Details of the Drug Combination

General Information of Drug Combination (ID: DCYXAKJ)

Drug Combination Name
Cefpodoxime Azithromycin
Indication
Disease Entry Status REF
Microbiota Phase 1 [1]
Component Drugs Cefpodoxime   DMJUNY5 Azithromycin   DMS6UOE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cefpodoxime
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [2]
Acute maxillary sinusitis N.A. Approved [2]
Acute otitis media AB00 Approved [2]
Bacterial infection 1A00-1C4Z Approved [3]
Pars planitis N.A. Approved [2]
Staphylococcus aureus infection N.A. Approved [2]
Streptococcal pneumonia N.A. Approved [2]
Cefpodoxime Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Penicillin binding protein (Bact PBP) TTJP4SM NOUNIPROTAC Binder [7]
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Cefpodoxime Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [8]
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Cefpodoxime Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Beta-lactamase (blaB) DEQAG48 A0A3Q9VXP1_CITAM Metabolism [9]
Beta-lactamase (blaB) DEEQ3RW K0GG60_CITBR Metabolism [9]
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Indication(s) of Azithromycin
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [4]
Bronchitis CA20 Approved [5]
Chancroid N.A. Approved [4]
Mycoplasma pneumoniae pneumonia N.A. Approved [4]
Staphylococcus aureus infection N.A. Approved [4]
Streptococcal pneumonia N.A. Approved [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [6]
Pneumonia caused by chlamydia N.A. Investigative [4]

References

1 ClinicalTrials.gov (NCT03098485) Healthy Patients & Effect of Antibiotics
2 Cefpodoxime FDA Label
3 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
4 Azithromycin FDA Label
5 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 065511.
6 ClinicalTrials.gov (NCT04332107) Azithromycin for COVID-19 Treatment in Outpatients Nationwide. U.S. National Institutes of Health.
7 Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseri... Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45.
8 Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
9 Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60.