428194.2014.924115. Epub 2014 Jun 25.
1063 Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2.
1064 Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia.Mol Cell Biol. 2018 Sep 28;38(20):e00259-18. doi: 10.1128/MCB.00259-18. Print 2018 Oct 15.
1065 PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway.Onco Targets Ther. 2019 Dec 12;12:10931-10941. doi: 10.2147/OTT.S233234. eCollection 2019.
1066 Chemotherapy-induced hypomethylation of N-myc downstream-regulated gene 4 in the bone marrow of patients with acute myeloid leukemia.Oncol Lett. 2017 May;13(5):3309-3313. doi: 10.3892/ol.2017.5839. Epub 2017 Mar 10.
1067 Expression profile analysis of long non-coding RNA in acute myeloid leukemia by microarray and bioinformatics.Cancer Sci. 2018 Feb;109(2):340-353. doi: 10.1111/cas.13465. Epub 2018 Jan 27.
1068 Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features.Cancers (Basel). 2019 Nov 22;11(12):1844. doi: 10.3390/cancers11121844.
1069 Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia.Genes Chromosomes Cancer. 2016 Nov;55(11):847-54. doi: 10.1002/gcc.22384. Epub 2016 Jul 4.
1070 Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia.Cancer Res. 2020 Feb 1;80(3):458-470. doi: 10.1158/0008-5472.CAN-18-2932. Epub 2019 Nov 29.
1071 UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.Nat Genet. 2018 Jun;50(6):883-894. doi: 10.1038/s41588-018-0114-z. Epub 2018 May 7.
1072 Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.Pediatr Transplant. 2018 Dec;22(8):e13291. doi: 10.1111/petr.13291. Epub 2018 Sep 15.
1073 miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.Leukemia. 2018 May;32(5):1180-1188. doi: 10.1038/s41375-018-0015-2. Epub 2018 Feb 2.
1074 All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.Cell Death Dis. 2019 Dec 10;10(12):944. doi: 10.1038/s41419-019-2172-2.
1075 Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.Oncogene. 2017 Jun 8;36(23):3263-3273. doi: 10.1038/onc.2016.471. Epub 2016 Dec 19.
1076 NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.Leuk Res. 2015 Jul;39(7):769-72. doi: 10.1016/j.leukres.2015.04.014. Epub 2015 May 7.
1077 The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.Nat Commun. 2019 Jan 11;10(1):172. doi: 10.1038/s41467-018-08076-y.
1078 SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.Sci Rep. 2019 Jun 24;9(1):9139. doi: 10.1038/s41598-019-45579-0.
1079 Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.Leukemia. 2015 Jun;29(6):1379-89. doi: 10.1038/leu.2014.350. Epub 2014 Dec 26.
1080 Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.Cancer Lett. 2007 Dec 8;258(1):38-44. doi: 10.1016/j.canlet.2007.08.005. Epub 2007 Sep 27.
1081 PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.Leuk Res. 2011 Oct;35(10):1367-75. doi: 10.1016/j.leukres.2011.03.024. Epub 2011 Apr 22.
1082 Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.Blood. 2018 Apr 19;131(16):1833-1845. doi: 10.1182/blood-2017-05-787226. Epub 2018 Jan 25.
1083 The Expression of the SLIT-ROBO Family in Adult Patients with Acute Myeloid Leukemia.Arch Immunol Ther Exp (Warsz). 2019 Apr;67(2):109-123. doi: 10.1007/s00005-019-00535-8. Epub 2019 Feb 28.
1084 tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia.Leuk Lymphoma. 2015;56(10):2931-44. doi: 10.3109/10428194.2015.1011157. Epub 2015 Feb 24.
1085 Ribosomal protein S14 silencing inhibits growth of acute myeloid leukemia transformed from myelodysplastic syndromes via activating p53.Hematology. 2014 Jun;19(4):225-31. doi: 10.1179/1607845413Y.0000000127. Epub 2013 Nov 25.
1086 shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis.Mol Med Rep. 2016 May;13(5):4400-6. doi: 10.3892/mmr.2016.5064. Epub 2016 Mar 30.
1087 Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia.Leukemia. 2017 Jan;31(1):213-221. doi: 10.1038/leu.2016.159. Epub 2016 Jun 3.
