Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTT9M6SH)

DOT Name TBC1 domain family member 21 (TBC1D21)
Synonyms Male germ cell Rab GTPase-activating protein
Gene Name TBC1D21
UniProt ID
TBC21_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00566
Sequence
MTTLSPENSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHP
FVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFTETRN
NIARDIQKIYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMMLFQLMVEHDH
ETFWLFQFFLQKTEHSCVINIGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWF
CFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLAC
NNLIDLDADELISAACVVYAELIQKDVPQTLKDFFL
Function
Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity.
Tissue Specificity Expressed in round and elongated spermatids (at protein level). Expressed specifically in adult testis and very weakly in fetal brain.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of TBC1 domain family member 21 (TBC1D21). [1]
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1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
CH-223191 DMMJZYC Investigative CH-223191 decreases the expression of TBC1 domain family member 21 (TBC1D21). [2]
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References

1 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
2 Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.