Details of the Drug Combination

General Information of Drug Combination (ID: DC79ITT)

• Drug Combination Name: Levamisole + Ethinyl Estradiol
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Levamisole (DM5EN79): Small molecular drug
  Ethinyl Estradiol (DMODJ40): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 65.54
  Bliss Independence Score: 65.54
  Loewe Additivity Score: 79.95
  LHighest Single Agent (HSA) Score: 79.97

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Levamisole

Disease Entry	ICD 11	Status	REF
Parasitic infection	1D0Y-1G2Z	Approved	[2]
Colon cancer	2B90.Z	Withdrawn from market	[3]

Levamisole Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Alkaline phosphatase tissue-nonspecific (ALPL)	TTMR5UV	PPBT_HUMAN	Inhibitor	[6]

Levamisole Interacts with 8 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[7]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[7]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Expression	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[7]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[7]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Decreases Expression	[7]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[7]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[8]

Indication(s) of Ethinyl Estradiol

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[4]
Female hypogonadism	GA30.6	Approved	[5]
Hot flushes	GA30	Approved	[4]
Obsolete atrophic vulva	N.A.	Approved	[4]

Ethinyl Estradiol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Agonist	[13]

Ethinyl Estradiol Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[14]

Ethinyl Estradiol Interacts with 6 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[15]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[16]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[17]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[18]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[17]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[19]

Ethinyl Estradiol Interacts with 280 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[18]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[20]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Hydroxylation	[17]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Hydroxylation	[17]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Increases Hydroxylation	[17]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[14]
Sulfotransferase 1E1 (SULT1E1)	OTGPJ517	ST1E1_HUMAN	Decreases Activity	[21]
Gamma-aminobutyric acid receptor subunit pi (GABRP)	OTGKA8WS	GBRP_HUMAN	Decreases Expression	[10]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Decreases Expression	[10]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)	OTFK8KDP	NHRF1_HUMAN	Increases Expression	[10]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[10]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Decreases Expression	[10]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[10]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[10]
Band 4.1-like protein 2 (EPB41L2)	OT6UABPM	E41L2_HUMAN	Increases Expression	[10]
Tetraspanin-1 (TSPAN1)	OTZQPIYK	TSN1_HUMAN	Decreases Expression	[10]
Microfibrillar-associated protein 3-like (MFAP3L)	OTNMHSAH	MFA3L_HUMAN	Increases Expression	[10]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[10]
Dysferlin (DYSF)	OTNSKJU0	DYSF_HUMAN	Decreases Expression	[10]
Gamma-butyrobetaine dioxygenase (BBOX1)	OTKEX4RK	BODG_HUMAN	Decreases Expression	[10]
Nebulette (NEBL)	OT2WH1NC	NEBL_HUMAN	Decreases Expression	[10]
ATP-dependent DNA helicase Q5 (RECQL5)	OTVZMP1Q	RECQ5_HUMAN	Decreases Expression	[10]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Decreases Expression	[10]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[10]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)	OTIXNT91	NDUB6_HUMAN	Increases Expression	[10]
Rap guanine nucleotide exchange factor 3 (RAPGEF3)	OTMOW4Z4	RPGF3_HUMAN	Decreases Expression	[10]
