Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMGH91T)

DOT Name Isopentenyl-diphosphate delta-isomerase 2 (IDI2)
Synonyms EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2
Gene Name IDI2
Related Disease
Chronic renal failure ( )
UniProt ID
IDI2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2PNY
EC Number
5.3.3.2
Pfam ID
PF00293
Sequence
MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFN
TKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPG
EQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELW
ELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Tissue Specificity Muscle-specific expression.
KEGG Pathway
Terpenoid backbone biosynthesis (hsa00900 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Cholesterol biosynthesis (R-HSA-191273 )
BioCyc Pathway
MetaCyc:HS07522-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Chronic renal failure DISGG7K6 Definitive Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Estradiol DMUNTE3 Approved Estradiol increases the expression of Isopentenyl-diphosphate delta-isomerase 2 (IDI2). [2]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of Isopentenyl-diphosphate delta-isomerase 2 (IDI2). [3]
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References

1 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms10023.
2 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
3 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.