Details of the Drug Combination

General Information of Drug Combination (ID: DCTMFNE)

• Drug Combination Name: OGX-427 + Paclitaxel
• Indication: Lung cancer; Prostate cancer; Bladder cancer; Ovarian cancer; Breast cancer; Status: Investigative [1]
• Component Drugs:
  OGX-427 (DMJTU8D): Antisense drug
  Paclitaxel (DMLB81S): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of OGX-427

Disease Entry	ICD 11	Status	REF
Bladder cancer	2C94	Phase 2	[2]
Breast cancer	2C60-2C65	Phase 2	[2]
Lung cancer	2C25.0	Phase 2	[2]
Ovarian cancer	2C73	Phase 2	[2]
Prostate cancer	2C82.0	Phase 2	[2]

OGX-427 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Heat shock protein 27 (HSP27)	TTMG98T	HSPB3_HUMAN	Modulator	[4]

Indication(s) of Paclitaxel

Disease Entry	ICD 11	Status	REF
Breast carcinoma	N.A.	Approved	[3]
Cutaneous melanoma	2C30	Approved	[3]
Cutaneous squamous cell carcinoma	2C30	Approved	[3]
Epithelial ovarian cancer	2B5D	Approved	[3]
Extragonadal germ cell tumor	N.A.	Approved	[3]
Fallopian tube neoplasm	N.A.	Approved	[3]
Gastroesophageal junction adenocarcinoma	2B71	Approved	[3]
Inflammatory breast cancer	2C62	Approved	[3]
Kaposi sarcoma	2B57	Approved	[3]
Lung adenocarcinoma	N.A.	Approved	[3]
Lung cancer	2C25.0	Approved	[3]
Non-small-cell lung cancer	2C25.Y	Approved	[3]
Ocular hypertension	9C61.01	Approved	[3]
Ovarian neoplasm	N.A.	Approved	[3]
Ovarian serous cystadenocarcinoma	N.A.	Approved	[3]
Pain	MG30-MG3Z	Approved	[3]
Pancreatic ductal carcinoma	2C10.0	Approved	[3]
Primary peritoneal carcinoma	N.A.	Approved	[3]
Testicular germ cell tumor	N.A.	Approved	[3]
Urethral cancer	2C93	Approved	[3]
Lung large cell carcinoma	N.A.	Investigative	[3]

Paclitaxel Interacts with 11 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[18]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[19]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[20]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[21]
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[22]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[23]
Multidrug resistance-associated protein 3 (ABCC3)	DTQ3ZHF	MRP3_HUMAN	Substrate	[24]
Multidrug resistance protein 3 (ABCB4)	DTZRMK5	MDR3_HUMAN	Substrate	[25]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[26]
TAP-like protein (ABCB9)	DT68UV2	ABCB9_HUMAN	Substrate	[27]
Multidrug resistance-associated protein 7 (ABCC10)	DTPS120	MRP7_HUMAN	Substrate	[28]

Paclitaxel Interacts with 478 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Expression	[29]
ATP-binding cassette sub-family C member 10 (ABCC10)	OT2JRWWJ	MRP7_HUMAN	Increases Expression	[30]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[30]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Response To Substance	[31]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Response To Substance	[32]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Response To Substance	[33]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Decreases Response To Substance	[34]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Increases Transport	[22]
Cyclin-dependent kinase 20 (CDK20)	OTOLNN68	CDK20_HUMAN	Decreases Expression	[35]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Increases ADR	[5]
Lipoprotein lipase (LPL)	OTTW0267	LIPL_HUMAN	Increases ADR	[5]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[36]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[37]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[35]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[38]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[38]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[10]
Poly polymerase 1 (PARP1)	OTIESHK4	PARP1_ARATH	Increases ADR	[5]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[39]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Increases Activity	[40]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[41]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Expression	[6]
Arylamine N-acetyltransferase 1 (NAT1)	OTCCNQ3H	ARY1_HUMAN	Decreases Activity	[42]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Decreases Expression	[43]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Decreases Expression	[36]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[36]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[44]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Decreases Activity	[44]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[44]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[45]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[46]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Decreases Expression	[8]
Sulfhydryl oxidase 1 (QSOX1)	OT4ZPK4P	QSOX1_HUMAN	Decreases Expression	[7]
Serine/threonine-protein kinase PLK4 (PLK4)	OTV8KZDZ	PLK4_HUMAN	Decreases Expression	[7]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Decreases Expression	[7]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[47]
Nucleoside diphosphate kinase, mitochondrial (NME4)	OT2JTT42	NDKM_HUMAN	Decreases Expression	[8]
Potassium channel subfamily K member 3 (KCNK3)	OTWMAV6G	KCNK3_HUMAN	Increases Expression	[8]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Increases Expression	[38]
Acyl-coenzyme A thioesterase 8 (ACOT8)	OTHY684G	ACOT8_HUMAN	Decreases Expression	[48]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Expression	[49]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[46]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[47]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Increases Expression	[50]
Mitogen-activated protein kinase 13 (MAPK13)	OT0W9GE7	MK13_HUMAN	Increases Expression	[8]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[51]
High affinity copper uptake protein 1 (SLC31A1)	OTXLRTUB	COPT1_HUMAN	Increases Expression	[30]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Increases Expression	[30]
N-glycosylase/DNA lyase (OGG1)	OTJ97TF3	OGG1_HUMAN	Increases Expression	[8]
Retinoschisin (RS1)	OTEW1ZM5	XLRS1_HUMAN	Decreases Secretion	[52]
Kunitz-type protease inhibitor 2 (SPINT2)	OTQV7BKQ	SPIT2_HUMAN	Decreases Expression	[47]
Adenylate cyclase type 6 (ADCY6)	OTFOY4WW	ADCY6_HUMAN	Decreases Expression	[7]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Increases Expression	[50]
Mitotic checkpoint protein BUB3 (BUB3)	OTU91HAU	BUB3_HUMAN	Increases Expression	[8]
Phospholipid phosphatase 2 (PLPP2)	OT0BQAXX	PLPP2_HUMAN	Decreases Expression	[47]
Myelin protein zero-like protein 2 (MPZL2)	OTKFNDUI	MPZL2_HUMAN	Decreases Expression	[47]
Dual specificity protein phosphatase CDC14B (CDC14B)	OTAESVOZ	CC14B_HUMAN	Decreases Expression	[35]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[53]
Death effector domain-containing protein (DEDD)	OTIL349E	DEDD_HUMAN	Decreases Expression	[7]
Serine hydrolase RBBP9 (RBBP9)	OT0Z04L6	RBBP9_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	OT90OWIO	TNF13_HUMAN	Increases Expression	[35]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)	OTIT4JL0	CLPX_HUMAN	Increases Expression	[8]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Increases Expression	[35]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Affects Expression	[54]
G1/S-specific cyclin-E2 (CCNE2)	OTBBUKQQ	CCNE2_HUMAN	Decreases Expression	[7]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[55]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[35]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[8]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Expression	[35]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[56]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases Expression	[47]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[47]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Increases Expression	[57]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Increases Phosphorylation	[58]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[59]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Increases Expression	[47]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Increases Expression	[47]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)	OTWJTCRK	PCCA_HUMAN	Decreases Expression	[8]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[53]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[60]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[61]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[62]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[63]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[64]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Decreases Expression	[7]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Phosphorylation	[65]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[35]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Decreases Expression	[48]
Prosaposin (PSAP)	OTUOEKY7	SAP_HUMAN	Decreases Expression	[7]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Increases Expression	[47]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Expression	[47]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[66]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[60]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Localization	[67]
Microtubule-associated protein tau (MAPT)	OTMTP2Z7	TAU_HUMAN	Decreases Expression	[68]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[69]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[69]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Increases Expression	[47]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Increases Expression	[47]
ADP/ATP translocase 1 (SLC25A4)	OTKYLK2J	ADT1_HUMAN	Decreases Expression	[7]
Bone morphogenetic protein 4 (BMP4)	OTPZMDFH	BMP4_HUMAN	Decreases Expression	[11]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Decreases Expression	[7]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[70]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Decreases Expression	[8]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[71]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[72]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Decreases Expression	[47]
Integrin beta-6 (ITGB6)	OTI3DJ7U	ITB6_HUMAN	Decreases Expression	[47]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[53]
DNA ligase 1 (LIG1)	OTEEQS43	DNLI1_HUMAN	Decreases Expression	[7]
Sodium/hydrogen exchanger 1 (SLC9A1)	OT6HNHFV	SL9A1_HUMAN	Decreases Activity	[73]
