Details of the Drug Combination

General Information of Drug Combination (ID: DCB6WEX)

Drug Combination Name
Enfuvirtide Valproic Acid
Indication
Disease Entry Status REF
HIV Infections Phase 1 [1]
Component Drugs Enfuvirtide   DM7YPM1 Valproic Acid   DMS49KH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Enfuvirtide
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [2]
Enfuvirtide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human immunodeficiency virus Glycoprotein 41 (HIV gp41) TTG90S6 ENV_HV1H2 Modulator [5]
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Enfuvirtide Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [6]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [6]
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Indication(s) of Valproic Acid
Disease Entry ICD 11 Status REF
Absence epilepsy N.A. Approved [3]
Epilepsy 8A60-8A68 Approved [3]
Glioblastoma 2A00 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Neuroblastoma 2D11.2 Investigative [3]

References

1 ClinicalTrials.gov (NCT00312546) Study of Valproic Acid to Treat HIV Infected Adults
2 Combinations of the first and next generations of human immunodeficiency virus (HIV) fusion inhibitors exhibit a highly potent synergistic effect a... J Virol. 2009 Aug;83(16):7862-72.
3 Valproic Acid FDA Label
4 Immunopharmacological management of COVID-19: Potential therapeutic role of valproic acid. Med Hypotheses. 2020 May 27;143:109891.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide. Clin Pharmacokinet. 2005;44(2):175-86.