Details of the Drug Combinations

General Information of This Drug (ID: DM13VTW)

Drug Name
Flucytosine   DM13VTW
Synonyms
Alcobon; Ancobon; Ancotil; Ancotyl; Flucitosina; Flucystine; Flucytosin; Flucytosinum; Flucytosone; Fluocytosine; Fluorcytosine; Fluorocytosine; Flucitosina [DCIT]; F0321; LT00771985; Ancobon (TN); Flucytosinum [INN-Latin]; GL663142 & 5FC; Ro 2-9915; Ro 29915 E/265601; Ro-2-9915; Flucytosine (JP15/USP/INN); Flucytosine [USAN:INN:BAN:JAN]; Cytosine, 5-fluoro-(6CI,7CI,8CI); GL663142 & 4-Amino-5-fluoropyrimidin-2(1H)-one; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-); 2-Hydroxy-4-amino-5-fluoropyrimidine; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 4-Amino-5-fluoro-2-hydroxypyrimidine; 4-Amino-5-fluoro-2-hyroxypyrimidine; 4-Amino-5-fluoropyrimidin-2(1H)-one; 5-FC; 5-Flucytosine; 5-Fluorocystosine; 5-Fluorocytosin; 5-Fluorocytosine; 5-Fluorocytosine-6-3H; 5-Flurocytosine; 5-fluoro cytosine; 5987P; 6-Amino-2-oxo-5-fluoropyrimidine; 6-amino-5-fluoro-1H-pyrimidin-2-one; 9074P
Indication
Disease Entry ICD 11 Status REF
Cryptococcal meningitis N.A. Approved [1]
Endocarditis BB40-BA42 Approved [2]
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Flucytosine + Idarubicin DC638RX Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Flucytosine + CHS-828 DC4JHV2 CHS-828 Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
Flucytosine + CHS-828 DCC68AB CHS-828 Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
Flucytosine + Rotenone DC1AJYO Rotenone Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
Flucytosine + Rotenone DCZ4CBC Rotenone Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
Flucytosine + Rotenone DCR1QK4 Rotenone Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
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⏷ Show the Full List of 6 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Flucytosine + Fluconazole DCUUT8M Fluconazole Cryptococcal Meningitis [4]
Flucytosine + Amphotericin B DCITR0Y Amphotericin B Cryptococcal Meningitis [5]
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References

1 Flucytosine FDA Label
2 Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01715922) Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa
5 ClinicalTrials.gov (NCT04140461) AmB Dose for Cryptococcal Meningitis