Integrin alpha-L (ITGAL)	OTCUQAIS	ITAL_HUMAN	Decreases Expression	[61]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Decreases Expression	[47]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[35]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Increases Expression	[60]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)	OTBZKX4P	ROA2_HUMAN	Decreases Expression	[7]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[47]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Decreases Expression	[48]
Follicle-stimulating hormone receptor (FSHR)	OT9MVMLI	FSHR_HUMAN	Decreases Expression	[11]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[69]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Increases Activity	[74]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Decreases Expression	[47]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[75]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Decreases Expression	[47]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[47]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[11]
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL)	OTP7Y0UF	ACADL_HUMAN	Decreases Expression	[8]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Expression	[56]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[35]
Adenylosuccinate synthetase isozyme 2 (ADSS2)	OTW26XXB	PURA2_HUMAN	Decreases Expression	[8]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Increases Phosphorylation	[76]
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)	OTFRWOLM	HNRH1_HUMAN	Decreases Expression	[7]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Increases Expression	[8]
Syndecan-2 (SDC2)	OTEEHY1D	SDC2_HUMAN	Increases Expression	[47]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Phosphorylation	[11]
Tyrosine-protein phosphatase non-receptor type 7 (PTPN7)	OTXYSIIV	PTN7_HUMAN	Increases Expression	[8]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[8]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Increases Expression	[47]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[53]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Increases Expression	[47]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[77]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[78]
Collagen alpha-1(XVIII) chain (COL18A1)	OTJFUH6O	COIA1_HUMAN	Increases Expression	[47]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Activity	[79]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[8]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Phosphorylation	[69]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[80]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Activity	[81]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Expression	[82]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[83]
Isocitrate dehydrogenase , mitochondrial (IDH2)	OTTQA4PB	IDHP_HUMAN	Decreases Expression	[7]
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	OTNWHUJ1	AL9A1_HUMAN	Increases Expression	[8]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Decreases Expression	[48]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Increases Expression	[84]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[35]
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)	OTEVK4WW	NDUV1_HUMAN	Decreases Expression	[7]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[85]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Decreases Expression	[48]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 7 (CDK7)	OTAO19PQ	CDK7_HUMAN	Increases Activity	[86]
Palmitoyl-protein thioesterase 1 (PPT1)	OTM3S4DE	PPT1_HUMAN	Decreases Expression	[48]
Dual specificity protein phosphatase 3 (DUSP3)	OTPJX9B4	DUS3_HUMAN	Decreases Expression	[7]
Matrix metalloproteinase-16 (MMP16)	OTSFQ2BJ	MMP16_HUMAN	Decreases Expression	[35]
Caspase-5 (CASP5)	OT0F2THD	CASP5_HUMAN	Increases Expression	[35]
Cyclin-H (CCNH)	OTKDU3SR	CCNH_HUMAN	Increases Expression	[8]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Decreases Expression	[8]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[47]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[35]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[35]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Increases Expression	[47]
Tumor protein D52 (TPD52)	OTPKSK43	TPD52_HUMAN	Decreases Expression	[47]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Cleavage	[70]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Activity	[87]
Eukaryotic initiation factor 4A-I (EIF4A1)	OTMTBX6N	IF4A1_HUMAN	Decreases Expression	[8]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[88]
Ras-related C3 botulinum toxin substrate 1 (RAC1)	OTKRO61U	RAC1_HUMAN	Decreases Expression	[7]
SH3 domain-binding protein 2 (SH3BP2)	OT90JNBS	3BP2_HUMAN	Decreases Expression	[8]
General transcription factor II-I (GTF2I)	OTUYL1TQ	GTF2I_HUMAN	Decreases Expression	[7]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Decreases Expression	[69]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Increases Expression	[30]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[49]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Increases Expression	[30]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Affects Localization	[59]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[10]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[35]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[38]
Heat shock protein beta-3 (HSPB3)	OTE67YM5	HSPB3_HUMAN	Increases Expression	[8]
Lymphocyte cytosolic protein 2 (LCP2)	OT57KE22	LCP2_HUMAN	Increases Expression	[8]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Increases Expression	[35]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Increases Cleavage	[81]
MAGUK p55 subfamily member 3 (MPP3)	OTNOL0HA	MPP3_HUMAN	Increases Expression	[8]
Rho-associated protein kinase 1 (ROCK1)	OTSXYVW1	ROCK1_HUMAN	Increases Expression	[7]
Short transient receptor potential channel 3 (TRPC3)	OTNR61OD	TRPC3_HUMAN	Increases Expression	[8]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)	OTTUU92F	ENPP2_HUMAN	Increases Expression	[47]
Protein-tyrosine kinase 6 (PTK6)	OT7NWIQ0	PTK6_HUMAN	Increases Expression	[7]
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Increases Expression	[56]
Protein BTG3 (BTG3)	OT9ANHVT	BTG3_HUMAN	Increases Expression	[8]
Src substrate cortactin (CTTN)	OTJRG4ES	SRC8_HUMAN	Decreases Expression	[8]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Decreases Expression	[35]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Expression	[35]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Increases Expression	[47]
Procollagen C-endopeptidase enhancer 1 (PCOLCE)	OTJXOAN4	PCOC1_HUMAN	Increases Expression	[47]
Transcription factor E2F5 (E2F5)	OT1XWING	E2F5_HUMAN	Increases Expression	[7]
Microtubule-associated protein RP/EB family member 1 (MAPRE1)	OTCVQD60	MARE1_HUMAN	Decreases Localization	[89]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[10]
Transcriptional regulator QRICH1 (QRICH1)	OTPVAX04	QRIC1_HUMAN	Increases Phosphorylation	[90]
Parafibromin (CDC73)	OT6JASZ1	CDC73_HUMAN	Decreases Expression	[35]
Inactive caspase-12 (CASP12)	OTY2W6FG	CASPC_HUMAN	Decreases Expression	[49]
Heme A synthase COX15 (COX15)	OTUIYHIW	COX15_HUMAN	Decreases Expression	[7]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[91]
Cell division cycle and apoptosis regulator protein 1 (CCAR1)	OTUXLQZZ	CCAR1_HUMAN	Increases Expression	[35]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)	OT5Q6SVK	SIR2_HUMAN	Decreases Expression	[53]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Increases Expression	[50]
Phospholipid-transporting ATPase ABCA7 (ABCA7)	OT51S50X	ABCA7_HUMAN	Increases Expression	[30]
Centromere protein S (CENPS)	OTZ4J391	CENPS_HUMAN	Increases Expression	[35]
NAD-dependent protein deacylase sirtuin-6 (SIRT6)	OTF755ZO	SIR6_HUMAN	Decreases Expression	[53]
Cholesterol transporter ABCA5 (ABCA5)	OT4B9D92	ABCA5_HUMAN	Increases Expression	[30]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Decreases Expression	[7]
Mucin-16 (MUC16)	OTHPPE67	MUC16_HUMAN	Decreases Expression	[92]
Rap guanine nucleotide exchange factor 5 (RAPGEF5)	OT53VS75	RPGF5_HUMAN	Increases Expression	[8]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Decreases Expression	[11]
Transcription factor AP-2 gamma (TFAP2C)	OTUDIW05	AP2C_HUMAN	Decreases Expression	[47]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[35]
Engulfment and cell motility protein 3 (ELMO3)	OTQHO9VM	ELMO3_HUMAN	Increases Expression	[8]
p53 apoptosis effector related to PMP-22 (PERP)	OTP0YL53	PERP_HUMAN	Increases Expression	[35]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[93]
Cell division cycle 5-like protein (CDC5L)	OTTPFUU5	CDC5L_HUMAN	Decreases Expression	[35]
M-phase phosphoprotein 6 (MPHOSPH6)	OT6E2S48	MPH6_HUMAN	Decreases Expression	[8]
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)	OTUKPFOK	ROAA_HUMAN	Decreases Expression	[7]
Transmembrane protein 243 (TMEM243)	OT8NQ79G	TM243_HUMAN	Increases Expression	[94]
Cell division cycle-associated protein 7 (CDCA7)	OT12HDZY	CDCA7_HUMAN	Decreases Expression	[35]
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)	OT2SZQI7	TMG4_HUMAN	Decreases Expression	[47]
TRIO and F-actin-binding protein (TRIOBP)	OTGB5WHC	TARA_HUMAN	Increases Expression	[8]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Expression	[30]
Bridging integrator 3 (BIN3)	OTMIWWDW	BIN3_HUMAN	Decreases Expression	[8]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[49]
NAD-dependent protein deacetylase sirtuin-7 (SIRT7)	OT5M4OT4	SIR7_HUMAN	Decreases Expression	[53]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Increases Expression	[47]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Increases Expression	[8]
ETS homologous factor (EHF)	OTY6TPWD	EHF_HUMAN	Decreases Expression	[47]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Increases Expression	[95]
DNA polymerase kappa (POLK)	OTKZ38JH	POLK_HUMAN	Decreases Expression	[7]
Protein Hook homolog 1 (HOOK1)	OTTTKV7V	HOOK1_HUMAN	Decreases Expression	[47]
PR domain zinc finger protein 4 (PRDM4)	OTD9PAZJ	PRDM4_HUMAN	Decreases Expression	[8]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Affects Expression	[54]
Neurabin-1 (PPP1R9A)	OTJL2TOC	NEB1_HUMAN	Decreases Expression	[7]
Matrix metalloproteinase-17 (MMP17)	OT5TMIQ6	MMP17_HUMAN	Decreases Expression	[35]