1088 Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Hum Mol Genet. 2014 Aug 15;23(16):4315-27. doi: 10.1093/hmg/ddu148. Epub 2014 Apr 4.
1089 RAS-Responsive Element-Binding Protein 1 Blocks the Granulocytic Differentiation of Myeloid Leukemia Cells.Oncol Res. 2019 Jul 12;27(7):809-818. doi: 10.3727/096504018X15451301487729. Epub 2019 Apr 8.
1090 p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia. Cancer Res. 2008 Nov 15;68(22):9358-66. doi: 10.1158/0008-5472.CAN-08-1860.
1091 SALL1 expression in acute myeloid leukemia.Oncotarget. 2017 Dec 15;9(7):7442-7452. doi: 10.18632/oncotarget.23448. eCollection 2018 Jan 26.
1092 Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.Mol Carcinog. 2018 Jun;57(6):735-744. doi: 10.1002/mc.22794. Epub 2018 Mar 6.
1093 SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.Pathol Res Pract. 2018 May;214(5):706-712. doi: 10.1016/j.prp.2018.03.010. Epub 2018 Mar 7.
1094 A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.Cell. 2018 Feb 22;172(5):1007-1021.e17. doi: 10.1016/j.cell.2018.01.032.
1095 Delineation of known and new transcript variants of the SETMAR (Metnase) gene and the expression profile in hematologic neoplasms.Exp Hematol. 2014 Jun;42(6):448-56.e4. doi: 10.1016/j.exphem.2014.02.005. Epub 2014 Mar 4.
1096 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.Nat Biotechnol. 2016 Feb;34(2):155-63. doi: 10.1038/nbt.3391. Epub 2015 Nov 30.
1097 INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.J Exp Clin Cancer Res. 2018 Jan 17;37(1):8. doi: 10.1186/s13046-018-0675-9.
1098 SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.Leuk Lymphoma. 2018 Apr;59(4):918-930. doi: 10.1080/10428194.2017.1344843. Epub 2017 Jul 6.
1099 Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.Biomolecules. 2019 Sep 19;9(9):505. doi: 10.3390/biom9090505.
1100 Tumor SHB gene expression affects disease characteristics in human acute myeloid leukemia.Tumour Biol. 2017 Oct;39(10):1010428317720643. doi: 10.1177/1010428317720643.
1101 Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability.BMC Cancer. 2019 May 10;19(1):435. doi: 10.1186/s12885-019-5633-1.
1102 Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.Cancer Sci. 2019 Jul;110(7):2200-2210. doi: 10.1111/cas.14033. Epub 2019 May 29.
1103 Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.Nucleic Acids Res. 2018 Apr 20;46(7):3412-3428. doi: 10.1093/nar/gky119.
1104 Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.Haematologica. 2008 Nov;93(11):1728-33. doi: 10.3324/haematol.13044. Epub 2008 Sep 11.
1105 Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4.Blood Cells Mol Dis. 2002 Mar-Apr;28(2):221-33. doi: 10.1006/bcmd.2002.0487.
1106 Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia.Leukemia. 2000 Jul;14(7):1247-52. doi: 10.1038/sj.leu.2401807.
1107 Smc3 is required for mouse embryonic and adult hematopoiesis.Exp Hematol. 2019 Feb;70:70-84.e6. doi: 10.1016/j.exphem.2018.11.008. Epub 2018 Dec 13.
1108 Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.Leuk Lymphoma. 2018 Oct;59(10):2423-2430. doi: 10.1080/10428194.2017.1387906. Epub 2017 Oct 18.
1109 SMG1 acts as a novel potential tumor suppressor with epigenetic inactivation in acute myeloid leukemia.Int J Mol Sci. 2014 Sep 25;15(9):17065-76. doi: 10.3390/ijms150917065.
1110 Wheat Germ Agglutinin as a Potential Therapeutic Agent for Leukemia.Front Oncol. 2019 Feb 21;9:100. doi: 10.3389/fonc.2019.00100. eCollection 2019.
1111 The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.Dev Cell. 2005 Jul;9(1):63-73. doi: 10.1016/j.devcel.2005.04.016.
