Details of the Drug Combination

General Information of Drug Combination (ID: DC9JA26)

Drug Combination Name
Heparin Cloxacillin
Indication
Disease Entry Status REF
Double Lumen Infection Phase 1 [1]
Component Drugs Heparin   DM4ZP3W Cloxacillin   DMUTL7O
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Heparin
Disease Entry ICD 11 Status REF
Aplastic anemia 3A70 Approved [2]
Bacteremia 1A73 Approved [2]
Burns N.A. Approved [2]
Coronary heart disease BA80.Z Approved [2]
Deep vein thrombosis BD71 Approved [2]
Disseminated intravascular coagulation 3B20 Approved [2]
Metabolic disorder 5C50-5D2Z Approved [2]
Pneumonia CA40 Approved [2]
Pulmonary embolism BB00 Approved [2]
Venous thrombosis BA43 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Diabetic angiopathy BD53.Y Investigative [2]
Indication(s) of Cloxacillin
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [5]
Staphylococcal pneumonia N.A. Approved [6]
Staphylococcus aureus infection N.A. Approved [6]
Sinusitis CA0A.Z Investigative [6]
Cloxacillin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [7]
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Cloxacillin Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [9]
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References

1 ClinicalTrials.gov (NCT00885300) Cloxacillin as Prevention of Double Lumen Infection in Hemodialysis Patients
2 Heparin FDA Label
3 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 090809.
4 Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020 Dec;9(1):727-732.
5 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 061454.
6 Cloxacillin FDA Label
7 Development of a receptor-based microplate assay for the detection of beta-lactam antibiotics in different food matrices. Anal Chim Acta. 2007 Mar 14;586(1-2):296-303.
8 Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet. 2003;18(1):16-22.
9 Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics. Toxicol In Vitro. 2019 Aug;58:51-59. doi: 10.1016/j.tiv.2019.03.015. Epub 2019 Mar 12.