Microtubule-associated protein RP/EB family member 3 (MAPRE3)	OTSCLETV	MARE3_HUMAN	Affects Localization	[89]
Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)	OTDKO9OO	DMTF1_HUMAN	Decreases Expression	[7]
RuvB-like 2 (RUVBL2)	OTGWJ4T4	RUVB2_HUMAN	Decreases Expression	[8]
C-type lectin domain family 11 member A (CLEC11A)	OT9KBH7C	CLC11_HUMAN	Increases Expression	[47]
Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)	OTND26XR	TN13B_HUMAN	Increases Expression	[35]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Decreases Expression	[7]
Protein-arginine deiminase type-2 (PADI2)	OTT40K94	PADI2_HUMAN	Decreases Expression	[8]
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22)	OTJMHX1V	TIM22_HUMAN	Increases Expression	[8]
Small ribosomal subunit protein mS40 (MRPS18B)	OT1K9PFX	RT18B_HUMAN	Decreases Expression	[8]
Transforming acidic coiled-coil-containing protein 3 (TACC3)	OTRNEZTA	TACC3_HUMAN	Decreases Expression	[8]
Sorting nexin-10 (SNX10)	OT05B7BT	SNX10_HUMAN	Affects Response To Substance	[13]
Superoxide dismutase (SOD2)	OT08HOR5	Q4ZJI1_HUMAN	Increases ADR	[5]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Affects Response To Substance	[13]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Response To Substance	[96]
Phospholipid phosphatase 1 (PLPP1)	OT0IIMI5	PLPP1_HUMAN	Decreases Response To Substance	[97]
Interleukin-17 receptor B (IL17RB)	OT0KDNSF	I17RB_HUMAN	Decreases Response To Substance	[97]
Oxysterol-binding protein-related protein 10 (OSBPL10)	OT0TFMBE	OSB10_HUMAN	Affects Response To Substance	[13]
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13)	OT0UOKIT	NDUAD_HUMAN	Affects Response To Substance	[13]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[13]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Response To Substance	[98]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Affects Response To Substance	[13]
Integrin beta-5 (ITGB5)	OT21MF51	ITB5_HUMAN	Decreases Response To Substance	[33]
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7)	OT2CHQQ1	NDUB7_HUMAN	Affects Response To Substance	[13]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Affects Response To Substance	[13]
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25)	OT2MR6O2	SNR25_HUMAN	Affects Response To Substance	[13]
Epidermal growth factor-like protein 6 (EGFL6)	OT331X59	EGFL6_HUMAN	Decreases Response To Substance	[16]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Affects Response To Substance	[13]
Cytidine deaminase (CDA)	OT3HXP6N	CDD_HUMAN	Affects Response To Substance	[99]
Collagen alpha-1(VII) chain (COL7A1)	OT3MIRZJ	CO7A1_HUMAN	Increases Response To Substance	[97]
Solute carrier family 12 member 2 (SLC12A2)	OT3ZJ3LH	S12A2_HUMAN	Decreases Response To Substance	[97]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)	OT4717TF	NDUB2_HUMAN	Affects Response To Substance	[13]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Affects Response To Substance	[13]
Deoxycytidylate deaminase (DCTD)	OT4FLFT4	DCTD_HUMAN	Affects Response To Substance	[13]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Decreases Response To Substance	[100]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Affects Response To Substance	[56]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Affects Response To Substance	[13]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Increases Response To Substance	[101]
Small ribosomal subunit protein uS15m (MRPS15)	OT5HRAPP	RT15_HUMAN	Affects Response To Substance	[13]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Affects Response To Substance	[76]
Signal recognition particle receptor subunit alpha (SRPRA)	OT5NMYTY	SRPRA_HUMAN	Affects Response To Substance	[13]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Response To Substance	[97]
Beta-sarcoglycan (SGCB)	OT5R5LAT	SGCB_HUMAN	Affects Response To Substance	[13]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Response To Substance	[16]
Transmembrane protein 135 (TMEM135)	OT63ZT3X	TM135_HUMAN	Affects Response To Substance	[13]
Farnesyl pyrophosphate synthase (FDPS)	OT6CKWV5	FPPS_HUMAN	Increases Response To Substance	[33]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Decreases Response To Substance	[33]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Response To Substance	[33]
Claudin-3 (CLDN3)	OT71MN9S	CLD3_HUMAN	Decreases Response To Substance	[97]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Affects Response To Substance	[13]
DNA-binding protein RFX5 (RFX5)	OT73KJ5P	RFX5_HUMAN	Decreases Response To Substance	[33]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Response To Substance	[102]
Large ribosomal subunit protein P1 (RPLP1)	OT7B0SIB	RLA1_HUMAN	Decreases Response To Substance	[33]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Decreases Response To Substance	[103]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Affects Response To Substance	[13]
Peroxisomal multifunctional enzyme type 2 (HSD17B4)	OT8733D7	DHB4_HUMAN	Affects Response To Substance	[13]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Response To Substance	[104]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Affects Response To Substance	[105]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Decreases Response To Substance	[106]
Transcriptional repressor CTCF (CTCF)	OT8ZB70U	CTCF_HUMAN	Decreases Response To Substance	[33]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Affects Response To Substance	[13]
Solute carrier family 22 member 18 (SLC22A18)	OT9C3KR4	S22AI_HUMAN	Decreases Response To Substance	[97]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30)	OT9DERT1	GILT_HUMAN	Decreases Response To Substance	[33]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Response To Substance	[33]
Beta-glucuronidase (GUSB)	OT9N1DK3	BGLR_HUMAN	Affects Response To Substance	[13]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Response To Substance	[33]
Proteasome subunit beta type-6 (PSMB6)	OT9VXPNW	PSB6_HUMAN	Affects Response To Substance	[13]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Affects Response To Substance	[13]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Response To Substance	[33]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)	OTA6ICI2	NUD4B_HUMAN	Affects Response To Substance	[13]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Response To Substance	[107]
Proteasome subunit alpha type-4 (PSMA4)	OTAD2XXI	PSA4_HUMAN	Affects Response To Substance	[13]
POM121 and ZP3 fusion protein (POMZP3)	OTAH2JOK	POZP3_HUMAN	Affects Response To Substance	[13]
Mediator of RNA polymerase II transcription subunit 4 (MED4)	OTALFN4S	MED4_HUMAN	Affects Response To Substance	[13]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Increases Response To Substance	[97]
Collagen alpha-3(VI) chain (COL6A3)	OTAS6R6I	CO6A3_HUMAN	Affects Response To Substance	[13]
MAP kinase-activated protein kinase 5 (MAPKAPK5)	OTAZHPVK	MAPK5_HUMAN	Affects Response To Substance	[13]
Desmoplakin (DSP)	OTB2MOP8	DESP_HUMAN	Affects Response To Substance	[13]
Large ribosomal subunit protein mL40 (MRPL40)	OTB2QZDY	RM40_HUMAN	Affects Response To Substance	[13]
Large ribosomal subunit protein uL16 (RPL10)	OTBHOZGC	RL10_HUMAN	Affects Response To Substance	[13]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Response To Substance	[108]
Probable ATP-dependent RNA helicase DDX23 (DDX23)	OTBJHS8C	DDX23_HUMAN	Affects Response To Substance	[13]
Coatomer subunit epsilon (COPE)	OTBKHBT7	COPE_HUMAN	Affects Response To Substance	[13]
Protein FAM3C (FAM3C)	OTBR6U9G	FAM3C_HUMAN	Affects Response To Substance	[13]
Transmembrane protein 134 (TMEM134)	OTBX9H9D	TM134_HUMAN	Affects Response To Substance	[13]
Tight junction protein ZO-3 (TJP3)	OTC1K8HC	ZO3_HUMAN	Decreases Response To Substance	[97]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Affects Response To Substance	[109]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Affects Response To Substance	[13]
Cytochrome c oxidase copper chaperone (COX17)	OTCP4LH2	COX17_HUMAN	Affects Response To Substance	[13]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Response To Substance	[33]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Affects Response To Substance	[13]
Integrin alpha-1 (ITGA1)	OTDITIST	ITA1_HUMAN	Increases Response To Substance	[16]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Affects Response To Substance	[110]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[13]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Decreases Response To Substance	[33]
Superkiller complex protein 8 (SKIC8)	OTDSQYDN	SKI8_HUMAN	Affects Response To Substance	[13]
DNA-binding protein RFXANK (RFXANK)	OTDX1026	RFXK_HUMAN	Affects Response To Substance	[13]
Transcription initiation factor TFIID subunit 1 (TAF1)	OTDYS5G4	TAF1_HUMAN	Affects Response To Substance	[111]
EF-hand calcium-binding domain-containing protein 7 (EFCAB7)	OTE0EG10	EFCB7_HUMAN	Affects Response To Substance	[13]
Glucose-6-phosphate isomerase (GPI)	OTEGSRXG	G6PI_HUMAN	Affects Response To Substance	[13]
GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)	OTEOT8GI	GFRP_HUMAN	Decreases Response To Substance	[97]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)	OTESFZSO	PTN13_HUMAN	Increases Response To Substance	[97]
Rho GDP-dissociation inhibitor 1 (ARHGDIA)	OTEXWJDO	GDIR1_HUMAN	Affects Response To Substance	[112]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Response To Substance	[33]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Affects Response To Substance	[13]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)	OTFBU4GD	P3C2A_HUMAN	Affects Response To Substance	[13]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Increases Response To Substance	[16]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Affects Response To Substance	[13]
Cytotoxic granule associated RNA binding protein TIA1 (TIA1)	OTGPN3P8	TIA1_HUMAN	Affects Response To Substance	[13]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Affects Response To Substance	[13]
Gasdermin-D (GSDMD)	OTH39BKI	GSDMD_HUMAN	Affects Response To Substance	[56]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Affects Response To Substance	[13]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Increases Response To Substance	[15]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Response To Substance	[113]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Response To Substance	[33]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Decreases Response To Substance	[114]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Affects Response To Substance	[13]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Affects Response To Substance	[13]
