Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT9G7XN)

• DTP Name: Peptide transporter 1 (SLC15A1)
• Gene Name: SLC15A1
• UniProt ID: P46059 (S15A1_HUMAN)
• VARIDT ID: DTD0021
• Synonyms: HPECT1; HPEPT1; Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; PEPT1; SLC15A1; Solute carrier family 15 member 1
• DTP Family: Proton-Dependent Oligopeptide Transporter (POT/PTR) Family
• Sequence:
  MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFV
  ALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPV
  HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTII
  TPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCI
  GFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQ
  GSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKK
  MAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP
  MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQK
  PEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQ
  PNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSV
  TGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVC
  VIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
• Function: This tranporter mediates intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides and may constitute a major route for the absorption of protein digestion end-products.
• Endogenous Substrate(s): H+
• TCDB ID: 2.A.17.4.9
• Gene ID: 6564
• Reactome Pathway: Proton/oligopeptide cotransporters (R-HSA-427975)

Molecular Interaction Atlas (MIA) of This DTP

52 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[4]
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[5]
Ampicillin	DMHWE7P	Bacterial infection	1A00-1C4Z	Approved	[6]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[7]
Bestatin	DM8L9D4	Acute myeloid leukaemia	2A60	Approved	[8]
Captopril	DM458UM	Hypertension	BA00-BA04	Approved	[9]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[10]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[11]
Cefamandole	DMNEXZF	Microorganisms infection	1A00-1A09	Approved	[12]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[13]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[14]
Cefixime	DMY60I8	Bacterial infection	1A00-1C4Z	Approved	[15]
Cefmetazole	DM42W1B	Bacterial infection	1A00-1C4Z	Approved	[12]
Cefoxitin	DMYTXVR	Bacterial infection	1A00-1C4Z	Approved	[13]
Cefpodoxime	DMJUNY5	Bacterial infection	1A00-1C4Z	Approved	[13]
Cefradine	DMUNSWV	Bacterial infection	1A00-1C4Z	Approved	[16]
Cefsulodin	DMQXLF3	Pseudomonas infection	1B92	Approved	[12]
Ceftibuten	DMWV2AG	Chronic bronchitis	CA20.1	Approved	[17]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[12]
Cefuroxime axetil	DM4CHN0	Bacterial infection	1A00-1C4Z	Approved	[12]
Cephalexin	DMD5JU8	Bacterial infection	1A00-1C4Z	Approved	[18]
Cephaloglycin	DMYZITL	Bacterial infection	1A00-1C4Z	Approved	[19]
Cyclacillin	DMHSJB4	Bacterial infection	1A00-1C4Z	Approved	[20]
Dexamethasone	DMMWZET	Rheumatoid arthritis	FA20	Approved	[21]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[20]
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[22]
Enalaprilat	DMPRBQV	Hypertension	BA00-BA04	Approved	[23]
Eprosartan	DM07K2I	Hypertension	BA00-BA04	Approved	[11]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[13]
Fosinopril	DM9NJ52	Hypertension	BA00-BA04	Approved	[7]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[21]
Irbesartan	DMTP1DC	Hypertension	BA00-BA04	Approved	[11]
Lisdexamfetamine	DM6W8V5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[24]
Lisinopril	DMUOK4C	Hypertension	BA00-BA04	Approved	[21]
Losartan	DM72JXH	Hypertension	BA00-BA04	Approved	[11]
Metoprolol	DMOJ0V6	Hypertension	BA00-BA04	Approved	[21]
Midodrine	DME2PY5	Orthostatic hypotension	BA21	Approved	[20]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[7]
Oseltamivir	DMGO72P	Influenza virus infection	1E30-1E32	Approved	[25]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[7]
Piperacillin	DMTBKF3	Bacterial infection	1A00-1C4Z	Approved	[13]
Ramipril	DM2R68E	Congestive heart failure	BD10	Approved	[7]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[26]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[7]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[21]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[27]
Temocapril	DM1A79H	High blood pressure	BA00	Approved	[28]
Temocaprilate	DMNX2QI	High blood pressure	BA00	Approved	[23]
Trandolapril	DM4L6EU	Hypertension	BA00-BA04	Approved	[7]
Valaciclovir	DMHKS94	Virus infection	1A24-1D9Z	Approved	[29]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[30]
Valsartan	DMREUQ6	Hypertension	BA00-BA04	Approved	[11]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[31]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[12]
Ceronapril	DMFBNI6	Major depressive disorder	6A70.3	Discontinued in Phase 2	[19]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metampicillin	DMQW5MH	Bacterial infection	1A00-1C4Z	Preclinical	[20]
QSP	DMASVOD	Fracture	ND56	Preclinical	[32]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carnosine	DMFYCB4	Discovery agent	N.A.	Investigative	[33]
NAAG	DMFGOW0	Discovery agent	N.A.	Investigative	[34]

Molecular Expression Atlas (MEA) of This DTP

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	7.54E-01	-1.25E-02	-8.78E-02
Adrenocortical carcinoma	2D11.Z	Kidney	9.62E-01	1.33E-02	9.34E-02
Alopecia	ED70	Skin from scalp	6.41E-03	-1.19E-01	-3.25E-01
Alzheimer's disease	8A20	Entorhinal cortex	4.57E-01	2.15E-02	1.72E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	4.91E-01	-4.60E-02	-4.22E-01
Aortic stenosis	BB70	Calcified aortic valve	7.50E-01	8.49E-02	1.64E-01
Apnea	7A40	Hyperplastic tonsil	7.98E-03	-4.79E-01	-1.92E+00
Arthropathy	FA00-FA5Z	Peripheral blood	5.85E-01	5.23E-03	5.13E-02
Asthma	CA23	Nasal and bronchial airway	3.70E-03	3.25E-01	6.33E-01
Atopic dermatitis	EA80	Skin	1.01E-02	-1.27E-01	-5.15E-01
Autism	6A02	Whole blood	1.71E-01	-6.13E-02	-2.67E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.65E-01	2.48E-01	9.96E-01
Autosomal dominant monocytopenia	4B04	Whole blood	7.66E-01	7.58E-02	5.54E-01
Bacterial infection of gingival	1C1H	Gingival tissue	2.55E-10	-3.14E-01	-8.42E-01
Batten disease	5C56.1	Whole blood	6.05E-01	-7.58E-03	-7.96E-02
Behcet's disease	4A62	Peripheral blood	4.94E-01	8.49E-02	6.54E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	5.18E-01	-3.24E-02	-2.35E-01
Bladder cancer	2C94	Bladder tissue	1.43E-04	6.43E-01	2.61E+00
Breast cancer	2C60-2C6Z	Breast tissue	6.30E-01	-4.57E-02	-1.74E-01
Cardioembolic stroke	8B11.20	Whole blood	1.45E-03	-1.88E-01	-7.59E-01
Cervical cancer	2C77	Cervical tissue	2.84E-04	-7.15E-01	-1.37E+00
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	4.31E-02	9.52E-02	6.09E-01
Chronic hepatitis C	1E51.1	Whole blood	4.46E-01	1.91E-02	1.16E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	8.28E-01	2.72E-02	1.72E-01
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	9.20E-01	2.66E-02	1.51E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	2.96E-01	3.29E-02	3.09E-01
Colon cancer	2B90	Colon tissue	2.26E-13	-3.30E-01	-6.83E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	1.72E-02	-1.88E-01	-2.37E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	4.26E-01	-7.99E-02	-5.90E-01
Endometriosis	GA10	Endometrium tissue	1.60E-03	4.78E-02	8.61E-02
Familial hypercholesterolemia	5C80.00	Peripheral blood	8.40E-01	9.36E-03	8.70E-02
Familial hypercholesterolemia	5C80.00	Whole blood	2.06E-08	-2.55E-01	-1.20E+00
Gastric cancer	2B72	Gastric tissue	4.43E-01	-9.42E-02	-4.71E-01
Glioblastopma	2A00.00	Nervous tissue	7.91E-20	-1.08E-01	-4.95E-01
Glioma	2A00.0Y-2A00.0Z	White matter tissue	3.18E-02	-2.81E-01	-5.64E-01
Head and neck cancer	2D42	Head and neck tissue	2.94E-07	1.87E-01	6.51E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	6.42E-01	-1.94E-02	-1.21E-01
Huntington's disease	8A01.10	Whole blood	1.34E-01	-8.16E-02	-5.38E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	8.20E-01	-2.45E-02	-1.48E-01
Immunodeficiency	4A00-4A20	Peripheral blood	1.71E-01	-5.24E-02	-7.18E-01
Influenza	1.00E+30	Whole blood	1.57E-03	4.03E-01	5.12E+00
Interstitial cystitis	GC00.3	Bladder tissue	9.85E-02	9.09E-02	2.10E+00
Intracranial aneurysm	8B01.0	Intracranial artery	4.95E-01	7.97E-02	3.40E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	5.95E-01	-4.54E-02	-8.40E-02
Ischemic stroke	8B11	Peripheral blood	6.82E-01	3.14E-02	1.95E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	5.61E-01	9.60E-03	5.00E-02
Lateral sclerosis	8B60.4	Cervical spinal cord	6.49E-01	-9.41E-02	-3.92E-01
Lateral sclerosis	8B60.4	Skin	5.01E-01	1.44E-02	1.27E-01
Liver cancer	2C12.0	Liver tissue	5.86E-03	-1.33E-01	-3.55E-01
Liver failure	DB99.7-DB99.8	Liver tissue	5.97E-03	-3.24E-01	-4.09E+00
Lung cancer	2C25	Lung tissue	3.38E-39	1.68E-01	1.05E+00
Lupus erythematosus	4A40	Whole blood	5.97E-05	7.35E-02	2.41E-01
Major depressive disorder	6A70-6A7Z	Whole blood	8.98E-01	7.59E-03	3.18E-02
Major depressive disorder	6A70-6A7Z	Hippocampus	6.91E-01	8.30E-03	7.24E-02
Melanoma	2C30	Skin	3.63E-04	-1.57E+00	-1.20E+00
Multiple myeloma	2A83.1	Bone marrow	7.60E-03	-2.12E-01	-1.22E+00
Multiple myeloma	2A83.1	Peripheral blood	2.32E-01	4.19E-02	3.72E-01
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	3.21E-01	-1.66E-01	-8.74E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	1.77E-01	7.03E-03	8.68E-02
Myelofibrosis	2A20.2	Whole blood	8.39E-01	6.47E-03	7.08E-02
Myocardial infarction	BA41-BA50	Peripheral blood	4.40E-01	1.28E-01	1.52E-01
Myopathy	8C70.6	Muscle tissue	9.01E-02	-9.48E-02	-8.24E-01
Neonatal sepsis	KA60	Whole blood	2.21E-02	4.49E-02	2.53E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	6.33E-02	-2.95E-01	-9.56E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	5.29E-01	1.26E-02	4.98E-02
Obesity related type 2 diabetes	5A11	Omental adipose tissue	2.60E-01	-7.43E-02	-1.15E+00
Olive pollen allergy	CA08.00	Peripheral blood	5.91E-01	1.93E-01	7.08E-01
Oral cancer	2B6E	Oral tissue	7.13E-01	-1.44E-01	-5.69E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	2.44E-01	-5.55E-01	-1.29E+00
Osteoporosis	FB83.1	Bone marrow	1.92E-02	3.03E-01	3.20E+00
Ovarian cancer	2C73	Ovarian tissue	1.94E-01	1.56E-04	6.10E-04
Pancreatic cancer	2C10	Pancreas	2.33E-02	-4.57E-01	-8.68E-01
Parkinson's disease	8A00.0	Substantia nigra tissue	1.74E-01	-8.96E-02	-5.59E-01
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	3.64E-01	-6.25E-02	-4.95E-01
Pituitary cancer	2D12	Pituitary tissue	8.20E-02	1.96E-01	9.40E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	3.49E-01	1.64E-01	7.68E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	8.18E-01	-5.00E-02	-5.59E-01
Polycythemia vera	2A20.4	Whole blood	4.82E-03	7.08E-02	6.37E-01
Pompe disease	5C51.3	Biceps muscle	8.69E-02	-7.68E-02	-1.03E+00
Preterm birth	KA21.4Z	Myometrium	4.60E-01	-7.84E-02	-2.96E-01
Prostate cancer	2C82	Prostate	1.31E-04	5.67E-01	1.00E+00
Psoriasis	EA90	Skin	4.78E-28	6.76E-01	1.50E+00
Rectal cancer	2B92	Rectal colon tissue	6.98E-02	-5.31E-01	-1.46E+00
Renal cancer	2C90-2C91	Kidney	2.56E-01	-3.85E-01	-9.21E-01
Retinoblastoma	2D02.2	Uvea	8.27E-01	9.03E-03	8.47E-02
Rheumatoid arthritis	FA20	Synovial tissue	4.41E-04	-7.89E-01	-2.51E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	3.82E-01	-2.23E-02	-1.99E-01
Schizophrenia	6A20	Prefrontal cortex	2.28E-01	-5.07E-02	-2.49E-01
Schizophrenia	6A20	Superior temporal cortex	9.68E-01	5.37E-02	5.24E-01
Scleroderma	4A42.Z	Whole blood	1.67E-05	2.89E-01	2.55E+00
Seizure	8A60-8A6Z	Whole blood	4.59E-01	-5.37E-02	-3.81E-01
Sensitive skin	EK0Z	Skin	8.33E-01	-4.90E-02	-4.03E-01
Sepsis with septic shock	1G41	Whole blood	2.36E-05	3.31E-02	1.64E-01
Shwachman-Diamond syndrome	3A70.0	Bone marrow	3.09E-01	2.24E-01	1.28E+00
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	4.58E-01	-1.87E-02	-1.30E-01
Simpson golabi behmel syndrome	LD2C	Adipose tissue	6.78E-01	4.53E-02	3.86E-01
Sjogren's syndrome	4A43.2	Salivary gland tissue	4.21E-01	-1.77E-01	-1.30E+00
Skin cancer	2C30-2C3Z	Skin	1.12E-25	-1.01E+00	-1.49E+00
Thrombocythemia	3B63	Whole blood	3.49E-01	4.47E-03	4.96E-02
Thrombocytopenia	3B64	Whole blood	6.44E-01	4.48E-02	1.51E-01
Thyroid cancer	2D10	Thyroid	4.52E-03	5.05E-02	2.20E-01
Tibial muscular dystrophy	8C75	Muscle tissue	1.45E-04	-1.96E-01	-1.71E+00
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.42E-01	1.17E-01	6.61E-01
Type 2 diabetes	5A11	Liver tissue	7.75E-01	7.79E-02	3.48E-01
Ureter cancer	2C92	Urothelium	7.36E-01	6.01E-03	3.44E-02
Uterine cancer	2C78	Endometrium tissue	2.25E-09	-2.86E-01	-3.05E-01
Vitiligo	ED63.0	Skin	7.61E-01	9.29E-02	2.28E-01

