Details of the Drug Combination

General Information of Drug Combination (ID: DCN645Y)

Drug Combination Name
Limaprost Pregabalin
Indication
Disease Entry Status REF
Neurologic Claudication in Patients With Lumbar Spinal Stenosis Phase 4 [1]
Component Drugs Limaprost   DMDA3G2 Pregabalin   DMDVP3B
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Limaprost
Disease Entry ICD 11 Status REF
Spinal stenosis FA82 Approved [2]
Indication(s) of Pregabalin
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Approved [3]
Epilepsy 8A60-8A68 Approved [4]
Pain MG30-MG3Z Approved [4]
Postherpetic neuralgia 1E91.5 Approved [4]
Vulvodynia N.A. Approved [4]
Chronic pain MG30 Investigative [4]
Neuralgia N.A. Investigative [4]
Pregabalin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Modulator [5]
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Pregabalin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
L-type amino acid transporter 1 (SLC7A5) DT48T0N LAT1_HUMAN Substrate [6]
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References

1 ClinicalTrials.gov (NCT01888536) A Study to Evaluate Efficacy of Opast Tabletfor Neurologic Claudication in Patients With Lumbar Spinal Stenosis
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5484).
4 Pregabalin FDA Label
5 Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76.
6 Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246.