1112 AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.Blood. 2018 Jan 4;131(1):131-143. doi: 10.1182/blood-2017-02-768762. Epub 2017 Oct 23.
1113 JAKs to STATs: A tantalizing therapeutic target in acute myeloid leukemia.Blood Rev. 2020 Mar;40:100634. doi: 10.1016/j.blre.2019.100634. Epub 2019 Oct 25.
1114 Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma.Mol Cancer Res. 2019 Apr;17(4):1002-1012. doi: 10.1158/1541-7786.MCR-18-0316. Epub 2019 Jan 11.
1115 SOX12: a novel potential target for acute myeloid leukaemia.Br J Haematol. 2017 Feb;176(3):421-430. doi: 10.1111/bjh.14425. Epub 2016 Nov 18.
1116 Low SOX17 expression: prognostic significance in de novo acute myeloid leukemia with normal cytogenetics.Clin Chem Lab Med. 2014 Dec;52(12):1843-50. doi: 10.1515/cclm-2014-0487.
1117 Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia.Leuk Res. 2018 Apr;67:32-38. doi: 10.1016/j.leukres.2018.02.001. Epub 2018 Feb 6.
1118 SOX6 blocks the proliferation of BCR-ABL1(+) and JAK2V617F(+) leukemic cells.Sci Rep. 2019 Mar 4;9(1):3388. doi: 10.1038/s41598-019-39926-4.
1119 Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia.Blood. 2015 Jun 18;125(25):3928-36. doi: 10.1182/blood-2014-06-580993. Epub 2015 May 4.
1120 The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies.Clin Cancer Res. 2004 Oct 1;10(19):6544-50. doi: 10.1158/1078-0432.CCR-04-0911.
1121 Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies.Blood. 2003 Feb 1;101(3):955-60. doi: 10.1182/blood-2002-06-1930. Epub 2002 Aug 22.
1122 LSD1/KDM1A inhibitors in clinical trials: advances and prospects.J Hematol Oncol. 2019 Dec 4;12(1):129. doi: 10.1186/s13045-019-0811-9.
1123 Elevated SPINK2 gene expression is a predictor of poor prognosis in acute myeloid leukemia.Oncol Lett. 2019 Sep;18(3):2877-2884. doi: 10.3892/ol.2019.10665. Epub 2019 Jul 25.
1124 Expression of sorcin predicts poor outcome in acute myeloid leukemia.Leuk Res. 2003 Feb;27(2):125-31. doi: 10.1016/s0145-2126(02)00083-8.
1125 STK3 is a therapeutic target for a subset of acute myeloid leukemias.Oncotarget. 2018 May 22;9(39):25458-25473. doi: 10.18632/oncotarget.25238. eCollection 2018 May 22.
1126 Spectrum and clinical implications of syntaxin 11 gene mutations in familial haemophagocytic lymphohistiocytosis: association with disease-free remissions and haematopoietic malignancies.J Med Genet. 2006 Apr;43(4):e14. doi: 10.1136/jmg.2005.035253.
1127 Expression of serologically identified tumor antigens in acute leukemias.Leuk Res. 2003 Jul;27(7):655-60. doi: 10.1016/s0145-2126(02)00230-8.
1128 Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?.Cancer Genet. 2017 Oct;216-217:74-78. doi: 10.1016/j.cancergen.2017.07.002. Epub 2017 Jul 31.
1129 TAF1 plays a critical role in AML1-ETO driven leukemogenesis.Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z.
1130 A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.Cancer Cell. 2018 Jan 8;33(1):13-28.e8. doi: 10.1016/j.ccell.2017.12.002.
1131 An update meta-analysis and systematic review of TAP polymorphisms as potential biomarkers for judging cancer risk.Pathol Res Pract. 2018 Oct;214(10):1556-1563. doi: 10.1016/j.prp.2018.07.018. Epub 2018 Jul 29.
1132 LIFR-CT3 induces differentiation of a human acute myelogenous leukemia cell line HL-60 by suppressing miR-155 expression through the JAK/STAT pathway.Leuk Res. 2014 Oct;38(10):1237-44. doi: 10.1016/j.leukres.2014.07.004. Epub 2014 Jul 22.
