Details of the Drug Combination

General Information of Drug Combination (ID: DC1CKPZ)

Drug Combination Name
TEM Aminolevulinic Acid Hydrochloride
Indication
Disease Entry Status REF
Lung adenocarcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Aminolevulinic Acid Hydrochloride   DMWNHPC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: HOP-62
Zero Interaction Potency (ZIP) Score: 0.42
Bliss Independence Score: 3.89
Loewe Additivity Score: 2.81
LHighest Single Agent (HSA) Score: 0.54

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Aminolevulinic Acid Hydrochloride
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [3]
Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protoporphyrinogen oxidase (PPOX) TTNFMS9 PPOX_HUMAN Modulator [4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCVQ1UG HL-60(TB) Investigative [5]
Glioma DCUB7LJ SF-268 Investigative [5]
Papillary renal cell carcinoma DCSVA1P ACHN Investigative [5]
Invasive ductal carcinoma DCVI4ZS T-47D Investigative [6]
Invasive ductal carcinoma DCBV0GM BT-549 Investigative [6]
Adenocarcinoma DCNZPHC DU-145 Investigative [1]
Adenocarcinoma DCQN8Y1 A549 Investigative [1]
Large cell lung carcinoma DC31L29 NCI-H460 Investigative [1]
Melanoma DCDGDPN MALME-3M Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.