General Information of This Drug (ID: DM0QV1J)

Drug Name
Baclofen   DM0QV1J
Synonyms
Arbaclofen; (R)-Baclofen; 69308-37-8; (R)-4-Amino-3-(4-chlorophenyl)butanoic acid; d-Baclofen; (-)-Baclofen; (R)-(-)-Baclofen; R-Baclofen; R-(-)-Baclofen; STX209; (3R)-4-amino-3-(4-chlorophenyl)butanoic acid; UNII-NYU6UTW25B; l-Baclofen; STX 209; (R)-4-Amino-3-(4-chlorophenyl)butyric Acid; NYU6UTW25B; CHEMBL301742; AK109161; Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-, (R)-; Benzeneporopanoic acid, (beta-(aminomethyl)-4-chloro-, (betaR)-; Arbaclofen [USAN:INN]; R-Baclofen RS; Arbaclofen (USAN); p-chlorophenyl GABA; ApoBaclofen; Atrofen; Baclofene; BaclofeneIrex; Baclofeno; Baclofenum; Baclon; Baclophen; Baclospas; Clofen; Gabalon; GenBaclofen; Genpharm; Kemstro; Lebic; Lioresal; NuBaclo; PMSBaclofen; ASTA Medica Brand of Baclofen; Alphapharm Brand of Baclofen; Apo Baclofen; Apotex Brand of Baclofen; Ashbourne Brand of Baclofen; Athena Brand of Baclofen; Baclofen AWD; Baclofen Alphapharm Brand; Baclofen Apotex Brand; Baclofen Ashbourne Brand; Baclofen Athena Brand; Baclofen Irex Brand; Baclofen Isis Brand; Baclofen Medtronic Brand; Baclofen Novartis Brand; Baclofen Pharmascience Brand; Baclofene Irex; Chlorophenyl GABA; Ciba Geigy Brand of Baclofen; Gen Baclofen; Irex Brand of Baclofen; Isis Brand of Baclofen; Lioresal Intrathecal; Medtronic Brand of Baclofen; Novartis Brand of Baclofen; Nu Baclo; Nu Pharm Brand of Baclofen; PMS Baclofen; Pharmascience Brand of Baclofen; B 5399; Ba 34647; Ba34647; C 34647Ba; AWD, Baclofen; Apo-Baclofen; Ba-34647; Ba34,647; Baclofen Ciba-Geigy Brand; Baclofen Nu-Pharm Brand; Baclofene [INN-French]; Baclofene-Irex; Baclofeno [INN-Spanish]; Baclofenum [INN-Latin]; CIBA34,647BA; Ciba-Geigy Brand of Baclofen; DL-Baclofen; GABA, Chlorophenyl; Gen-Baclofen; Kemstro (TN); Lioresal (TN); Nu-Baclo; Nu-Baclofen; Nu-Pharm Brand of Baclofen; PCP-GABA; Pms-Baclofen; Ba-34,647; Baclofen (R,S); Ciba 34,647-Ba; Baclofen (JP15/USP/INN); Baclofen [USAN:INN:BAN:JAN]; Beta-(4-Chlorophenyl)gaba; CIBA-34,647-BA; Beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; Beta-(Aminomethyl)-p-chlorohydrocinnamic acid; Beta-(p-Chlorophenyl)-gamma-aminobutyric acid; DL-4-Amino-3-p-chlorophenylbutanoic acid; Gamma-Amino-beta-(p-chlorophenyl)butyric acid; Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-(9CI); (+-)-Baclofen; (+/-)-BACLOFEN; (+/-)-beta-(Aminoethyl)-4-chlorobenzenepropanoic acid; (+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; (inverted question mark)-Baclofen; 4-Amino-3-(4-chlorophenyl)butanoic acid; 4-Amino-3-(4-chlorophenyl)butyric acid; (R)-4-Amino-3-(4-chloro-phenyl)-butyric acid
Indication
Disease Entry ICD 11 Status REF
Multiple sclerosis 8A40 Approved [1]
Fragile X syndrome LD55 Phase 3 [2]
Therapeutic Class
Muscle Relaxants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