Secretoglobin family 1D member 2 (SCGB1D2)	OTSYWZAQ	SG1D2_HUMAN	Increases Expression	[10]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[10]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Increases Expression	[10]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[10]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Expression	[10]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Expression	[10]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Expression	[10]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)	OTWJTCRK	PCCA_HUMAN	Increases Expression	[10]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Increases Expression	[10]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[10]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Increases Expression	[10]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[10]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[10]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[10]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[10]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Decreases Expression	[10]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Decreases Expression	[10]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Decreases Expression	[10]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[10]
Alkaline phosphatase, germ cell type (ALPG)	OTCIM29R	PPBN_HUMAN	Increases Expression	[10]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Increases Expression	[10]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[10]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[10]
Endothelin-2 (EDN2)	OTQ7RCPI	EDN2_HUMAN	Decreases Expression	[10]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Increases Expression	[10]
Fibroblast growth factor receptor 2 (FGFR2)	OTLOPACK	FGFR2_HUMAN	Decreases Expression	[10]
Galanin peptides (GAL)	OTB3VPTO	GALA_HUMAN	Increases Expression	[10]
Fibroblast growth factor receptor 3 (FGFR3)	OTSAXDIL	FGFR3_HUMAN	Decreases Expression	[10]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Affects Expression	[10]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[10]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Decreases Expression	[10]
Transcription factor HIVEP2 (HIVEP2)	OTVOMCW4	ZEP2_HUMAN	Decreases Expression	[10]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Decreases Expression	[10]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[10]
Activin receptor type-1B (ACVR1B)	OT778HIQ	ACV1B_HUMAN	Decreases Expression	[10]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Increases Expression	[10]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Increases Expression	[10]
Exosome RNA helicase MTR4 (MTREX)	OTSQY30V	MTREX_HUMAN	Increases Expression	[10]
G protein-activated inward rectifier potassium channel 1 (KCNJ3)	OTHQG16J	KCNJ3_HUMAN	Decreases Expression	[10]
Retinol-binding protein 2 (RBP2)	OTR8QG5V	RET2_HUMAN	Decreases Expression	[10]
LIM domain kinase 2 (LIMK2)	OTRJD7VZ	LIMK2_HUMAN	Decreases Expression	[10]
ADP-ribosylation factor 3 (ARF3)	OTYYQX85	ARF3_HUMAN	Decreases Expression	[10]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[10]
Phosphoserine phosphatase (PSPH)	OTV1PVAX	SERB_HUMAN	Decreases Expression	[10]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Decreases Expression	[10]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Decreases Expression	[10]
Low-density lipoprotein receptor-related protein 2 (LRP2)	OTZ6W681	LRP2_HUMAN	Decreases Expression	[10]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Increases Expression	[10]
Cyclic AMP-responsive element-binding protein 5 (CREB5)	OTJDUJPI	CREB5_HUMAN	Increases Expression	[10]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Decreases Expression	[10]
Amino acid transporter heavy chain SLC3A1 (SLC3A1)	OT56V01A	SLC31_HUMAN	Decreases Expression	[10]
Cadherin-18 (CDH18)	OTC06P9H	CAD18_HUMAN	Decreases Expression	[10]
Calcyphosin (CAPS)	OTC9GZ2M	CAYP1_HUMAN	Increases Expression	[10]
Transcription factor Dp-2 (TFDP2)	OTKQFX5H	TFDP2_HUMAN	Decreases Expression	[10]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)	OTKUW1WT	PDE3A_HUMAN	Decreases Expression	[10]
Next to BRCA1 gene 1 protein (NBR1)	OTVRL7J9	NBR1_HUMAN	Decreases Expression	[10]
Pericentriolar material 1 protein (PCM1)	OTFM133C	PCM1_HUMAN	Decreases Expression	[10]
Neutral amino acid transporter B(0) (SLC1A5)	OTE2H26Q	AAAT_HUMAN	Increases Expression	[10]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Decreases Expression	[10]
Dual specificity protein phosphatase 5 (DUSP5)	OTH96RA7	DUS5_HUMAN	Increases Expression	[10]
