Details of the Drug Combination

General Information of Drug Combination (ID: DC4W9SH)

Drug Combination Name

BIO-300 Vinflunine

Indication

Disease Entry	Status	REF
Mixed endometrioid and clear cell carcinoma	Investigative	[1]

Component Drugs

BIO-300 DMJ7NVI

Vinflunine DMTJAEP

N.A.

Small molecular drug

High-throughput Screening Result

Testing Cell Line: IGROV1

Zero Interaction Potency (ZIP) Score: 0.24

Bliss Independence Score: 3.43

Loewe Additivity Score: 1.98

LHighest Single Agent (HSA) Score: 7.53

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Anaplastic large cell lymphoma	DCINVKA	SR	Investigative	[5]
Astrocytoma	DCW4QSJ	SNB-19	Investigative	[5]
Childhood T acute lymphoblastic leukemia	DC1DGTQ	CCRF-CEM	Investigative	[5]
Chronic myelogenous leukemia	DCZGARG	K-562	Investigative	[5]
Glioblastoma	DCM5X09	SNB-75	Investigative	[5]
Glioma	DCE2RTA	SF-295	Investigative	[5]
Glioma	DCS57CK	SF-539	Investigative	[5]
Carcinoma	DCB8VR3	MCF7	Investigative	[6]
Adenocarcinoma	DCAJO7H	HCT-15	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCFPX4H	OVCAR-8	Investigative	[1]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2	Clinical pipeline report, company report or official report of Humanetics.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6	Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.