1133 The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate- or high-risk acute myeloid leukemia in first complete remission.Blood. 2012 Jun 7;119(23):5584-90. doi: 10.1182/blood-2011-11-389809. Epub 2012 Apr 24.
1134 Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia.Am J Transl Res. 2019 Jun 15;11(6):3450-3460. eCollection 2019.
1135 Investigation of copy-number variations of C8orf4 in hematological malignancies.Med Oncol. 2011 Dec;28 Suppl 1:S647-52. doi: 10.1007/s12032-010-9698-6. Epub 2010 Sep 29.
1136 Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations.Hum Pathol. 2017 Mar;61:41-48. doi: 10.1016/j.humpath.2016.11.003. Epub 2016 Nov 16.
1137 Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute myeloid leukemia.J Pediatr Hematol Oncol. 2012 Jan;34(1):43-6. doi: 10.1097/MPH.0b013e3182277276.
1138 Analysis of HFE and TFR2 gene mutations in patients with acute leukemia.Leuk Res. 2005 Jun;29(6):661-4. doi: 10.1016/j.leukres.2005.01.001. Epub 2005 Feb 12.
1139 TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.Leukemia. 2015 May;29(5):1018-31. doi: 10.1038/leu.2014.307. Epub 2014 Oct 28.
1140 A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis.EMBO Mol Med. 2017 Jul;9(7):933-949. doi: 10.15252/emmm.201607180.
1141 Aurora A and NF-B Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.Cancer Res. 2017 Jan 15;77(2):494-508. doi: 10.1158/0008-5472.CAN-16-1004. Epub 2016 Nov 10.
1142 TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia.J Hematol Oncol. 2016 Nov 25;9(1):128. doi: 10.1186/s13045-016-0360-4.
1143 Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses.J Biomed Sci. 2019 Aug 31;26(1):63. doi: 10.1186/s12929-019-0557-2.
1144 Secretion and Expression of Matrix Metalloproteinase-2 and 9 from Bone Marrow Mononuclear Cells in Myelodysplastic Syndrome and Acute Myeloid Leukemia.Asian Pac J Cancer Prev. 2016;17(3):1519-29. doi: 10.7314/apjcp.2016.17.3.1519.
1145 Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition.Oncotarget. 2017 May 9;8(19):31959-31976. doi: 10.18632/oncotarget.16657.
1146 Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.Blood. 2008 Apr 15;111(8):4338-47. doi: 10.1182/blood-2007-07-103291. Epub 2008 Feb 7.
1147 AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.Blood. 2011 Apr 21;117(16):4328-37. doi: 10.1182/blood-2009-09-242545. Epub 2011 Jan 18.
1148 TMEM18: A Novel Prognostic Marker in Acute Myeloid Leukemia.Acta Haematol. 2018;140(2):71-76. doi: 10.1159/000492742. Epub 2018 Sep 10.
1149 Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth.Cancer Med. 2019 May;8(5):2348-2359. doi: 10.1002/cam4.2074. Epub 2019 Mar 7.
1150 Prognostic role of TPD52 in acute myeloid leukemia: A retrospective multicohort analysis.J Cell Biochem. 2019 Mar;120(3):3672-3678. doi: 10.1002/jcb.27645. Epub 2018 Sep 11.
1151 Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.J Clin Invest. 2018 Aug 31;128(9):3819-3825. doi: 10.1172/JCI120787. Epub 2018 Aug 6.
1152 Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.Am J Med Sci. 2019 Feb;357(2):111-115. doi: 10.1016/j.amjms.2018.10.015. Epub 2018 Nov 20.
1153 Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFB pathway and overexpressed in AML.Int J Oncol. 2013 Jul;43(1):246-54. doi: 10.3892/ijo.2013.1924. Epub 2013 Apr 29.
1154 MicroRNA-126 attenuates cell apoptosis by targeting TRAF7 in acute myeloid leukemia cells.Biochem Cell Biol. 2018 Dec;96(6):840-846. doi: 10.1139/bcb-2018-0017.
1155 Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.Clin Lymphoma Myeloma Leuk. 2015 Feb;15(2):115-127.e15. doi: 10.1016/j.clml.2014.07.011. Epub 2014 Aug 12.