Protein Dok-7 (DOK7)	OTR2V7HO	DOK7_HUMAN	Increases Expression	[10]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[10]
Piercer of microtubule wall 1 protein (PIERCE1)	OTONT0CN	PIRC1_HUMAN	Decreases Expression	[10]
Retrotransposon Gag-like protein 5 (RTL5)	OT9ZJR3N	RTL5_HUMAN	Decreases Expression	[10]
Protein phosphatase 1J (PPM1J)	OTM6GDJJ	PPM1J_HUMAN	Increases Expression	[10]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Increases Expression	[10]
Disabled homolog 2-interacting protein (DAB2IP)	OTF456VC	DAB2P_HUMAN	Affects Expression	[10]
Muscleblind-like protein 2 (MBNL2)	OTF7CF1F	MBNL2_HUMAN	Decreases Expression	[10]
Anoctamin-1 (ANO1)	OTSREUNI	ANO1_HUMAN	Increases Expression	[10]
Proline-rich membrane anchor 1 (PRIMA1)	OT9ITT3P	PRIMA_HUMAN	Decreases Expression	[10]
Prolyl 3-hydroxylase 2 (P3H2)	OTY84H6U	P3H2_HUMAN	Decreases Expression	[10]
E3 ubiquitin-protein ligase TRIM22 (TRIM22)	OTJBLG5R	TRI22_HUMAN	Decreases Expression	[10]
Solute carrier family 25 member 45 (SLC25A45)	OTP7EAUM	S2545_HUMAN	Decreases Expression	[10]
PACRG-like protein (PACRGL)	OT5DEP0X	PACRL_HUMAN	Increases Expression	[10]
N-acetylaspartate synthetase (NAT8L)	OTA96AVN	NAT8L_HUMAN	Decreases Expression	[10]
Retinoic acid-induced protein 3 (GPRC5A)	OTPOCWR7	RAI3_HUMAN	Decreases Expression	[10]
Two pore channel protein 2 (TPCN2)	OTLAF3ED	TPC2_HUMAN	Decreases Expression	[10]
LIM domain only protein 3 (LMO3)	OTR7AJHN	LMO3_HUMAN	Decreases Expression	[10]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[10]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)	OT83O8WI	ES8L1_HUMAN	Decreases Expression	[10]
Complexin-3 (CPLX3)	OT0YTMN2	CPLX3_HUMAN	Decreases Expression	[10]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Decreases Expression	[10]
Protein kinase C-binding protein NELL1 (NELL1)	OTF3TX3N	NELL1_HUMAN	Decreases Expression	[10]
LIM/homeobox protein Lhx4 (LHX4)	OTVX3J6S	LHX4_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase MIB2 (MIB2)	OTJCC3HS	MIB2_HUMAN	Decreases Expression	[10]
Dedicator of cytokinesis protein 10 (DOCK10)	OTI3MBLV	DOC10_HUMAN	Decreases Expression	[10]
Galactose mutarotase (GALM)	OT7UPL4D	GALM_HUMAN	Decreases Expression	[10]
Endoplasmic reticulum resident protein 27 (ERP27)	OTVMGE2H	ERP27_HUMAN	Decreases Expression	[10]
Hedgehog-interacting protein (HHIP)	OT77RQYS	HHIP_HUMAN	Decreases Expression	[10]
TSC22 domain family protein 3 (TSC22D3)	OT03UM03	T22D3_HUMAN	Decreases Expression	[10]
Neurturin (NRTN)	OT4PAKUY	NRTN_HUMAN	Increases Expression	[10]
Ras-like protein family member 11B (RASL11B)	OTHEVZS6	RSLBB_HUMAN	Decreases Expression	[10]
Mitochondrial ribosome-associated GTPase 1 (MTG1)	OTC9U1LI	MTG1_HUMAN	Decreases Expression	[10]
Melanophilin (MLPH)	OT7ADCXL	MELPH_HUMAN	Increases Expression	[10]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Increases Expression	[10]
Keratin-associated protein 2-1 (KRTAP2-1)	OTV1SGF2	KRA21_HUMAN	Decreases Expression	[10]
Keratin, type I cytoskeletal 23 (KRT23)	OTQW6UAG	K1C23_HUMAN	Decreases Expression	[10]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1)	OT38HXJP	CRLD1_HUMAN	Increases Expression	[10]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2)	OTAQD3YV	ARNT2_HUMAN	Decreases Expression	[10]
Plexin-A4 (PLXNA4)	OT5XKB3Q	PLXA4_HUMAN	Decreases Expression	[10]
Palmdelphin (PALMD)	OTRLOZ4Y	PALMD_HUMAN	Decreases Expression	[10]
Transcription and mRNA export factor ENY2 (ENY2)	OTTNU8RK	ENY2_HUMAN	Decreases Expression	[10]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2)	OT661S7D	SCUB2_HUMAN	Decreases Expression	[10]
Cytochrome P450 26B1 (CYP26B1)	OT92XA92	CP26B_HUMAN	Decreases Expression	[10]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[10]
Cytokine-inducible SH2-containing protein (CISH)	OT8T5NYL	CISH_HUMAN	Increases Expression	[10]
ATPase family AAA domain-containing protein 3A (ATAD3A)	OTWF6HBP	ATD3A_HUMAN	Decreases Expression	[10]
Kv channel-interacting protein 1 (KCNIP1)	OTGLGK1R	KCIP1_HUMAN	Decreases Expression	[10]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Increases Expression	[10]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Increases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Increases Expression	[10]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Decreases Expression	[10]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Decreases Expression	[10]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Decreases Expression	[10]
