Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUDL2HG)

DOT Name	Calcium homeostasis modulator protein 4 (CALHM4)
Synonyms	Protein FAM26D
Gene Name	CALHM4
UniProt ID	CAHM4_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	6YTK; 6YTL; 6YTO; 6YTQ
Pfam ID	PF14798
Sequence	MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPA LILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLA VTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALL HRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHS RLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDE DNEEDRSRGIELKP
Function	Pore-forming subunit of a voltage-gated ion channel.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the methylation of Calcium homeostasis modulator protein 4 (CALHM4).	[1]
Fulvestrant	DM0YZC6	Approved	Fulvestrant increases the methylation of Calcium homeostasis modulator protein 4 (CALHM4).	[2]
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References

1	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.