Polycystin-2 (PKD2)	OTIXBU8H	PKD2_HUMAN	Increases Response To Substance	[97]
G/T mismatch-specific thymine DNA glycosylase (TDG)	OTJB0YIH	TDG_HUMAN	Affects Response To Substance	[13]
E3 ubiquitin-protein ligase FANCL (FANCL)	OTJC7QPQ	FANCL_HUMAN	Affects Response To Substance	[13]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Decreases Response To Substance	[97]
Transmembrane protein 168 (TMEM168)	OTJKZ6G9	TM168_HUMAN	Affects Response To Substance	[13]
Plakophilin-2 (PKP2)	OTJOVF68	PKP2_HUMAN	Decreases Response To Substance	[97]
C-X-C chemokine receptor type 6 (CXCR6)	OTK9R50G	CXCR6_HUMAN	Decreases Response To Substance	[33]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Increases Response To Substance	[97]
NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1)	OTKBUQXP	NDUA1_HUMAN	Affects Response To Substance	[13]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Increases Response To Substance	[97]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases ADR	[5]
Galectin-4 (LGALS4)	OTKQCG0H	LEG4_HUMAN	Decreases Response To Substance	[97]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Affects Response To Substance	[13]
Leukocyte surface antigen CD47 (CD47)	OTLDZ0KZ	CD47_HUMAN	Decreases Response To Substance	[33]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Affects Response To Substance	[13]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Response To Substance	[98]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Response To Substance	[15]
Peptidyl-prolyl cis-trans isomerase B (PPIB)	OTLPH6KN	PPIB_HUMAN	Affects Response To Substance	[13]
Annexin A8 (ANXA8)	OTLSSQCY	ANXA8_HUMAN	Increases Response To Substance	[97]
Keratin, type II cytoskeletal 7 (KRT7)	OTLT3JFN	K2C7_HUMAN	Increases Response To Substance	[97]
Lysosome-associated membrane glycoprotein 2 (LAMP2)	OTLUGEJC	LAMP2_HUMAN	Affects Response To Substance	[13]
Peroxiredoxin-2 (PRDX2)	OTLWCY9T	PRDX2_HUMAN	Affects Response To Substance	[13]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Response To Substance	[16]
Furin (FURIN)	OTM2665Z	FURIN_HUMAN	Decreases Response To Substance	[33]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8)	OTMEAWKO	NDUS8_HUMAN	Affects Response To Substance	[13]
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8)	OTMFG2YY	ALG8_HUMAN	Affects Response To Substance	[13]
Glutathione S-transferase Mu 5 (GSTM5)	OTMMBFY8	GSTM5_HUMAN	Decreases Response To Substance	[33]
Unconventional myosin-Va (MYO5A)	OTMWLP3E	MYO5A_HUMAN	Increases Response To Substance	[97]
Integral membrane protein 2B (ITM2B)	OTMXEPXB	ITM2B_HUMAN	Affects Response To Substance	[13]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2)	OTMZD4PW	SUCB1_HUMAN	Affects Response To Substance	[13]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Response To Substance	[97]
L-lactate dehydrogenase A chain (LDHA)	OTN7K4XB	LDHA_HUMAN	Increases Response To Substance	[115]
Proto-oncogene serine/threonine-protein kinase mos (MOS)	OTNMQPFJ	MOS_HUMAN	Increases ADR	[5]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases ADR	[5]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1)	OTNYXOZO	KCMA1_HUMAN	Affects Response To Substance	[13]
G-protein coupled receptor 35 (GPR35)	OTO23NRK	GPR35_HUMAN	Decreases Response To Substance	[97]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Response To Substance	[97]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Response To Substance	[116]
Arginine/serine-rich protein 1 (RSRP1)	OTOAZLCL	RSRP1_HUMAN	Affects Response To Substance	[13]
Malectin (MLEC)	OTOPGRF5	MLEC_HUMAN	Affects Response To Substance	[13]
Oncostatin-M-specific receptor subunit beta (OSMR)	OTORWHPL	OSMR_HUMAN	Increases Response To Substance	[97]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Decreases Response To Substance	[117]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Affects Response To Substance	[13]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Affects Response To Substance	[13]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[13]
Prostaglandin E synthase 3 (PTGES3)	OTPPQWI0	TEBP_HUMAN	Affects Response To Substance	[13]
Large ribosomal subunit protein uL23 (RPL23A)	OTPYLCCX	RL23A_HUMAN	Decreases Response To Substance	[33]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Increases Response To Substance	[33]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Increases Response To Substance	[97]
Membrane cofactor protein (CD46)	OTQ8NWJD	MCP_HUMAN	Increases Response To Substance	[33]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)	OTQBDO45	GFPT1_HUMAN	Decreases Response To Substance	[97]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Response To Substance	[118]
MAPK/MAK/MRK overlapping kinase (MOK)	OTQK7M9V	MOK_HUMAN	Affects Response To Substance	[13]
Keratin, type I cytoskeletal 23 (KRT23)	OTQW6UAG	K1C23_HUMAN	Increases Response To Substance	[16]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Affects Response To Substance	[13]
