Details of the Drug Combination

General Information of Drug Combination (ID: DC7NK6T)

• Drug Combination Name: Trimethobenzamide + Etonogestrel
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Trimethobenzamide (DMPP4DT): Small molecular drug
  Etonogestrel (DMKA8J4): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 27.37
  Bliss Independence Score: 27.37
  Loewe Additivity Score: 34.18
  LHighest Single Agent (HSA) Score: 34.22

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Trimethobenzamide

Disease Entry	ICD 11	Status	REF
Nausea	MD90	Approved	[2]
Nausea and vomiting	MD90	Approved	[3]
Vomiting	MD90	Approved	[2]

Indication(s) of Etonogestrel

Disease Entry	ICD 11	Status	REF
Contraception	QA21	Approved	[4]

Etonogestrel Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Binder	[5]

Etonogestrel Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[6]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Trimethobenzamide FDA Label
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7590).
• [5] Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.
• [6] The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel. Br J Clin Pharmacol. 2005 Jul;60(1):69-75.