Rho family-interacting cell polarization regulator 2 (RIPOR2)	OTXB6LIR	RIPR2_HUMAN	Decreases Expression	[10]
Transcription factor HES-2 (HES2)	OTMWY2KV	HES2_HUMAN	Increases Expression	[10]
Tolloid-like protein 2 (TLL2)	OTHZ4TBL	TLL2_HUMAN	Increases Expression	[10]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[20]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Affects Activity	[20]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)	OTX8L3M5	SAHH2_HUMAN	Affects Expression	[11]
Putative hydrolase DDAH2 (DDAH2)	OT8Q40G2	DDAH2_HUMAN	Affects Expression	[11]
Integrin beta-3 (ITGB3)	OTWCK1K6	ITB3_HUMAN	Affects Expression	[11]
Small integral membrane protein 6 (SMIM6)	OTRGL3O1	SMIM6_HUMAN	Affects Expression	[11]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Affects Expression	[11]
Integrin beta-6 (ITGB6)	OTI3DJ7U	ITB6_HUMAN	Affects Expression	[11]
Deoxyribonuclease-1 (DNASE1)	OTM4KWB3	DNAS1_HUMAN	Affects Expression	[11]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Affects Expression	[11]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Affects Expression	[11]
Homeobox protein MOX-1 (MEOX1)	OTJEMT2D	MEOX1_HUMAN	Affects Expression	[11]
Diacylglycerol kinase epsilon (DGKE)	OTWS86AS	DGKE_HUMAN	Affects Expression	[11]
Cadherin-6 (CDH6)	OT81Y80S	CADH6_HUMAN	Affects Expression	[11]
Phospholipid-transporting ATPase ID (ATP8B2)	OTH5WJ09	AT8B2_HUMAN	Affects Expression	[11]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Affects Expression	[11]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Affects Expression	[11]
Sclerostin domain-containing protein 1 (SOSTDC1)	OTAKDNSM	SOSD1_HUMAN	Affects Expression	[11]
Transmembrane protein 64 (TMEM64)	OTO9IDFD	TMM64_HUMAN	Affects Expression	[11]
Echinoderm microtubule-associated protein-like 6 (EML6)	OTE1MUQS	EMAL6_HUMAN	Affects Expression	[11]
PX domain-containing protein kinase-like protein (PXK)	OTSP1WLK	PXK_HUMAN	Affects Expression	[11]
Protein limb expression 1 homolog (LIX1)	OT1CPNCC	LIX1_HUMAN	Affects Expression	[11]
Uncharacterized protein FAM241A (FAM241A)	OTC12ETA	F241A_HUMAN	Affects Expression	[11]
RalBP1-associated Eps domain-containing protein 2 (REPS2)	OTSE3TRP	REPS2_HUMAN	Affects Expression	[11]
Syntaxin-binding protein 6 (STXBP6)	OTUEKTIP	STXB6_HUMAN	Affects Expression	[11]
POC1 centriolar protein homolog B (POC1B)	OTDIMIRZ	POC1B_HUMAN	Affects Expression	[11]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)	OT0EDNV9	GTR12_HUMAN	Affects Expression	[11]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Affects Expression	[11]
Peroxidasin homolog (PXDN)	OTFGGM9R	PXDN_HUMAN	Affects Expression	[11]
Secreted frizzled-related protein 3 (FRZB)	OTTO3DPY	SFRP3_HUMAN	Affects Expression	[11]
DNA endonuclease RBBP8 (RBBP8)	OTRHJ3GI	CTIP_HUMAN	Affects Expression	[11]
Transmembrane protease serine 4 (TMPRSS4)	OTCCGY2K	TMPS4_HUMAN	Affects Expression	[11]
Cdc42 effector protein 3 (CDC42EP3)	OTUZ3U9Z	BORG2_HUMAN	Affects Expression	[11]
Teneurin-1 (TENM1)	OTSKSU4V	TEN1_HUMAN	Affects Expression	[11]
RNA polymerase II elongation factor ELL2 (ELL2)	OTZJRTFM	ELL2_HUMAN	Affects Expression	[12]
Mothers against decapentaplegic homolog 6 (SMAD6)	OTUZZWUD	SMAD6_HUMAN	Affects Expression	[12]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[22]
RAS guanyl-releasing protein 1 (RASGRP1)	OTX9WN2E	GRP1_HUMAN	Affects Expression	[12]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Expression	[23]
Cytochrome c oxidase subunit 3 (COX3)	OTNNGBYJ	COX3_HUMAN	Increases Expression	[24]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Increases Expression	[25]
Plasminogen (PLG)	OTWWIPPY	PLMN_HUMAN	Increases Expression	[26]
Renin (REN)	OT52GZR2	RENI_HUMAN	Increases Activity	[27]
ATP synthase subunit a (ATP6)	OTPHOGLX	ATP6_HUMAN	Increases Expression	[24]
Antithrombin-III (SERPINC1)	OTDFATG0	ANT3_HUMAN	Decreases Activity	[26]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Increases Expression	[27]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Increases Expression	[28]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Decreases Expression	[29]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Decreases Activity	[30]
