Details of the Drug Combination

General Information of Drug Combination (ID: DCRFWH0)

• Drug Combination Name: Taxol + Plicamycin
• Indication: Colon carcinoma; Status: Investigative [1]
• Component Drugs:
  Taxol (DMUOT9V): Small molecular drug: 3D MOL is unavailable
  Plicamycin (DM7C8YV): Small molecular drug: 3D MOL is unavailable
• High-throughput Screening Result:
  Testing Cell Line: KM12
  Zero Interaction Potency (ZIP) Score: 13.21
  Bliss Independence Score: 10.44
  Loewe Additivity Score: 6.87
  LHighest Single Agent (HSA) Score: 9

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Taxol

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Pancreatic cancer	2C10	Phase 3	[4]
Gastric adenocarcinoma	2B72	Phase 2	[5]
Ovarian cancer	2C73	Phase 2	[5]

Taxol Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Apoptosis regulator Bcl-2 (BCL-2)	TTJGNVC	BCL2_HUMAN	Modulator	[2]
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Modulator	[2]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[3]
Testicular cancer	2C80	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[6]
Lung cancer	2C25.0	Investigative	[7]
Ovarian cancer	2C73	Investigative	[7]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[9]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[10]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[11]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[11]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[11]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[12]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[12]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[13]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[8]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[14]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[15]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[16]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[8]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[17]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[14]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[18]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[19]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult T acute lymphoblastic leukemia	DCYHN6O	MOLT-4	Investigative	[20]
Anaplastic large cell lymphoma	DCSXTP0	SR	Investigative	[20]
Childhood T acute lymphoblastic leukemia	DCDC5O7	CCRF-CEM	Investigative	[20]
Chronic myelogenous leukemia	DCMJOXQ	K-562	Investigative	[20]
Clear cell renal cell carcinoma	DCL4Z7F	A498	Investigative	[20]
Glioblastoma	DCKW2MV	SNB-75	Investigative	[20]
Glioma	DCSIN75	SF-539	Investigative	[20]
Plasma cell myeloma	DC3XFH5	RPMI-8226	Investigative	[20]
Carcinoma	DC1ZGE9	RXF 393	Investigative	[1]
Carcinoma	DCU7MOJ	MCF7	Investigative	[1]
Invasive ductal carcinoma	DC3ONFM	BT-549	Investigative	[1]
Invasive ductal carcinoma	DCUZACQ	HS 578T	Investigative	[1]
Adenocarcinoma	DC7VPE0	DU-145	Investigative	[21]
Adenocarcinoma	DC86HIN	A549	Investigative	[21]
Adenocarcinoma	DCLNKO8	HCT116	Investigative	[21]
Adenocarcinoma	DCAGCHC	SW-620	Investigative	[21]
Adenocarcinoma	DCX8VYZ	HCC-2998	Investigative	[21]
Amelanotic melanoma	DCV8S3U	MDA-MB-435	Investigative	[21]
Cutaneous melanoma	DCJ1IHX	SK-MEL-28	Investigative	[21]
Cutaneous melanoma	DCEAN0G	SK-MEL-5	Investigative	[21]
High grade ovarian serous adenocarcinoma	DC9SA5G	OVCAR-5	Investigative	[21]
Lung adenocarcinoma	DCT1NJN	HOP-62	Investigative	[21]
Malignant melanoma	DCMKTHX	LOX IMVI	Investigative	[21]
Melanoma	DCPCIHF	UACC-257	Investigative	[21]
Ovarian serous cystadenocarcinoma	DC0ME06	SK-OV-3	Investigative	[21]
Pleural epithelioid mesothelioma	DC7Q6KU	NCI-H226	Investigative	[21]

References

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• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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• [21] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.