Details of the Drug Combinations

General Information of This Drug (ID: DM0798Z)

Drug Name

NLG8189 DM0798Z

Synonyms

1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 2/3	[1]
Pancreatic cancer	2C10	Phase 2	[1]
Prostate cancer	2C82.0	Phase 2	[1]
Acute myeloid leukaemia	2A60	Phase 1	[1]
Brain cancer	2A00	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
NLG8189 + Docetaxel	DCN59VF	Docetaxel	Unspecified Adult Solid Tumor, Protocol Specific	[2]
NLG8189 + Docetaxel	DCDJZEC	Docetaxel	Non-small Cell Lung Cancer	[3]
NLG8189 + Temozolomide	DCS0C1F	Temozolomide	Glioblastoma Multiforme	[4]
Temozolomide + NLG8189	DC2GZ2I	Temozolomide	Brain cancer	[5]
NLG8189 + Temozolomide	DCFCWYM	Temozolomide	Glioblastoma	[6]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT01191216) 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors
3	ClinicalTrials.gov (NCT02460367) Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancer
4	ClinicalTrials.gov (NCT02052648) Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	ClinicalTrials.gov (NCT04049669) Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG