Details of the Drug Combination

General Information of Drug Combination (ID: DCOJF9R)

Drug Combination Name
Tropicamide Proparacaine
Indication
Disease Entry Status REF
Anisocoria Phase 4 [1]
Component Drugs Tropicamide   DM1D90W Proparacaine   DMLS39E
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Tropicamide
Disease Entry ICD 11 Status REF
Mydriasis LA11.62 Approved [2]
Tropicamide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Muscarinic acetylcholine receptor M4 (CHRM4) TTQ3JTF ACM4_HUMAN Antagonist [4]
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Tropicamide Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Increases Response To Substance [5]
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Indication(s) of Proparacaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [3]
Proparacaine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Modulator [6]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Cataract DCF22HP N. A. Phase 1 [7]
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References

1 ClinicalTrials.gov (NCT05238233) Wearing-Off Period of Pharmacological Dilation and Anisocoria
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7319).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7283).
4 The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 rec... Psychopharmacology (Berl). 2007 Oct;194(3):347-59.
5 Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease. Neuroreport. 1996 Mar 22;7(4):918-20. doi: 10.1097/00001756-199603220-00017.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 ClinicalTrials.gov (NCT02895074) Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts