General Information of Drug Combination (ID: DCTFH1A)

Drug Combination Name
TEM Altretamine
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Altretamine   DMKLAYG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HCT116
Zero Interaction Potency (ZIP) Score: 3.38
Bliss Independence Score: 5.84
Loewe Additivity Score: 1.01
LHighest Single Agent (HSA) Score: 0.59

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Altretamine
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Approved [3]
Altretamine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [4]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Astrocytoma DCYE9HA SNB-19 Investigative [5]
Clear cell renal cell carcinoma DCD6FV5 A498 Investigative [5]
Renal cell carcinoma DCN571O SN12C Investigative [5]
Colon adenocarcinoma DCQ9S40 COLO 205 Investigative [6]
Invasive ductal carcinoma DCYOYF6 HS 578T Investigative [6]
High grade ovarian serous adenocarcinoma DC2AWUL OVCAR-5 Investigative [1]
Malignant melanoma DC276NB LOX IMVI Investigative [1]
Minimally invasive lung adenocarcinoma DC81Q8J NCI-H322M Investigative [1]
Mixed endometrioid and clear cell carcinoma DC5EWEH IGROV1 Investigative [1]
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⏷ Show the Full List of 9 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7112).
4 Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agen... Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.