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Increases Expression	[29]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[31]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases Expression	[32]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[33]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[34]
Histidine-rich glycoprotein (HRG)	OTPLUFOG	HRG_HUMAN	Decreases Expression	[35]
Sex hormone-binding globulin (SHBG)	OTPWU5IW	SHBG_HUMAN	Increases Expression	[36]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Affects Activity	[37]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[29]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Affects Expression	[12]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Affects Expression	[38]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Decreases Expression	[25]
Vitamin K-dependent protein S (PROS1)	OTXQWNOI	PROS_HUMAN	Decreases Expression	[26]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Increases Activity	[39]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Affects Expression	[12]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Increases Expression	[25]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Affects Expression	[12]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Affects Expression	[12]
Serine/threonine-protein kinase pim-1 (PIM1)	OTWEKXTU	PIM1_HUMAN	Affects Expression	[12]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Affects Expression	[12]
Beta-1,4-galactosyltransferase 1 (B4GALT1)	OTBCXEK7	B4GT1_HUMAN	Increases Expression	[40]
Fos-related antigen 1 (FOSL1)	OT9YTYMB	FOSL1_HUMAN	Affects Expression	[12]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Increases Expression	[41]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Decreases Expression	[31]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[42]
Myelin and lymphocyte protein (MAL)	OTBM30SW	MAL_HUMAN	Affects Expression	[12]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[31]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Activity	[43]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)	OTTWCZYM	ALS_HUMAN	Decreases Expression	[29]
ETS translocation variant 5 (ETV5)	OTE2OBM4	ETV5_HUMAN	Affects Expression	[12]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Affects Expression	[12]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2)	OTO70C5O	SO1A2_HUMAN	Decreases Expression	[23]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[44]
NADP-dependent malic enzyme (ME1)	OTSVEUQE	MAOX_HUMAN	Affects Expression	[12]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Affects Expression	[12]
Cysteine--tRNA ligase, cytoplasmic (CARS1)	OTOUZF6O	SYCC_HUMAN	Affects Expression	[12]
Serine--tRNA ligase, cytoplasmic (SARS1)	OTFKXQ1O	SYSC_HUMAN	Affects Expression	[12]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Affects Expression	[12]
Inhibin beta E chain (INHBE)	OTOI2NYG	INHBE_HUMAN	Affects Expression	[12]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Affects Expression	[12]
Transformer-2 protein homolog beta (TRA2B)	OTZYQW52	TRA2B_HUMAN	Increases Expression	[45]
Small ribosomal subunit protein RACK1 (RACK1)	OTZBCQ1U	RACK1_HUMAN	Increases Expression	[46]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[47]
Schlafen family member 5 (SLFN5)	OTT1AESL	SLFN5_HUMAN	Affects Expression	[12]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Affects Expression	[12]
Four and a half LIM domains protein 2 (FHL2)	OT0OAYWT	FHL2_HUMAN	Affects Expression	[12]
Hepatic sodium/bile acid cotransporter (SLC10A1)	OTUJVMCL	NTCP_HUMAN	Decreases Expression	[23]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Activity	[48]
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Increases Expression	[39]
Erythroferrone (ERFE)	OTSES1HA	ERFE_HUMAN	Affects Expression	[12]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)	OTIH6283	FGD3_HUMAN	Affects Expression	[12]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)	OTGFK4MH	NHRF3_HUMAN	Increases Expression	[40]
Early estrogen-induced gene 1 protein (EEIG1)	OT2BMEAE	EEIG1_HUMAN	Increases Expression	[40]
Very-long-chain (HACD2)	OTAZO9F6	HACD2_HUMAN	Affects Expression	[12]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Affects Expression	[12]
Ly6/PLAUR domain-containing protein 1 (LYPD1)	OT0HSGML	LYPD1_HUMAN	Affects Expression	[12]