Solute carrier family 22 member 3 (SLC22A3)	OTQYGVXX	S22A3_HUMAN	Affects Response To Substance	[13]
Nuclear body protein SP140 (SP140)	OTQZHFMT	SP140_HUMAN	Affects Response To Substance	[13]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Response To Substance	[16]
E3 ubiquitin-protein ligase CHFR (CHFR)	OTRAD2TT	CHFR_HUMAN	Decreases Response To Substance	[119]
Large ribosomal subunit protein mL63 (MRPL57)	OTRB659E	RT63_HUMAN	Affects Response To Substance	[13]
Protein CREG1 (CREG1)	OTRHJ8HK	CREG1_HUMAN	Affects Response To Substance	[13]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)	OTRHPFO2	AN32A_HUMAN	Affects Response To Substance	[13]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Increases Response To Substance	[97]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Response To Substance	[97]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Response To Substance	[97]
Arrestin-C (ARR3)	OTRZ00CH	ARRC_HUMAN	Decreases Response To Substance	[33]
MHC class I polypeptide-related sequence B (MICB)	OTS2DVDW	MICB_HUMAN	Increases Response To Substance	[97]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Affects Response To Substance	[13]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)	OTS9YK3E	KCC2B_HUMAN	Affects Response To Substance	[13]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Response To Substance	[16]
Rhotekin (RTKN)	OTSS8XR6	RTKN_HUMAN	Decreases Response To Substance	[120]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Decreases Response To Substance	[104]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Affects Response To Substance	[13]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Response To Substance	[16]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Affects Response To Substance	[13]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Response To Substance	[121]
Amyloid beta precursor like protein 2 (APLP2)	OTTFE53M	APLP2_HUMAN	Affects Response To Substance	[13]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Decreases Response To Substance	[16]
Fascin (FSCN1)	OTTGIHTM	FSCN1_HUMAN	Increases Response To Substance	[97]
Keratin, type I cytoskeletal 13 (KRT13)	OTTYSKGX	K1C13_HUMAN	Decreases Response To Substance	[33]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Decreases Response To Substance	[122]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Response To Substance	[33]
N-acetylgalactosaminyltransferase 7 (GALNT7)	OTUJSCAO	GALT7_HUMAN	Affects Response To Substance	[13]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)	OTUUNQBT	DAD1_HUMAN	Increases ADR	[5]
Mitochondrial Rho GTPase 2 (RHOT2)	OTV8WT2L	MIRO2_HUMAN	Affects Response To Substance	[13]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Decreases Response To Substance	[16]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Increases Response To Substance	[15]
Integrin beta-1-binding protein 1 (ITGB1BP1)	OTVQFNGS	ITBP1_HUMAN	Affects Response To Substance	[13]
U2 small nuclear ribonucleoprotein A' (SNRPA1)	OTWJZFAP	RU2A_HUMAN	Affects Response To Substance	[13]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Response To Substance	[16]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Response To Substance	[16]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Response To Substance	[123]
Transmembrane protein 59 (TMEM59)	OTX4EKES	TMM59_HUMAN	Affects Response To Substance	[13]
Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)	OTX8SZOT	NUD15_HUMAN	Affects Response To Substance	[13]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Response To Substance	[33]
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3)	OTXL10N9	NDUA3_HUMAN	Affects Response To Substance	[13]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Affects Response To Substance	[105]
Neuroendocrine protein 7B2 (SCG5)	OTXSJMT1	7B2_HUMAN	Affects Response To Substance	[13]
Peripheral myelin protein 22 (PMP22)	OTXWYWCZ	PMP22_HUMAN	Decreases Response To Substance	[33]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Response To Substance	[16]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Increases Response To Substance	[33]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Affects Response To Substance	[13]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Decreases Response To Substance	[33]
Proteasome subunit beta type-1 (PSMB1)	OTYRFBAH	PSB1_HUMAN	Affects Response To Substance	[13]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Increases Response To Substance	[33]
ADP-ribosylation factor 3 (ARF3)	OTYYQX85	ARF3_HUMAN	Affects Response To Substance	[13]
V-type proton ATPase catalytic subunit A (ATP6V1A)	OTYZ2S9E	VATA_HUMAN	Affects Response To Substance	[13]
Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13)	OTYZQJD3	TIM13_HUMAN	Affects Response To Substance	[13]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Decreases Response To Substance	[124]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[13]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Affects Response To Substance	[13]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Affects Response To Substance	[13]

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