Details of the Drug

General Information of Drug (ID: DM0798Z)

• Drug Name: NLG8189
• Synonyms: 1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 2/3	[1]
Pancreatic cancer	2C10	Phase 2	[1]
Prostate cancer	2C82.0	Phase 2	[1]
Acute myeloid leukaemia	2A60	Phase 1	[1]
Brain cancer	2A00	Phase 1	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 218.25
  Logarithm of the Partition Coefficient (xlogp); -1.3
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C12H14N2O2
  IUPAC Name: (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
  Canonical SMILES: CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
  InChI: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
  InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N
• Cross-matching ID:
  PubChem CID: 405012
  CAS Number: 110117-83-4
  DrugBank ID: DB12827
  TTD ID: D0B5HS
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Indoleamine 2,3-dioxygenase 1 (IDO1)	TTZJYKH	I23O1_HUMAN	Inhibitor	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)