Drug Affinity of This DTP Assessed by Cell Line

Approved Drug(s)

Drug Name	Highest Status	Cell Line	Affinity	REF
Aminolevulinic acid hci	Approved	Oocytes-PEPT1	Km = 394 microM	[35]
Aminolevulinic acid hci	Approved	Oocytes-PEPT1	Km = 1600 microM	[4]
Bestatin	Approved	Human enterocyte-like 2 cells (Caco-2)-PEPT1	Km = 340 microM	[8]
Cefadroxil	Approved	Human cervical cancer cell line (Hela)-PEPT1	Km = 7.97 microM	[11]
Cephalexin	Approved	Human enterocyte-like 2 cells (Caco-2)-PEPT1	Km = 7.97 microM	[36]
Oseltamivir	Approved	Human cervical cancer cell line (Hela)-PEPT1	Km = 8590 microM	[25]
Oseltamivir	Approved	Human enterocyte-like 2 cells (Caco-2)-PEPT1	Km = 6540 microM	[25]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 1640 microM	[37]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 2200 microM	[38]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 2700 microM	[38]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 5400 microM	[38]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 6600 microM	[38]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 7400 microM	[38]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 2.2 microM	[39]
Valaciclovir	Approved	Chinese hamster ovary (CHO) cells-PEPT1	Km = 7.4 microM	[39]
Valaciclovir	Approved	Human enterocyte-like 2 cells (Caco-2)-PEPT1	Km = 292 microM	[40]
Valaciclovir	Approved	Madin-Darby canine kidney (MDCK) cells-PEPT1	Km = 3.8 microM	[39]
Valaciclovir	Approved	Oocytes-PEPT1	Km = 5940 microM	[41]
Valaciclovir	Approved	Xenopus oocytes-PEPT1	Km = 5.9 microM	[39]

The Drug Therapeutic Target (DTT) Role of This DTP

• DTP DTT Name: Solute carrier family 15 member 1 (SLC15A1) DTT Info
• DTP DTT Type: Literature-reported

5 Investigative Drug(s) Targeting This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4-AMBA	DMYNASR	Discovery agent	N.A.	Investigative	[1]
Lys[Z(NO2)]-Pro	DMJX4GA	Discovery agent	N.A.	Investigative	[2]
[11C]GlySar	DM5Q08F	Discovery agent	N.A.	Investigative	[3]
[14C]GlySar	DMGLQ72	Discovery agent	N.A.	Investigative	[3]
[3H]GlySar	DMFEYLS	Discovery agent	N.A.	Investigative	[3]

References

• [1] Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr. 2005 Jun;135(6):1491-5.
• [2] A novel inhibitor of the mammalian peptide transporter PEPT1. Biochemistry. 2001 Apr 10;40(14):4454-8.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984).
• [4] Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther. 2010 Jan;332(1):220-8.
• [5] Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
• [6] Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
• [7] Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41.
• [8] Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol. 1993 Aug;265(2 Pt 1):G289-94.
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