1156 Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.Oncotarget. 2015 Feb 20;6(5):2794-811. doi: 10.18632/oncotarget.3056.
1157 Contribution and prognostic value of TSGA10 gene expression in patients with acute myeloid leukemia (AML).Pathol Res Pract. 2019 Mar;215(3):506-511. doi: 10.1016/j.prp.2019.01.003. Epub 2019 Jan 7.
1158 The presence of central nervous system disease at diagnosis in pediatric acute myeloid leukemia does not affect survival: a Children's Oncology Group study.Pediatr Blood Cancer. 2010 Sep;55(3):414-20. doi: 10.1002/pbc.22511.
1159 Proteomic analysis of childhood de novo acute myeloid leukemia and myelodysplastic syndrome/AML: correlation to molecular and cytogenetic analyses.Amino Acids. 2011 Mar;40(3):943-51. doi: 10.1007/s00726-010-0718-9. Epub 2010 Aug 14.
1160 Transcription factor AP-2 regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression.Int J Biochem Cell Biol. 2013 Aug;45(8):1647-56. doi: 10.1016/j.biocel.2013.04.024. Epub 2013 May 6.
1161 Refined graft-versus-host disease/relapse-free survival in transplant from HLA-identical related or unrelated donors in acute myeloid leukemia.Bone Marrow Transplant. 2018 Oct;53(10):1295-1303. doi: 10.1038/s41409-018-0169-6. Epub 2018 Apr 16.
1162 Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study.Leukemia. 2018 Dec;32(12):2558-2571. doi: 10.1038/s41375-018-0268-9. Epub 2018 Oct 1.
1163 Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Blood. 2012 Aug 16;120(7):1473-84. doi: 10.1182/blood-2011-12-395335. Epub 2012 Jun 26.
1164 BAALC and ERG expression levels at diagnosis have no prognosis impact on acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.Ann Hematol. 2018 Aug;97(8):1391-1397. doi: 10.1007/s00277-018-3331-8. Epub 2018 Apr 25.
1165 Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells.Oncotarget. 2017 Mar 7;8(10):16220-16232. doi: 10.18632/oncotarget.8742.
1166 HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b.PLoS One. 2013 Dec 11;8(12):e83018. doi: 10.1371/journal.pone.0083018. eCollection 2013.
1167 Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.J Chemother. 2011 Jun;23(3):150-7. doi: 10.1179/joc.2011.23.3.150.
1168 Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy.Br J Haematol. 2018 Mar;180(6):919-924. doi: 10.1111/bjh.15129. Epub 2018 Feb 14.
1169 MiR-182-5p regulates BCL2L12 and BCL2 expression in acute myeloid leukemia as a potential therapeutic target.Biomed Pharmacother. 2018 Jan;97:1189-1194. doi: 10.1016/j.biopha.2017.11.002. Epub 2017 Nov 11.
1170 MicroRNA-204 Potentiates the Sensitivity of Acute Myeloid Leukemia Cells to Arsenic Trioxide.Oncol Res. 2019 Sep 23;27(9):1035-1042. doi: 10.3727/096504019X15528367532612. Epub 2019 Apr 8.
1171 Basophils (Bsp-1+) derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34.Blood. 1989 Feb 15;73(3):777-81.
1172 BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy.Haematologica. 2013 Dec;98(12):1886-95. doi: 10.3324/haematol.2013.087452. Epub 2013 Jun 28.
1173 Upregulation of CD200 is associated with Foxp3+ regulatory T cell expansion and disease progression in acute myeloid leukemia.Tumour Biol. 2013 Feb;34(1):531-42. doi: 10.1007/s13277-012-0578-x. Epub 2012 Nov 18.
1174 CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1.Sci Rep. 2013 Oct 4;3:2861. doi: 10.1038/srep02861.
1175 C/EBP deregulation results in differentiation arrest in acute myeloid leukemia.J Clin Invest. 2012 Dec;122(12):4490-504. doi: 10.1172/JCI65102. Epub 2012 Nov 19.
1176 The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase-dependent cleavage of calreticulin in AML patients.Blood. 2012 Sep 27;120(13):2690-9. doi: 10.1182/blood-2012-02-412759. Epub 2012 Aug 22.
1177 Methylation-independent CHFR expression is a potential biomarker affecting prognosis in acute myeloid leukemia.J Cell Physiol. 2018 Jun;233(6):4707-4714. doi: 10.1002/jcp.26253. Epub 2018 Jan 15.
1178 New fusion transcripts identified in normal karyotype acute myeloid leukemia.PLoS One. 2012;7(12):e51203. doi: 10.1371/journal.pone.0051203. Epub 2012 Dec 12.
1179 Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBP to prevent Trib1-driven acute myeloid leukemia.Blood Adv. 2017 Sep 1;1(20):1682-1693. doi: 10.1182/bloodadvances.2017007054. eCollection 2017 Sep 12.
1180 In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia.Oncotarget. 2017 Jan 24;8(4):6341-6352. doi: 10.18632/oncotarget.13856.
1181 Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.Nature. 2012 Jan 11;481(7382):506-10. doi: 10.1038/nature10738.
1182 DOCK4 deletion at 7q31.1 in a de novo acute myeloid leukemia with a normal karyotype.Cell Oncol (Dordr). 2013 Oct;36(5):395-403. doi: 10.1007/s13402-013-0145-5. Epub 2013 Aug 27.
1183 Acute myeloid leukemia with t(7;21)(q11.2;q22) expresses a novel, reversed-sequence RUNX1-DTX2 chimera.Int J Hematol. 2012 Aug;96(2):268-73. doi: 10.1007/s12185-012-1112-z. Epub 2012 Jun 4.
1184 The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.Cell Death Dis. 2012 Oct 25;3(10):e413. doi: 10.1038/cddis.2012.151.
1185 Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3.Blood. 1998 Mar 1;91(5):1700-5.
1186 A novel t(4;16)(q25;q23.1) associated with EGF and ELOVL6 deregulation in acute myeloid leukemia.Gene. 2013 Oct 15;529(1):144-7. doi: 10.1016/j.gene.2013.07.105. Epub 2013 Aug 9.
1187 Eomes(+)T-bet(low) CD8(+) T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia.Cancer Res. 2019 Apr 1;79(7):1635-1645. doi: 10.1158/0008-5472.CAN-18-3107. Epub 2019 Feb 1.
1188 High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia.J Transl Med. 2019 Jun 6;17(1):191. doi: 10.1186/s12967-019-1926-z.
1189 FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.Leuk Res. 2012 Nov;36(11):1339-46. doi: 10.1016/j.leukres.2012.06.011. Epub 2012 Aug 16.
1190 Reduced Relapse Incidence with FLAMSA-RIC Compared with Busulfan/Fludarabine for Acute Myelogenous Leukemia Patients in First or Second Complete Remission: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant. 2018 Nov;24(11):2224-2232. doi: 10.1016/j.bbmt.2018.07.007. Epub 2018 Aug 7.
1191 Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation.Biochem Biophys Res Commun. 2013 Aug 23;438(2):283-8. doi: 10.1016/j.bbrc.2013.07.056. Epub 2013 Jul 24.
1192 Array-based DNA methylation profiling in acute myeloid leukaemia.Br J Haematol. 2011 Oct;155(1):65-72. doi: 10.1111/j.1365-2141.2011.08801.x. Epub 2011 Jul 26.
1193 GPX3 methylation in bone marrow predicts adverse prognosis and leukemia transformation in myelodysplastic syndrome.Cancer Med. 2017 Jan;6(1):267-274. doi: 10.1002/cam4.984. Epub 2016 Nov 28.
1194 FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.Mol Oncol. 2013 Jun;7(3):402-18. doi: 10.1016/j.molonc.2012.11.003. Epub 2012 Nov 29.
1195 A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination.Leukemia. 2019 Jul;33(7):1773-1782. doi: 10.1038/s41375-019-0385-0. Epub 2019 Jan 29.
1196 Growth and differentiation effects of Homer3 on a leukemia cell line.Asian Pac J Cancer Prev. 2013;14(4):2525-8. doi: 10.7314/apjcp.2013.14.4.2525.
1197 Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.PLoS One. 2011;6(11):e28011. doi: 10.1371/journal.pone.0028011. Epub 2011 Nov 23.
