Details of the Drug Combination

General Information of Drug Combination (ID: DCZGARG)

Drug Combination Name
BIO-300 Vinflunine
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs BIO-300   DMJ7NVI Vinflunine   DMTJAEP
N.A. Small molecular drug
High-throughput Screening Result Testing Cell Line: K-562
Zero Interaction Potency (ZIP) Score: 1.93
Bliss Independence Score: 2.02
Loewe Additivity Score: 0.52
LHighest Single Agent (HSA) Score: 3.36

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Anaplastic large cell lymphoma DCINVKA SR Investigative [1]
Astrocytoma DCW4QSJ SNB-19 Investigative [1]
Childhood T acute lymphoblastic leukemia DC1DGTQ CCRF-CEM Investigative [1]
Glioblastoma DCM5X09 SNB-75 Investigative [1]
Glioma DCE2RTA SF-295 Investigative [1]
Glioma DCS57CK SF-539 Investigative [1]
Carcinoma DCB8VR3 MCF7 Investigative [5]
Adenocarcinoma DCAJO7H HCT-15 Investigative [6]
High grade ovarian serous adenocarcinoma DCFPX4H OVCAR-8 Investigative [6]
Mixed endometrioid and clear cell carcinoma DC4W9SH IGROV1 Investigative [6]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of Humanetics.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
6 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.