Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTX31RLZ)

DOT Name Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2)
Synonyms CD158 antigen-like family member J; NK receptor 183 ActI; Natural killer-associated transcript 5; NKAT-5; p58 natural killer cell receptor clone CL-49; p58 NK receptor CL-49; CD antigen CD158j
Gene Name KIR2DS2
UniProt ID
KI2S2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1M4K; 4N8V; 7DUU
Pfam ID
PF00047
Sequence
MSLMVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFEHFLL
HREGKYKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDI
VITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGT
FQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGN
PRHLHVLIGTSVVKIPFTILLFFLLHRWCSNKKNAAVMDQEPAGNRTVNSEDSDEQDHQE
VSYA
Function Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
KEGG Pathway
Antigen processing and presentation (hsa04612 )
.tural killer cell mediated cytotoxicity (hsa04650 )
Reactome Pathway
DAP12 interactions (R-HSA-2172127 )
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Methotrexate DM2TEOL Approved Methotrexate decreases the expression of Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2). [1]
Simvastatin DM30SGU Approved Simvastatin decreases the expression of Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2). [2]
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References

1 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
2 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.