Details of the Drug Combination

General Information of Drug Combination (ID: DCO6TRQ)

Drug Combination Name
Butorphanol Remifentanil
Indication
Disease Entry Status REF
Pain Phase 1 [1]
Component Drugs Butorphanol   DM5KYPJ Remifentanil   DMZTXCH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Butorphanol
Disease Entry ICD 11 Status REF
Pain MG30-MG3Z Approved [2]
Butorphanol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Opioid receptor delta (OPRD1) TT27RFC OPRD_HUMAN Agonist [4]
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Butorphanol Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Increases Activity [5]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Affects Localization [6]
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Indication(s) of Remifentanil
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [3]
Remifentanil Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Agonist [7]
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References

1 ClinicalTrials.gov (NCT02043366) Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7591).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7292).
4 Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16.
5 In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances. Arch Toxicol. 2020 Nov;94(11):3819-3830. doi: 10.1007/s00204-020-02855-7. Epub 2020 Jul 31.
6 Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell Rep. 2018 Apr 17;23(3):866-877. doi: 10.1016/j.celrep.2018.03.087.
7 The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevent... Pain. 2009 Jan;141(1-2):88-96.