Scavenger receptor class B member 1 (SCARB1)	OTAE1UA1	SCRB1_HUMAN	Affects Splicing	[45]
Stonin-2 (STON2)	OT01JHHE	STON2_HUMAN	Affects Expression	[12]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Affects Expression	[12]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Activity	[49]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Expression	[23]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Affects Expression	[12]
Mediator of RNA polymerase II transcription subunit 8 (MED8)	OTSIZ1I7	MED8_HUMAN	Affects Expression	[12]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Expression	[23]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Affects Expression	[12]
G-protein coupled estrogen receptor 1 (GPER1)	OTUK0TDC	GPER1_HUMAN	Increases Expression	[33]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[50]
Protein associated with UVRAG as autophagy enhancer (RUBCNL)	OTMQIDOI	PACER_HUMAN	Affects Expression	[12]
Tetratricopeptide repeat protein 12 (TTC12)	OTDB24YV	TTC12_HUMAN	Affects Expression	[12]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Affects Expression	[12]
Matrix-remodeling-associated protein 5 (MXRA5)	OTXZBWCU	MXRA5_HUMAN	Affects Expression	[12]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)	OT8NJE5D	SI1L2_HUMAN	Affects Expression	[12]
Kelch-like protein 14 (KLHL14)	OTYOS55H	KLH14_HUMAN	Affects Expression	[12]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Affects Expression	[12]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Affects Expression	[12]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1)	OTY8J0S4	ZNT1_HUMAN	Affects Expression	[12]
SET-binding protein (SETBP1)	OTKGCOSR	SETBP_HUMAN	Affects Expression	[12]
Sulfotransferase 2A1 (SULT2A1)	OT0ISKQ4	ST2A1_HUMAN	Increases Metabolism	[51]
Sulfotransferase 1A1 (SULT1A1)	OT0K7JIE	ST1A1_HUMAN	Increases Metabolism	[51]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Uptake	[52]
Cytochrome P450 (CYP2B)	OTDDG81I	Q14097_HUMAN	Increases ADR	[53]
Sulfotransferase 1B1 (SULT1B1)	OTH0RQYA	ST1B1_HUMAN	Increases Metabolism	[51]
Sulfotransferase 1A3 (SULT1A4)	OTHJ8WWV	ST1A3_HUMAN	Increases Sulfation	[54]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Increases Hydroxylation	[17]
Fibroblast growth factor 4 (FGF4)	OTNVV3ZG	FGF4_HUMAN	Increases ADR	[53]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Affects Metabolism	[55]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Increases Hydroxylation	[17]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7210).
• [4] Ethinyl estradiol FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7071).
• [6] Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9.
• [7] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [8] Levamisole can reduce the high serum tumour necrosis factor-alpha level to a normal level in patients with erosive oral lichen planus. Clin Exp Dermatol. 2007 May;32(3):308-10. doi: 10.1111/j.1365-2230.2006.02343.x.
• [9] Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80.
• [10] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [11] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [12] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [13] 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
• [14] P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.
• [15] Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. Drug Metab Rev. 2004 Oct;36(3-4):497-509.
• [16] Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
• [17] The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12.
• [18] Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
• [19] The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects. Br J Clin Pharmacol. 2003 Aug;56(2):232-7.
• [20] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [21] Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.
• [22] Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. Toxicol In Vitro. 2017 Jun;41:114-122. doi: 10.1016/j.tiv.2017.02.023. Epub 2017 Mar 1.
• [23] UDCA and CDCA alleviate 17-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats. Toxicol Appl Pharmacol. 2016 Nov 15;311:12-25. doi: 10.1016/j.taap.2016.10.011. Epub 2016 Oct 12.
• [24] Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis. 1998 Dec;19(12):2187-93. doi: 10.1093/carcin/19.12.2187.