1198 The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia.Exp Cell Res. 2018 Apr 15;365(2):185-193. doi: 10.1016/j.yexcr.2018.02.036. Epub 2018 Mar 6.
1199 JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/-catenin/CCND1 signaling.J Clin Invest. 2018 May 1;128(5):1737-1751. doi: 10.1172/JCI93198. Epub 2018 Mar 26.
1200 KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia.Blood. 2011 Apr 7;117(14):3869-80. doi: 10.1182/blood-2010-10-312736. Epub 2011 Feb 10.
1201 A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22).Cancer Genet. 2012 Nov;205(11):608-11. doi: 10.1016/j.cancergen.2012.10.001. Epub 2012 Oct 24.
1202 The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer.Front Immunol. 2019 Jul 11;10:1594. doi: 10.3389/fimmu.2019.01594. eCollection 2019.
1203 Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population.Cancer Sci. 2011 Aug;102(8):1462-8. doi: 10.1111/j.1349-7006.2011.01965.x. Epub 2011 May 25.
1204 Detection of prognostic methylation markers by methylC-capture sequencing in acute myeloid leukemia.Oncotarget. 2017 Nov 30;8(66):110444-110459. doi: 10.18632/oncotarget.22789. eCollection 2017 Dec 15.
1205 The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
1206 MN1 and PTEN gene expression in acute myeloid leukemia.Cancer Biomark. 2017;18(2):177-182. doi: 10.3233/CBM-160235.
1207 Phase Ib Study of Glasdegib, a Hedgehog Pathway Inhibitor, in Combination with Standard Chemotherapy in Patients with AML or High-Risk MDS.Clin Cancer Res. 2018 May 15;24(10):2294-2303. doi: 10.1158/1078-0432.CCR-17-2824. Epub 2018 Feb 20.
1208 MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.Blood. 2012 Sep 27;120(13):2719-22. doi: 10.1182/blood-2012-04-422352. Epub 2012 Jun 7.
1209 A three-way translocation of MLL, MLLT11, and the novel reciprocal partner gene MYO18A in a child with acute myeloid leukemia.Cancer Genet. 2012 May;205(5):261-5. doi: 10.1016/j.cancergen.2012.02.006.
1210 NKL homeobox gene activities in normal and malignant myeloid cells.PLoS One. 2019 Dec 11;14(12):e0226212. doi: 10.1371/journal.pone.0226212. eCollection 2019.
1211 Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia.Leukemia. 2012 Feb;26(2):289-95. doi: 10.1038/leu.2011.200. Epub 2011 Aug 9.
1212 Nebulette is the second member of the nebulin family fused to the MLL gene in infant leukemia.Cancer Genet Cytogenet. 2010 Apr 15;198(2):151-4. doi: 10.1016/j.cancergencyto.2009.12.013.
1213 NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies.Mol Cancer Ther. 2012 Apr;11(4):1006-16. doi: 10.1158/1535-7163.MCT-11-0765. Epub 2012 Feb 7.
1214 Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.Leuk Res. 2012 Oct;36(10):1300-3. doi: 10.1016/j.leukres.2012.06.010. Epub 2012 Jul 9.
1215 Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy.Ann Hematol. 2017 Apr;96(4):559-565. doi: 10.1007/s00277-016-2912-7. Epub 2017 Jan 5.
1216 miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.Oncogene. 2013 Aug 1;32(31):3648-54. doi: 10.1038/onc.2012.398. Epub 2012 Sep 10.
1217 Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients.Leuk Res. 2010 Jul;34(7):942-5. doi: 10.1016/j.leukres.2010.01.008. Epub 2010 Jan 31.
1218 Nuclear phospholipase C in biological control and cancer.Crit Rev Eukaryot Gene Expr. 2011;21(3):291-301. doi: 10.1615/critreveukargeneexpr.v21.i3.50.
1219 POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15).Mol Cancer. 2013 Jan 18;12:5. doi: 10.1186/1476-4598-12-5.
1220 Aberrant methylation of the RIZ1 gene in myelodysplastic syndrome and acute myeloid leukemia.Leuk Res. 2011 Apr;35(4):516-21. doi: 10.1016/j.leukres.2010.08.002. Epub 2010 Sep 9.
