Details of the Drug Combination

General Information of Drug Combination (ID: DCQKRS1)

Drug Combination Name
Pramlintide Insulin
Indication
Disease Entry Status REF
Type-1 diabetes Phase 1 [1]
Component Drugs Pramlintide   DM0EZ9Q Insulin   DMB7CE0
Small molecular drug N.A.

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Pramlintide
Disease Entry ICD 11 Status REF
Type-1/2 diabetes 5A10-5A11 Approved [2]
Pramlintide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucagon-like peptide 1 receptor (GLP1R) TTVIMDE GLP1R_HUMAN Agonist [4]
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Indication(s) of Insulin
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [3]
Insulin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Insulin-degrading enzyme (IDE) DE9OSW8 IDE_HUMAN Metabolism [5]
Insulin-degrading enzyme (ide) DE0QGHP A0A0C1JXV9_9BACT Metabolism [6]
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Insulin Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Islet amyloid polypeptide (IAPP) OT5Z8ERW IAPP_HUMAN Increases ADR [7]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Increases ADR [7]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Increases ADR [7]
Vasopressin V1a receptor (AVPR1A) OTKR8AFL V1AR_HUMAN Increases ADR [7]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7482).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5012).
4 Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
5 Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 3;44(17):6513-25.
6 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
7 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.