Details of the Drug Combinations

General Information of This Drug (ID: DM0GUSX)

• Drug Name: Ranitidine (DM0GUSX)
• Synonyms: Achedos; Acidex; Alquen; Atural; Axoban; Biotidin; Coralen; Curan; Duractin; Ezopta; Fendibina; Gastrial; Gastridina; Gastrolav; Gastrosedol; Istomar; Kuracid; Logast; Mauran; Melfax; Microtid; Noctone; Ptinolin; Quantor; Quicran; RND; Radinat; Randin; Raniben; Raniberl; Ranibloc; Ranidine; Ranifur; Ranin; Raniogas; Raniplex; Ranisen; Raniter; Ranitidin; Ranitidina; Ranitidinum; Ranitiget; Ranitin; Rantacid; Rantidine; Ratic; Raticina; Sampep; Sostril; Taural; Terposen; Ulceranin; Ulcex; Ultidine; Urantac; Verlost; Vesyca; Vizerul; Weichilin; Weidos; Xanidine; ZANTAC; Zantab; Zantadin; Zantic; Ranitidine HCL; Rantidine HCL; Nu-Ranit; Rani-Q; Rani-nerton; Ranitidina [INN-Spanish]; Ranitidine (TN); Ranitidinum [INN-Latin]; Ul-Pep; Zantac (TN); Ranitidine (USAN/INN); Ranitidine [USAN:BAN:INN]; N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; (E)-1-N'-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine; (E)-N-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine; (E)-N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1,1-diamine

Indication

Gastric ulcer; ICD 11: DA60; Status: Approved [1]; Gastrinoma; ICD 11: 2C10.1; Status: Approved [1]; Peptic ulcer; ICD 11: DA61; Status: Approved [2]

• Therapeutic Class: Antiulcer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ranitidine + Omeprazole	DCOLNCA	Omeprazole	Cough	[3]
Ranitidine + Vandetanib	DCRLAF7	Vandetanib	Medullary Thyroid Cancer	[4]
Ranitidine + Fostamatinib	DC5B6G0	Fostamatinib	Pharmacokinetics	[5]
Ranitidine + Omeprazole	DC5KN8C	Omeprazole	Eustachian Tube Dysfunction	[6]

References

• [1] Ranitidine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1234).
• [3] ClinicalTrials.gov (NCT00668317) Bronchial Hyper-responsiveness in Reflux Cough
• [4] ClinicalTrials.gov (NCT01539655) Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib
• [5] ClinicalTrials.gov (NCT01682408) Assess Pharmacokinetics of Fostamatinib in Fed and Fasted State in Combination With Ranitidine to Assess Bioavailability
• [6] ClinicalTrials.gov (NCT02123498) The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux