Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTSU9HHH)

DOT Name Keratin-associated protein 4-7 (KRTAP4-7)
Synonyms Keratin-associated protein 4.7; Ultrahigh sulfur keratin-associated protein 4.7
Gene Name KRTAP4-7
UniProt ID
KRA47_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF13885
Sequence
MVSSCCGSVCSDQGCSQDLCQETCCRPSCCQTTCCRTTCYRPSCCVSSCCRPQCCQSVCC
QPTCCRPTCCETTCCHPRCCISSCCRPSCCMSSCCKPQCCQSVCCQPTCCRPSCCRPCCC
LRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC
Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Tissue Specificity Expressed in the hair follicles.
Reactome Pathway
Keratinization (R-HSA-6805567 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Keratin-associated protein 4-7 (KRTAP4-7). [1]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Keratin-associated protein 4-7 (KRTAP4-7). [2]
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References

1 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
2 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.