Details of the Drug Combinations

General Information of This Drug (ID: DM2HG4X)

Drug Name
Prednisone   DM2HG4X
Synonyms
Adasone; Ancortone; Bicortone; Cartancyl; Colisone; Cortan; Cortidelt; Cotone; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dehydrocortisone; Dekortin; Dellacort; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Diadreson; Econosone; Encorton; Encortone; Enkortolon; Enkorton; Fiasone; Hostacortin; Incocortyl; Juvason; Kortancyl; Lisacort; Lodotra; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisona; Prednisonum; Prednitone; Prednizon; Prednovister; Presone; Pronison; Pronisone; Rectodelt; Retrocortine; Servisone; Sone; Sterapred; Supercortil; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid; Dellacort A; Delta E; Delta cortelan; Liquid Pred; Origen Prednisone; Prednisone Intensol; Zenadrid [veterinary]; P1276; U 6020; Apo-Prednisone; Delta E.; Delta-Cortelan; Delta-Cortisone; Delta-Cortone; Delta-Dome; Delta-E; Delta1-Cortisone; Delta1-Dehydrocortisone; Di-Adreson; In-Sone; Me-Korti; Meticortelone (TN); Meticorten (TN); Meticorten (Veterinary); Metrevet (Veterinary); Prednicen-M; Prednisona [INN-Spanish]; Prednisone [INN:BAN]; Prednisonum [INN-Latin]; SK-Prednisone; Zenadrid (veterinary); Delta(sup 1)-Cortisone; Delta(sup 1)-Dehydrocortisone; Delta(sup1)-Cortisone; Delta-1-Cortisone; Delta-1-Dehydrocortisone; Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone; (1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione; (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione; (8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione; 1,2-Dehydrocortisone; 1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione; 1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione; 1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione; 1-Cortisone; 1-Dehydrocortisone; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione; 17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
Indication
Disease Entry ICD 11 Status REF
Acute asthma CA23 Approved [1]
Addison disease 5A74.0 Approved [1]
Allergic rhinitis CA08.0 Approved [1]
Angioedema 4A00.15 Approved [1]
Autoimmune haemolytic anaemia 3A20 Approved [1]
Childhood acute lymphoblastic leukemia N.A. Approved [1]
Congenital adrenal hyperplasia 5A71.01 Approved [1]
Crohn disease DD70 Approved [1]
Dermatitis herpetiformis EB44 Approved [1]
Diamond-Blackfan anemia N.A. Approved [1]
Epicondylitis N.A. Approved [1]
Erythema multiforme N.A. Approved [1]
Inflammation 1A00-CA43.1 Approved [2]
Inflammatory bowel disease DD72 Approved [1]
Multiple sclerosis 8A40 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Plasma cell myeloma 2A83.1 Approved [1]
Polymyalgia rheumatica N.A. Approved [1]
Primary cutaneous T-cell lymphoma N.A. Approved [1]
Prostate adenocarcinoma N.A. Approved [1]
Psoriasis EA90 Approved [1]
Psoriatic arthritis FA21 Approved [1]
Rheumatic heart disease N.A. Approved [1]
Sarcoidosis 4B20.5 Approved [1]
Serum sickness N.A. Approved [1]
Skin disease EA00-EM0Z Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [1]
Systemic lupus erythematosus 4A40.0 Approved [1]
Atopic dermatitis EA80 Phase 1 [3]
Eczema EA80-EA89 Phase 1 [3]
Acquired thrombocytopenia N.A. Investigative [1]
Asthma CA23 Investigative [1]
Beta-thalassemia major N.A. Investigative [1]
Classic Hodgkin lymphoma N.A. Investigative [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Follicular lymphoma 2A80 Investigative [1]
Rheumatoid arthritis FA20 Investigative [1]
Trichinellosis N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Prednisone + Ruxolitinib DCG9TTD Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [5]
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7 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
ABIRATERONE + Prednisone DCTT9F0 ABIRATERONE Hormone-Resistant Prostate Cancer [6]
Docetaxel + Prednisone DCH4ST3 Docetaxel Prostate Cancer [7]
Methylprednisolone + Prednisone DCDDCQB Methylprednisolone IgA Nephropathy [8]
Prednisone + Dipyridamole DCLZX45 Dipyridamole Rheumatoid arthritis [9]
ABIRATERONE + Prednisone DC81FZT ABIRATERONE Castration Levels of Testosterone [10]
Cabazitaxel + Prednisone DCYV9OC Cabazitaxel Hormone-Resistant Prostate Cancer [11]
Prednisone + Tofacitinib DC7TPNO Tofacitinib Arthritis, Rheumatoid [12]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 Prednisone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7096).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Certain corticosteroid could improve severe COVID-19, say researchers. May 20, 2020
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6 ClinicalTrials.gov (NCT01503229) Abiraterone Acetate in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
7 ClinicalTrials.gov (NCT00598858) Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the Prostate
8 ClinicalTrials.gov (NCT01392833) Steroids and Azathioprine in Advanced IgAN
9 ClinicalTrials.gov (NCT01612377) Long Term Safety Trial of z102 and Prednisone in Patients With Moderate to Severe Rheumatoid Arthritis. U.S. National Institutes of Health.
10 ClinicalTrials.gov (NCT02703623) Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
11 ClinicalTrials.gov (NCT02844582) Cabazitaxel and Prednisone in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
12 ClinicalTrials.gov (NCT04928066) The Efficacy and Safety of Tofacitinib (TF) With Iguratimod (IGU) on RA