Details of the Drug Combinations

General Information of This Drug (ID: DM1YBHK)

• Drug Name: Rifabutin (DM1YBHK)
• Synonyms: Alfacid; Ansamycin; Ansatipin; Ansatipine; Assatipin; Mycobutin; RBT; Rifabutina; Rifabutine; Rifabutinum; Grunenthal Brand of Rifabutin; Kenfarma Brand of Rifabutin; Pfizer Brand of Rifabutin; Rifabutin Pfizer Brand; Rifabutina [Spanish]; Rifabutine [French]; Rifabutinum [Latin]; Antibiotic LM 427; LM 427; LM427; DRG-0085; LM-427; Mycobutin (TN); Rifabutin [USAN:BAN:INN]; Rifabutin (JAN/USP/INN); Mycobutin, Ansamycin, LM 427, Ansatipine, Rifabutin; (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,18,20-trihydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethyl-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin; Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptameth; 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV; 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S; 4-N-isobutylspiropiperidylrifamycin S

Indication

Mycobacterium infection; ICD 11: 1B10-1B21; Status: Approved [1]; Tuberculosis; ICD 11: 1B10-1B14; Status: Approved [1]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rifabutin + Panobinostat	DCR6GEW	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Rifabutin + Idarubicin	DCSDOMO	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rifabutin + Lopinavir	DC6HB95	Lopinavir	HIV	[3]
Rifabutin + Buprenorphine	DCCQ0P8	Buprenorphine	Opioid Dependency	[4]
Rifabutin + Azithromycin	DCMXYGQ	Azithromycin	Mycobacterium Avium Complex	[5]
Rifabutin + Bedaquiline	DCQ2NGW	Bedaquiline	Tuberculosis	[6]
Rifabutin + GS-9620	DCDMDVS	GS-9620	Human Immunodeficiency Virus Type 1 (HIV-1) Infection	[7]
Rifabutin + GSK1265744	DCMCEK3	GSK1265744	Infection, Human Immunodeficiency Virus	[8]
Rifabutin + Rifampicin	DC1JG10	Rifampicin	Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)	[9]
Rifabutin + Bedaquiline	DCC63N1	Bedaquiline	Tuberculosis, Pulmonary	[10]
Rifabutin + Pyrazinamide	DCRGZZB	Pyrazinamide	Pulmonary Tuberculosis	[11]
Rifabutin + Isoniazid	DC6OKQQ	Isoniazid	Tuberculosis	[12]
Rifabutin + Esomeprazole	DCA81FZ	Esomeprazole	Helicobacter Infections	[13]
Rifabutin + Vonoprazan	DC78K1O	Vonoprazan	Helicobacter Pylori Infection	[14]
Rifabutin + Nevirapine	DCKX0CV	Nevirapine	HIV Infections	[15]

References

• [1] Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT00743470) A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects
• [4] ClinicalTrials.gov (NCT00877591) Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications
• [5] ClinicalTrials.gov (NCT00598962) Use of Azithromycin and Rifabutin Administered 3 Times Weekly for the Treatment of M. Avium Complex (MAC) Lung Disease
• [6] ClinicalTrials.gov (NCT01341184) TMC207 +/- Rifabutin/Rifampin
• [7] ClinicalTrials.gov (NCT05458102) Drug-Drug Interaction Study of Vesatolimod in Adults With HIV-1 Who Have Very Low or Undetectable Virus Levels
• [8] ClinicalTrials.gov (NCT03149848) Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
• [9] ClinicalTrials.gov (NCT04630145) A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
• [10] ClinicalTrials.gov (NCT05766267) Short-course Regimens for the Treatment of Pulmonary Tuberculosis
• [11] ClinicalTrials.gov (NCT02256696) Assessing PA-824 for Tuberculosis (the APT Trial)
• [12] ClinicalTrials.gov (NCT03891901) A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin
• [13] ClinicalTrials.gov (NCT04652284) Effectiveness of Rifabutin for Treatment of Helicobacter Pylori
• [14] ClinicalTrials.gov (NCT05874544) Rescue Therapy for Helicobacter Pylori Infection
• [15] ClinicalTrials.gov (NCT02184078) Study to Determine the Effects of Nevirapine (VIRAMUNE) on the Steady State Pharmacokinetics of Rifabutin (MYCOBUTIN) in HIV+ Patients