Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTXQR5J9)

DOT Name N-formyl peptide receptor 3 (FPR3)
Synonyms FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2
Gene Name FPR3
UniProt ID
FPR3_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00001
Sequence
METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVN
TICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIA
LDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNF
AFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPL
RVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPI
LYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin.
Tissue Specificity Detected in various tissues with highest expression in lung.
KEGG Pathway
Neuroactive ligand-receptor interaction (hsa04080 )
Neutrophil extracellular trap formation (hsa04613 )
Staphylococcus aureus infection (hsa05150 )
Reactome Pathway
Formyl peptide receptors bind formyl peptides and many other ligands (R-HSA-444473 )
G alpha (i) signalling events (R-HSA-418594 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of N-formyl peptide receptor 3 (FPR3). [1]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of N-formyl peptide receptor 3 (FPR3). [2]
Calcitriol DM8ZVJ7 Approved Calcitriol decreases the expression of N-formyl peptide receptor 3 (FPR3). [3]
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References

1 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
2 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
3 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.