Details of the Drug Combination

General Information of Drug Combination (ID: DC39ITG)

• Drug Combination Name: Terazosin + Mebutamate
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Terazosin (DM3JCVS): Small molecular drug
  Mebutamate (DM0KYI4): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 22.89
  Bliss Independence Score: 22.89
  Loewe Additivity Score: 39.34
  LHighest Single Agent (HSA) Score: 39.35

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Terazosin

Disease Entry	ICD 11	Status	REF
Benign prostatic hyperplasia	GA90	Approved	[2]

Terazosin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Antagonist	[4]

Indication(s) of Mebutamate

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Approved	[3]

Mebutamate Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator	[5]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7302).
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis. 2002;5(2):88-95.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.