Details of the Drug Combination

General Information of Drug Combination (ID: DCSO2UD)

Drug Combination Name

Cycloguanil Mebutamate

Indication

Disease Entry	Status	REF
Chronic myelogenous leukemia	Investigative	[1]

Component Drugs

Cycloguanil DMC520D

Mebutamate DM0KYI4

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: KBM-7

Zero Interaction Potency (ZIP) Score: 56.15

Bliss Independence Score: 56.15

Loewe Additivity Score: 69.46

LHighest Single Agent (HSA) Score: 69.46

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Cycloguanil

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[2]

Cycloguanil Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[2]
------------------------------------------------------------------------------------

Indication(s) of Mebutamate

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Approved	[3]

Mebutamate Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator	[4]
------------------------------------------------------------------------------------

References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.