Details of the Drug Combination

General Information of Drug Combination (ID: DCL1ZPE)

Drug Combination Name
Tetrahydrouridine Eltanexor oral
Indication
Disease Entry Status REF
Hodgkin lymphoma Investigative [1]
Component Drugs Tetrahydrouridine   DMR5GSB Eltanexor oral   DM7CLEZ
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: U-HO1
Zero Interaction Potency (ZIP) Score: 5.82
Bliss Independence Score: 11.59
Loewe Additivity Score: 1.66
LHighest Single Agent (HSA) Score: 1.81

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Tetrahydrouridine
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Tetrahydrouridine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cytidine deaminase (CDA) TTQ12RK CDD_HUMAN Modulator [4]
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Tetrahydrouridine Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Decreases Activity [5]
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Indication(s) of Eltanexor oral
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 1/2 [3]
Myelodysplastic syndrome 2A37 Phase 1/2 [3]
Prostate cancer 2C82.0 Phase 1/2 [3]
Eltanexor oral Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Exportin-1 (XPO1) TTCJUR4 XPO1_HUMAN Inhibitor [3]
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References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(13):1991-7.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.
5 Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans--toxicological implications. J Toxicol Sci. 2011 Aug;36(4):411-22.