62 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohexamide + Baclofen DCS04EG Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Allopurinol + Baclofen DCTX36I Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Anamorelin + Baclofen DCB0BEA Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Baclofen DC8UVBE Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Artemisinin + Baclofen DCDGCBO Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Atovaquone + Baclofen DCI375Z Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Aprepitant DC16T3Y Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Gefitinib DCBUQ59 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Citalopram DCSHADA Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + IT-141 DCT83O8 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Metyrosine DCJO8KJ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Carglumic acid DCWUJHZ Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + K-134 DC93QVH K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Memantine DCG0YE4 Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Niclosamide DCFKKK8 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Tiagabine DCUXLTV Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Diazoxide DC3X4VF Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Fenoprofen DC8D80N Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Maprotiline DC9XY89 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Oxyphenbutazone DCC4NKZ Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Hyodeoxycholic acid DCQSYEY Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Quinine DCYIGNV Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Lacosamide DCI27B7 Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Auranofin DCWVTLB Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Vorinostat DCKEW0J Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Cerivastatin DCJE0HQ Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Baclofen + Acetohydroxamic Acid DC4Q45X Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Baclofen DCEODI7 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Baclofen DCNLYV5 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Baclofen DC35ASV Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Baclofen DCR204S Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chloroquine + Baclofen DCUIUIU Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cycloguanil + Baclofen DCAS6MP Cycloguanil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxorubicin + Baclofen DCI1I0U Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Baclofen DCXHXN6 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Enalaprilat + Baclofen DC1UEM1 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Baclofen DCAV70W Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Estramustine + Baclofen DC5KVCN Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fibrates + Baclofen DCR9CXN Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Baclofen DCXAMUA Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
FORMESTANE + Baclofen DCQG2CN FORMESTANE Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ginsenoside Rb1 + Baclofen DCD71J9 Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Guanfacine + Baclofen DCWRC0S Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imatinib + Baclofen DC9F7EV Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Kanamycin + Baclofen DCSTZA5 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Baclofen DCMIUH1 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Lubiprostone + Baclofen DC8WGR4 Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
LY03004 + Baclofen DCU1HRF LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metaxalone + Baclofen DCODTW9 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methotrexate + Baclofen DCWY2O7 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Baclofen DCT19SN Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pargyline + Baclofen DCAY4II Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Baclofen DCM5LBK PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pinacidil + Baclofen DCIMY85 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ribavirin-TP + Baclofen DCTANI9 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rifampin + Baclofen DCRB2VL Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Teriflunomide + Baclofen DCA62QC Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Testosterone cypionate + Baclofen DCTCKIS Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + Baclofen DCZ4JOM Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Baclofen DCGMF2F Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trimethobenzamide + Baclofen DCT4NX0 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
WAY-100635 + Baclofen DC9N8SE WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 62 DrugCom(s)
5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Baclofen + Desipramine DC4796I Desipramine GERD [4]
Baclofen + Lorazepam DC6PA2K Lorazepam Alcohol Withdrawal Delirium [5]
Baclofen + Opipramol DCU5ULC Opipramol Drug Abuse [6]
Baclofen + Ibuprofen DCRC7BJ Ibuprofen Low Back Pain [7]
Diazepam + Baclofen DC0FXE9 Diazepam Alcohol Use Disorder [8]
------------------------------------------------------------------------------------

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1084).
2 ClinicalTrials.gov (NCT01706523) Open Label Extension Study of STX209 (Arbaclofen) in Autism Spectrum Disorders. U.S. National Institutes of Health.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01265550) A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
5 ClinicalTrials.gov (NCT00597701) Treating Alcohol Withdrawal With Oral Baclofen
6 ClinicalTrials.gov (NCT03065998) Double Blind Placebo Control Opipramol-Baclofen Treatment for Addiction
7 ClinicalTrials.gov (NCT03068897) Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
8 ClinicalTrials.gov (NCT03293017) Baclofen in Managing Acute Alcohol Withdrawal