1221 The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.Mol Cancer Res. 2013 Aug;11(8):815-27. doi: 10.1158/1541-7786.MCR-12-0695. Epub 2013 May 3.
1222 Deregulation of protein phosphatase expression in acute myeloid leukemia.Med Oncol. 2013 Jun;30(2):517. doi: 10.1007/s12032-013-0517-8. Epub 2013 Feb 26.
1223 PURA, the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functions.Gene. 2018 Feb 15;643:133-143. doi: 10.1016/j.gene.2017.12.004. Epub 2017 Dec 6.
1224 Characterization of purine-rich element binding protein B as a novel biomarker in acute myelogenous leukemia prognostication.J Cell Biochem. 2018 Feb;119(2):2073-2083. doi: 10.1002/jcb.26369. Epub 2017 Oct 18.
1225 Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Blood. 2011 Nov 10;118(19):5235-45. doi: 10.1182/blood-2011-04-351817. Epub 2011 Sep 22.
1226 Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.Exp Hematol. 2012 Mar;40(3):177-186.e6. doi: 10.1016/j.exphem.2011.11.008. Epub 2011 Nov 25.
1227 Methylation level of Rap1GAP and the clinical significance in MDS.Oncol Lett. 2018 Dec;16(6):7287-7294. doi: 10.3892/ol.2018.9503. Epub 2018 Sep 26.
1228 Impact of HLA Allele Mismatch at HLA-A, -B, -C, and -DRB1 in Single Cord Blood Transplantation.Biol Blood Marrow Transplant. 2020 Mar;26(3):519-528. doi: 10.1016/j.bbmt.2019.11.001. Epub 2019 Nov 9.
1229 Targeting the GFI1/1B-CoREST Complex in Acute Myeloid Leukemia.Front Oncol. 2019 Oct 9;9:1027. doi: 10.3389/fonc.2019.01027. eCollection 2019.
1230 DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia.Oncotarget. 2013 Oct;4(10):1712-20. doi: 10.18632/oncotarget.1280.
1231 Repression of the RHOH gene by JunD.Biochem J. 2011 Jul 1;437(1):75-88. doi: 10.1042/BJ20100829.
1232 Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing.Leukemia. 2011 May;25(5):821-7. doi: 10.1038/leu.2011.19. Epub 2011 Feb 22.
1233 Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery.J Hematol Oncol. 2014 Jan 9;7:5. doi: 10.1186/1756-8722-7-5.
1234 Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality.Cancer Res. 2017 Jan 1;77(1):207-218. doi: 10.1158/0008-5472.CAN-16-1386. Epub 2016 Oct 26.
1235 Long noncoding RNA NEAT1 modulates cell proliferation and apoptosis by regulating miR-23a-3p/SMC1A in acute myeloid leukemia.J Cell Physiol. 2019 May;234(5):6161-6172. doi: 10.1002/jcp.27393. Epub 2018 Sep 24.
1236 Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias.Clin Chim Acta. 2012 Oct 9;413(19-20):1542-8. doi: 10.1016/j.cca.2012.06.025. Epub 2012 Jun 29.
1237 Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.PLoS One. 2012;7(3):e33213. doi: 10.1371/journal.pone.0033213. Epub 2012 Mar 29.
1238 A Pilot Study of Aberrant CpG Island Hypermethylation of SPRED1 in Acute Myeloloid Leukemia.Int J Med Sci. 2019 Jan 1;16(2):324-330. doi: 10.7150/ijms.27757. eCollection 2019.
1239 Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients.Eur J Haematol. 2017 Dec;99(6):544-552. doi: 10.1111/ejh.12972. Epub 2017 Oct 13.
1240 Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1.Mol Pharmacol. 2010 May;77(5):828-35. doi: 10.1124/mol.109.061507. Epub 2010 Feb 16.
1241 Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90.J Biosci Bioeng. 2012 Jul;114(1):96-103. doi: 10.1016/j.jbiosc.2012.02.016. Epub 2012 Mar 17.
1242 TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.Cell Death Dis. 2013 Apr 4;4(4):e573. doi: 10.1038/cddis.2013.107.