• [25] Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives. Thromb Haemost. 1996 Nov;76(5):729-34.
• [26] Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study. J Clin Endocrinol Metab. 2007 Jun;92(6):2074-9. doi: 10.1210/jc.2007-0026. Epub 2007 Mar 20.
• [27] Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. J Clin Endocrinol Metab. 2000 Nov;85(11):4331-7. doi: 10.1210/jcem.85.11.6932.
• [28] Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
• [29] Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex. J Clin Endocrinol Metab. 2000 May;85(5):1918-22. doi: 10.1210/jcem.85.5.6527.
• [30] Estrogenic Compounds or Adiponectin Inhibit Cyclic AMP Response to Human Luteinizing Hormone in Mouse Leydig Tumor Cells. Biology (Basel). 2019 Jun 11;8(2):45. doi: 10.3390/biology8020045.
• [31] Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur J Endocrinol. 2005 Apr;152(4):597-604. doi: 10.1530/eje.1.01880.
• [32] Oral ethinyl estradiol, but not transdermal 17beta-estradiol, increases plasma C-reactive protein levels in men. Thromb Haemost. 2000 Aug;84(2):359-60.
• [33] Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
• [34] Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
• [35] Estrogens reduce plasma histidine-rich glycoprotein (HRG) levels in a dose-dependent way. Thromb Haemost. 1995 Mar;73(3):484-7.
• [36] Oral contraceptives moderately effect bone resorption markers and serum-soluble interleukin-6 receptor concentrations. Calcif Tissue Int. 2002 Jan;70(1):11-21. doi: 10.1007/s002230020035. Epub 2001 Dec 21.
• [37] Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. Arch Toxicol. 2022 Jul;96(7):1975-1987. doi: 10.1007/s00204-022-03291-5. Epub 2022 Apr 18.
• [38] Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity. Toxicology. 2014 Jun 5;320:46-55. doi: 10.1016/j.tox.2014.03.007. Epub 2014 Mar 28.
• [39] Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta. 2005 Sep 30;1745(3):300-9. doi: 10.1016/j.bbamcr.2005.03.012. Epub 2005 Apr 12.
• [40] Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
• [41] Increased expression of estrogen receptor beta in human uterine smooth muscle at term. Eur J Endocrinol. 2000 Jan;142(1):92-9. doi: 10.1530/eje.0.1420092.
• [42] Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. Pediatr Dev Pathol. 2007 Nov-Dec;10(6):446-54. doi: 10.2350/06-04-0079.1.
• [43] Synthetic estrogen-mediated activation of ERK 2 intracellular signaling molecule. Gynecol Endocrinol. 2003 Oct;17(5):423-8. doi: 10.1080/09513590312331290338.
• [44] Novel full logistic model for estimation of the estrogenic activity of chemical mixtures. Toxicology. 2016 Jun 1;359-360:58-70. doi: 10.1016/j.tox.2016.06.017. Epub 2016 Jun 29.
• [45] Regulation of alternative splicing of liver scavenger receptor class B gene by estrogen and the involved regulatory splicing factors. Endocrinology. 2007 Nov;148(11):5295-304. doi: 10.1210/en.2007-0376. Epub 2007 Aug 2.
• [46] Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation. Toxicology. 2022 Oct;480:153321. doi: 10.1016/j.tox.2022.153321. Epub 2022 Sep 13.
• [47] Detection of MDM2 alterations in cultured human hepatocytes treated with 17beta-estradiol or 17alpha-ethinylestradiol. Anticancer Res. 2002 May-Jun;22(3):1545-51.
• [48] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [49] Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity. Environ Sci Technol. 2002 Oct 15;36(20):4410-5. doi: 10.1021/es010323a.
• [50] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [51] Sulfation of environmental estrogen-like chemicals by human cytosolic sulfotransferases. Biochem Biophys Res Commun. 2000 Jan 7;267(1):80-4. doi: 10.1006/bbrc.1999.1935.
• [52] Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3. J Pharmacol Exp Ther. 2004 Apr;309(1):156-64. doi: 10.1124/jpet.103.062091. Epub 2004 Jan 13.
• [53] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [54] Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol. Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
• [55] Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6. Chem Res Toxicol. 2006 Feb;19(2):279-87. doi: 10.1021/tx050256o.