Details of the Drug Combination

General Information of Drug Combination (ID: DCD84SY)

Drug Combination Name
Iboctadekin FOZIVUDINE TIDOXIL
Indication
Disease Entry Status REF
Ovarian cancer Phase 1 [1]
Component Drugs Iboctadekin   DMHS29U FOZIVUDINE TIDOXIL   DMUD0IN
N.A. Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Iboctadekin
Disease Entry ICD 11 Status REF
Non-hodgkin lymphoma 2B33.5 Phase 1 [2]
Ovarian cancer 2C73 Phase 1 [2]
Iboctadekin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Interleukin-18 (IL18) TTRICUF IL18_HUMAN Modulator [4]
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Indication(s) of FOZIVUDINE TIDOXIL
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Discontinued in Phase 2 [3]
FOZIVUDINE TIDOXIL Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human immunodeficiency virus Reverse transcriptase (HIV RT) TT84ETX POL_HV1B1 Inhibitor [5]
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References

1 Clinical pipeline report, company report or official report of GlaxoSmithKline.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008435)
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007452)
4 Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study. Cancer Immunol Res. 2013 Sep;1(3):168-78.
5 Fozivudine tidoxil as single-agent therapy decreases plasma and cell-associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med. 2011 May-Jun;25(3):413-8.