Details of the Drug Combination

General Information of Drug Combination (ID: DC4V2C6)

Drug Combination Name
Misoprostol Dinoprostone
Indication
Disease Entry Status REF
Premature Rupture of Membranes at Term Phase 1 [1]
Component Drugs Misoprostol   DMHVJFK Dinoprostone   DMTYOPD
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Misoprostol
Disease Entry ICD 11 Status REF
Medical abortion JA00.1Z Approved [2]
Postpartum haemorrhage JA43 Approved [3]
Misoprostol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostacyclin receptor (PTGIR) TTOFYT1 PI2R_HUMAN Antagonist [5]
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Misoprostol Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [6]
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Indication(s) of Dinoprostone
Disease Entry ICD 11 Status REF
Medical abortion JA00.1Z Approved [4]
Dinoprostone Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin E2 receptor EP2 (PTGER2) TT1ZAVI PE2R2_HUMAN Antagonist [8]
Prostaglandin F2-alpha receptor (PTGFR) TTT2ZAR PF2R_HUMAN Antagonist [8]
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Dinoprostone Interacts with 18 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [9]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [10]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [11]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [12]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [11]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [13]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [10]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [10]
Organic anion transporter 4 (SLC22A11) DT06JWZ S22AB_HUMAN Substrate [10]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [14]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [15]
Organic solute transporter subunit alpha (SLC51A) DTMEQ32 OSTA_HUMAN Substrate [16]
Organic solute transporter subunit beta (SLC51B) DT1V9AJ OSTB_HUMAN Substrate [16]
Organic anion transporting polypeptide 1C1 (SLCO1C1) DTPYCQ4 SO1C1_HUMAN Substrate [17]
Organic anion transporting polypeptide 2A1 (SLCO2A1) DT021JD SO2A1_HUMAN Substrate [15]
Organic anion transporting polypeptide 3A1 (SLCO3A1) DTVNRXW SO3A1_HUMAN Substrate [18]
Organic anion transporting polypeptide 4A1 (SLCO4A1) DT8H2IC SO4A1_HUMAN Substrate [15]
Organic anion transporting polypeptide 5A1 (SLCO5A1) DTYVQ5M SO5A1_HUMAN Substrate [19]
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⏷ Show the Full List of 18 DTP(s)
Dinoprostone Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [20]
Cytochrome P450 4F2 (CYP4F2) DE3GT9C CP4F2_HUMAN Metabolism [21]
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Dinoprostone Interacts with 88 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) OT3062CA SO2A1_HUMAN Increases Transport [22]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Increases Transport [23]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Affects Transport [24]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Decreases Activity [25]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases Phosphorylation [26]
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) OT251CI0 ATF1_HUMAN Increases Phosphorylation [26]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [26]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [27]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Increases Expression [28]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [29]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [29]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Increases Activity [30]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Increases Expression [31]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Increases Expression [31]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Increases Expression [31]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Phosphorylation [32]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [32]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Increases Expression [33]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [34]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [35]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Decreases Expression [35]
C-C motif chemokine 22 (CCL22) OTT3QJC2 CCL22_HUMAN Increases Expression [36]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [37]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [38]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [39]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [40]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [36]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [41]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Decreases Expression [42]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [43]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Decreases Expression [44]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Increases Secretion [41]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Increases Secretion [41]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [36]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Secretion [45]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [36]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [46]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Decreases Expression [38]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Expression [36]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [36]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [36]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [47]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Expression [6]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [48]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Activity [49]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [36]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Activity [50]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [50]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Increases Expression [51]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [52]
Cytokine receptor common subunit gamma (IL2RG) OTRZ3OMY IL2RG_HUMAN Decreases Expression [53]
C-C chemokine receptor type 7 (CCR7) OTHFUOYE CCR7_HUMAN Increases Expression [36]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [38]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Increases Secretion [41]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [54]
Prostaglandin E2 receptor EP4 subtype (PTGER4) OT2GBV06 PE2R4_HUMAN Increases Activity [55]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Activity [56]
Interleukin-12 receptor subunit beta-1 (IL12RB1) OTM1IJO2 I12R1_HUMAN Decreases Expression [57]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [54]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [38]
Nuclear receptor ROR-gamma (RORC) OTUBFRPC RORG_HUMAN Increases Expression [6]
C-C chemokine receptor type 5 (CCR5) OTP5FMZ4 CCR5_HUMAN Decreases Expression [36]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [44]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Increases Expression [36]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [58]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [56]
C-C motif chemokine 17 (CCL17) OTIKW21L CCL17_HUMAN Increases Expression [36]
Interleukin-12 receptor subunit beta-2 (IL12RB2) OTDLV8H8 I12R2_HUMAN Decreases Expression [57]
Interleukin-22 (IL22) OTW31FU9 IL22_HUMAN Decreases Expression [6]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [6]
Interleukin-26 (IL26) OT2WYCW4 IL26_HUMAN Decreases Expression [6]
T-box transcription factor TBX21 (TBX21) OT3UK5KE TBX21_HUMAN Decreases Expression [6]
Glycoprotein hormones alpha chain (CGA) OT00U3Y3 GLHA_HUMAN Increases Secretion [59]
Short transient receptor potential channel 7 (TRPC7) OT3F0RUV TRPC7_HUMAN Increases Response To Substance [60]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Increases Abundance [52]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Abundance [61]
Platelet-derived growth factor subunit A (PDGFA) OTCMZ0W8 PDGFA_HUMAN Increases Abundance [50]
Glutathione S-transferase Mu 2 (GSTM2) OTG4WT05 GSTM2_HUMAN Affects Chemical Synthesis [62]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Increases Chemical Synthesis [63]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Abundance [64]
Fibroblast growth factor 20 (FGF20) OTJIQ8YZ FGF20_HUMAN Increases Abundance [65]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Increases Secretion [66]
Vasopressin V1a receptor (AVPR1A) OTKR8AFL V1AR_HUMAN Increases ADR [67]
Glutathione S-transferase Mu 3 (GSTM3) OTLA2WJT GSTM3_HUMAN Affects Chemical Synthesis [62]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Secretion [68]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Abundance [69]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Increases Secretion [70]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Metabolism [71]
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⏷ Show the Full List of 88 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Cervical Ripening DC0WYT9 N. A. Phase 1 [72]
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References

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3 Misoprostol FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1916).
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30 PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells. J Endocrinol. 2007 Sep;194(3):595-602.
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32 Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. Toxicol Sci. 2010 Apr;114(2):204-16.
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60 PGE2-induced apoptotic cell death in K562 human leukaemia cells. Cell Physiol Biochem. 2006;17(5-6):201-10. doi: 10.1159/000094125. Epub 2006 Jun 20.
61 Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme. Oncogene. 2007 Jul 26;26(34):4999-5009. doi: 10.1038/sj.onc.1210303. Epub 2007 Mar 19.
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67 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
68 Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):349-59. doi: 10.1016/j.taap.2015.09.009. Epub 2015 Sep 15.
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