Details of the Drug Combinations

General Information of This Drug (ID: DM05FXR)

Drug Name
Meclofenamic acid   DM05FXR
Synonyms
Arquel; Meclofenamate; Acide meclofenamique; Acido meclofenamico; Acidum meclofenamicum; Meclophenamic acid; CL 583; INF 4668; Acide meclofenamique [INN-French]; Acido meclofenamico [INN-Spanish]; Acidum meclofenamicum [INN-Latin]; INF-4668; Meclomen (free acid); Meclofenamic acid (USAN/INN); Meclofenamic acid [USAN:INN:BAN]; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; 2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
Indication
Disease Entry ICD 11 Status REF
Ankylosing spondylitis FA92.0 Approved [1]
Dysmenorrhea GA34.3 Approved [2]
Joint pain ME82 Approved [1]
Menorrhagia GA20.50 Approved [2]
Osteoarthritis FA00-FA05 Approved [3]
Pain MG30-MG3Z Approved [4]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Analgesics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

41 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Meclofenamic acid DCZ05JX 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
10-hydroxycamptothecin + Meclofenamic acid DC7I819 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Acamprosate + Meclofenamic acid DCVY9NE Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Allopurinol + Meclofenamic acid DC8PDK2 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Arfolitixorin + Meclofenamic acid DCHZCKO Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Artemisinin + Meclofenamic acid DC138IF Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Asenapine + Meclofenamic acid DCIM2WL Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
BIO-300 + Meclofenamic acid DCB6QI2 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bortezomib + Meclofenamic acid DC8XXV0 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Brincidofovir + Meclofenamic acid DCZ9MOY Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cerivastatin + Meclofenamic acid DCC22EP Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Dexmedetomidine + Meclofenamic acid DC8BWUQ Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Diazoxide + Meclofenamic acid DC410PM Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Gefitinib + Meclofenamic acid DCFJEZP Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Itraconazole + Meclofenamic acid DCNKCYF Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Maprotiline + Meclofenamic acid DC8WJKK Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Methotrexate DC2DFZU Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Fomepizole DCRTD3W Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Dronedarone DCRE4SQ Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + VR-776 DCTSVE6 VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Imatinib DCDB6N4 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Darunavir DCD414O Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Moricizine DC3C1SP Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Maprotiline DCQIM2L Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Aciclovir DCI9Z1I Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Meclofenamic acid + Raltegravir DCPBZZX Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mefloquine + Meclofenamic acid DCSYOET Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Memantine + Meclofenamic acid DCSBEUQ Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Methocarbamol + Meclofenamic acid DCQFTU9 Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Methylene blue + Meclofenamic acid DCDSM75 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Miglustat + Meclofenamic acid DCD3XKS Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mycophenolic acid + Meclofenamic acid DCY0ZON Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Naltrexone + Meclofenamic acid DC075YD Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Niclosamide + Meclofenamic acid DCY7YQT Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Nizatidine + Meclofenamic acid DCBNT7A Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pinacidil + Meclofenamic acid DC6MQA8 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Pyrazinamide + Meclofenamic acid DCRKPRU Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Quinine + Meclofenamic acid DCQUSE7 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
SCH 727965 + Meclofenamic acid DCTGMPR SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Spironolactone + Meclofenamic acid DC36WTU Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Vorinostat + Meclofenamic acid DCG97F6 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
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⏷ Show the Full List of 41 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7219).
2 Use of meclofenamic acid in gynecology and obstetrics: effects on postsurgical stress. Clin J Pain. 1991;7 Suppl 1:S60-3.
3 Quantitation of indomethacin in serum and plasma using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol. 2010;603:297-305.
4 Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer. Front Oncol. 2022 Apr 21;12:870636.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.