Details of the Drug Combination

General Information of Drug Combination (ID: DCF7Z76)

Drug Combination Name
Esmolol Tecadenoson
Indication
Disease Entry Status REF
Atrial Fibrillation Phase 1 [1]
Component Drugs Esmolol   DM51TYR Tecadenoson   DM9T6MS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Esmolol
Disease Entry ICD 11 Status REF
Acute supraventricular tachycardia BC81 Approved [2]
Esmolol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [4]
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Esmolol Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [5]
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Indication(s) of Tecadenoson
Disease Entry ICD 11 Status REF
Atrial fibrillation BC81.3 Discontinued in Phase 3 [3]
Cardiac arrhythmias BC9Z Discontinued in Phase 3 [3]
Tecadenoson Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protein kinase C (PRKC) TTYVX59 NOUNIPROTAC Binder [6]
Adenosine A1 receptor (ADORA1) TTK25J1 AA1R_HUMAN Agonist [7]
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Tecadenoson Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Substrate [8]
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References

1 ClinicalTrials.gov (NCT00713401) Safety Study of Tecadenoson to Treat Atrial Fibrillation
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7178).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5592).
4 Beta-1 selective adrenergic antagonist landiolol and esmolol can be safely used in patients with airway hyperreactivity. Heart Lung. 2009 Jan-Feb;38(1):48-55.
5 Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432.
6 Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001;40(1):55-63.
7 CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009.
8 Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22.