Details of the Drug Combination

General Information of Drug Combination (ID: DC0XZK2)

Drug Combination Name
Indocyanine green Guanosine-5'-Monophosphate
Indication
Disease Entry Status REF
Gastrointestinal Diseases Phase 1 [1]
Component Drugs Indocyanine green   DM2NQUY Guanosine-5'-Monophosphate   DM3SLZK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Indocyanine green
Disease Entry ICD 11 Status REF
Gastrointestinal disease DE2Z Approved [2]
Indocyanine green Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [4]
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Indication(s) of Guanosine-5'-Monophosphate
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [3]
Guanosine-5'-Monophosphate Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Presynaptic density protein 95 (DLG4) TT9PB26 DLG4_HUMAN Inhibitor [5]
Phosphodiesterase 5A (PDE5A) TTJ0IQB PDE5A_HUMAN Inhibitor [5]
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [5]
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) TTBL49X HGXR_PLAFG Inhibitor [5]
Cytomegalovirus DNA polymerase (CMV UL54) TT1U2YM DPOL_HCMVA Inhibitor [5]
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Guanosine-5'-Monophosphate Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
GDP-mannose 4,6 dehydratase (GMDS) OTWV79YD GMDS_HUMAN Affects Binding [6]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Decreases Activity [7]
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References

1 ClinicalTrials.gov (NCT01034670) Advanced Gastrointestinal Endoscopic Imaging
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4844).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5123).
4 Primovist, Eovist: what to expect? J Hepatol. 2012 Aug;57(2):421-9.
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25.
7 Chemical modifications of alpha1,6-fucosyltransferase define amino acid residues of catalytic importance. Biochimie. 2003 Mar-Apr;85(3-4):303-10. doi: 10.1016/s0300-9084(03)00074-9.