Details of the Drug Combination

General Information of Drug Combination (ID: DCSVA1P)

Drug Combination Name
TEM Aminolevulinic Acid Hydrochloride
Indication
Disease Entry Status REF
Papillary renal cell carcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Aminolevulinic Acid Hydrochloride   DMWNHPC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: ACHN
Zero Interaction Potency (ZIP) Score: 0.46
Bliss Independence Score: 0.4
Loewe Additivity Score: 1.26
LHighest Single Agent (HSA) Score: 1.2

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Aminolevulinic Acid Hydrochloride
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [3]
Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protoporphyrinogen oxidase (PPOX) TTNFMS9 PPOX_HUMAN Modulator [4]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCVQ1UG HL-60(TB) Investigative [1]
Glioma DCUB7LJ SF-268 Investigative [1]
Invasive ductal carcinoma DCVI4ZS T-47D Investigative [5]
Invasive ductal carcinoma DCBV0GM BT-549 Investigative [5]
Adenocarcinoma DCNZPHC DU-145 Investigative [6]
Adenocarcinoma DCQN8Y1 A549 Investigative [6]
Large cell lung carcinoma DC31L29 NCI-H460 Investigative [6]
Lung adenocarcinoma DC1CKPZ HOP-62 Investigative [6]
Melanoma DCDGDPN MALME-3M Investigative [6]
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⏷ Show the Full List of 9 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
6 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.