Details of the Drug Combination

General Information of Drug Combination (ID: DCCDS9D)

• Drug Combination Name: Valrubicin + Plicamycin
• Indication: Colon adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Valrubicin (DMOYJFK): Small molecular drug: 3D MOL is unavailable
  Plicamycin (DM7C8YV): Small molecular drug: 3D MOL is unavailable
• High-throughput Screening Result:
  Testing Cell Line: COLO 205
  Zero Interaction Potency (ZIP) Score: 4.04
  Bliss Independence Score: 2.32
  Loewe Additivity Score: 0.72
  LHighest Single Agent (HSA) Score: 1.46

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Valrubicin

Disease Entry	ICD 11	Status	REF
Bladder cancer	2C94	Approved	[2]
In situ carcinoma	N.A.	Approved	[3]
Urinary bladder cancer	N.A.	Approved	[3]
Psoriasis vulgaris	EA90	Phase 2	[4]

Valrubicin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Inhibitor	[7]

Valrubicin Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[8]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[4]
Testicular cancer	2C80	Approved	[4]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[5]
Lung cancer	2C25.0	Investigative	[6]
Ovarian cancer	2C73	Investigative	[6]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[10]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[11]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[12]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[12]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[13]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[13]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[14]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[9]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[15]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[16]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[17]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[9]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[18]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[15]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[19]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[20]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Astrocytoma	DCPB8OE	U251	Investigative	[21]
Chronic myelogenous leukemia	DCSMY4W	K-562	Investigative	[21]
Clear cell renal cell carcinoma	DCW1ARM	A498	Investigative	[21]
Glioma	DCY1GF4	SF-295	Investigative	[21]
Renal cell carcinoma	DCS7F2R	UO-31	Investigative	[21]
Invasive ductal carcinoma	DC1LPRA	BT-549	Investigative	[1]
Adenocarcinoma	DCSTK81	A549	Investigative	[22]
Adenocarcinoma	DCGQPVA	HCT116	Investigative	[22]
Amelanotic melanoma	DCNDQIQ	MDA-MB-435	Investigative	[22]
Cutaneous melanoma	DC4I2CK	SK-MEL-28	Investigative	[22]
High grade ovarian serous adenocarcinoma	DCN27KX	OVCAR-5	Investigative	[22]
Lung adenocarcinoma	DC6OBD5	HOP-62	Investigative	[22]
Lung adenocarcinoma	DCXPKWA	MDA-MB-231	Investigative	[22]
Lung adenocarcinoma	DCQKAVO	NCI-H522	Investigative	[22]
Malignant melanoma	DCQWWIG	UACC62	Investigative	[22]
Melanoma	DCR54V6	MALME-3M	Investigative	[22]
Melanoma	DCPRQX4	UACC-257	Investigative	[22]
Melanoma	DCQQIZB	SK-MEL-2	Investigative	[22]
Mixed endometrioid and clear cell carcinoma	DCW04JH	IGROV1	Investigative	[22]

References

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• [3] Valrubicin FDA Label
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• [18] CREB/Sp1-mediated MCL1 expression and NFB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells. Toxicol Appl Pharmacol. 2022 Jan 15;435:115847. doi: 10.1016/j.taap.2021.115847. Epub 2021 Dec 25.
• [19] Sp sites contribute to basal and inducible expression of the human TNIP1 (TNF-inducible protein 3-interacting protein 1) promoter. Biochem J. 2013 Jun 15;452(3):519-29. doi: 10.1042/BJ20121666.
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