Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVOL6GA)

• DOT Name: Fascin-3 (FSCN3)
• Synonyms: Testis fascin
• Gene Name: FSCN3
• Related Disease:
  Non-insulin dependent diabetes
  Adenocarcinoma
• UniProt ID: FSCN3_HUMAN
• Pfam ID: PF06268
• Sequence:
  MDETEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSLGRRQTWEILVSNEHET
  QAVVRLKSVQGLYLLCECDGTVCYGRPRTSHHGCFLLRFHRNSKWTLQCLISGRYLESNG
  KDVFCTSHVLSAYHMWTPRPALHVHVILYSPIHRCYARADPTMGRIWVDAAVPCLEECGF
  LLHFRDGCYHLETSTHHFLSHVDRLFSQPSSQTAFHMQVRPGGLVALCDGEGGMLYPQGT
  HLLLGMGCNPMRGEEWFILQHCPTWVSLRSKTGRFISVIYDGEVRAASERLNRMSLFQFE
  CDSESPTVQLRSANGYYLSQRRHRAVMADGHPLESDTFFRMHWNCGRIILQSCRGRFLGI
  APNSLLMANVILPGPNEEFGILFANRSFLVLRGRYGYVGSSSGHDLIQCNQDQPDRIHLL
  PCRPGIYHFQAQGGSFWSITSFGTFRPWGKFALNFCIELQGSNLLTVLAPNGFYMRADQS
  GTLLADSEDITRECIWEF
• Function: Acts as an actin bundling protein.
• Tissue Specificity: Expressed in testis.

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Non-insulin dependent diabetes	DISK1O5Z	Strong	Genetic Variation	[1]
Adenocarcinoma	DIS3IHTY	moderate	Biomarker	[2]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the expression of Fascin-3 (FSCN3).	[3]

References

• [1] Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.Nat Commun. 2016 Jan 28;7:10531. doi: 10.1038/ncomms10531.
• [2] Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.BMC Cancer. 2006 Oct 9;6:241. doi: 10.1186/1471-2407-6-241.
• [3] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.